Lupron and depression

I just had my first shot of Lupron yesterday. I have an oversize uterus and will need to have it removed. I am 40 and do not plan on having any more kids, so that is cool. I am taking the shot to shrink my fibroids down to have the less invasive surgery because they are extremely huge at the moment. The same day I took the shot, I felt extremely drowsy and had to lay down to take a nap. I woke up and felt full of energy. The next day, slight tension in the neck and headache but that is it so far. I have some Premarin Estrogen tablets to take just in case of the hot flashes and night sweats but I am not taking those things unless I have to. I already had severe hot flashes and night sweats before all of this, so I am use to it..so its not a big deal..I also already had severe mood swings, extremely lethargic, and bouts of depression before all of this, so I really want notice the difference. So, so far, so good. I am not experiencing any side effects from the shot as of yet that I was already going through, anyhow..Each person is different..

I am so glad that I found this website I thought I was loosing my mind. Maybe I have, I used to be really quick on decisions, I was able to remember things and concentrate since I have been on lupron I cannot remember things at all. I feel like a complete idiot when before I used to feel kind of smart. On top of that I have had massive hot flashes for about a year.
I had laparoscopic surgery in May 2008 for endometriosis, held of on taking lupron for a few months than finally gave into my doctors advice to take lupron in July 2008. I had my last lupron shot in February 2009 and still am having hot flashes, memory loss, depression, weight gain, and still no period. Which after all of this is the scariest part of the whole thing. I went to my doctor today and she told me that I should have started my period already and I may have now gone into menopause permanently.
Wow what a great way to start the day sorry you cannot have kids because you could be in menopause. HAS ANYONE HAD THERE PERIOD RETURN AFTER NOT HAVING ONE FROM LUPRON AFTER 6.5 MONTHS? I am really worried that my chance to have a child is no more after having surgery to prevent this very thing from happening. HELP.

Hi. I just had a laproscopy done 3 weeks ago for endometriosis. I am 26 yrs old and have been dealing with this pain for almost 2 yrs now and it is the worst pain in my entire life. My doctor is now suggesting Lupron because even after the laproscopy the endometriosis was level 4 and had bonded to my intestines and literally trapped my ovaries and uterus against the lining of my stomach. The pain was a 15 to say the least and the past 3 mos it had landed me in the E.R. Finally the docs figured it out. I started my period 2 weeks after the surgery and the pain was still pretty bad. An 8. Now I am seriously considering Lupron. My health is on the line and this pain is not right. At this point I am considering a hysterectomy if Lupron does not work. Any help suggestions please? Monday I follow up with the Dr.

I am a male 61 who had 2 years of lupron for prostate cancer. It has been a little over 6 years since my last treatment and I am still suffering from the side effects. I have headaches 24/7 and am very sensitive to heat. I have ended up in the hospital twice due to extreme heat. My psa is slowing coming back and I may have to have lupron again, God help me! I also suffer from depression, maybe from being ill for so long, I also have occasional bouts with nausea.

ok, so I am 28yrs old just had my second lap for endo and my doctor has recommended lupron, after reading this I am soooooooooo scared to even get near this med. Its like you either take this with the hope of saving fertility and no pain..or not and have endo ravage your body and you will live with unbearable pain!!! I have no idea what to do, my post-op surgery appt is this week, and i am so scared after reading this. Is there anyone that did not have weight gain, headaches etc...anyone that can testify that lupron actually worked for them? Cause right now its my health on the line, my ability to have children, my ability to have a normal life free of endo pain or these crazy, horrible side effects...please help me!!!

I had laproscopic surgery done in May to remove an ovarian cyst. At that time it was confirmed that I have endometriosis. I have always had very difficult periods and at times constant pelvic pain. I have experimented with many different types of birth control and had finally given up on them because they all cause me varying degrees of depression. After my surgery my doctor recommended Lupron because I cannot take the pill. I had my first injection in September. I only did the one dose because I could not tolerate the depression that followed. At times I was nearly suicidal because I was so depressed. I have also gained weight and completely lost my sex drive...

