Lupron and mood swings

I got diagnosed with endometriosis about a month ago and had emergency surgery. I had my first shot of Lupron a week after my surgery. I am now experiences the hot flashes, mood swings,and not being in the "mood". I have not noticed anyone else saying anything about the side effects being not in the "mood". I am only 24 years old and getting married in February. I need help!!!! I am suppose to get my second shot on the 23rd of this month. I am not sure if I should get it or not. My husband-to-be and I would like to start a family right after our wedding. I feel so bad for him I don't want him to have to turn to movies or anything else to have to get pleased. I am still young and should not be going through this. I need help and don't know what to do.
mpluv05

For me, it has been about 10 years, I think, since I was on lupron. I got a shot every 3 months for almost 2 years. At the time, the Dr. told me that the Lupron was still in the experimental stages but they thought it would be beneficial for me to try. I had a mini lap done because of a softball sized cyst rupturing so she couldn't see anything in my abd with the regular lap. I was diagnosed with stage 4 endo and started not long after on the lupron. I do not envy any woman that has or is going through menopause because the mood swings and hot flashes that I remember, were aweful.
Since the end of my Lupron, many years ago, I have noticed a few things that I never really put in line with the shots, ex...severe headaches, bad memory loss (to the point that I sometimes cannot remember things I just did), joint and muscle pain.
For me, the Lupron was a God send for the endo, I was cleared after about a year and went back 2 years ago for another lap and that was clear of endo but I have bad adhesions.
Before all of this started, I was a very active person with horseback riding, clogging (a type of celtic dance), and a very dependable person. Things are getting worse for me and I am only 32 yrs. old.
This is one of those moments, I know there was a reason for me to write this but now after being so long from reading the other comments, I cannot remember what my point was. No need to delete this though.
If anyone knows of anything that I can do to help with the memory issues, please help me out. All kidding aside, I cannot remember to take the vitamins that are suppose to help me remember.

I am a 27 year old female and I have stage 4 endo and have had lots of rupturing ovarian cysts. The laporoscopy was pretty ineffective for me and I tried birth control and had severe vaginal bleeding during intercourse. So my doctor wanted to do 3 months of Lupron Depot and add back therapy with Premarin.
I have only had one shot of Lupron and that was on 10/16/09. I noticed side effects with in 24 hours. I had severe joint pain especially noticed in the right hip ( I was injected in my right side) severe migraines, awful mood swings, short term memory loss and that was all in my first week on the shot. I started feeling better like 10 days after the shot, but that was only short lived. Now even after three weeks into the shot, I am in so much pain in my joints, it is difficult to take care of my two toddler boys and my home. I now have a crazy rash on my butt, and still have so much pain in my body as well as feeling numb in my toes, left arm, and fingers. This drug appears to be more ineffective than effective and I feel like women need to explore other options before going down this unknown path. I found out through research on the internet that the Premarin that I was taking as an add-back is made from PREGNANT HORSE URINE and that the horses are treated like crap so everyone can get rich off them. There has to be other options for people that have already gone through the nightmare of endometriosis. I would take endo over these side effects any day.

I'm 24 and just recently finished my lupron treatment for endo. I'm still having some of the side effects and have yet to start my period again. I honestly would've rather had surgery again for endo than go through months of the side effects. The memory problems, overall fogginess, night sweats, insomnia, mood swings, hot flashes, and just the stress and complete crappy quality of life I've had most of this year has completely affected all aspects of my life. It's not easy at work, at home with my husband- surgery took a day or so to recovery from and this has been a nightmare for months and months. I'd really think about it and research the benefits for you vs the side effects before doing it. If there are any other options- I'd absolutely consider them.

ok, so I am 28yrs old just had my lap for endo on October 1 and my doctor has recommended lupron, and am going to be getting the med in a week to 2weeks,but after reading this I am soooooooooo scared to even get near this med. Its like you either take this with the hope of saving fertility and no pain..or not and have endo ravage your body and you will live with unbearable pain!!! I have no idea what to do,and i am so scared after reading this. Is there anyone that did not have weight gain, headaches etc...anyone that can testify that lupron actually worked for them? did any one have a baby after doing this. my bigs thing is being able to have a baby. Cause right now its my health on the line, my ability to have children, my ability to have a normal life free of endo pain or these crazy, horrible side effects...please help me!!!

Well this is my second go around with Lupron. In 2004 I was on it for 7 months for the treatment of Fibroids, at the time I was 25 and I was told the only other choice was a hysterectomy. Well my doctor at the time said the side effects would not be bad and so did not give me anything for the mood swings and hot flashes. This almost caused a divorce, I guess I was pretty bad! Well it did the job, but I did gain 30lbs. Five years later, I was diagnosed with endometriosis. I was informed that I needed another go of Lupron. Well in those 5 years I had lost 100lbs and was feeling good. I started the Lupron in Feb. of 2009 and have gained almost half of that weight back and still no period. I have not had any children and it is looking like the next step for me is a hysterectomy. My depression that I thought I had under control worsened considerably and now am on 2 different depression medications. The only positive thing I would have to say is that the pain is gone for now and this time they gave me something for hotflashes and mood swings.

My 8 year old daughter started Lupron about six months ago due to precocious puberty. She started her period about eight months ago so we saw an Endocrinologist who told me there were NO SIDE EFFECTS. With the second shot, I noticed mood swings and tearfulness that I had never seen before. With the third shot, she had a rash for one day that was relieved by Benadryl. She no longer has mood swings and has not had a rash again but she has gained 8 pounds and I have noticed hair loss. The front of her hair is twice as long as the back. Her doctor has recommended that she stay on the shots until she is 11. Now that she is 9, I have decided to stop the shots and we will just have to deal with her having a cycle so young. It was a difficult decision for me to start her on the injections, but I made the decision believing that there were no side effects. This may be true in some patients, but it was not true for us. I just hope she can lose the weight and that the hair loss is not permanent.

