PredniSONE side effects

I have Autoimmune Hemolytic Anemia (AIHA), was diagnosed in Feb. 2008. Have been ill for several years and finally it came to a head in Feb. I had a blood transfusion and then in the hospital 6 days later with a hgb of 4.0. I was so toxic and my blood so screwed up I nearly died. I was given another transfusion then (total of 5 pints of packed red blood cells) and started on Prednisone. For 3 days given liquid Pred injections, starting at 1000mg, tapering down to 250mg., then on the pill form at 100mg. Sweat poured off of me dosing down. I was off work for 2 months. I am still tapering but am now at 1mg. DR. added another drug, Danazol, after getting to about 10mg because my blood started going crazy again. My side affects with Prednisone have been, Euphoria, no depression, LOTS of hyper brain activity, thoughts running a 100 miles an hour but body at slow speed.Visual problems and a feeling of being highly drugged. 2 to 3 hours of sleep each night, compulsive behaviors and a lot of pacing back and forth. Couldn't hold my concentration because my mind wandered so much. Extreme Tremors in my back, hands and head. Wanted to talk constantly, if no one was around I talked to my Chihuahua or the TV. My cheeks puffed up and became hard and had a fat pocket puffed up on left side of my neck. My dog thought I was crazy, she was tired of the lights being on at 3 or 4 in the morning. Legs looked skinny but didn't gain weight until I got to about 60mg. Gained 25 lbs total. Tapering caused bad spasms in my calves, feet and hands. Thigh muscles would get extremely weak each time I went down a dose. At 50mg I started getting sleepy and could hardly stay awake. Went back to work at 35mg and couldn't remember how to sign on to my computer. Some memory problems since I was in the hospital, couldn't remember how to spell words I knew as a young girl. Started having hip pain about 3 months into the Pred, that hasn't stopped. At 10mg feet, knees, shoulders hurt deep in the sockets, muscles below my neck knot up, may take a while to totally get off this. Read on a couple of blogs where people cut a 1mg tab into 4 pieces to taper off the Pred. because of side effects. Had thrush in the beginning and break outs of shingles. I hope to God I never have to get back on this drug again, it is so HARD on the body but it did do what it was given for, to repress my immune systems. My next step is Spleen surgery, hope this is a cure for me, am sick and tired of being sick and tired. Wouldn't advise anyone to take Pred unless it's a life or death situation. It's prescribed too liberally and people have multiple problems, worse than I have experienced. I've probably forgotten some things, but there's enough I've mentioned to give you an Idea it's not good, but if Pred is all you have then you do what you gotta do!! My puffy cheeks have went down though, now my hair has become curly but at least I have hair and my chihuahua stills loves me!!!

i have been an asthmatic since the age of 2 years old i am now 24 years old. preds as i call it has been a part of my life since then. i have a number of reactions to it from gaining 30 lbs in les than 6 months to almost definitely hallucinating. i urinate frequently,my hubby says that i'm a leaking tap. i cry and grumble at times for no reason: yes mood swings like rain in spring time. i even threw away my wallet after a dose of preds three months ago. i laugh uncontrollably. i get depressed. sleep for long hours one time and then become insomniac for days. i am super hyper. i am creative and expressive and get even better for a few hours after taking preds. also i appear to have an attention disorder at times. i have acute hearing i.e i hear like a fox really well and then some day si behave like an 89 year old with a hearing aid. i get rashes on allergic reactions to things i've been using all my life like band-aid.i don't like it in fact when the doctor gives me 8 to be taken 3 times daily for a week, i take two and feel better without all the side effects. i am so fat its a shame. i was tall and lean and sexy now i am tall heavy and my hubby still says sexy. we all hate it don't we?!

Started taking prednisone about 3 months ago for a serious flare-up of my Sciatica. My Sciatica was so bad that I couldn’t even stand up. After a couple days of prednisone, I was able to walk, but still had pain on my left side, from my back down to the tip of my big toe. Symptoms started getting better, but then the side effects started. Gain 40 lbs, can’t sleep, muscles are so weak it’s hard to walk, blurred vision… one day (laying on my bed) I noticed I couldn’t even see the clock on the cable box anymore. Lumps started appearing. One on my wrist and one big one on my upper arm. I cut my finger 5 days ago and it still hasn’t closed up completely yet. It even still bleeds. I know on the side of my pill bottle it says “This medicine may lower your ability to fight off infections”, but man! It sucks when you have a little cut that just won’t heal. Anyway, I’m sick of the side effects and they only seem to be getting worse. I’m stopping today! I would rather fight through the pain of my Sciatica than to deal with all these side effects. I just hope (and pray) that the side effects go away without doing (if not already) major damage.

After reading previous postings, my experience seems so minor. I was on prednisone for about 2 weeks, starting at 50mg per day for 5 days, then 40mg for 2 days, 30 mg for 2 days, 20 mg for 2 days, then 10 mg for 2 days. I was put on it for severe poison ivy. I experienced sleeplessness, irritability, very quick to be irrationally angry and also had drastic changes in my triglyceride levels. I was hungry all the time, and extremely restless. 3 weeks before starting treatment my triglyceride level was 108, and cholesterol was 205. 5 days after treatment ended, my triglyceride level was 216, and cholesterol 214, all after being on a completely Vegan diet the whole time. It's my understanding that prednisone makes your body be in a state of alert while taking this drug, juicing you up to complete fight or flight status 24/7 while on it. Even 7 days later after being off of it, my patience is still limited. I will never take this stuff again.

Hello everyone! I just want to thank each and every one of you for your postings. On more than one occasion I would come to this site because without all of you I probably would have truly lost my mind. I just want to give a brief history of what's been going on with me because if it can help one other person then it's all worth it. In 2005, I go vaccinated for chickenpox, I work in health care, never had them, and wanted to start having children since I'm 36. A month after the vaccine I broke out in a horrific rash ALL OVER and had it until April of 2008. I went to the hospital where I had the vaccine, 5 dermatologists, 3 Infectious Disease, various medical doctors and no one knew what it was. This April, I was admitted to the hospital with Autoimmune Hemolytic Anemia. After 3 hematologists, the last one feels the vaccine threw my immune system into a tizzy. I started with 60mg of Prednisone and eventually got down to 2.5mg. The hemolysis(body produces antibodies that attacks it own body) started again so I went to a new Hematologist and was put back up to 30mg and just got put down to 10mg today. Right now my biggest concern is the hair loss. I use to have such thick hair and now I cry almost daily because I loose so much. I am going to try the Ensure like someone posted just to see if that helps. I drink protein shakes, take Silica, multivitamins (Solgar) that have biotin, and going to try Nioxin shampoo. I have terrible mood swings and now I feel like I am going through withdrawal. It's almost like I want to take more just to feel better. I know that sounds crazy. The big fat moon face, my joints feel like they pop out, confused easily, can't sleep, and just can't really leave my house and live a normal life since April. I HATE IT!!! The only thing that helps me feel better when the daily prednisone "kicks in" is walking and exercising. I feel so bad for everyone this drug is just awful. I get angry because not one person told me what life was going to be like on prednisone. I think that is just mean. That's why these postings are so important. I know this is entirely to long but I feel so much better getting my story out there. Did everyone's hair eventually grow back. I don't know if I will have any left next month. Thank you all so much.
GG

