Metoprolol Tartrate and lopressor

03/11/09 went in to have a blood test the MD had ordered. I met with the Md-- told him that the metoprolol 100mg twice a day had not agreed with me. I asked to change my prescription to what i had been taking before -- Norvasc 5mg twice a day along with a diuretic. A week later I went for my lab results. The AST(SGOT) 232 and ALTSGPT) 516, being dangerously high. Md asked if I had ever had hepatitis B. My answer was no. I asked him to check my blood test results of 11/08. The results were AST(SGOT) 24 and ALT(SGPT) 37. I told him I thought it could be the Metoprolol. The Md told me he wanted for me to have CAT scan and to refer me to a GI doctor. Went home praying to the GOOD LORD and received peace about this whole situation. I searched on the internet and found on ****** Metoprolol-induced hepatitis: is the rate of oxidation related to drug-induced hepatotoxicity?L. MS.
University Department of Pharmacology and Therapeutics, Royal Hallamshire Hospital, Sheffield, United Kingdom. Hepatology. 1989 Jan;9(1):163-4. Also found Hepatic toxicity is reported in at least one case report. ******
" 56-year-old female with a history of migraine headaches developed seronegative hepatitis associated with metoprolol. Her signs and symptoms resolved within 48 hours after discontinuing metoprolol, and were reproducible on rechallenge."
My results for hepatits were negative.On 3/31/09 I had lab tests and 4/01/09 the Md faxed my results AST(SGOT) 29 and ALT(SGPT) 43. I have not gone back to the doctor. I am taking milk thistle daily. I have learned a valuable lesson and am passing it on to others.

I have taken lopressor for several years and the main side effects for metroprolol at least in my case are:

1. vivid dreams with irritating situations that Icannot control
2. Transit pain in the lower abdominal wall that goes and comes invariably