I have severe endometriosis and am even severely anemic from the cysts that developed and my monthly cycle. I was going to an Oncologist for a year to receive iron infusions every three months. It is a two hour process. Not bad, but boring and sad because I was surrounded by cancer patients there getting chemo. I began my lupron shots May 2009 and it has been a Godsend! The pain is gone, I have more energy, I feel more alert and I am not sleepy all the time. My OB/GYN did put me on Wellbutrin as soon as I started getting the mood swings and that has been a tremendous help as well. The hot flashes and night sweats are really the only side effects I have to contend with. My OB/GYN wants to give me a prescription for low dose hormones but I refuse. I have lost a lot of weight over the years (174 lbs.) and am PETRIFIED of gaining it back. She told me that it was very likely that I would gain weight with the hormone replacement. I'd rather have the hot flashes and night sweats than gain any weight back as I worked sooooo hard to get it off and keep it off. Does anyone have any suggestions of any natural products such as herbs, minerals, vitamins, etc... that would help with those two side-effects?

lupron makes me a bad person. i easily get irritated even on very little things. mood swings is very out of this world. i'm on my day 4 of lupron and i can't control my emotion anymore. i do deep breaths to try to control it but it doesn't work for me. i really have to shout my emotion or else i feel i will burst or die of heart attack. i don't know what to do anymore. i have to be relaxed to have a successful ivf. need your advice.

im currently on my fourth month of treatment with lupron and would like to know if anyone that had fertility problems was able to conceive after a course of lupron...? im 32 and have 2 beautiful children, but would like one more before i undergo a hysterectomy...i have been diagnosed with endometriosis, adenomyosis and severe pelvic adhesion's. i was in so much pain that it was ruining my life...the lupron has been pretty great this time around...six years ago i did it without any add-back therapy, but this time im taking progesterone along with it and the side affects have been minimal...still have mood swings and a decreased sex drive, but no hot flashes or night sweats. its definitely worth the pain relief...for me anyways.

I am in the middle of my second month after getting the first shot (for 1 month) and the second ( for 3 months). I have recurrent fibroids and ovarian cysts that caused a lot of pain and severe bleeding.
I was scared to try Lupron. I consulted with my uncle who is an OB/Gyn and he told me that the version they use now is very safe, with side effects like many other drugs...
My doctor gave me options for the treatment, but because I want to get pregnant again (already have a 2 1/2 yr. old boy), hysterectomy was out of the question. The doctor removed some of my fibroids laparoscopically before I got pregnant with my son, but since they "showed up" again, he recommended to treat them with Lupron instead of removing them trough surgery, because the surgery leaves scarring that can later interfere with fertility.
Anyway, YES I have experienced many side effects mentioned here: hot flashes, mood swings, a couple of headaches, and some "bloating". The worst side effect for me has been insomnia...but they really haven't been that terrible...you learn to deal with them. I am in no pain and didn't get my period this month.
I guess everybody is different and they experience everything in a unique way.
My suggestion is to try it if you really need it and weigh in the pros and cons objectively.
Good luck!

ok, so I am 28yrs old just had my second lap for endo and my doctor has recommended lupron, after reading this I am soooooooooo scared to even get near this med. Its like you either take this with the hope of saving fertility and no pain..or not and have endo ravage your body and you will live with unbearable pain!!! I have no idea what to do, my post-op surgery appt is this week, and i am so scared after reading this. Is there anyone that did not have weight gain, headaches etc...anyone that can testify that lupron actually worked for them? Cause right now its my health on the line, my ability to have children, my ability to have a normal life free of endo pain or these crazy, horrible side effects...please help me!!!

Just received 2nd Lupron shot and like so many others, severe fatigue and severe dizziness - cannot drive. Lots of headaches, and pressure in my head, blurred vision and an asthmatic feeling in chest and throat. I'm wheezing and having difficulty taking deep breaths. All this to reduce the pain of endo - I'm not sure which is worse.. I figured I could deal with the hot flashes and mood swings, but this is brutal. I feel really "drugged" and out of it. I hope the pain actually improves because I still have no life.

I just went in for my second shot of Lupron (out of a series of 6) for treatment of stage IV endometriosis. The most noticeable side effect I experienced was during my first menstrual cycle after my first dose of Lupron. I had never experienced menstrual pain or cramping (even though I had advanced endometriosis) until after Lupron. I have a fairly high pain tolerance and yet the cramping for the first 2 days of my period were almost debilitating. I had extremely heavy bleeding and have had spotting daily ever since (app.18 days). I have gained about 3 pounds because I have no energy at all. I'm usually active and work out 4-5 times a week but by the time I get off work, I'm too fatigued to do so (hence the weight gain I guess). I have hot flashes and night sweats all the time. The most recent side effect is high blood pressure. I have never had high blood pressure in my life (I'm a healthy 25-year-old woman) and when I went in for my 2nd Lupron shot today, they told me I all of a sudden do. I don't seem to have mood swings but do feel depressed and sometimes more anxious than normal. I have experienced a decreased interest in sex as well.

I am 26 years old and I was diagnosed with endometriosis last year (2008). I had pain in my lower abdomen for years and doctors always told me nothing was wrong but I knew there was. Finally a doctor did an ultrasound and found a 7cm mass on my left ovary. I also had a slightly smaller mass on my right ovary. My doctor told me that he would need to do a lap to remove the masses and possibly remove my left ovary because he could hardly see any ovarian tissue on the ultrasound. Thank goodness when he did the lap I was able to keep but ovary but he told me that I had one of the worst cases of endo he had seen. My right ovary was stuck to the wall of my abdomen due to the endo and I even had endo on my bowel. He removed what he could but not all of it was removable. He suggested that I go on Lupron for 6 months to "shrink" the rest of the endo. I have been on Lupron for 3 months. I just went and got my second 3 month injection. I have had some side effects such as Headaches, Bone pain, Hot Flashes, Insomnia, Drowsiness, Increased appetite and major Mood Swings. All of which come and go. I try to stay active but I don't over do it. It seems to help with the joint pain. Most of my side effects were in the first 2 months of getting the injections. I am told all the time that everyone reacts differently to Lupron and there is a pill you can take to reduce the side effects of Lupron but it does reduce the effects of the Lupron so my doctor suggested that I not take it unless the side effects were unbearable. I don't remember what it is called but if you are one of those people having major side effects ask your doctor.

I'm a 26 year old female that has had the lovely experience of taking Lupron twice in my life. I was diagnosed with endometriosis at the age of 19 after having a lap. I had been suffering from excruciating back pain for months. The lap only helped for 3 months and then the pain returned. My doctor recommended Lupron for 4 months and so I jumped at the chance to feel better. I actually did ok with the shots. I experienced the hot flashes, fatigue and crazy mood swings but I was willing to try anything to feel better. After the 4 months, my life returned to normal and I had 5 good years of pain free life with normal periods. My body on the other hand did not react well to birth control so I couldn't use it. For the last 2 yrs, my husband and I having been trying to conceive with no luck. 1 yr ago my periods took a wild turn. I began bleeding so heavily that I was bleeding thru my tampons every 5 min and began passing clots the size of a half dollar. These episodes would last for bout 3 hrs. This continued for 3 months and so my doctor recommended Lupron again. I was cautious about taking it again, but I was desperate. This time around I suffered from weight loss, nausea, severe bilat hip pain (due to low bone density), and receding gums along with all the usual Lupron side effects. My dentist said my gums and teeth looked like I was 60 or 70. FYI, I have never even had a cavity!!! I'm now 3 months post Lupron. I still haven't started my period again but my symptoms have subsided. Its just a waiting game now. I hope to get pregnant soon but I will probably go on fertility drugs very soon. All I can say about this drug is that it worked for me the first time and I hope it did the second time. It definitely was not easy and I don't recommend anyone going into it lightly. Good luck to anyone who is thinking about it and I feel blessed to have gotten out of it with a lot less problems than other men and women