My 15 year old son was put on prednisone for orbital pseudo tumor about 5 weeks ago.He hasn't had many side effects except vomiting and the pattern seems to be every other day he has tapered down from 40 mg. to 20 mg. I thought maybe the pseudo tumor might be causing vertigo , i don't know if vertigo is sporadic like this? The vomiting didn't begin until right before his next day reduction on his prednisone. I don't know what to think of this drug at this point ,it did make his eye which was swollen completely shut, begin opening up about 5 hours after his initial dose of 40mg.But i don't know why he is vomiting off and on and it didn't completely stop his eye from hurting. Now the doctors want to biopsy his eye muscle since he is not responding well to prednisone reduction.God be with you all who are struggling with this medicine.

Hi All,

I was diagnosed with dermatologists when I was 14 years old and put on very high dosage of prednisone to get my disease under control (40 mg a day at the beginning). My muscle enzymes were out of control (CPK was almost 8,500 when it should be less than 215) and I was barely mobile, huge amounts of weight loss, alopecia, Raynaud's, etc. That was 11 years ago and I am now almost 100% better. Prednisone saved my life, but the side-effects were TERRIBLE! Especially for a girl going through puberty. Kids at school don't understand you're sick, and they can be extremely cruel. Luckily for me a large number of my family members are in the medical profession all over the world and my parents were able to pool knowledge to find the best treatment for me without all the horrible side effects. An uncle in Germany suggested I take a Prednisone alternative widely available in Europe called Diflazacort. This medicine is not available in the states apparently because the FDA thought it was exactly like Prednisone so was unnecessary. I'm sure this is some pharmaceutical company lobbying to preserve Prednisone's monopoly on inflammatory diseases, but regardless it makes finding Diflazacort difficult for Americans. This is a HUGE shame since this medicine gave me ALL of the benefits of Prednisone with NONE of the side effects. My mood swings, water retention, increased appetite, hazy brain, thinning skin, etc etc etc ALL stopped with Diflazacort. This wasn't only true for me either. A family friend had been diagnosed with Crohn's at the time and he was put on Diflazacort from the beginning of his treatment after seeing how I reacted to it and NEVER had any of the negative side effects I had to deal with. Really this drug was like a miracle for me. Prednisone prevented my sure death, but Diflazacort gave me my life back in its entirety. I've now been off of any steroid for 7 years and my muscles are fully back to normal. Some of the fat deposits Predinose caused still linger, but to most people's eyes I'm totally back to normal. I wish I could find everyone having problems with Prednisone side-effects and tell them about Diflazacort. Even though it isn't available in the states (although I heard recently they are trying to get it approved again since a number of studies showed Diflazacort is much more effective treating Crohn's than Prednisone is) you can get it on the internet or if you have doctor friends abroad as I did. I'm always wary of buying drugs over the internet since there's no control so I would suggest contacting doctors in Europe or Asia directly or through your doctor here in the states. Anyways, I wanted everyone to know that some people do get better and I wish you all the best of luck!

Hi All,

I was diagnosed with dermatologists when I was 14 years old and put on very high dosage of prednisone to get my disease under control (40 mg a day at the beginning). My muscle enzymes were out of control (CPK was almost 8,500 when it should be s no control so I would suggest contacting doctors in Europe or Asia directly or through your doctor here in the states. Anyways, I wanted everyone to know that some people do get better and I wish you all the best of luck!

I was put on PredniSONE for my asthma. On day two of taking it I started to feel really awful. I couldn't lay down, sit down or stand without feeling like I was going to explode. So hubby took me to emergency. My blood pressure was sky high. 201 over 90, they put me on a fluid retention iv drip. I had retained way to much fluid and it made my blood pressure go skyhigh.

I have asthma and have been prescribed prednisone several times for it. Every time i take it i break out in an awful acne looking rash all over my arms and my chest and sometimes even my face. it doesn't start until about 3 days after i have started the medicine and it doesn't go away for about 2 weeks and it itches the whole time. I told my doctors that every time they would try to prescribe it and they did not believe me they said no one could be allergic to prednisone but it has happened to me 6 times now and it has never happened before i had prednisone or on many other medicine since then.i finally got them to switch the steroid to a different kind but every kind seems to do it. i had to refuse steroids the last time i was in the hospital for my asthma they just would not accept that i could not take the medicine.

eat avocados to help with cramps. No one tells u that prednisone depletes potassium. Better avocados than banana because prednisone also raises your blood sugar.

I have two experiences with Prednisone to share: I am a 52 year old woman, married, no kids. One year ago I came down with a serious case of shingles on the top and inside of my left eyelid. What started out as a bump that looked like a pimple or a bite on a Friday afternoon (and I don't have acne), spread across and under my eyelid by Mon, morning, up into my eyebrow and down the side of my nose. My eye felt like there was glass in it every time I blinked. I got to the doctor on Mon, the dermatologist on Tues and the opthamologist on Wed. All confirmed shingles. I have never felt anything to excruciating in my life! The dermatologist prescribed a 3-week descending dose of Pred starting with 6 pills a day. I was also given Gabapentin (a nerve blocked), Acyclovir, a muscle relaxant, pain medication and two separate eye drops, one of which was also low-dose Pred. After the 3 week course of treatment was done, I had to continue for another week, but with lower doses.
Side effects: I did not notice any side effects except that my appetite was seriously jacked up! I ate anything and everything -- and then some! Food was my best friend and I hogged everything in site! In hindsight, when I try to assess myself and any changed, I guess I do have some attitude issues in that I am quicker to anger, quicker to react and respond and seem to "snap" a lot quicker.... Oh yeah I am also on antidepressants.... I now have one droopy eyelid due to the nerve damage from the Shingles and permanent damage to the cornea and tear ducts.... However I am not really sure how much of that is due to the Shingles and how much is due to the Prednisone.

My 89-year old mother was hospitalized in August for emphysema and chronic lung disease, she was down to 81 lbs. They treated & released her and she was on a descending dose of Prednisone for a week. She needed to gain some weight & gained 3 lbs! This was very good.... She is still smoking and her doctor will NOT insist she quit (I think they have given up). They put her back on a 2-week course of Pred again last week. Her appetite is back up Yeah! but she has some serious attitude and anger issues. We are only 1 week into the 2 weeks and I don't know how our family is going to stand taking care of this evil old woman during this Prednisone treatment, and afterwards. I'm sorry I ever let the doctor put her back on it--- however she is gaining weight and getting (falsely) stronger, which she needed.

