PredniSONE and liver

I'm 15 years old and i've been taking prednisone for a few months, and from what i've read i'm on a really high dose. i was diagnosed with rheumatoid arthritis and another autoimmune disorder concerning my muscles at the same time. my doctor told me prednisone was my only choice; it was either that or i would lose the ability to walk. he told me there'd be side effects, but i had no idea it'd turn out like this or i would have fought harder for another course of action. i started out on 30mg twice a day, and since then was weaned down to 20mg twice a day and now i'm down to 30mg once a day. i've been looking up a bunch of information trying to figure out if there's a way to lessen the side effects or any hope at all that they will get better. apparently there isn't much. after reading a bunch of these stories i gotta say i'm not feeling great about this. i totally understand everything everyone is going through. i'm sure you can imagine what it's like being smack in the middle of high school with a huge puffy face, acne so bad on my face, chest, back, neck, and shoulders that wearing a bra could put me in tears, and mood swings so bad i've lost friends over it. everyone knows how brutal high school can be, where appearance and attitude are everything. and i try to tell my doctor about it and he literally looks at me like i'm a whiny teenager and says "you're just going to have to deal with it." and people like my mom and my closest friends don't get it either. nobody understands how beyond frustrating it is. i'll get into the worst moods and not have a reason for it, but i'll stay angry for hours or burst into tears over someone looking at me the wrong way. it'll get to the point where i have to isolate myself from other people because the abrubt mood changes get so bad. as bad as i hate to admit it, the pain from the arthritis is gone now and supposedly my muscles are doing better too. developing arthritis caused me to have to quit cheerleading, something i've loved doing for 6 years, because the pain got to the point where i couldn't get my arms above my head or bend my knees. however, i'd almost rather deal with the horrible joint pain than deal with the side effects of prednisone. if your doctor gives you and alternative method, take it. i've always been confident in the way i look and really outgoing and happy and now i sometimes catch myself thinking about suicide. that's shocking to me because i've got so much going for me, but this medicine makes me miserable. and when i complain about it, anyone i'm talking to just looks at me like i'm being a cry baby. my mom does too, she'll say things like "you just have to do this. i know it's not what you want but to be honest i'm sick of hearing you bitch about it."
i feel a little better knowing other people feel the same way - like nobody gets whats going on with them. the prednisone does give me days of really great euphoria and days when i feel like i could run a marathon, but waking up in the morning to the acne and huge face puts me to tears every day. i have to pee all the time, usually getting up at 2 or 3 am. i don't sleep well anymore and i do sweat all the time. which also sucks being a teenage girl. i'm always hungry, and when i eat i never feel full so i don't know when to stop. my neck and face have put on so much weight that when people see me in the halls or out and about they ask me what happened. mind you these are people i don't talk to, just ones i know from classes or whatever. and it's pretty bad when teenage boys i've never really talked to ask what happened to your face. kind of a blow to the ego, or whatever is left of it at this point.
i'd like to know if, as my dosage gets lowered, the side effects will diminish and when i'm off the prednisone completely if they will disappear altogether. any help there?
or if there is any way to help the acne or puffy face

my doctor just put me on something called methotrexate or something like that to help wean me off the prednisone, and does anyone know what those side effects will do? or if they'll affect the prednisone side effects?
i'm constantly obsessing over gaining weight and what my skin looks like and what i eat and how heavy my face feels and the occasional pressure in my eyes to the point where i just want to be put out of my misery.
and after reading other people's stories i really don't understand why this drug is still given out as freely as it is. but maybe all doctors are like mine, they just don't get it.
best of luck to anyone who's on prednisone, my heart goes out to you; i'm right there with you
sorry this became like a book it wasn't meant to be this long