Just after the new year I went to the ER with extreme vomiting, diarrhea and abdominal pain. It turns out that my gallbladder is only functioning at 10%. I have since learned that this is probably due to the Lupron injection (my doctor never mentioned this as a possible side effect!! but I discovered other sites that mention it and my GI confirmed) I am visiting a surgeon tomorrow to discuss removal of my gallbladder and I am wondering if any other women out there have had similar experiences and what the outcomes were??

I live in CT and I am going to look for an OB/GYN that specializes in endo. Please let me know if anyone has recommendations for a doc in CT too.

Thank you!!

I WAS DIAGNOSED WITH ENDO ABOUT 10 YEARS AGO WHEN I WAS 21 YEARS OLD. I WAS TOLD I WOULD HAVE TO HAVE A TOTAL HYSTERECTOMY BY THE TIME I WAS 25. I LIVED OUT OF STATE AND DID NOT LIKE THE DOCTOR I WAS SEEING SO I JUST DISMISSED IT. YEARS LATER AFTER MOVING BACK HOME AND GETTING MARRIED TO A WONDERFUL MAN WHO DOES NOT HAVE CHILDREN ( I HAVE TWO) I WENT TO MY OLD DOCTOR THAT I WAS REALLY COMFORTABLE WITH. TOLD HIM ALL OF MY SYMPTOMS AND ABOUT MY PAINFUL PERIODS AND HOW ME AND MY HUSBAND HADN'T GOTTEN PREGNANT AFTER FOUR YEARS OF TRYING. HE SCHEDULED ME FOR A LAPROSCOPY TO LOOK AROUND AND SEE WHAT WAS GOING ON. HE IS ALSO A FERTILITY SPECIALIST SO I KNEW HE WOULD TRY TO DO WHATEVER POSSIBLE FOR US TO HAVE A CHILD. I HAD A CHOCOLATE CYST ON MY RIGHT OVARY, ENDO, AND THE ENDO HAD FUSED MY BOWELS TO THE LEFT SIDE OF MY ABDOMEN. I HAD ALWAYS HAD PROBLEMS WITH CONSTIPATION BUT I JUST THOUGHT I WAS LIKE ALOT OF OTHER WOMEN. HE TOOK CARE OF ALL OF THAT AND WHEN I WOKE UP HE TOLD ME HE WOULD LIKE FOR ME TO GO ON LUPRON ONCE A MONTH FOR THREE MONTHS. THIS WAS ON SEPT. 11TH. I HAD READ ALL THE BLOGS BEFORE HAND ABOUT LUPRON AND I WAS VERY SKEPTICAL AND JUST PLAIN SCARED ABOUT TAKING IT. MY DOC TOLD ME IT WOULD HELP W/ THE PAIN AND AFTER TAKING IT FOR THREE MONTHS IT WOULD HELP US GET PREGNANT. I TOOK MY FIRST INJECTION BEFORE I LEFT THE HOSPITAL THAT DAY. THE FIRST COUPLE OF WEEKS I REALLY COULDN'T TELL ANY SIDE EFFECTS EXCEPT FOR HOT FLASHES. THEN THE HEADACHES STARTED. I HAD ALWAYS GOTTEN MIGRAINES, BUT THESE ARE 100 TIMES WORSE. I COMPLETED MY THREE MONTH CYCLE OF TAKING LUPRON ON NOV 6TH. I HAVE TURNED INTO A MOODY, CRANKY, ANGRY PERSON. IT IS UNCONTROLLABLE. AFTER MY LAST SHOT BEGAN TO WEAR OFF I GOT A HEADACHE SO BAD MY HUSBAND HAD TO PICK ME UP FROM WORK AND TAKE ME TO THE E.R. THEY TOLD ME IT WAS HORMONAL AND THAT I WOULD JUST HAVE TO DEAL W/ IT. THEY GAVE ME A SHOT AND SOME SAMPLES OF BUTALBITAL. THE SHOT DIDN'T DO ANYTHING AND THE BUTALBITAL ONLY MADE ME SLEEPY. I HAD THIS HEADACHE FOR OVER A WEEK. THEN IT JUST WENT AWAY. WHEN I HAD MY LAST SHOT MY DOC TOLD ME I WOULD HAVE A PERIOD WITHIN 6 TO 8 WEEKS AND WHEN I OVULATE AFTER THAT I SHOULD GET PREGNANT. IT TOOK ME OVER TEN WEEKS TO START. I FINALLY STARTED MY PERIOD A COUPLE OF DAYS AGO. I FEEL AS IF I HAVE ALREADY HAD A CHILD WITH ALL THE BLEEDING AND THE PAIN. IT IS UNBEARABLE. I FEEL SO SORRY FOR EVERYONE AROUND ME BECAUSE I DON'T EVEN KNOW THAT I AM BEING HORRIBLE. THROUGH THE LUPRON I HAVE GAINED 20 POUNDS, HAVE HAD SEVERE HEADACHES, HAVE BECOME VERY FORGETFUL, VERY VERY MOODY, AND JUST FEEL LIKE A TOTAL DEFERENT PERSON AND NOT IN A GOOD WAY. I WILL NEVER TAKE LUPRON AGAIN!! NEVER. IF ME AND MY HUSBAND DO NOT GET PREGNANT AFTER THIS I WILL JUST HAVE THE HYSTERECTOMY AND BE DONE WITH IT. I AM HOPING I BECOME LESS MOODY SINCE NOW MY BODY IS STARTING TO GO BACK TO NORMAL. OR AT LEAST I HOPE IT IS. HOW AM I SUPPOSED TO GET PREGNANT WHEN I AM SO MOODY THAT NO ONE CAN STAND TO BE AROUND ME? PLUS I NEVER WANT TO HAVE SEX. DOES ANYONE KNOW EXACTLY HOW LONG IT TAKES LUPRON TO TOTALLY GET OUT OF YOUR SYSTEM?