I was prescribed the 4mg methylprednisolone pack along with 50 mg tramadol for acute tendinitis in my wrist. I took the first 3 days of the prednisone and only 2 doses of the tramadol over the three days. For a total of 60 mg of prednisone.

The first day I had hot flashes and insomnia but attributed it to the tramadol because I had never taken it before and had taken the prednisone several years ago for poison ivy with no adverse reactions. I didn't take the tramadol the second night and then took it again last night along with my daily dose of prednisone. I had extreme difficulty falling asleep, heart burn, hot flashes; and tossed and turned all night trying to fall asleep. At around 2am, I began to have difficulty breathing, tightening in my chest, confusion, and racing thoughts. It felt as though my throat was closing up on me. My anxiety progressed to the point that I was pacing back and forth. I woke my husband up and told him to prepare to take me to the ER. After calling my insurance's 24 hour help line, it was recommended that I go to the ER. I had an x-ray, blood work, urine drug screen, and echocardiogram. Luckily, everything was negative. The ER doctor told me that I likely had a reaction to the prednisone and commented that some people will experience these symptoms when taking it. He stated that he had a similar reaction when he took it and it felt like he was climbing the walls, which is an accurate description of my experience that night. He recommended that I either stop taking it altogether or call my primary care provider and cut it down. He prescribed me xanax and administered some to me at the ER which greatly helped. The next day I stopped taking the pred but am still having dizziness, chest tightness, hot flashes, and mental dullness. I have decided to never take this medication again. Fortunately, I don't have any of the physical sx that some have experienced, and my heart goes out to you. I think the mental symptoms were traumatic enough for me and can't imagine having both as I would be a basket case. I have mood swings, some melancholia, and am very fatigued.

I think it is imperative to research any medication that is prescribed to you before you take it. Many providers will say that side effects are rare, but my experience is that side effects are more common than rare. My prayers go out to those of you who are going through what I am going through. I hope that it clears our systems quickly because this is no way to live. I'd rather put up with the pain of tendinitis or carpel tunnel than to have these symptoms.

My daughter, 21yo, took prednisone off/on for 4 months, both oral and IV form, with the highest dose of 90mg over a two week period. The risk of bone death (Osteonecrosis, aka Avascular Necrosis) is not disclosed as a risk and 7,000 people a year get this from steroids! They gloss it over under the guise of "bone pain" or "bone fracture" near the osteoporosis risk so you think that by taking calcium and vit D supplements you're protected. What's really going on here is that the steroids cause the bone to die so if you have pain, PLEASE INSIST on an MRI because a regular x-ray will not show ON until it's in the advanced stages..and then you'll most certainly need joint replacement.
I'm not making light of the weight gain, or loss of hair or any of the myriad of other side effects that come with this drug, but when you're told that the joints in your body are dead...and that they'll eventually become brittle and break and cause so much pain it is often compared to bone cancer, then you'll really want to sue someone. But, I've tried that...it doesn't work. Because the drug is FDA approved...the manufacturer can't be held liable.

My daughter has ON in her right shoulder, both elbows, both wrists, both knees, and both ankles. She's considered "collateral damage" by the medical/legal communities because Prednisone is the "gold standard." This disease is a slow progressing disease which is often found as late as 10 years after stopping the steroid treatment. If you find it early enough, some surgical options exist to prevent the collapse of your bones, so if you have joint pain...PLEASE investigate with an MRI

Earlier this summer, I developed a case of shingles. It went away, but about a week ago a similar rash broke out. I thought that it was a second bout of shingles, but my doctor assured me that it would be impossible to contract the disease on different parts of my body. Because I am not home with my ordinary doctor, I had to see another doctor, who was unsure of what the rash could be, but nevertheless prescribed with with 50mg of Prednisone daily. I took my first dose today, and am reluctant to continue. I don't want to be a victim of any of the side effects, but am unsure as to whether there is another way to go about getting rid of the rash. Any advice that could be given so as to not have to continue with the Prednisone would be great. I don't want the rapid weight gain, depression, mood swings, etc.

My friend's mom who was in great health took this stuff and got osteoporosis and diabetes, became depressed, and then she died.

My 12 year old son has been on 60 mg of Prednisone for two weeks now. His side effects have not been bad at all up to this point. He's gained about 6 pounds. His brain is unusually active right after taking the drug, and this effects lasts a few hours. He's always been a wildly creative kid but prednisone seems to intensify is creativity and the productivity of his brain. He has Tourette Syndrome and his tics waned overnight after beginning the meds so that is a big bonus if prednisone is responsible for that. He has always been an insomniac since he was a baby but prednisone makes him sleepy, so sleepy he takes naps during the day and goes to bed early, sleeping soundly all night, so soundly he had an accident and wet his bed last night. His head sweats when he sleeps. He has infrequent periods of mild irritability. His appetite has increased but not unnaturally so. Seems like he finally has a sustained healthy appetite. He goes to 45 mg for two weeks tomorrow so I'm interested to see what new side effects this brings on. No stomach problems despite taking this along with very high doses of antibiotic. Maybe the prevacid he takes with Lactobacillus is helping with that and the fact that he takes his meds with small meals or lots of fluid.

what did anyone use as an alternative???....my daughter is currently having a severe wasp reaction, has been told to take prednisone, and I don't want to give it to her.

I have Crohns and had a flare up so I'm back on 40mg of Prednisone. I've been on 40mg now for 3 weeks and I start to tapper off in another 3 weeks. Well every time I start the prednisone again I get new side effects. This time, my gum are bleeding all the time and the pain in my knees are horrible! I still get the regular side effects, ie: Mood swings, joint pain, sleeplessness, sweating, swelling of my legs and hands, wanting to eat everything under the sun, moon face and my hair falls out! I wish the drug manufactures could develop a drug that would not be so hard on our bodies. I have to struggle with the pros and cons with every flare up. Do I want the weight gain, mood swings and hair loss or do I want to look good and be very sick! I'm 37 and was 16 when I found out I had Crohns.

Reading some of the other side effects (after posting my most recent side effects) has made me think back a long time to when I was about 10 or so, and my asthma had been acting up- I was given a sort-of high dose of prednisone. For about two-six months after taking it, I had really severe knee pain, sometimes where I couldn't even walk around the grocery store. Eventually, it went away, and I distinctly remember my mom asking my doctor a few years later if it could be the cause (too high a dose and no weaning off), and the doctor said it was possible. Sometimes, I will have general knee pain for no specific reason, but luckily it doesn't happen very often.

Once I came back to Buffalo to school and had taken my first allergy shot, my asthma flared up majorly, so my doctor put me on 10mg prednisone for 8 days, while at the same time putting me on Symbicort (and also at the same time, I have been taking 75mg Doxycycline for my skin issue), and it caused me to get thrush, even though I was rinsing my mouth after symbicort. I was given the impression by the P.A. I saw that taking Prednisone increases your chances of getting thrush. Has anybody else ever experienced this?

