Simvastatin side effects

I am an active 60 year old.After being checked for diabetes I was told I was borderline and chose to try by changing my diet. Three months later at my next visit UI was told I was improved but my cholesterol was far too high and prescribed 40mg Simvastatin.Between then and the nest three monthly check I had numerous symptoms. My calfs throbbed, my shoulder ached and my sex drive decreased and I was always tired. The most frightening thing of all though was my concentration. I would be riding my motorbike or driving the car and suddenly snap to and realize my mind had been wondering and my concentration gone. (Ive had numerous near accidents.)
IU read on this site about "memory loss" and wondered if this was what was happening to me. My last three month visit was last week, my cholesterol is almost normal so I am stopping the pills and seeing what happens.
Steveb

I started simvastin on Aug 11. Lately I got severe lower back ache every time I get up in the middle of the night and every morning but the lower back ache goes away as I starts my day after 1 hour. I am also experience short memory loss.
Pls advice if this is a serious side effect of the drug.
Thanks....hw

please can u tell me does anybody on this site suffer from memory loss cause they are taking simvastatin

I have muscle pain, weakness, and chronic lower back pain. Started statin drug, Simvastatin, on 11/21/07. I take no other drugs. Within two weeks, I could not sit without severe lower back pain. Reported problem to family medical doctor on 1/11/08. M.D. sent me to physical therapy for 8 sessions. No relief from physical therapy so I requested an X-ray on 3/20/08. X-ray shows very mild degeneration at one lower vertebrae. M.D. sent me to an orthopaedics doctor who recommended continued physical therapy. Went to a Chiropractor instead. After six chiropractic sessions with little relief, I made an appointment with an Osteopathic doctor. My M.D. sent me to a rheumatologist who prescribed high dose naproxen for two weeks. The rheumatologist ordered and X-ray of my lower back area. The lower back X-ray produced no negatives. The rheumatologist's next step will be to order and MRI of my lower back area. The D.O. suspects statin induced myopathy and because of hyper reflexes he ordered an MRI of my brain and cervical spine. I am now recommended to a neurologist who specializes in the diagnosis of multiple sclerosis. Am I getting the run around? Only one doctor said I might have statin induced myopathy. The rest will not even mention the statin drug theory. I just pray for ache and pain relief. I have some improvement after four months off of the statin which I believe is quite a strong point that it was the statin drug and not some unknown condition. I don't think arthritis or MS conditions improve. All I know is that I had no health issues before taking the simvastatin. Good luck to everyone who has or is taking a statin drug. BEWARE!!!

I have been on simvastatin for about 1 month. I have some stomach discomfort and what bothers me most is the awful taste in my mouth in the morning. I take this medication before bed.

started taking simvastatin 3 months ago after having a stroke straight away started feeling nausea and diarrhea was told at the time while still in hospital it was probably the tablets but nothing was done about it, since then i have been back to the docs twice, had 2 different types of anti sickness pills, none have worked, which is worse when awaking in the mornings, when i run gagging to the toilet, plus diarrhea tablets, which i am having to take at least 3 to 4 times a week, was told i could not stop taking the simvastatain tablets as i needed them, surly i am not supposed to live my life feeling constantly sick and the rest of the time sat on the toilet, plus panic attacks and depression of which i am also on medication for and my migraine attacks have gotten worse. and a awful taste in my mouth all the time all in all not a happy bunny

43 year old lady taking this drug about 2 months first a low dose but without doctor seeing me he put me on 40mg a day getting bad headaches and hair loss anyone else suffing hair loss