I am in month 4 of a 4 month Lupron shot that my doctor gave to prepare for surgery. I was told I might get hot flashes, loss of libido, increased urinary symptoms for a few weeks. No one said anything and there was absolutely nothing in all the drug leaflets they gave me that would have prepared me for the the horror story that my life was about to become. As if having cancer was not bad enough.Since day 2 I have suffered so many bad side effects that I have lost count. The worst is insomnia and nothing has helped including high doses of Ambien. They suggested Lunesta but my health insurance company balked and even if they had said yes, my co-payment would be unaffordable. This stuff is more expensive than gold. I am exhausted all the time. I have terrible memory problems that are so bad that I can be talking to some I know really well and not remember their name. I am unable to concentrate on anything, my mood swings are unbelievable, I feel mentally disoriented and dissociated all the time, high blood pressure, racing pulse, high blood sugar, hot flashes, raging night sweats, dizziness, bad balance. The side effects that I can handle include nausea, headaches, diarrhea, joint and muscle pain. I am supposed to be on Lupron for 2 years. The only difference I see with my Lupron experience and others here is that my gender is MALE and I have early stage prostate cancer. Being male, my other serious Lupron side effect is complete impotence which is going to go on for a long while due to the radiation. I had radioactive seed implants into my prostate gland done a week ago and I have to follow this with 5 weeks of beam radiation. Lupron seems to be an equal opportunity drug. Lupron has messed me up so badly that for the past 5 weeks I have been off work on disability status with no chance of going back for at least a month and my Dr thinks that may be optimistic. No one seems to know how long it will take to get back to some kind of normal. I just could not function at work and ended up in my doctors office having a complete emotional meltdown. I would caution anyone, male or female, to consider Lupron very carefully before having it.

After 3 months of the lupron, I decided to stop taking it. Within the first week of the first shot, I was having side effect. I have never been physically or mentally violent. I was blowing up at my boyfriend. I couldn't control my anger, and I didn't care. It got so bad that my boyfriend was considering moving out. So I went to my family doctor and he put me on zoloft, clonazepam, and propranolol for the mood swings, hot flashes, and temper. Also I wouldn't sleep through the night without waking up due to hot flashes. I haven't taken the shot in two months and the pain is coming back. I had no sex drive while I was on the shot and still really don't. I'm not really sure what to do next. The shot does relieve the pain, but the side effects are just overwhelming.

I had laproscopic surgery done in May to remove an ovarian cyst. At that time it was confirmed that I have endometriosis. I have always had very difficult periods and at times constant pelvic pain. I have experimented with many different types of birth control and had finally given up on them because they all cause me varying degrees of depression. After my surgery my doctor recommended Lupron because I cannot take the pill. I had my first injection in September. I only did the one dose because I could not tolerate the depression that followed. At times I was nearly suicidal because I was so depressed. I have also gained weight and completely lost my sex drive...

Just after the new year I went to the ER with extreme vomiting, diarrhea and abdominal pain. It turns out that my gallbladder is only functioning at 10%. I have since learned that this is probably due to the Lupron injection (my doctor never mentioned this as a possible side effect!! but I discovered other sites that mention it and my GI confirmed) I am visiting a surgeon tomorrow to discuss removal of my gallbladder and I am wondering if any other women out there have had similar experiences and what the outcomes were??

I live in CT and I am going to look for an OB/GYN that specializes in endo. Please let me know if anyone has recommendations for a doc in CT too.

Thank you!!

I WAS DIAGNOSED WITH ENDO ABOUT 10 YEARS AGO WHEN I WAS 21 YEARS OLD. I WAS TOLD I WOULD HAVE TO HAVE A TOTAL HYSTERECTOMY BY THE TIME I WAS 25. I LIVED OUT OF STATE AND DID NOT LIKE THE DOCTOR I WAS SEEING SO I JUST DISMISSED IT. YEARS LATER AFTER MOVING BACK HOME AND GETTING MARRIED TO A WONDERFUL MAN WHO DOES NOT HAVE CHILDREN ( I HAVE TWO) I WENT TO MY OLD DOCTOR THAT I WAS REALLY COMFORTABLE WITH. TOLD HIM ALL OF MY SYMPTOMS AND ABOUT MY PAINFUL PERIODS AND HOW ME AND MY HUSBAND HADN'T GOTTEN PREGNANT AFTER FOUR YEARS OF TRYING. HE SCHEDULED ME FOR A LAPROSCOPY TO LOOK AROUND AND SEE WHAT WAS GOING ON. HE IS ALSO A FERTILITY SPECIALIST SO I KNEW HE WOULD TRY TO DO WHATEVER POSSIBLE FOR US TO HAVE A CHILD. I HAD A CHOCOLATE CYST ON MY RIGHT OVARY, ENDO, AND THE ENDO HAD FUSED MY BOWELS TO THE LEFT SIDE OF MY ABDOMEN. I HAD ALWAYS HAD PROBLEMS WITH CONSTIPATION BUT I JUST THOUGHT I WAS LIKE ALOT OF OTHER WOMEN. HE TOOK CARE OF ALL OF THAT AND WHEN I WOKE UP HE TOLD ME HE WOULD LIKE FOR ME TO GO ON LUPRON ONCE A MONTH FOR THREE MONTHS. THIS WAS ON SEPT. 11TH. I HAD READ ALL THE BLOGS BEFORE HAND ABOUT LUPRON AND I WAS VERY SKEPTICAL AND JUST PLAIN SCARED ABOUT TAKING IT. MY DOC TOLD ME IT WOULD HELP W/ THE PAIN AND AFTER TAKING IT FOR THREE MONTHS IT WOULD HELP US GET PREGNANT. I TOOK MY FIRST INJECTION BEFORE I LEFT THE HOSPITAL THAT DAY. THE FIRST COUPLE OF WEEKS I REALLY COULDN'T TELL ANY SIDE EFFECTS EXCEPT FOR HOT FLASHES. THEN THE HEADACHES STARTED. I HAD ALWAYS GOTTEN MIGRAINES, BUT THESE ARE 100 TIMES WORSE. I COMPLETED MY THREE MONTH CYCLE OF TAKING LUPRON ON NOV 6TH. I HAVE TURNED INTO A MOODY, CRANKY, ANGRY PERSON. IT IS UNCONTROLLABLE. AFTER MY LAST SHOT BEGAN TO WEAR OFF I GOT A HEADACHE SO BAD MY HUSBAND HAD TO PICK ME UP FROM WORK AND TAKE ME TO THE E.R. THEY TOLD ME IT WAS HORMONAL AND THAT I WOULD JUST HAVE TO DEAL W/ IT. THEY GAVE ME A SHOT AND SOME SAMPLES OF BUTALBITAL. THE SHOT DIDN'T DO ANYTHING AND THE BUTALBITAL ONLY MADE ME SLEEPY. I HAD THIS HEADACHE FOR OVER A WEEK. THEN IT JUST WENT AWAY. WHEN I HAD MY LAST SHOT MY DOC TOLD ME I WOULD HAVE A PERIOD WITHIN 6 TO 8 WEEKS AND WHEN I OVULATE AFTER THAT I SHOULD GET PREGNANT. IT TOOK ME OVER TEN WEEKS TO START. I FINALLY STARTED MY PERIOD A COUPLE OF DAYS AGO. I FEEL AS IF I HAVE ALREADY HAD A CHILD WITH ALL THE BLEEDING AND THE PAIN. IT IS UNBEARABLE. I FEEL SO SORRY FOR EVERYONE AROUND ME BECAUSE I DON'T EVEN KNOW THAT I AM BEING HORRIBLE. THROUGH THE LUPRON I HAVE GAINED 20 POUNDS, HAVE HAD SEVERE HEADACHES, HAVE BECOME VERY FORGETFUL, VERY VERY MOODY, AND JUST FEEL LIKE A TOTAL DEFERENT PERSON AND NOT IN A GOOD WAY. I WILL NEVER TAKE LUPRON AGAIN!! NEVER. IF ME AND MY HUSBAND DO NOT GET PREGNANT AFTER THIS I WILL JUST HAVE THE HYSTERECTOMY AND BE DONE WITH IT. I AM HOPING I BECOME LESS MOODY SINCE NOW MY BODY IS STARTING TO GO BACK TO NORMAL. OR AT LEAST I HOPE IT IS. HOW AM I SUPPOSED TO GET PREGNANT WHEN I AM SO MOODY THAT NO ONE CAN STAND TO BE AROUND ME? PLUS I NEVER WANT TO HAVE SEX. DOES ANYONE KNOW EXACTLY HOW LONG IT TAKES LUPRON TO TOTALLY GET OUT OF YOUR SYSTEM?