I started taking prednisone when I was only 12 years old and I was on it for about a year and a half. At the age of 10, I was diagnosed with glaucoma, uveitis and cataracts and for about 10 years now I have had all these illnesses. My experience with prednisone had been HORRIBLE. Within two months alone, I gained 50 pounds, my skin started to get really really thin, I started to develop stretch marks ALL over my body with the only exception of my face and hands. I started to get the chipmuk cheeks to the point that my family was afraid that I was going to literally explode. My liver was damaged. My kidney was damaged. The vertebrates in my spine where being chipped away. There was a point in that year and a half where the doctors told me that there was a 70% chance of me going blind. The bottom line was that PREDNISONE WAS BRINGING NOTHING FOR ME EXCEPT RUIN. On top of that, I was constantly depressed. Kids at school would point at laugh hysterically at me. And if people weren't laughing, they were struck by fear and were trying to figure out what exactly I was. I remember this one instance in my school cafeteria where one girl stood up on the lunch table, pointed at me and screamed SHE'S AN ALIEN!!

I was and still am scarred physically and emotionally. My arms and stomach are really saggy because the skin is soo thin. As I said my entire body is scarred with stretch marks. I can't show the slightest bit of my body to anyone because I am so ashamed, embarrassed and afraid of peoples judgments. I am afraid that no one will ever want to be in a relationship with me.

All I can tell you is that though I stopped using it about six and a half years ago, this dreaded drug has truly ruined my life from the very start of my childhood.

My 7 year old female Siberian Husky, Niceah is suffering with her second serious flare-up of IBD. She was taking 20 mgs. of prednisone every 12 hours for several days. We are now down to 12 mgs. daily and working towards 12mgs. every other day. She is lethargic and her body and belly have swollen frightfully to the point where it is difficult for her to lie down without grunting and sighing. She pants heavily. She drinks and eats constantly. Her nose is dry. Her tummy grumbles all day and night. I have been boiling chicken breast and mixing it with sweet potato and Enzymes & Probiotics. I am currently working with a holistic advisor concerning Niceah's diet once she has weened off the prednisone. The side effects of this drug are frightening and I am so worried that something more permanent and damaging will occur. Has anybody experienced this?? If so, I would appreciate any advise. Robin. copher370@aol.com

Hi everyone.
I was prescribed prednisone for a hand injury that the swelling would not go down. I took it for 4 weeks. In the end of the first week I started breaking out in a rash that itched like crazy. They were small bumps that had nothing in them and they itched so bad I scratched them raw in my sleep. I informed the doctor about the rash and he told me it was to late in the game to get any side effects. This medicine also caused me to become very irate from any little thing. It also made me to lose my job while under a workers comp doctors care. This was about 6 years ago and I still am battling the rashes. They come and go but when they are apparent they take a long time to go away. I used to heal very fast but now it takes forever for an injury to heal. I have had blood work done and even had my liver checked out. They say I am as healthy as a horse so to speak. The rashes have scarred me all over. The bumps would turn to sores that took about 6 months to heal and they hurt, burned and itched all the time. I tried everything to control the itch and pain. I finally mixed aspirin with alcohol and some lotion together and this helped enough to get a fairly good night sleep as I was becoming exhausted. I am learning to deal with it in time but I will never be the same. My thinking is far from my normal thinking.
I had a list of side effects from prednisone and it was four pages long and the very first one was, Instant Death! The only side effect I was told by the doctor was that I might become easily irritated. In my opinion I think all doctors should give you an option after he has presented you with ALL the side effects of a prescribed drug and let you be the judge if you should take it or not. I now have a different doctor and he has prednisone as a drug I can not take. This medicine might be good for some people but it can have life changing effects for those that can not take it.
I feel for anyone that has had bad effects from it and hope you get over it some day.