I am 49 yr old male and was diagnosed with a severe upper respiratory infection. Was put on Prednisone for 20 days. I never did experience depression, but I did experience the hyper state and was full of energy big time. It was actually nice ...had felt better than I had in a long time. Two of the side effects that I have been experiencing is sweating a lot more than normal ... I mean just the littlest of exercise and my shirt is soaked. Also my back and the back of my neck has broken out with acne ... that really hurts. I am using Desoximetasone which is a prescription cream and it has almost cleared all my acne up. I was about 250lbs and lost to 235lbs in the twenty days I was on it. I never changed my eating habits ...weight just fell off ...... man I wish they could put that it another pill without all the side effects. Now that I have been off for a couple of weeks ...I have gained some of the weight back ... but I'm really trying to change my eating habits and get back to 235 and go lower.
I wonder if everyone posting would also put their blood type on their comments. There are so many different opinions of Prednisone ...there has to be a reason why you have so many effects for some and very little for others. I did research this drug while I ws taking it and read that if you take it for longer than 30 days that your body will stop making the natural prednisone that it makes. Thats why you hear when people take it for long periods of time ...you are destined to take for the rest of your life.
As far as lung condition, I can breathe again and I think I'm totally cured ... I have a follow up with my lung doctor next week.
My prayers are with you guys .... I agree .. I don't think I want to take Prednisone ever again. My blood type is AB+

Hi I am a 44 year old asthma patient. I have had asthma since the age 2 and have been on & off prednisone since that time. As a child until age 20 I was on predinsone daily. My question is has anyone experienced nerve problems due to long time use? I do have muscle weakness and spasms, but I am interested in if anyone has had nerve problems. Please email me at ****** and refer to prednisone.

How interesting to find this site! I, too, was diagnosed with temporal arteritis on February 29 (no more leap years for me!). Because I was already blind in one eye (had no idea) and losing sight in the other eye, I was put on 100 mg daily of prednisone. I had no idea of what I was in for. Since that time I have been able to taper down to 42.5 mg daily, but I don't think I've missed a single side effect. Horrific headaches. A 25-pound weight gain so rapidly it was unbelievable, moon face like I've never seen, was thrown into diabetes right away. My blood pressure went haywire, my cholesterol went haywire (had never had problems with either of them). I think I agree that the most debilitating has been the muscle weakness and leg cramps. I have no balance, have had 3 serious falls. The latest is my skin is breaking down and I'm losing my hair. What hair I have is like somebody held a match to it and frizzed it. I'm short of breath, keep trying to exercise and it's like climbing a high-altitude mountain. Swelling of my feet to where I can wear NO shoes except for Crocs in about three sizes bigger than I ever wore in my life. Now I have a liver problem, am being sent to an "ultra-specialist" for this. The good news is that my remaining eyesight has been stable, and I am very thankful for that. I have been assured by multiple specialists that I would have been blind by now if not for the prednisone. Although it is very difficult for me to read by the time night arrives, and that was my chief "hobby." The other part of this whole sad saga (ha) is how much money my husband and I have been out this year -- unbelievable. Lab tests or doctors every single week and sometimes every single day. I am now under the care of 5 different specialists (ophthalmology, rheumatology, cardiology, hepatology and internal medicine), and it has been so incredibly expensive. This is even with fairly decent insurance. I have been told that I have at least six more months to go on this treatment, and then possibly another year on methotrexate. Thank God I have NOT experienced the depression that seems to be a common thread here. I am trusting in Him to get me through this itme and to come out on the other side completely cured. But it does get difficult in the meantime.

I took prednisone for 6 days ( the pack). Six the first day and five the next till day six I had one pill left. I have never experienced hair loss like this. I have a patch of hair that fell out in a circle the size of a 50 cent piece. I didn't notice it really falling out but noticed a bald spot and I freak out. I came on line to get info about this medication. This drug was ordered for me because I have severe pain in my back due to osteoarthritis, sciatica and back surgery. I was told taking this would help with the inflammation and might relieve some of the pain symptoms. Well, I think the pain would be better then the side effects that I suffer. I had loss of appetite and acne on my face. I feel dizzy and bloated. I pee all the time and seems like i visit the bathroom much more often for other reasons too. I have felt like a crazy lady and have less patience than normal. I hope that this does not last for ever. This is a small amount of the medication. I am sorry for those of you that have experienced a long period of time on this medication. I pray for you that they will find another alternative with less effects to your bodys.

So far not too bad. I have a flare up of proctitis and my doctor prescribed prednisone (20 mg 3x a day). Side effects are occasionally feeling sickly, occasionally a very noticeable heartbeat, a bit more irritable and feeling rather thirsty. So not too bad, I am seeing my doctor again in 3 days time and will take it from there.

Hi everyone,

i need to tell you about what just happened to me, because it seems most people are definitely not informed of all the possible side effects of prednisone - not only just relating to the dose of prednisone you take but also for how long.

I have been using prednisone for almost 14 years now, the doctors all tell me i'm unlikely to ever get off prednisone now because i've been on it too long. I know all about it's usual side effects (water retention, mood swings, thinning of all tissues including blood, acne, anemia, etc etc).

One side effect i was not advised of, not even in any educational material about prednisone either, was that long-term dependence can lead to Acute Adrenal Crisis. Which is deadly if not diagnosed and treated promptly. Thus i nearly died two weeks ago. I became rapidly ill with vague symptoms that i now know are symptoms of acute adrenal crisis. *THE ONLY REASON THE ACUTE ADRENAL CRISIS OCCURRED WAS BECAUSE OF LONG-TERM USE OF PREDNISONE*. Not many doctors will warn patients in advance of this. It is however, very very important that people are aware that long-term use of prednisone needs to be very carefully weighed with the benefits of using prednisone (i was started on prednisone in 1995 to treat severe Crohn's Disease).

Acute adrenal crisis can happen over weeks, months or years - in other words, it can come on so slowly that by the time you know there's something wrong you're already very very ill and in great danger.

I am very glad to have found this website and i hope you will all refer anyone who has any experience with prednisone to this site - education and knowledge is power - the power to stay alive.

(by the way, the treatment for acute adrenal crisis is to load up on prednisone - seems i'll probably never be free of this drug unless i can get my adrenal glands to begin working again (as prednisone "takes over" for the adrenal glands and they effectively go to sleep, and this is especially true for long-term use)).

My sympathies to everyone who has to go through the many nasty experiences with prednisone, especially the young children (I had to start it when i was 16). It really does mess with your body and mind, and in my case, became lethal.