I started Lupron in April of 2008. The year before this I worked HARD to lose 80 lbs. I finally got down to my goal weight because I was tld my endometriosis symptoms could be relieved if I wasn't overweight. I had a laparoscopy in March of 2008 confirming my diagnosis- Lupron was a last minute decision because of my age and status the doctor didn't want to do the hysterectomy right away. My endometriosis is spread throughout the body- including the lungs. While Lupron helped with the pain I was experiencing, it caused other pain. Pain that I can no longer even deal with. I became lethargic, depressed, and angry. My hair was falling out in large clumps. I didn't gain weight right away.. except a pound the first shot and three pounds hte second shot but I figured that was alright if it was only like 15 lbs total. I oculd deal with that. Here I am almost a year later. my last injection was in August. I gained a total of 47 pounds. I am a fat slob. I couldn't work out because my bones hurt so bad while taking the medication. No one around me knows what I went through physically. They al think that it was just some excuse to be a lazy fat cow but it truly HURT to move. Just simply walking from my bedroom door to my bed killed me. It hurt my ribs, my knees, my shins, my back. There were times when I couldn't even get out of my bed ebcause I just didn't have the energy. Then the depression started shortly after losing a large amount of hair. By now I am thinking about how ugly i've become on top of how fat I am. Nothing went right but my doctor pushed the shot. I figured hes the one with years of experience he couldn't possibly be this wrong. I trusted him. When I would go to him with complaints of my weight gain he would tell me to stop eating. The problem was... I wasn't eating. I was too sick to my stomach to bother. Then when I would get hungry i'd over eat. I bled a lot through the shots and I still had pain here and there but I was too afraid of what he'd put me on next if I complained. I started to forget simple things. My career was going down hill because they were sick of me not being 100% commited to my job any more. I cried all the time. I finally got sick of the weight gain while I was on my shots and I decided to work out regardless of how I felt and three times I passed out in the gym and was transported to the hospital where I had to listen to their advice on being overweight WHICH WASNT THE REASON I WAS PASSING OUT TO BEGIN WITH but no one wnats to hear what I have to say. Every one just assumed that I was this pig who never worked out in her life and over did it this time. What no one understood was that three months before the incident i was my average weight. I was tachycardic all the time- my normal resting heart rate while i was on my shots was 162. During a work out it would get up to 220!

Ive been off them since August and I haven't lost a single pound. I get up at 4am every day and work out. I park as far away as possible. I use the stairs instead of elevators. I eat healthy. I cut out extra sugars and stopped rewarding myself when I deserve it. I started these shots at 155lbs and today I am 215. Ive been on a strict monitored diet, diet pills and work out regimens and I am still 215. My knees kill me nad sound like velcro when I walk- ive even fallen a couple of times because they hurt that bad. My back still hurts and my neck still wont turn to the right completely because of a nerve that pinches or what have you in there that sends the sharp pain through my face when I move. I still have the depression but i think thats more because of my weight now than it is anything else.. and I finally ended up losing my job.

I recently saw my OB for a follow-up where he stuck me on yet another birth control. This one makes me vomit and gives me stomach cramps so Ive decided im done. I won't take another pill because its making me worse. Id rather have my uterus fall on the floor than pop another drug.

I went from a rational non-emotional women to a crazy person!!! I feel awful. I would rather have pain than feel this way. I can't sleep though constantly fatigued. Achy body, headaches. Everything tastes like cardboard so I'm not eating well though I have gained a few pounds. I am severely emotional. I almost left my husband this weekend whom I adore, can't stop crying, very depressed and irritable. I want nothing more than to be alone and sleep, which no one can live that way. I am a mother of 3, a wife, and have a full time job. I can't function properly. I will never undergo hormone treatment after I get through this! I am currently on Lupron, just had laporoscopy 2 weeks ago for the 5th time all for endometriosis and I'm only 25. I started Premarin today to assist this anxiety and mood swings. Wish my family and I luck.

i took lupron only once and stopped because of all the side effects. immediate side effects were back pain, MAJOR DEPRESSION and mood swings, blurry vision with extra sleep in the eyes.

i have endo and had a laporoscopy for it but still had pain so doc said to use lupron. it is the worst drug i have had to take with the most side effects. I ONLY HAD ONE SHOT and i STILL HAVE BACK PAIN 6 months later!!!!! i am a drummer and now cannot play the drums. i have tried acupuncture but did not work for me just made pain worse. i also have gotten more acne, blurry vision, stomach issues. my life is not the same and now i have the side effects from LUPRON AND ENDO.

I went to docs for the back pain told them i took lupron they cannot find anything wrong. i went to a rhumatologist also. i am supposed to get a bone scan to see if they can find anything but they are doubtful. the only thing that helps with the side effects are back rubs, heating pads, tiger balm, taking walks, breaks from the computer and an occasional puff from mary jane seems to be the only things that help.