I am a little past my 2 weeks with my 1st luprone shot- 1 month. At first my pain symptoms didn't go away at all until one day(after a week and a half after the shot) I got my period and a serious hot flash. From then on I only get sweats and hot flashes at night. I am extremely fatigued. I am used to working long hour days, i.e. +12 hours, but I can't even hack making it through 3 hours these days. Other symptoms include: terrible migraines(all day), nausea, depression, terrible back and joint pain, my arms fall asleep all the time, pain a injection site, loss of appetite-slight weight loss, hair loss, and slight mood swings. This is the second time I have ovarian cysts, but now the doc's think I have endo too.

I had my second Lupron shot this last mid October that lasts, supposedly, 3 months. So I will be 5 months in this mid December and I have to say I was one of the people who was fine with Lupron...up until now. I had and have all of the typical side effects of hot flashes, headaches, memory loss, mental fog, etc. Then I had my first ever migraine a week ago that knocked me on my butt for 2 days. My memory loss and depression are by far, by far, the worst side effect I have experienced. At this point I am concerned my memory problems and mind fog will not go back to normal, which has already adversely affected by daily life. I was one of the people who spoke positive of this injection even after reading all the horror stories but now I am beginning to wonder if they were right on some levels. When reading all the different experiences I would get confused and wouldn't know what to believe. I am not saying I would change things, the jury is still out as to whether the benefits will outweigh the difficulties, but my personal experience and symptoms have been getting worse just in the last few weeks, so that would be between month 4 and 5 on it. I could lead a pretty normal life up until recently and I'm a pretty tough person, I clean houses for a living and work hard with a packed schedule so I am not just stating little symptoms I experience but ones that actually have affected my daily life. Just being honest so you know what to possibly expect, depending on your body's reaction. That is a point to keep in mind, everyone's body reacts differently but if the majority of people are saying the SAME side effects, makes you wonder if there is a consistent pattern.

One thing I will tell you that has helped me is B vitamins regularly in your system and staying as active as possible. Write things down to remind you for the memory issues, don't over-commit to things because of the mental affects-it hits you hard when you can't follow through, and try to watch your sugar intake, which messes with your emotions. Hope this is helpful.
I would love to know from someone who has the same symptoms (which looks like almost everyone who is on it) and who is now off of Lupron for at least a few months, if the symptoms of memory loss and mind fog go away. Is my memory permanently damaged?