Please pass on all your information relating to use of prednisone to everyone you can - it really is that important and seems to be the only way to avoid most of the disasters related to prednisone use.

take care everyone,
Linda
(Australia)

Several years ago I saw a doctor at the University of Iowa Hospital and Clinics in Iowa City, IA and was diagnosed with a chronic disease. Although most researchers and scientists will tell you lifestyle and dietary changes are essential when diagnosed with a chronic disease, my doctor, Dr. Anne L., told me they don't matter. In the spirit of "Do no harm," dietary and lifestyle changes are often the first things doctors recommend their patients change.

Instead of harmless lifestyle changes, I was put me on a lot of dangerous prescription drugs. One of those dangerous drugs was prednisone.

It didn't help my disease, but its side effects have been devastating and debilitating. And these side effects are particularly annoying because I was told this was a drug that didn't have side effects. (And when I learned about the side effects, I wanted to stop using it, but my doctor told me I'd die if I did. So I had to keep using it. Once you're on prednisone, you can't stop taking it abruptly. It really can kill you. So before you take it, you need to be informed. If you later found out its a drug you don't want to take, you can't just stop.)

But this is what I really wanted to say.

Look, prednisone's a bad drug, and most doctors don't prescribe it so casually anymore, but under the care of a good MD, its effects can be managed. Most docs will tell you right away when you go on prednisone about the side effects that most people are concerned about, like weight gain and acne. The fact is, those things actually matter not just superficially, not just for self-esteem, but in terms of people's overall health and even for managing the chronic disease for which prednisone is likely prescribed. If one becomes depressed, this not only affects one's overall general health, but for many chronic diseases, it can cause the disease itself to relapse. And because prednisone itself carries a risk of depression, managing such side effects, side effects that are likely to make a patient become depressed, is paramount.

Certainly most doctors will readily prescribe either topical acne treatments oral antibiotics for cystic acne which prednisone often induces. For the weight gain itself, ignoring the chronic disease for which prednisone is probably being prescribed, doctors often recommend a different diet to the patient.

My point is just that prednisone isn't as evil when you have an average or mediocre doctor.

Now, on the other hand, prednisone really is a bad drug to begin with. So under the care of a bad doctor, it's almost inevitable that you're going to experience permanent side effects and yes, under such incompetent care, this drug could easily ruin your life. That's what happened with me.

So make sure you have a good or at least mediocre doctor if you're using this drug.

And as far as dietary and lifestyle changes, I've been able to manage my disease solely with dietary and lifestyle changes. So I didn't need prednisone in the first place. Regardless, I would never take this drug again and I would not recommend anyone else take it unless you have exhausted every other possible option, unless you know you're doctor is competent, unless you know about the risks and side effects and what to do when they occur.

I never would've taken if I knew about the side effects. It's really quite stupid to use this drug as a first-line treatment, which is how it was used in my case. It should only be used as a last resort, if at all.

If I had never taken prednisone, I would be perfectly healthy today. My chronic disease itself doesn't influence my daily life at all anymore. But every single day the side effects of prednisone are evident and debilitating and will be for the rest of my life.

MY FATHER WAS DIAGNOSED WITH TEMPORAL ARTHRITIS. HE HAS BEEN ON PREDNISONE FOR ABOUT 5 MONTHS NOW, STARTING FROM 80MG/DAY. HE HAS TAPERED DOWN TO 40 MG/DAY,,BUT TH SIDE EFFECTS ARE STARTING TO BECOME UNBEARABLE.
WATER RETENTION,,SWELLING, MUSCLE PAIN,,WEAKNESS.
HE IS 80 YEARS OLD,,AND IT IS REALLY TAKING A TOLL ON HIM. IF ANYONE CAN GIVE ME ANY HELP OR INFO TO COUNTER SOME OF THE SIDE EFFECTS(MUSCLE PAIN AND WEAKNESS MOST IMPORTANT) IT WOULD BE GREATLY APPRECIATED.
THANK YOU.

I have long standing lung problems and after recent infection have just had 6 day course of 40mg prednisalone, which ended 3 days ago. since stopping the steroids i feel terrible my face is swollen i am in pain everywhere i have the runs i feel sick im dizzy by breathing isn't good. I telephoned the doctor to ask if he could leave me a prescription tili get to see him tomorrow and he refused as he says my symptoms are not due to prednisalone which i know are. ive been prescribed steroids for my lung condition for 30 years on and off so i know exactly what they do to me. i am so angry and depressed that i cannot get help.

My 12 yr. old son has to start this drug tomorrow. It's a long story I don't want to go into right now about why he has to take it, sort of irrelevant to the side effects he will experience. I'm glad I found this site and I will post our experience as we go along. He's going to be on 60 mg for 2 weeks, 45 for the next two, and it drops from there but they expect him to be on it for 4 to 6 months. Our doctor did not tell us much about side effects but gave us a brochure on it which definitely glosses over everything you all have mentioned here. One of my concerns is how this will affect his growth since he is just starting to grow a lot. More later.

This is my second bout with what my doctor thinks is erlickiosis. The first time I was at the point where I could only move like an old man doing "the nursing home shuffle". Everything was swollen. Feet, hands, knees even my jaw was hurting. I couldn't stand on my own even though two weeks prior I was walking 3-5 miles per day on some good size hills. I was hospitalized and given steroid injections. Within 12 hours I was standing on my own. I was given Perdnisone 30 mg X 3 days 20 mg X 3 days 10 mg X 3 days 5 mg X 4 days. Except for some insomnia and peeing 5 times a night there were no other effects. Within 2 days I was crippled again. Now my GP was in Africa and my Internist was leaving for vacation in India. Internist would not put me back on Prednisone because he wanted me to see a Rhumatologist. I made an appointment but it was SIX WEEKS OFF. Two days later i was admitted to a different hospital. This one was where my Rhumatologist had access. Long story short Prednisone 80 mg 7 days 60 mg 7 days 40,20,10mg 7 days each. Had to start taking insulin again. Glucose never went over 200. Avg glucose last 5 weeks is 120. Gained 5 pounds because I work out every day with free weights and lots of cardio. Hopefully, I won't have to many side effects when weaning is accomplished.

hi everyone, i'm a 36 y.o. male and have been on and off of prednisone for 25 yrs. my experience has always been more positive than negative with taking this drug. it has helped me to breath better and has made me to feel extra healthy and even physically stronger. but i have my suspicions about this drug also. it has given me a false since of good health and i feel like i want to keep taking it just to feel better. i have only taken the drug after an asthma attack for about 5-7 days. early on the only side effect was increased appetite and occasional insomnia. but the last time i took this drug the doctor increased the milligrams and a VERY UNUSUAL side effect occurred that never happened before. I HAD HALLUCINATIONS! i have never had these side effects before and on the leaflet of possible side effects that came from the pharmacist for the very first time i saw hallucinations listed as a possible side effect. the hallucinations were damn near demonic in nature. the experience went like this... i woke up in the middle of the night to use the bathroom and on my way to the bathroom i passed my dresser mirror and in the mirror was writing on the mirror in a mist! just like it would be when you get out of the shower and take your finger and write on the mirror. THERE WERE LEGIBLE WORDS ON MY MIRROR! mind you this is in my bedroom and the shower was off! at that point i refused to read what i saw in the mirror! it was weird enough what i saw i didn't need to read it. i refused to be fearful at that point cause i realized i was hallucinating and not getting a haunting. when i woke up later i went back to the mirror and of course no writing in the mirror. IF THERE IS ANYONE WHO HAS EXPERIENCED THIS PLEASE TELL ME YOUR STORY PERSONALLY! MY EMAIL IS ******! i would like to know that i'm not alone in this. to make it easier for me to see your response please type prednisone in the subject box on the email cause i receive a ton of emails and spam. and i would really like to hear other stories and experiences of taking this drug with very weird side effects!

