Lupron and estrogen

7-18-2008
I HAD THE DEPO LUPRON SHOT IN 2004 FOLLOWING A LAP. AFTER THE FIRST SHOT (A 1 MONTH) FAILED MY DR. GAVE ME A 3 MONTH SHOT, IMMEDIATELY FOLLOWING I HAD SEVERE JOINT PAIN, INDIGESTION, COUGH, DEPRESSION, DIZZINESS, HOT FLASHES PLUS A LOT MORE. AFTER 2 MONTHS I DEVELOPED A LUMP IN MY BREAST, MY DR GAVE ME ESTROGEN (THEY ARE NOT SUPPOSE TO BE USED TOGETHER. I WENT ALMOST INSANE!!! NOW 4 YEARS LATER MY TEETH ARE GETTING CAVITIES IM 37 AND HAD MY FIRST ON AT 35.
MY JOINTS ARE VERY PAINFUL I LIVE ON ALEIVE AND IBUPROPHAN.
MY DOCTORS SAY THERE IS NOTHING WRONG WITH MY JOINTS (GO FIGURE). TO AN ONE WHO IS THINKING OF THIS SHOT FOR ANY RX DON'T.

I discovered I had endometriosis in March 2000 at which time I had surgery to remove what was there, then the gyn followed up with the Depo-Lupron shots for six months. To help with the hot flashes, mood swings etc. My doctor put me on a very low dose of Estrogen which helped. I was having fertility issues before this and when I finished up the shots and the time had ran out and still had no period, my doctor put me on fertility drugs to give my body a jump start, and in April 2001 we found out we were pregnant, during which time my teeth started deteriating and by the time I have my second and last child in March 2003, I had to have major dental work done. I blame the lupron shot for this issue, apparently my calcium level dropped. I told my gyn about it and he said he had never heard of any such thing before as a side affect of the drug. I pretty muched laughed in his face and told him to advise future patients to increase the calcium while on the drug. Then recently I discovered like a lot of you that there are some really serious side affects from Lupron. Since this after having my last child I went on the Depo Prevera shot for 6 months, gained unsightly weight, so I got off of that and got my tubes tied in 2004, then by March of 2006 I knew my endometriosis was back full fledge and in June 2006 I had to have a hysterectomy. My only long term affects from the Lupron and Prevera shots is still trying to lose some of the weight and living in pain during every meal but due to the extreme affect it took on my teeth, I can not afford even with insurance to get all the work needed done!!!! If I had to do it over again, I would have had the surgery and then worked on getting pregnant immediately, because long term..... It isnt worth the "preventative" HaHaHa!!!!

My daughter took Lupron as a 14 year old, perfectly normal teenager with the exception of endometriosis. She is now a 33 year old shell of the vibrant teen she was. She is bi-polar, maniac depressive. The changes in her were immediate and startling to say the least. I feel like it ruined her life. I have just started investigating the terrible side effects and was shocked to see so many other people whom lives it destroyed. If anyone has advice, anything to get help, please reply.

Hi...I'm glad I found this sight! I don't recommend Lupron; I think its bad side effects outweigh its good ones.

I only took one 3-month shot of Lupron in July of '07. I had horrible hot flashes...which I was told to expect, but the vaginal dryness, lack of sex drive, weight gain, breast changes, vaginal dysfunction, and, I believe the high blood pressure I now have is associated with this drug. I actually started looking for side effects online because my blood pressure has been elevated ever since taking Lupron. It is now January '08, and I still don't feel normal!

Hi All,
Just wanted to share a positive Lupron experience. I began Lupron in Dec 2005 and ended in Jan 2007. I took monthly Lupron shots for a year straight. However, my Dr. prescribed an add back drug called Norethindrone which I took once daily the entire time I was on Lupron. The only side effect I had was about a 10 pound weight gain. When I asked my doctor if this was from the Lupron he said maybe 3 or 4 pounds of it. I was eating right and exercising during this time period but was still gaining weight. About a month after I came off Lupron I began losing weight and was able to fit into my old clothes a few months later. I am sure it was the Lupron that caused me to gain weight.
If you are taking Lupron without any add back drug, this seems when all of the other horrible side effects come into play. Just wondering if anyone had a really bad experience even while taking the add back drug.