DO NOT TAKE LUPRON THIS DRUG IS BAD!!!!!!!!!!!!!!

I was diagnosed with seven fibroids, with some the size of a golf ball. My doctor was talking about a hysterectomy, I'm 52, but I opted instead for Lupron. Before I couldn't bend over and had a lot of pain in my stomach. I am going on my third shot, and yes, I have gained weight. And I am tired a lot, but these small side effects are nothing compared to the pain i was in before. I am also taking a give back hormone pill that helps with the bone loss and mood swings. I have not had any of the other problems that others seems to have. I am hoping this will shrink them so no surgery is necessary.

I am a little past my 2 weeks with my 1st luprone shot- 1 month. At first my pain symptoms didn't go away at all until one day(after a week and a half after the shot) I got my period and a serious hot flash. From then on I only get sweats and hot flashes at night. I am extremely fatigued. I am used to working long hour days, i.e. +12 hours, but I can't even hack making it through 3 hours these days. Other symptoms include: terrible migraines(all day), nausea, depression, terrible back and joint pain, my arms fall asleep all the time, pain a injection site, loss of appetite-slight weight loss, hair loss, and slight mood swings. This is the second time I have ovarian cysts, but now the doc's think I have endo too.

Only on it for 1 month so far and already having issues. I apparently have the worst case of endometriosis all my doctors have seen, including a cancer specialist that had to do all my surgeries because of the severity. Granted, I am only 31 years old and have had a full hysterectomy. So, after 3 surgeries I am still having severe abdominal pain and bleeding (don't know where that is coming from since I don't have a uterus anymore) so they said try Lupron and I finally gave in. Now I started getting such severe pain in my lower back that I can't stand for longer than 15 minutes and terrible side aches. I started getting headaches (which I already take pills for for years now),and have gotten the hot flashes as well. What are we to do ladies? I am so sick of complaining to the doctors about pain. You feel as if you are a big cry baby. What are my options here and does this ever stop?

I was absolutely miserable on lupron. It all started with a softball sized cyst on my L. ovary that burst and landed me in the hospital from the pain. I didn't even know it was there! The Dr. went in to take it out with the scope, and told me that I had stage 3 endometriosis. I never had any pain, so I find it hard to believe that I even had endo. At any rate, he told me in order for it not to come back, I would have to go on Lupron. He told me I may have some hot flashes and vaginal dryness..I read the brochure on it and I thought the side effects would be worth saving my reproductive tract.
I gained 30 lbs during my 4 months on lupron. The hot flashes were terrible, I would have 2 or 3 in an hour, drip sweat, and then freeze. The vaginal dryness was so bad it itched internally, I had to use massive amounts of lube to have sex--which was nearly impossible because my boyfriend couldnt stand to sleep with me constantly moving around, dripping sweat, throwing blankets on and off. I began to have anxiety attacks and terrible mood swings.

I wouldn't recommend this medication to anyone, ever. I was on the monthly dose,refused to stay on the medication after 4 months (June), and just finally got my period a few days ago. I still get occasional hot flashes, especially during or after drinking alcohol. I am doing about an 1 1/2 hours of cardio a day, besides using my bike for transportation, eat clean 90% of the time, and weight train a few days a week. The scale is not budging and I've been at that for about 6 weeks. It is frustrating to say the least. Does anyone know how long it takes your body to get back to normal??

I had 3 injections of lupron Jan Feb and March and I stopped. I still feel lousy, my bones ache. Ever since the first shot I have not felt good thinking that this would help me, it did not. I wish people would stop talking about the price of this medication and start talking about the side affects. I sit and cry from my aches, I won't even go back to any Doctor. Thank-God that it is only so severe 3 weeks out of the month. has anyone experienced such side affects. and by the way my period never did stop and I am still in much pain from that.

I just went to the Dr. for my second Lupron injection and to get some help with the side effects. Menopausal/emotional me, started crying!!! Gawd! I went in with my list of side effects from the last 3 months (and it was long!) and wondered what was worse, the pain of endometriosis or the life changing side effects of Lupron. My Dr. is wonderful and spent an hour with me; he decided to put me on Provera (progesterone or add-back therapy) for a week to see if the side effects improve. If they do, I get my second dose of Lupron in a week. If not, we stop it all and let my body slowly try to get back to normal (although I have never known what "normal" is since endometriosis) and see how the "therapy" worked. He is strongly encouraging me to follow through with the 6 month course as that is the recommended length of time for the best results. I'm 5'8" and have lost 10 lbs. in the last three months, I'm down to 107 lbs. He told me to try and eat more if I could (although my nausea is constant 24hrs. a day) and make sure to take a daily vitamin and calcium for bone loss. He said that he has never heard of blurred vision to be a side effect of Lupron, "But every woman is effected differently." I'm really hoping the Provera works - any kind of relief is better than this! I'm still having 3-4 hotflashes every hour with extreme exhaustion/fatigue, night sweats, daily migraine headaches, nausea 24hrs. a day, life changing mood swings, and shaky hands. He kept reminding me that this only 6 months out of my life - it's not forever ... forever feels like an awful long time when you can barely get out of bed!

I'm on my second series of the lupron shot, I am also a very young age of 17 years old tying to conquer endo and it's symptoms.... At age 13 I received my first laparoscopy and have been on birth control since "becoming a woman". I have terrible cramps and creeping lower back pain that makes me feel weak and exhausted all the time. I should be full of energy,but i just have terrible mood swings, lost love interest, severe mood swing, extreme hot flashes, memory loss, I've lost so much weight ..... I have lost from 125 lbs to 111lbs in maybe a month. I get very sick to my stomach and vomit when something doesn't appease me such as the smells of certain things, room temperatures, or even if someone around me is smoking. Lupron does take care of my extreme menstrual pains i did have, but sometimes i just wake up to dread the day.... It just feels like anything can make me feel upset and empty on the inside, no one wants to feel like that. From April 08- July 08

I have had endo for about 9 years now. 6 surgeries later, I decide to try the Lupron Shot. I took the 3 month dose twice. I did not experience any side effects until the 2nd month, which included hot flashes, mood swings, sleepiness, no interest in sex, weight gain, horrible headaches, loss of memory, pains in all my bones, breast tenderness, blured vision and so on. I am now off the shot after being on it for 6 months, and I am worse now then I was then. My pain is back from the Endo, my stomach feels like there is a huge ball in it, I have extremes of sever diarrhea to constipation. I feel like Im going to throw up every other hour..sometimes I do. My bones hurt worse than ever. I still have no memory and I cannot concentrate very well. My Dr. will not allow me to have a hyst because he feels I am to young. I am 27 married with a child..how much older do I have to be to get some relief? So, yes I liked Lupron, it did help. but I would rather get this crap taken out than go through all of this again.