I was prescribed prednisone (prednisone burst) for my endolymphatic hydrops (inner ear disorder). My initial dose was 80 mg for 4 days and then tapered down over the next 2 weeks. I took my last 5 mg today. I to have experienced the mood swings, along with extra energy, anxiety, fatigue, stiff neck muscles, sore leg muscles, weak leg muscles, nausea, sweaty palms and feet. I decided to go on prednisone after my doctor said it would help rule out autoimmune disease. I will never go on this drug again unless it is life threatening situation. It is a very nasty drug and my family has had to live with me during this difficult time. I'm leaving my condition up to the Great Physician!

i am a 42-year old woman diagnosed with chronic angioedema and it has become life threatening. the doctors say that it's idiopathic--can't tell what's causing it--and don't seem to know how to treat it (or me for that matter--my primary care doctor no longer wants to treat me, wasn't even kind enough to refer me out, the allergist most condescendingly said that in 20 years he's never seen or heard of someone so affected, and my dentist won't touch me because of my allergy to lidocaine.) i've been living with a daily minimum of 75 mg. of benadryl for the last four years but sometimes i've got to up that dosage to round-the-clock so some days as high as 450 mg. i'm allergic to meat protein, sea food, dairy, sodium and most spices, and certain fruits and vegetables. about 3 weeks ago i had a vegan meal at an indian restaurant and the spices accelerated my condition so on the drive back from the eatery my throat began to close and swallowing and breathing became difficult. i have had about 8 such episodes since then and twice have had to call 911 for emergency treatment to get things under control. on my first visit to the er about 2 weeks ago, in addition to the shot of epinephrine, i was given an iv in which they put a shot of benadryl and a shot of some sort of steroid. the doctor gave me a script for prednisone which was on a sliding scale (low dosage, one week.) i ended back up in the er about 4 days later and was given the benadryl and same steroid (think it started with an "s") again, and pepcid (doctor said it was for g-i and would help to limit the histamine being released into my system. since then, i have gotten the swollen belly side effect which i believe is from the prednisone (the angioedema causes blood vessels to swell beneath the skin but i don't think any swelling of this magnitude can be attributed to that). i have yet to find out if this swelling can be reversed with treatment or will go away of it's own accord. i've tried reading up on the reversal of the side effects but just hear more about how horrific they are--you all are truly in my prayers, keep your heads up!!!--so if anyone has experienced the dissipation of the side effects, please let me know and how soon after discontinuing the drug i can expect this disfigurement to go away. i too am dealing with depression for which i am prescribed but i dare not take the meds--far more too many side effect which with to deal and like some others here, i have no support system. i am the mother of the most wonderful 10-year old girl -- she is my heart and my world--but i dare not have her live with me because of this life threatening/altering/controlling condition.

sharing and hoping for good feedback.

blessings.

-vanessa w.

I have had trouble with eczema/psoriasis for several years and it has spread to most of my body. Hands, arms, elbows, back, chest and stomach, hips, back-side of my thighs, knees, bottoms of my feet, scalp, inside my ears, forehead, what haven't I mentioned? So far, Prednisone is the only medication I can take that clears it up. Trouble is, the doc won't let me take it long enough to completely clear the rash before I'm tapered off. After reading some of the other posts, I've got to say that I've never noticed any adverse reaction. My appetite is up a little, but my energy level is also up and I burn off any extra calories. I sleep better (no itching) and for longer periods, wake feeling better, have a better outlook for the day and am ready to go. I'm a salesman, so my mental attitude is important, and my wife and family all agree that I'm less moody and in a generally better frame of mind while taking Prednisone. I've noticed no stomach or bowel distress except for being a little less regular than normal. But no constipation and no diarrhea. I'm 61 so a few muscular aches and pains and joint stiffness are to be expected, but I've noticed no unusual incidents. While I don't advocate taking large doses (define large doses???) for long periods, I've read that taking Prednisone on an every-other-day basis can be effective while greatly reducing the risk of side-effects. I think Prednisone has been a real "miracle drug" for me and just wish there was something as effective without the side-effects.

I was prescribed Prednisone along with an H2 Blocker and an Antihistamine for a severe chemical reaction to using old lotion in a tanning bed. I only laid 2x, but I am severely paying for it now. I was only prescribed Prednisone for a 9 day treatment. By the 3rd day I had the acne. I suffered with Acne all of my life until I was 18 (I am 27 now) ... and haven't looked back at that terrible part of my life since... well, now I am faced to stare right back at it. Literally. I have only been off of the prednisone for 2 days, but I can not WAIT to get my life back. If I could take back the last 2 weeks over something so stupid and cosmetic as tanning, I certainly would. I have never had any previous problems with any of this, and this is the first time I have really had an allergic reaction to anything.... typically, Benadryl would have cured me. Although this time incurable with Benadryl and Cortisone, I regret the Prednisone. Severely. I hope this goes away within at least three weeks.. as my husband is coming home from Iraq and that is not the welcome home I want him to have (even if he is much less superficial about it then I am). Sigh.

This is an evil drug, far more dangerous than most illegal drugs. It ruined my life. I wish I had never been put on it. It was the first drug I, a teenager, was put on, having just been diagnosed with my disease.

I hadn't tried other drugs or other treatments; medical guidelines, I know now, say not to use this drug unless the disease is both severe and other treatments have failed. Well, I hadn't tried other treatments yet, so I shouldn't have been put on this drug. And yet the doctor I was assigned, Dr. Anne Sullivan at the University of Iowa's hospital, thought I needed to be on it, told me it was safe, that it didn't have any side effects, and that I would be completely healthy again in a few weeks.

If I had been told about the side effects, as doctors are supposed to do, according to both legal and medical standards, if my doctor had honestly answered my questions about side effects, I never would've taken it. And I'd advise others to never take this terrible drug. I would rather die than take this drug again.

It did nothing for my disease, but it did give me quite a few side effects, some which, according to the doctors I've subsequently went to, are permanent and long-lasting and there's nothing you can do about them; they're just permanent.