I just took my first of six shots 2 days ago. I'm already experiencing a general hot feeling, hot flashes and insomnia. I'm worried after reading these posts. ... My doctor did not explain the severity of the side effects prior to recommending the drug. Should I continue the treatment? My endometriosis only effects my life during my periods, and have no symptoms while im not menstruating. However, my period pain is so severe it impairs my ability to function. What do i do?

I was on Lupron for endo 4 and 5 years ago, two times. The second time without add back therapy. I started migraines at that time and basically had them for 2 years almost non-stop. I am ultra sensitive to estrogen level. I also had joint aches, night sweats, and severe depression. I finally had a hysterectomy two years ago and got rid of my migraines with a nice steady dose of estrogen. I can't lose the weight. I still have joint pain.

I am 27 years old and have just recently completed six months of lupron. I had my last shot in January 2006. The treatment was for endometriosis. I had been in pain for over 10 years when I finally had a laporoscopy to diagnose the endo. I also experienced "mild" side effects from the lupron. But, let me state first that I CANNOT take any sort of hormonal birth control because of the estrogen. Everytime I have tried BC I have had mini strokes. During my pregnancy I also had a mini stroke due to the increase in estrogen.
While on the lupron, I actually felt better than I have felt in a long time. I had the occassional hot flashes, night sweats, and a lot of weight gain. I gained around 25 pounds in four months. I don't recall any other severe side effects. However, I was also on Elavil (anti-depressant) the entire treatment. So I'm not sure if that helped or not. My problem is that now after being off of lupron, I am having horrible feelings of nausea, dizziness, fatigue and horrible headaches. I went to the doctor today because of an excrutiating headache I have had for three days now. It is a weird headache. It only hurts in one spot on the top right side of my head and hurts when I move my head quickly or move my eyes. The doctor did blood work to check my thyroid and has scheduled a CT scan for next week.
Has anyone ever experienced severe side effects after completing lupron? I am wondering if it is the estrogen coming back. Am I better off to be on the lupron? If anyone has any comments or suggestions, please reply.

I am 24, and was diagnosed with endo at 18 after suffering excrutiating pain since I was 11 when the "curse" started. I started lupron for a six month period prior to my second lap, and I felt hot flashes more than anything. I was so excited about not having any pain that I forced myself to ignore anything else. After the surgery, I felt pain during my periods, but it wasn't bad at all. Slowly, but surely, the pain returned, and became just as bad as when I was 18.

Last year,(spring of 2003), I couldn't take it anymore, and none of the painkillers worked at all, so my Dr. put me back on lupron in Sept. of 2003.

I HAVE NOW TAKEN LUPRON FOR 21 MONTHS OUT OF MY LIFE!!! It was my choice to do so, because of the pain, and in hopes that I am saving a few eggs in my one ovary. I still experience hot flashes, but not as bad or as frequent as before. The bad news is I have gained 40 pounds, and exercise does NOT help. I do have migraines, but only once in a while, and I do have trouble remembering a lot of things. I constantly forget words, to pay bills, and even names of people I see everyday.

THE WORST IS THE WEEK BEFORE THE SHOT IS DUE. I BECOME AN EMOTIONAL MESS, CRYING, SHAKING, DEPRESSED, AND VERY NEEDY. Nothing helps, but when I get the shot, I'm ok. I tell my fiance it's my estrogen fighting testosterone, and he seems to buy it. Inside I'm paranoid.

I am also having trouble with my eyes. It's hard to focus on anything, they feel itchy, watery, and the pain from the migraine is worsened when I can't get my eyes to focus.

I plan to stop the shot in sept of 2005, and hope to start a family. IF THERE IS ANYONE OUT THERE WHO HAS TAKEN LUPRON FOR MORE THAN SIX MONTHS, PLEASE EMAIL ME AT ******