PredniSONE and top of the world

my grandmother started prednisone the day after the fourth of july and that Sunday in the car she thought the radio was on, but when she went to turn it off it was off, she hears joy to the world all the time. Sometimes its louder than others but its always there. She started out on 40 mg a day for polymyalgia, now she is being tapered off of it but her doctor says shes not a typical patient and there is no way the prednisone triggered it. I think it has to be it cause it happened about three days after she started taking it. Anyone know anything about this kinda thing happening?******

This is my second course of Prednisone after several UC flare-ups. First time I was on 40mg for 2 weeks, then tapered down for two weeks. My first few days on Prednisone were great. I finally had energy, I was in a great mood and finally felt like I was living again. After 4-5 days, the weight/bloating began. My fingers and ankles began to swell, then my face. I no longer felt "alive" anymore, more slovenly. None of my clothes were fitting either. I developed a very noticeable "muffin-top" that made buttoning my pants difficult and wearing and snug t-shirts embarrassing. I returned to my doctor after my two week course (prior to tapering) and found that not only did I gain 12 pounds in two weeks, but my blood pressure had increased dramatically. I was assured that once I quit the Prednisone, my weight should return to what it was, as well as my blood pressure. Sure enough, they did.

I would have to say the very worse part of taking this medicine, for me, was not the two weeks that I was on my 40mg course, nor was it the two week taper, but the two weeks after stopping the medication. My energy level was completely zapped, but I couldn't sleep. I also had the worse headaches and mood swings. I would snap at my family for the smallest of reasons. This medicine introduced a side of myself that I never want to meet again.

Unfortunately, here it is 2 months later and I have been prescribed another course of Prednisone due to another colitis flare-up. I thought I was prepared for what this medicine will do to me since I experienced it once before. However, this time is nothing like the last. Unlike last time, I have yet to feel "on top of the world". My bloat came on quicker this time, as did my mood swings. I am depressed and really hating what I have become. Fortunately, I have enough sense to realize a lot of my depressive thoughts and mood swings are a result of the Prednisone, but it doesn't make it easier. My vision is blurred and for the first time I understand what others are talking about when they speak of foggy brain. I am physically present, but definitely not coherent. I just want this medicine out of my system. I would rather deal with the intense cramping and bloody stools from my colitis, then have to ever go on this medicine again.