People don't talk about the psychological effects of steroids, but they should; they're serious. And, no, they don't just go away when you stop taking the drug. If the drug makes you bipolar, you're not just going to just go back to being you're regular self. Bipolar disorder, depression, anxiety, these things don't just go away on their own.

I had no problem with mental illness before taking this drug, and yet I'm still severely depressed to this day, part of that, perhaps, is from what the drug did to me, that is, the physical side effects, but part of, I suspect, is just that it changed my personality, like it changed my brain chemistry.

Go here-******to learn about the psychiatric effects of prednisone.

Excerpts:

"Although a powerful therapeutic option, corticosteroids are associated with serious adverse effects, both physiologic and psychiatric. While the somatic adverse effects of corticosteroid therapy (Table 1) have been extensively researched and widely described, the neuropsychiatric adverse effects have received less attention."

"In our literature review, we found that the potential psychiatric adverse effects of corticosteroids span a symptom spectrum from subtle mood changes to full-blown affective syndromes and frank psychosis."

"The most commonly reported corticosteroid-induced psychiatric disturbances are affective, including mania, depression, or mixed states."

"Cognitive deficits, particularly declarative or verbal memory deficits, have been well documented during both long- and short-term corticosteroid therapy."

"More severe cognitive impairment consistent with delirium or dementia has also been described."

"In a case-control study of 20 patients receiving long-term low-dose corticosteroid therapy (prednisone, 7.5 mg/d for >6 months) and 14 volunteers with similar illnesses who were not receiving corticosteroid therapy, Bolanos et al9 found a 60% lifetime risk of corticosteroid-induced mood or anxiety disorder."

"The corticosteroid dosage is the most important risk factor for the development of psychiatric symptoms."

"Psychiatric disturbances can occur at any point during corticosteroid treatment, including almost immediately after initiation and even after cessation of treatment."

"Corticosteroid-induced psychiatric disturbances are common and include mania, depression, psychotic or mixed affective states, cognitive deficits, and minor psychiatric disturbances (irritability, insomnia, anxiety, labile mood)."

"It is important that clinicians in all specialties become aware of the potential psychiatric adverse effects associated with corticosteroids and explain these effects to their patients."

"Which patients will experience corticosteroid-induced psychiatric disturbances cannot be predicted. Dosage is the most important risk factor for the development of adverse effects, with patients receiving less than 40 mg/d at minimal risk, those taking 40 to 80 mg/d at moderate risk, and patients receiving more than 80 mg/d at high risk. Most patients will develop symptoms during the first week of treatment, and more than 90% will develop symptoms by 6 weeks."

Side effects: mixed bipolar disorder/manic-depression, suicidal ideation, cystic acne, scars on my face, panic attacks, severe anxiety, rage, euphoria, sadness, impulsiveness, confusion, memory loss, hard to concentrate and remember, thin skin, delayed healing ability, bruises, premature aging, rapid heart beat, heart palpitations, high blood pressure, higher cholesterol, thyroid disease, sweating all over, itching all over, joint pain, increased appetite, massive weight gain, stretch marks, hormones out of balance now, dry eyes, so dry my eyelids stick to my eyes, so dry I can't wear contacts any more, permanent red eyes, blurry vision, vision worsened, eye pain, eyes sensitive to light, migraines, and yellow skin.

I was put on PredniSone for a lung virus that i developed asthma due to. I had been border line asthmatic for 10yrs. Dosage was 6tabs 3days, 5 tabs 3days ...etc... I am two days from finishing my dosage and I have had sever leg cramps for the past week. I wake up 2 to3 times a night and have to walk around. I wake up at least 3 times and are able to straighten up enough and go back to sleep. I have also had to get up 2 to 3 times a night to urinate. This is uncommon for me. Hopefully with discontinued use these side effects will stop. I need to get a good night rest. I will never want to take PredniSone again.

My daughter is 12 and just started taking Prednisone 5 days ago (40mg - she weighs 105lbs) .. I've been watching her salt intake - tonight she looks a little pale to me - is that a side effect? has anyone else experienced that? She has Ulcerative colitis (2 years this month) - started w/asacol, colazol, 6mp (gave her pancreatits) now is on methotrexate since Nov '07 - was put on prednisone because of a recent flare - to me none of these medications have put her into remisson - always goes 3-5 times a day - sometimes blood - sometimes not - don't know if prednisone will help - so afraid of the side effects -
Dr. said if it doesn't - Remicade will be the next option - after that surgery - only thing - my daughter has never complained of pain - except when she was on 6mp -
sorry for babbling - just so scared...

Prescribed Prednisol & Predsol June 2007 for acute ulcerative colitis. Three months, oral and rectal, got it under control.September 07 got large fluid appearances both knees which took two weeks to subside completely.
Soon after & whilst playing golf got stabbing pain left Achilles. Repaired by op. Thereafter commenced getting aches in muscles and joints and generally across entire body structure. Extreme pain in rt hip, imaged and shown as necrosis of femur joint. April 08 rt hip joint replaced. Continual muscular pain overnight which abates with movement during day causes sleep deprivation and consequential lethargy.
Most interested in proven supplements and/or prescription antidote!

Hi

I just started taking 20mg of Prednisone for a shoulder injury. So far I have all but loss my appetite, which sounds strange to me since my doctor told me to expect to gain weight very quickly. I have also loss my need to sleep. I was up from Saturday 11:15 am morning the first day I began Prednisone and wasn't able to get to sleep until Sunday night around 10:00pm. I'm sweating like I'm constantly being rained on, it is so darn annoying. I also started to lose my voice last night and then again today, is that normal with is drug? I'm so full of energy all I do is clean our house, work out in my flower beds, etc. I'm kinda of scare of this drug and I'm glad I will be off of it next Tuesday unless my shoulder isn't better when I start physical therapy tomorrow. I wish you all the best while you are taking this drug.

Keep us posted on how you are doing.

Marlene

I was prescribed 20mg 3x daily for five days to treat "Reactive Airway Disease/Bronchitis." Yesterday was my 5th and final day of taking the medication and I noticed both of my shins began hurting for no apparent reason when I walked. I didn't think it had anything to do with Prednisone. Then, last night, I suddenly felt weak as if my blood sugar had dropped tremendously and ate a grapefruit while trembling with weakness to stop this feeling. Again, I made no association with this and Prednisone. Last night as well, I noticed that my shoulders suddenly became achey on both sides of my backbone for no apparent reason. This morning, I woke up and the pain from my shoulders had spread to my hips and the entire area between my shoulders and hips is tender to the touch. Today, after not taking any of the medication, I feel mentally blurry, have moments of what feels to be low blood sugar and flu-like symptoms. I'm also still experiencing the muscle pain in my back and hips although my shins seem better. My pharmacist told me to call my Dr. and seemed surprised to learn I was not weaned off this medication. All of the symptoms I have described above are side-effects that should be reported to a Dr. immediately, according to my pharmacist. Another less-serious side-effect that began yesterday is swelling in my feet, hands, stomach and face. I also had diarrhea today.