I discovered I had endometriosis in March 2000 at which time I had surgery to remove what was there, then the gyn followed up with the Depo-Lupron shots for six months. To help with the hot flashes, mood swings etc. My doctor put me on a very low dose of Estrogen which helped. I was having fertility issues before this and when I finished up the shots and the time had ran out and still had no period, my doctor put me on fertility drugs to give my body a jump start, and in April 2001 we found out we were pregnant, during which time my teeth started deteriating and by the time I have my second and last child in March 2003, I had to have major dental work done. I blame the lupron shot for this issue, apparently my calcium level dropped. I told my gyn about it and he said he had never heard of any such thing before as a side affect of the drug. I pretty muched laughed in his face and told him to advise future patients to increase the calcium while on the drug. Then recently I discovered like a lot of you that there are some really serious side affects from Lupron. Since this after having my last child I went on the Depo Prevera shot for 6 months, gained unsightly weight, so I got off of that and got my tubes tied in 2004, then by March of 2006 I knew my endometriosis was back full fledge and in June 2006 I had to have a hysterectomy. My only long term affects from the Lupron and Prevera shots is still trying to lose some of the weight and living in pain during every meal but due to the extreme affect it took on my teeth, I can not afford even with insurance to get all the work needed done!!!! If I had to do it over again, I would have had the surgery and then worked on getting pregnant immediately, because long term..... It isnt worth the "preventative" HaHaHa!!!!

I got my shot in Oct after 30 days of extremely heavy bleeding almost resulting in a blood transfusion. I got my shot in Nov. Still no period 9 months later. My doctor is telling me that it stays in people's systems for different period of time. I went through the night sweats and mood swings and now finally weight gain but NOOOO period. I'm 39, I hope I never get it again.

I ONLY HAD ONE INJECTION AND THE SIDE EFFECTS WERE HORRIBLE. I HAVE A 2 YEAR OLD LIL BOY WHO IS WONDERFUL. WHEN HE WAS A YEAR AND A HALF I WENT TO THE HOSPITAL FOR SEVERE BLEEDING AND FOUND OUT THAT I HAD BEEN PREGNANT AND WAS HAVING A MISCARRIAGE. THEN 6 MONTHS LATER I HAD AN IRREGULAR PERIOD WHICH HAD NEVER HAPPENED BEFORE. I HAD ONE AND THEN TWO WEEKS LATER HAD ANOTHER AND IT WAS VERY PAINFUL. I WENT TO SEE MY GYN AND HE DID A VAGINAL ULTRASOUND AND TOLD ME I HAD A CYST THE SIZE OF A GOLF BALL ON MY LEFT OVARY. HE PUT ME OF A HIGH DOSE OF BIRTH CONTROL TO DISSOLVE IT. TWO WEEKS LATER I HAD TO GO BACK TO THE DR BC I WAS STILL IN A LOT OF PAIN. THE DR THEN TOLD ME HE WAS GONNA DO A LAPROSCOPE. WHEN I CAME OUT OF SURGERY THEY HAD INFORMED ME THAT I HAD ENOMETRIOSIS AND THAT MY BLADDER WAS STUCK TO MY UTERUS AND MY UTERUS WAS STUCK TO MY ABDOMINAL WALL. I ALSO HAD THE ENOMETRIOSIS ALL OVER MY OVARIES, UTERUS, AND BLADDER. IT WAS VERY PAINFUL. MY DR SUGGESTED THAT I TAKE A 6 MONTH TREATMENT OF LUPRON. SO I DECIDED TO GIVE IT A TRY. I TOOK ONLY ONE INJECTION AND THE SIDE EFFECTS WERE HORRIBLE. I HAD MOOD SWINGS, HOT FLASHES, STOMACH PAIN, CRAMPS, FATIGUE, TIREDNESS, JOINT PAIN, SWELLING, WEIGHT GAIN ETC... I CALLED MY DR AND HE PRESCRIBED A HORMONE PILL WHICH DID NOTHING. SO I DECIDED NOT TO TAKE ANYMORE INJECTIONS. THAT WAS ALMOST 3 MONTHS AGO. I AM STILL IN SEVERE PAIN SOMETIMES IT IS HARD TO GET OUT OF BED (WHICH I HAVE TO GET UP EARLY EVERY MORNING I HAVE A 2 YEAR OLD). I STILL HAVEN'T HAD A PERIOD AND IM EXTREMELY RESTLESS AT NIGHT I AM TIRED BUT CANT SLEEP. DOES ANYONE KNOW WHEN I SHOULD EXPECT A PERIOD??

I am 30 years old and have been put on Depo Lupron after a laproscopy to help with endometriosis. I am 2 months into a 6 month course (one shot every 3 months) of Depo Lupron and my life has drastically changed. I started feeling life altering hot flashes and night sweats two days after the first shot and nearly drown myself in sweat 24 hours a day. I experienced a little postpardum depression after giving birth 6 years ago but have found myself sunk into a sinking hole of depression and anger like I've never felt before. I bawl at McDonald's commercials and become enraged if the dishwasher isn't loaded properly! I am ecstatic one minute and severely depressed the next. I have even had thought of suicide since being on this shot. I am normally a very outgoing, athletic, cheerful, happy person - but since taking this shot, I have become a stanger in my own head. I tell my family all the time that I need to "go stick my head in the freezer" to cool off because of the horrific hot flashes. I have to carry a handheld fan with me 24 hours a day and sleep with ice packs to keep cool. Since the shot started 2 months ago, I have lost all sexual drive, am thoroughly exhausted by 9am and find myself crying at my desk at work by late afternoon because I am so tired. My family thinks I am going crazy and I've never fought more with my husband. My daughter has gone to grandma's for awhile because I'm just so tired and irritable that I feel like an awful mother. Migraines have also come full circle since the onset of the shot as well as blurred vision and shaky hands. I'm a little achy throughout the as well. I know that everyone responds to medication differently, but I'm finding a lot of people with the same side effects as myself and have to wonder why the doctors don't warn patients about these types of problems before prescribing medications such as Depo Lupron. I don't think I'll be going back for the second shot. Could it get any worse?

I have been on Lupron for not even a month yet. My side effects are bad headaches, the pain has not gone away, I am still having my period, I have terrible mood swings, I have trouble sleeping, I have no sex drive at all, (my husband hates that) I get shortness of breath sometimes. I get hot flashes, they don't really last long, but when they hit, they hit. I get stomach aches and nausea sometimes. I think the worst thing about me is that I am in the Army. One doctor that I was seeing did a sonogram, a CT scan(i think), and put me on birth control pills, but none of that worked. She said there was nothing wrong with me and that I was making it all up. She said I needed to go to mental health. I finally got referred to OBGYN. The doctor there did a laproscopy, but let her tell it, she doesn't even know if I have endometriosis. She said I have a lot of scar tissue, but she can't say if it is endometriosis. Why are you treating me for endometriosis if you don't know for sure if I have it? The worst part of all is that I am supposed to be deploying to Iraq next month and I am still in pain. Yall please pray for me...