I just completed my last Lupron shot. It really did wonders for the extreme pain. But the other side effects were extreme such as the anxiety, depression, sleepless night and have just been dealing with the high blood pressure. This decision to take this shouldn't be taken lightly, do what works for you. But always research for yourself!

I had 2 lupron shots back in April and May and it was the worst decision of my life. I now have SEVERE panic attacks, depression and loss of appetite. I was a very healty 33 year old woman and very active and now all I want to do is stay in bed. I was NEVER informed by my doctor of any side effects other than I MIGHT get a little moodier (angry) easier. That never happened. For 2 months straight all I did was cry. I would wake up crying and go to bed crying. I have never had any past experience with depression and I have already seen a psychiatrist and 4 other doctors. I finally saw a new OBGYN and she informed me that the 2nd shot that I received went straight to my head and it messed with the chemicals in my brain. I am a wreck. I have no energy and it's all I can do to just get out of bed and go to work. Had I known about ANY of these side effects, I would have NEVER taken this drug. This drug needs to be banned completely and thrown in the trash can before any other woman goes thru this. I was on the verge of being suicidal. I am a Christian woman and would never harm myself but the thoughts were always there. I would wake up with a severe panic attack and they would come all during the day. The doctor that originally gave me the shots told me I had psychological issues and HE HIMSELF called and got me an appointment with a psychiatrist. Ladies, we are not crazy. These are real symptoms and it is all because of these shots. It messes with the chemicals in your brain. And had I know that, I would have said HECK NO to them. My endometriosis is much more tolerable than these stupid, insane shots. Please do not take them if at all possible. I do not want one more woman to go thru what I have been through and still going through. I now am on anti depressants to try to get the chemicals in my brain back to where they should be. I just hope and trust in the Lord that I will eventually get through this.

7-18-2008
I HAD THE DEPO LUPRON SHOT IN 2004 FOLLOWING A LAP. AFTER THE FIRST SHOT (A 1 MONTH) FAILED MY DR. GAVE ME A 3 MONTH SHOT, IMMEDIATELY FOLLOWING I HAD SEVERE JOINT PAIN, INDIGESTION, COUGH, DEPRESSION, DIZZINESS, HOT FLASHES PLUS A LOT MORE. AFTER 2 MONTHS I DEVELOPED A LUMP IN MY BREAST, MY DR GAVE ME ESTROGEN (THEY ARE NOT SUPPOSE TO BE USED TOGETHER. I WENT ALMOST INSANE!!! NOW 4 YEARS LATER MY TEETH ARE GETTING CAVITIES IM 37 AND HAD MY FIRST ON AT 35.
MY JOINTS ARE VERY PAINFUL I LIVE ON ALEIVE AND IBUPROPHAN.
MY DOCTORS SAY THERE IS NOTHING WRONG WITH MY JOINTS (GO FIGURE). TO AN ONE WHO IS THINKING OF THIS SHOT FOR ANY RX DON'T.

I am 30 years old and have been put on Depo Lupron after a laproscopy to help with endometriosis. I am 2 months into a 6 month course (one shot every 3 months) of Depo Lupron and my life has drastically changed. I started feeling life altering hot flashes and night sweats two days after the first shot and nearly drown myself in sweat 24 hours a day. I experienced a little postpardum depression after giving birth 6 years ago but have found myself sunk into a sinking hole of depression and anger like I've never felt before. I bawl at McDonald's commercials and become enraged if the dishwasher isn't loaded properly! I am ecstatic one minute and severely depressed the next. I have even had thought of suicide since being on this shot. I am normally a very outgoing, athletic, cheerful, happy person - but since taking this shot, I have become a stanger in my own head. I tell my family all the time that I need to "go stick my head in the freezer" to cool off because of the horrific hot flashes. I have to carry a handheld fan with me 24 hours a day and sleep with ice packs to keep cool. Since the shot started 2 months ago, I have lost all sexual drive, am thoroughly exhausted by 9am and find myself crying at my desk at work by late afternoon because I am so tired. My family thinks I am going crazy and I've never fought more with my husband. My daughter has gone to grandma's for awhile because I'm just so tired and irritable that I feel like an awful mother. Migraines have also come full circle since the onset of the shot as well as blurred vision and shaky hands. I'm a little achy throughout the as well. I know that everyone responds to medication differently, but I'm finding a lot of people with the same side effects as myself and have to wonder why the doctors don't warn patients about these types of problems before prescribing medications such as Depo Lupron. I don't think I'll be going back for the second shot. Could it get any worse?