I have now tapered to 10mg prednisone every other day and will end 75mg Cytoxan Aug 19th. Just went to the Dr. and she said protein is back in urine (bad) but also rising in blood. (good) I can continue to taper prednisone but will have to have another 24 hr urine speciman to determine wether I have to go on cyclosporine. Was originally diagnosed with Minimal Change Disease, but now she thinks it could be another kidney disease. Has anyone had successful tapering with the addition of cyclosporine? Does the urine protein ever get higher? What about side effects of cyclosporine.

Hi All - I have been off prednisone for one week and I am not doing as well as I thought I would be at this stage. My symptoms are not flaring, which is a very good thing but I am so tired and feeling very depressed and low energy. I thought I'd feel great once I was off the evil prednisone but so far I am feeling almost as bad as when I was on it. My moon face has not started to go away, which sucks, but I guess I have to be patient. I am so tired of this situation as it feels never ending. Part of the problem is I have continued to work throughout my ordeal, and it's been very hard at times to carry on like a normal person who is not sick. I have been sick since last November (with an autoimmune disorder) and I had really hoped by this time that I'd be on my way to being better :( Prednisone saved my life but the side effects are horrendous, as are the after affects of it. Good luck to all who are taking it. I share your pain and frustration.

My son is suffering from psychosis because of prednisone. He had severe poison ivy and was given 10 day course of pills that tapered and a shot. Since then he has been in the psych ward for a week , released given respirdal and lithium. After 3 weeks we tried to wean him from the respidal but the psychosis came right back. ;He is 17 and never had any symptoms of psychosis or mania before. He has every symptom now. BTW his psychosis did not appear until he was finished with the prednisone for several days. Will he ever recover?????

I was prescribed a 6 day pack of 4mg Methylprednisolone (Medrol) at the ER for an allergic reaction I was having to a gel that I used on my sking. The Medrol worked great at stopping the allergic reaction. My swelling, pain, and rash began to rapidly clear up. Unfortunately I began to have many side effects. On day 5 I was unable to get out of bed I was so tired and dizzy. I had a headache and mental confusion and unclear thinking. I called my primary care provider on a Sunday to ask if it is okay to stop taking the steroid. She said it was and that it was unlikely the medrol was causing my symptoms. She told me I had a virus. I told her the symptoms I was having were listed as side effects on the drug info sheet but she did not believe me. IA few days later I made an appointment to see a doctor, not the same one who took my phone call. This doctor said all of my symptoms were from the Medrol. She knew because of personal experience she saw in her mother who was also taking steroids. She told me medrol can cause a manic response or a depressive, the latter is what I was having. As part of my exam she wanted me to have blood work but said I should wait at least 2 weeks to allow the drug to get out of my system. It is now 19 days since my appointment and I am still having side effects: nausea, complete lack of appetite, dizzy, and tired all the time. I put a call in to my doctor today and am waiting to hear back. I am sorry that I took this medication, will never take again. How long will it take for this med to get completely out of my system so that I feel normal again?
A friend told me her mother had a manic episode on steroids. When I was younger I took steroids for a brief period and had much milder side effects.

After a year of battling effects from an eye injury, an optho-neurologist finally came to the conclusion that I had orbital inflammatory psuedo tumor. I was told to take 60 mg immediately and then take 2-40mg doses (AM and early afternoon). On Friday, July 18th I took 60 mg at 6:30 p.m. and was so nauseous and barely slept. That next day I took 40mg in the morning and another 40mg around 2:30 p.m.. Although I had been, throughout the year, experiencing pain in my left eye and cheek..what I experienced by 4:00p.m. that next day was more severe than ever. I started having shooting pain and a headache so excruciating that I was in tears. (I had two children naturally).
By 10:30 I had several hours of this pain when the worst happened. The left side of my face drooped and I had difficulty speaking. By the time I got to the hospital I could not move my left arm and left leg. After five days in the hospital and every test imaginable (cat scan, MRI, EKG, etc) they ruled out all stroke, MS and anything else that would show up on these tests. During the hospital stay (although they did not cite prednisone for this event), they started tapering me off. I went from 80 to 50 in one of these days and thought I would DIE. There was no pain reliever/narcotic strong enough to take away the headache. I spent ten days tapering and prayed every day for the end. Sweating, no sleep, crying and did I mention...my headache has still NOT gone away. I have a couple of hours here and there without this pain but for the most part I have been in this hell even after my taper. The clincher is that NO ONE at the hospital or afterwards would admit that this was a side effect but they also could not provide a response. It took three weeks for me to work my way back to walking and using the left side of my body. Has anyone heard of this before? Good luck to all of you, it has meant a lot to read your comments.

My husband initially took Prednisone after getting strange lesions, severe joint pain, severe fatigue and severe stomach cramps/nausea. It worked great he was tapered off and no problems for about 18 months. Then he go sick again (2/08) and has been up and down on Prednisone for 7 months- currently taking 60 mg. daily. Some doctors think he has Wegener's, but testing is inconclusive (Wegener's starts with upper respiratory stuff, which he also had). His mood swings are severe and he's a different person, twitching, hand trembling, muscle spams, malaise, anxiety/depression, very fatigued, insomnia, severe stomach cramps/vomiting. How do you tell which symptoms are the Prednisone and which are the disease process? They want to taper him to make him sick enough to get some test results that show organ damage or something, but everyone chickens out and he ends up getting increased. How long should he be on Prednisone and not be put on something stronger?

I have been prescribed Prednisone after I had an adverse reaction to an antibiotic which i was taking after an insect bite became infected. I am covered in a sore extremely itchy rash of weels all over my body.

I took 6x5 mg of Presnisone with breakfast and as I was feeling ill because of the rash I took it easy and lay on the sofa suddenly about 60 to 90 minutes after taking the pills I had an overwhelming feel of wanting to be sick and diarrhea, my head was spinning and I came out in a cold sweat. I become very anxious and felt like I would die, so quickly and severely did this come upon me.

All I could do was lie down and let it pass. fortunately my husband was at home and I felt reassured that if needed he would ring for emergency treatment. after a while this feeling passed but did return about an hour later. It took about six hours before I could move my head without feeling sick.

I spoke to my GP on the phone and he said I shouldn't have had a reaction like that, it was not the usually side effect! Reading the post on this forum I think it most definitely a side effect of Prednisone.

Now I have to decide whether to take it again tomorrow I am still very itchy and the rash hasn't got any better but no worse. My GP suggested taking 3x 5mg for breakfast and 3x 5mg with lunch.

I only have to hopefully take it for one more day after that. I do feel for those of you who have no choice but to take.