Are you aware about short and long term side effects of this Devil's drug??? Of course, everybody reacts differently while take or withdraw. But there are high number of people who react terribly bad!!! Doctors do not want to recognize and discuss this. They just keep silent... Do you know exactly how Prednisone works??? Nobody knows this for sure, even doctors!!! From my personal experience, and despite gradual withdrawal, I developed extremely high blood pressure, weakness, panic attacks, depression! Practically it ruined my normal life! Doctors have no clue how to deal with its devastating side effects. Steroids are not selective. When you take a steroid, the drug infiltrates the nucleus of every single one OF YOUR CELLS AND STARTS MONKEYING AROUND WITH GENES IT FINDS THERE!!! It probably plays with hundreds of genes. And just a small number of these genes control the pain and inflammation associated with inflammatory diseases, so steroids turn many of these genes off which is good thing. However, because steroids are not selective, they also regulate the genes that control kidney, liver, BRAIN, and HEART function - which is not good thing!!! It is likely that steroid treatment plays with other genes, too, including those we do not know about a lot right now...So, Prednisone pervades the entire body, which increases the likelihood of short-term side effects and long-term DAMAGE. My advice is: THINK TWICE BEFORE TAKING PREDNISONE!!!

After my father's office was flooded by an AC backup at his workplace in June 2006, and as a result mold grew in the carpeting & walls. He got very, very sick & his doctor put him on Prednisone for almost a year. No local doctor nor specialist told us of the dangers of being on a steroid for more than a few weeks. My father kept getting sicker & sicker until one day in March of 2007 we had to rush him to the ER. There his doctor arrived, put MORE prednisone directly into his veins and as my father grew weaker & sicker we knew we had to get him out of there. We took him to Shands in Gainesville and they immediatly began their magic. It took a good week or so to undo the immediate damage that Prednisone had done to my father. It took until this month (October) until his liver & vital organs started working properly again and reached safe levels. In fact, he's still being carefully monitored by his Shands doctor to ensure his body will continue healing itself. His new doctor told me that if we hadn't taken my dad to Shands that day, he would absolutely be dead. Prednisone is a very lethal, dangerous drug if perscribed for more than a few weeks at most! Please, if your doctor wants you to take this steroid any longer than that, go see another doctor immediatly! It will save your life.

1-21-07 After 5 days of Prednisone 40mg per day (treatment for Gout), and 4 days off,

1-30-07 started back on Pred at 20mg. 1/3xday for 3 days, 1/2xday for 3 days and 1/1x for 3 days.

regular meds: Lisinipril 20mg daily, Coumadin 5mg daily (adjusted for Prednisone) and Lipitor, 20mg daily for 3 years (stopped on 1-24-07 due to Gout)

1-14-07 Symptoms: rash on lower stomach and groin area, frequent uninating (especially at night), neck and shoulder ache and
1-13-07 lab reports "liver elevated" and "irregular white blood count" (not sure if high or low).

I will appreciate any help you can offer.

My problem is my liver ruben levels are way elevated. I am off preednisone now, but I hope it was the prednsione causing this. Because other my eyes turnign yellow and gondis are setting in from blockage ot the liver.

Gypsi,
I have seen Doctor after Doctor no one knows what is causing the dibilitation of my body I am only 35 this has been happening on and off since 19. I have no idea what is wrong. They check my liver , bones and kidneys once a year I have MRI every three months. I have at times not been able to see and then go to 20/20. I think the depression is going to be what kills me to be honest I have and can live with the pain and handicapped problems but being sad and fighting to not be is har. I am however developing a new problem and think it is the prednisone I have sharp stabbing pain in my neck where ones thyroid glands would be. And I am the fattest I have ever been I am not able to excersize much because I have just bought a exersize ball I am going to try it.
I guess I will stop whining ... thanks for listening
Angela

Have been on Prednisone before(3 times in the past year and a half) but always low doses-10mg,down to 2.5mg over 10 days. This time I went from 20mg, weening down to 5mgs,been on it for a total of 5 weeks now for Rheumetoid Arthritis.Before that was on Relifen,then clinoril-both caused side effects with my liver. Was worried about the whole "moon face, weight gain" thing. Have heard such horror stories about it,even at that low of a dose. So far ,have not gained any weight, in fact have lost 3 pounds in the past 4 weeks.Can move my hand again with out major pain.The only side effects I have had are easy bruising,muscle pain in legs and very dry mouth. Will be weened off completly in another week, then going to start Mobic.