I am taking Lupron as I had horrible endometriosis, two large-grapefruit sized tumors and several smaller implants removed. I lost my right ovary, and part of my left in the process. I am 28, newly married, otherwise healthy, and I want to have children, so I went on Lupron that my surgeon/OB suggested- monthly for six months. I read a lot of side effects and was TERRIFIED to go on it.

My own husband is an M.D. and I made him call different doctors in his hospital to see what they had to say...in a few days he called about 5 different OBs. Thankfully, they said that those that had side effects that were extremely severe was pretty rare. Still, I was scared.

I am now into my second month on Lupron and I have to say that the side effects aren't nearly as severe as I thought they would be. No hot flashes, no hair loss, no crazy depression, no anything else. I DO have fatigue, but it's manageable with coffee and extra sleep. I have some mood swings- mostly I feel more grumpy. The most noticeable and bothersome is the lack of sex drive and vaginal dryness. I also have trouble achieving "the big O."

Still, so far, very manageable. I'm not sure if it'll be worse if time goes on. But I feel like everything on the internet is really negative. I'm not discounting the tales of people who have had a bad time, but I wanted to put out there that it isn't always the worst thing in the world.

My husband and I found out he had Meatastic prostate cancer 13 months ago..We went to the doctor because his lymph glands were hudge.. He has been on the Lupron injections ever since.. He had really bad hot flashes for the 1st few months but that has past, but now he is very moody and angry for no reason.. He yells and gets angry over the littlest things i think he is going crazy and he is driving me nuts, he has no desire for me and is rude and acts like he don't even like me sometimes.. it is torture to me..He has depression he doesn't enjoy anything like he use to.. whenever we go try to have fun he gets all stressed and makes the fun turn into miserable..He acts as if he has no problems..He has some big rashes on his legs and crack and I am pretty sure it is from the Lupron shot also.. he has a little aches and pains. Very tired all the time..just about a week ago we found out the Lupron shot is not working very well anymore, his psa level went up to a 15..I am thankful for the shot because i know it has saved him some time to be here.. I love him so much, but the way he is now has caused me to feel like he is a grouchy roommate on his period 24/7.. There is other things like casodex to take but i heard it does not work as well as the Lupron..Hopefully one of these days they can find something that works even better then Lupron without the side affects..The lupron Shot has helped many people live longer, but what about the quality of life he is miserable but I am sure he rather be alive and miserable.. Good luck to everyone with the Lupron shot, it is a trying time when they or you go through these changes and do not understand why you feel negative and unhappy..

WELL I HAD AN OPERATION ON OCT 2006. THEY MUTILATED ME LIKE A COW. THEN I STARTED LUPON SHOTS FOR SIX MONTHS. BUT THE SIDE EFFECTS ARE THE WORTS ONE BECAUSE THE WEIGHT I GAINED, DEPRESSION, HIVES, EATING TOO MUCH, DRY SCALP, DRY SKIN, BLOATNESS, URINE INFECTIONS, INSOMIA, HEADACHES, NAUSEA, VOMITING, AND UPSET STOMACH. WELL IT WAS A TERRIBLE EXPERINCE NOT TO MENTION HOW EXPENSIVE THE SHOTS COME OUT. SO I FEEL ALL YOU GIRLS THAT HAVE GONE THROUGH THIS. HANG IN THERE.