Well what more can be said really ? most all of us have suffered a great deal for a long time with going to a bunch of quack dr.'s listening to drug reps (Pushers) sell their dope and we all want to believe there is hope but there is none .these problems we have know one knows the actual cause so therefore there won't be a cure . sure there are a few success stories but for the majority these side effects are only the beginning I really don't want to bear children anymore due to i am afraid of what I put in my body and are my plumbing problems hereditary? I couldn't live with myself knowing that I passed on all theese problems to my child. I have been off lupron now for well I can't remember what year it was I think it was 2005or 2006 and I am still having issues.....................
Bone/Joint pain , MEMORY , G I problems , Weight gain , Depression , Tired all the time , Dizzyness , I can't walk straight , heart palpatations , upset stomach , impatient , the hair thinning has got better , but the dandreff hasn't , i'm irritable , moody , and my fave acne the night sweats went away after they gave me the northindrone it really helped and the prozac really helped with the sever mood swings . But I am not myself I haven't been in a long time . the worst side effect is a broken spirit. the con's FAR outweigh the pro's

pain killers and muscle relaxers with a laporoscopy with a briliant surgeon like a endocrinoligist not a plain GYN Along with a great diet and exercise and maybe throw some metformin in for kicks and that my friends is a great start . we do have alternitives . we just have to search for them sometimes .

Hi: My doctor has suggested me lupron depot 3.75mg for three months before doing supracervical laparoscopy. I did ask the doctor about the side effects and she said that you might get hot flashes and mood swings. Thats all she said about the side effects. My first shot is on Tuesday April 15/08. After reading all these experiences i am so scared to take them and planning to talk to the doctor again and looking into the abdominal hystrectomy instead of supracervical laparoscopy. Do you guys think that because it is 3.75mg and not 7 or more mg it might not have that many side effects.
God, I am so confused now, please help me out here.

Mood swings week following injections, slight hair loss, memory loss, headaches day of injection and couple days after, lack of concentration. Just had last (6th) injection about 11 days ago and started spotting about 5 days ago and cramping? Oh, also other major PMS symptoms, craving chocolate, salty things, very very irritable, and acne on chin area, neck, and shoulders? It caught me off guard a little considering I haven't had a period in almost 5 months. I assumed the Lupron would still be in my system? Called dr. and of course all they could say is "sometimes this happens and to wait till I come in for my follow up appt."? No explanation as to why? I was under the assumption that I wouldn't start AF or have these symptoms for another month or two. However, even with all of these side effects I have no pain, YET. I'm hoping for the best, also hoping I don't get divorced soon from all the moodiness!

I am a 43 year old women with 2 children. After my second child I started having problems with infections and pain during sexual intercourse After 5 years and 3 doctors I was diagnosed with endometriosis. I had surgery and still had some discomfort so my doctor suggested the Lupron shots. I was very concerned about the side effects. I talked to my husband and prayed about it a lot and decided to go with the injections. I just had my last of 6 Lupron injections the other day. I have experienced most of the side effects such as fatigue, mood swings, joint pain, lack of desire for sex and night sweats but have handled it pretty well. I was very concerned about the weight gain so I started a pretty intense exercise schedule (work out everyday) I have lost 5 pounds and feel the exercise helps with the fatigue. Even though I did experience the side affects due to the fact that I did not take my add back therapy like I should have I feel so much better than before I started the Lupron injections.

I am 50 years old...nearly bled to death from fibroids and became anemic. I had extremely heavy periods and had to receive a transfusion of 2 units of blood when my blood count went down to 7. My options were 1) Do
nothing...2) Take 6 months of Lupron to hopefully bump me into menopause....3) Fibroid embellization...4) Hysterectomy. I am trying to avoid a hysterectomy....and needed time to get my blood count up before any other procedure. I have had some of the side affects...hot flashes, mood swings, night sweats,.....but I had them before because I was pre-menapausal anyway so there is really no difference. Have not noticed any weight gain and I get my 3rd shot today. Everyone's body is different...for now Lupron has been a life saver for me.

I am taking Lupron as I had horrible endometriosis, two large-grapefruit sized tumors and several smaller implants removed. I lost my right ovary, and part of my left in the process. I am 28, newly married, otherwise healthy, and I want to have children, so I went on Lupron that my surgeon/OB suggested- monthly for six months. I read a lot of side effects and was TERRIFIED to go on it.

My own husband is an M.D. and I made him call different doctors in his hospital to see what they had to say...in a few days he called about 5 different OBs. Thankfully, they said that those that had side effects that were extremely severe was pretty rare. Still, I was scared.

I am now into my second month on Lupron and I have to say that the side effects aren't nearly as severe as I thought they would be. No hot flashes, no hair loss, no crazy depression, no anything else. I DO have fatigue, but it's manageable with coffee and extra sleep. I have some mood swings- mostly I feel more grumpy. The most noticeable and bothersome is the lack of sex drive and vaginal dryness. I also have trouble achieving "the big O."

Still, so far, very manageable. I'm not sure if it'll be worse if time goes on. But I feel like everything on the internet is really negative. I'm not discounting the tales of people who have had a bad time, but I wanted to put out there that it isn't always the worst thing in the world.

hi I'm 28 yrs old and have been diagnosed with endo. i have been taking the Lupron shot since August 07. I'm only suppose to be on them for a year. 2 weeks after my 1st shot, i started getting severe headaches w/ nosebleeds. also, I'm so exhausted all the time. after my 2nd shot i started passing out with severe headaches. i told my doc about it and she took me off the shot til i got a cat scan which came out normal. at the beginning of February 08, i was back in the er room 3x in a matter of 48 hours, thats when an ob/gyn at the hos. gave me another shot of Lupron. since i got this 3rd shot, i started having severe migraines and passing out again along with extreme exhaustion. I'm very angry my doc won't do the hysterectomy. she says, I'm too young. but the shot sends u into perimenopause, whats the difference. i was taking the hormones as well before my doctor took me off the shot but they made me really, really angry all the time. when the doc at the hos. gave me the shot, she didn't put me back on the hormones. this shot is suppose to help me but instead its ruining my life. i have severe headaches and exhaustion with the shot and severe pain without the shot. i don't know what to do. I'm not suppose to have any pain after i get off the shot for up to like months or years i was told. the shot started to where off at the end of January and i had to get it again in February when i was originally suppose to take my 3rd shot. i still have pain in my stomach, it just makes it tolerable. my other side effects r: mood swings, hot flashes, night sweats, no sex drive, extreme nausea, depression, stomach pains, swelling in my stomach, weight gain, and of course severe headaches. this is effecting my life so much. i do not recommend getting the depro lupron shot to anyone. of course everyone is different, but if the shot effects u like this, i recommend u not taking it. i will not be taking my next 1. i will be calling my doc 1st thing tomorrow morning cuz i passed out Friday with my 6 year old daughter here and no one else. i have been so afraid of this happening with my kids here and it has happened. as a mother u don't want your children to have to go thru something like that without no one else around. has anyone else had these side effects? i can live with most of them, but i can't live with the extreme exhaustion and severe headaches with passing out. thank u for listening.