SIX MONTHS OF LUPRON AND I AM AFRAID A LIFETIME OF MISERY. I HAVE BEEN OFF THE POISIONOUS DRUG NOW FOR 3 MONTHS AND STILL HAVING NO RELIEF OF THE ACHES AND PAINS IN MY BODY AND MY MAIN PROBLEM THE 35 LBS OF FLAB THAT IS HANGING ON ME NOW THAT JUST WONT GO AWAY. I DONT HAVE THE NIGHT SWEATS OR HOT FLASHES MUCH ANYMORE I DO STILL HAVE SLEEPLESS NIGHTS AND BOUTS OF DEPRESSION. I JUST WANT THE OLD ME BACK. SOMEBODY TELL ME THAT THERE IS SOME HOPE THAT MY BODY WILL RESTORE ITSELF TO NORMAL. HOW LONG DO I HAVE TO WAIT FOR MY WEIGHT TO BE NORMAL AGAIN OR WILL I HAVE TO SUFFER WITH THIS FOREVER? MY SHOULDERS AND HIPS BOTH ACHE ALL THE TIME THIS DRUG IS AWFUL AND I AM SO ANGRY WITH MY MONEY HUNGREY DOCTOR WHO MADE OVER $3000.00 FOR MY PAIN. TO ALL OF YOU CONSIDERING THIS DRUG IT IS MY EXPERIENCE AND OPINION NOT TO DO IT, YOU WILL REGRET IT MOST LIKELY. JUST DO YOUR RESEARCH DON T BE A FOOL LIKE I WAS. I THOUGHT WELL DOCTOR KNOWS BEST THAT IS A TOTALLY WRONG. GOD BLESS AND HANG IN THERE EVERYONE. THAT IS ALL WE CAN DO I GUESS. THIS DRUG SHOULD BE BANNED.
KELLY

I underwent prostate cancer IMRT radiation in 2005. As part of the treatment, I was given three four month doses of Lupron Depot. Men who get this drug experience a reduction of testosterone, wright gain, hot flashes, and sometime depression. I had all of those.

Toward the end of 2005, about two months after my last injection, I noticed a tingling, sometimes burning sensation in my right fool near the toes. Over the past year or so, the sensation has spread to my other foot and sometimes up my leg.

My symptoms have all the earmarks of peripheral neuropathy. So far, my motor functions are okay, and I have been checked for diabetes, and found not to have it, which is a relief.

I did have an attack of Bell's Palsy back in 1973, and it was treated with heat and cortisone. It never came back. I see from some of the web sites that there is a connection between Bell's Palsy and peripheral neuropathy, and and also a connection with Lupron and peripheral neuropathy.

I realize there is little I can do about it, but I think the physicians who prescribe Lupron for prostate cancer should also make their patients aware of this possible side effect.

Addendum to success story:

The longer I do not have my period, the better for the endo, as it does not grow without a period. My doctor and I have decided to think about inserting an IUD w/hormones in the 12th month. I need to research that first.

Forgot to add a couple of things to the side effects--I have had a substantial weight gain and short-term memory loss. The depression comes and goes (I suspect that some of my personal circumstances have a lot to do with that rather than the shot)

I am 38, no kids. I am 1 week away from my 3rd Lupron shot for endo., diagnoised after lapro. I have the night sweats and hot flashes, extreme moodiness, mild pelvic pain, but the worst for me so far is the memory loss. I am literally drawing a blank on things.. this is scary. I find writing things down keeps me on track. No headaches or depression or muscle pain as of yet, hopefully none is coming. Thanks for hearing me out.

I'm 18 and I've been off Lupron for 3 months now. I was on it for 6 months for my endo. I still have all my site effects from when I was taking it. Those site effects include hot flashes every 15 min, bone and joint aches, back pain and depression. During the six months of taking Lupron I was able to deal with all of these site effects because my OBGYN told me these are normal site effects and it's worth it because I shouldn't have any pain from endo for at least 3 years after the treatment. Now 3 months later, I still have not had a period, I still have all the site effects, and the pain I had with my endo has come back. My doctor said this is normal so I just hope the pain and site effects go away soon. I'm going to be pretty angry if the past 6 months of this was all for nothing.