I was taking Lupron shot for severe endo and ando. The best 6 months of my life!! I was feeling so much better, no more Pepcid ac and Advil! I wasn't crutched over holding my stomach at work all the time....I no longer had to take off work for 7 days out the month, I wasn't in pain. I have hot flashes, but so what....it was worth it. I don't recall any mood swings, I'm more moody off the Lupron because I'm always in so much pain. Lupron worked for me. My options was the shot or a full hysterectomy. I will probably have the hysterectomy eventually, but right now, I'm trying to get my doctor to give me the shot again. I was reading and some of you have been on the shot for a year or longer....I was told I could only be on it for 6 months.

I have taken Lupron injections for almost a week now. Me, and my husband are focusing on the end result...the baby. I am different than usual(as far as mood swings), but it is comforting to know that it will change here soon. It's also helpful to read other's issues with the drug, so I know I a not the only one.
Yesterday, my girlfriend came over to visit...I was crying uncontrollably....which I never do that! I also get VERY snappy with people..especially my husband. I am mad so much more and more intensely

Hello Everyone,

First I would like to address those who had terrible reactions to the drug. My heart goes out to you and please don't be offended when I tell you this: Life is a risk and when it comes to science there are never guaranties. With anything you will have a side effect good or bad. You will be a Guinea pig no matter who you are or what drug you take, because everyone reacts differently. Some good and Some Bad.

Second, to those of you who are looking into this for a cure, sorry unfortunately like cancer this is a reoccurring disease. The drug is to help calm your system down and to give your body a rest. I would have to say Lupron saved my life. After all the years of pain and suffering, and hospital visits that occurred due to the severe pain. After having surgery to remove these areas and the doctor who recommended this drug to me was a life saver. I was on it for a year and was put on the NuvaRing afterwards and had mood swings and hot flashes, BUT Ladies...No PERIODS and NO MORE PAIN!! Yeah I gained a little weight, but that was water weight, you can go to your local health food store to buy herbal diuretics and exercise...excercise. I agree Lupron isn't for everyone, but either is another drug out there. You take a chance with any chemical you put in your body. It is HOPE that encourages us to try these medications. I have to say 10 years later I had a beautiful little boy and yes they say even pregnancy gives you relief, but unfortunately for me I had a C-section. Causing me more scar tissue and a reoccurred of severe endometriosis. Due to funds and no insurance I have had to be put on a sister drug called Depo-Provera. It is similar side effects, but ladies take my advice. Lupron isn't for everyone, but I think if you are a good candidate for the drug, try it. It might make a difference in your life...I pray it is positive!!

I have been on Lupron Depot for a year and a half, and it has been terrible. I am a stage 3 endometriosis patient; I was diagnosed last year on my first day of school. They did a laparoscopy, D&C, and cystoscopy. I have experienced nausea, weight gain, mood swings, paranoia, night sweats, hot flashes, dizziness and have had to be hauled out of school in a wheelchair on many occasions. This is all while on Lupron Depot. It has barely taken my pain away, but I will say that at first it worked amazingly. I don't know if my system is just immune to it now, or what. I had to leave school today because of chest pain and my pulse was 111 bpm. Before I started Lupron, I was told that I "may experience some mild hot flashes at first, if anything." The hot flashes are absolutely brutal. I went from being a straight A student to barely scraping by, trying to get weeks of makeup work done. I have always been a sane, calm person, but when i went on Lupron, after about a month also had to go on Prozac because I was so incredibly paranoid and mood-swingy. I also went from a size 2 to a size 7 in about 2 months! I exercise regularly, I ride my horse everyday, and I eat right. I've always been in shape, but Lupron made me gain so much weight!!! I wouldn't recommend Lupron, but I don't really see what other choice there is, since they have already tried the pill and that stopped working after about a month. I'm so frustrated, and I can't take it anymore! Menopause and pain from endo are making me miss my life. I can never go out, I always have to call in to work, and I haven't been in school consistently for about a month.

To anyone considering going on Lupron Depot, I would think long and hard about whether you are ready to deal with the side effects of Lupron.

I took one injection of Lupron for fibroids in Nov. 2001. It totally changed my life, I am no longer the same person I was before. It started with severe migraine headaches for 14 days straight and attacks of nausea, lack of appetite. I used to have a strong stomach - now I was very easily nauseated. I never went for the second shot. I began to have panic attacks regularly (I had not had them for over 20 yrs). I was tired all the time, and a person who used to work out at the gym 5 days a week - eventually I quit. Now I just walk. I feel about 65 yrs old (I am just 49). I look old, my face began to droop, my hair thinned. I had bouts of depression coupled with general anxiety. My migraines worsened. My sex drive dropped to zero, I feel almost "sexless". I used to be confident, now I was afraid of everything. I now suffer from irritable bowel syndrome - with bouts of diarrhea, bloating and severe gas pains. I have trouble eating sometimes.. I have had all the tests and no one can find anything wrong with me,and none of the doctors think all these problems are due to Lupron. But, I know - I was NOT like this before Lupron. It ruined my life. I just wish my doctor would have informed me of all the terrible side effects - she only told me about hot flashes. I looked into suing her for malpractice but the lawyers said they could not build a case with no real medical evidence that my symptoms are caused by Lupron. I just wish I had known then what I know now. I tell everyone - NEVER take Lupron. Six years later and I still feel like this. Oh what I wouldn't give to have not taken that drug.

I had the worst experience of my life. It has been very hard for everyone around me to understand what I have been going through physically and mentally. I read one of the other posts about feeling like the "hulk" when your mood swings come on and it is no joke. I've lost friends and my boyfriend of three years. I have been off Lupron now for a month and I still haven't regained any strength. I used to actively go to the gym 4-5 days a week, now I'm lucky if I can make it through a one hour session every month. This medication was also recommended highly by my doctor without a description of the side affects. It was the most miserable experience of my life. There are plenty of other treatments out there and I beg for you to try them first.

I am reading these posts and see a horrible pattern of doctors not informing their patients of the possible side effects of this product. I, too, was informed by my doctor that the side effects we minimal. HA! The mood swings are brutal and the night sweats/hot flashes are almost hourly! I've also had localized chest pain beyond my left breast (like a muscle pull) since about a week after receiving the shot. I will be having an endometrial ablation in 2 weeks and this dose of Lupron will have worn off by the beginning of December and I can't wait!