I am having surgery in two weeks (laparascopy, hysteroscopy, and uterine ablation). My doctor gave me a shot of Lupron to prepare my body for the surgery. I had to ask for information regarding the drug as none was offered. One side effect stated was increase in depression, which concerned me because I am on anti-depressants. I talk to my psych med doctor and he didn't seem concerned. Well, I immediately had symptoms of forgetfulness and confusion. My depression increased significantly (I cried for six days straight), I could not function normally, I broke up with my boyfriend whom I love very much because I thought my world was coming to an end, and on and on, migrane, hip and pelvic pain, weakness, sleeplessness, lack of appetite. Two weeks after the injection I am finally starting to come to reality and trying to fix the mess I made emotionally. Apparently, there was a medication I could have been given to counteract or lessen some of these side effects, but no one bothered to tell me. My advise, if you are feeling any side effects, contact your doctor immediately. I"m only glad I only had to have one shot and would NEVER get another.

I had my 5th and last injection in February 2006, I have yet to have a period, weight gain, depression, loss of sexual appetite, severe cramps. I feel like I am 50 and I'm only 35. I lost my job becuase of sickness, I have mood swings. I cannot take much more of this, please write to me if this has happened to you.

hot flashes, night sweats, memory impairments, burning of the skin, changes in vision, inability to concentrate, back pain and muscle pain, acne, depression, abdominal pain, gastrointestinal changes, constipation, irritability, and head aches. I have been thoroughly tested by just about every doctor and specialist and there seems to be no underlying cause for my symptoms other than the Lupron Depot 11.25 injection I took before symptoms began.

I hope many people read this. I was treated for endometriosis at age 29, 1995 with 6 months of lupron injections. yes, it may have gotten rid of some of the problems like period cramps, but I have developed permanent memory loss; my short term memory is shot; I had the worst depression during those 6 months. The thing that bothers me the most is that 11 years later, I still have memory issues. I wish I had known back then that the medication was not even FDA approved for infertility.

I took Lupron shots in 2001 for endometriosis, I quit after 3 months because I had lost 14 pounds (I started out at 109 pounds so that was significant). I have a depression in my hip where I received the shots (my doctor did not alternate sites as I have read is recommended), it feels like a hole in the tissue. Anyone else have long term injection site problems?

I am in my fifth injection and I feel: hot flashes, night sweats, back and shoulder pain, vaginal dryness, diminished libido, memory loss, diminished concentration, depression. My doctor wants that I take Aygestin but I have fear because I read that can cause blood clots.

I recently received my 4th shot of Lupron in a series of 6 for the treatment of endometriosis. I went through this 5 years ago and had much less side effects. This time has been very rough. Depression, suicidal thoughts, severe abdominal pain, bleeding still hasn't completely stopped after 4 months, severe vaginal dryness, decreased libido and difficulty maintaining my weight. I am so unsure about the 5th and 6th shot. I can't take 8 more weeks of deterioration. Any suggestions?

I had my first shot of Lupron a week ago for undiagnosed endo. I feel like I'm goin gcrazy, you don't know what is from the shot and what isn't. I have had a headache that feels like my eyes are poppin gout of my head for four days straight...trouble sleeping, my appetite is gone. I cry and hell at the people i love. They didn't tell me about the depression. I have a history of it, but have been ok for five years, if this brings it back I don't know what i'll do. This board has made me feel so much better.

Complicated migraines, scar tissue on brain, traveling parasthesia, hypertension, thyroid nodules, hair loss, insomnia, memory loss, depression, fatigue, decreased libido, increased: cholesterol, triglycerides, & liver enzymes, gastro-intestinal disorder, etc...............

Headache, dizziness, depression, insomnia, hot flashes, light headed, nausea after 2 months of being on the shot.
Good things no menstration less pain. HELP

Memory problems, hot flashes, clumsy, night sweats, depression and anxiety, moody, arm swelled after the shot, this is only my second shot and my last!

Extreme weakness and joint pain. Fast heart beat. Breathless. Hunger. (see list below) Went to several specialsts for the weakness. Finally had thyroid test and found it is hyperactive. I strongly recommend anyone with two or more of these symptoms: extreme fatigue or weakness, fast heart, breathlessness, sleeplessnes, weakness, depression, irratibility - to get their thyroid checked. It apears Lupron can create a thyroid imbalance in some people