I'am only 26 but I have been a insulin dependent diabetic since the age of three. Being a diabetic for so long has made it difficult for my body to maintain normal cholesterol and triglceride levels. (I'am not overweight and I am very active) At 19 I was put on lipitor but it gave me severe stomach pains when I called the doctor they told me "it was just a side effect" and should subside. I wasn't on it for very long when I found out I was expecting and had to stop taking it anyway (can't take statins while your pregnant it can cause severe birth defects) Anyways, after I had my daughter they said my cholesterol was fine and they weren't going to put me back on anything. Yes! Until just recently my doctor discovered that my triglceride and cholesterol levels were so high he had the lab re-draw my blood tests! Odd because I feel perfectly fine. Because of the stomach pains years ago with Lipitor he put me on Simvisatin and Antara. Every since I have been on the Simvastatin my cholesterol levels are perfect but I am soo tired all the time. When ever I tell my doctor he says it's because I am a young mother of three and work full time. But this is a different kind of tired. I seriously could drink a five shot extra strength espresso and fall asleep this isn't normal. All my blood work is fine. It has to be a side effect.

Started in Jan. this year on 10mg dose. Came off in May for three months as I was experiencing nausea, joint pain and depression. Had to go back on last week as cholesterol is sky high. This time 40mg - feel violently sick, keeping going to the loo about -10 times between 7am and 10 am. and so tired am staying in bed most of day. Phoned the pharmacist today who says to stop taking over the weekend see my doctor on Monday as there is an alternative to Simvastatin that does not given so many problems and to try taking porridge each morning as this can significantly reduce cholesterol naturally?? Will give it a try, YUKKK......

Am 47 y/o male have been taking 10mg since June 30, 2008. Over last couple of weeks have had bouts of severe leg pain, not cramps but just achy. Also have lower back pain especially in morning when waking. Problem is i have chronic back pain so hard to distinguish between the two but it just feels different. Also bouts of fatigue. Called my doctor and was told that the aches in legs not a problem because the side effect is cramping not soreness. I don't buy that.

i am 55 and have been taking simvastatin for about 2 years although my cholestrol was under 5. over the last few months have had pain in my knees which i thought may be arthritis and then about 2 months ago the pain started in my left foot and became so severe that i had to change to an automatic car, still believing up until today that arthritis must be getting worse although my foot xray came back normal, i found this website today as my finger and thumb joints are hurting so much i cant hold anything and every muscle aching so much i just wanted to cry.after reading these letters i realize that even the choking feeling im sometimes getting isn't a menopausal panic attack and now i have checked my simvastatin leaflet an d box and realize that although my last cholesterol reading was only 3.5 one of my doctors has put my tablets up from 10 mg to 20 mg so big question is this an overdose ? im not taking another one of these pills an see what progress my health makes. i am slightly worried about heart disease and will look into herbal type as my parents use these,have never taken statins and are 90 and 87 so i think this speaks for itself,thanks everyone who has helped me diagnose my own illness!!!

My husband was prescribed 40mg of this drug 2 years back,for his high cholesterol reading. He is an ex-services and has always been extremely fit, he was tired for almost a year, then he began having headaches to the point he had a brain scan, because he thought he had a tumor. He also has had knee and neck joint problems and now the joints of his fingers are giving him pain He now wakes up each morning feels really ill and feels as though hes being strangled, the sensation lasts sometime for hours and he has to lie down. His doctor said it was blood pressure but he keeps a monitor and his pressure has been normal. His doctor said he should continue to take it, but when you read all the symptoms that people are getting while taking this drug it makes you realize they are all just guinea pigs for a large scale trial of the drug

I'm 58 years old and I've been on 10 mg Simvastatin for 14 months since I was diagnosed with Diabetes 2. Also Metformin and Glipiside as my bs got up to 499 at diagnosis with high cholesterol.

I had NO IDEA that my suffering the past year could possibly be tied to one of the drugs I've been prescribed. In the first three months after diagnosis, my Diabetes was controlled and I've even backed off some of the meds. My cholesterol also came down beautifully. However, the debilitating weakness and muscle aches (which has increased over the 14 mos.) has become so bad (especially this last week) that I came to the Internet looking for possible reasons for 'body ache'.

And get this: I take a packet of vitamins every day which includes a daily dose of Q10... BUT I haven't been able to take them for about a week and this last week I felt like I was ready for a wheel chair~!!! Worse than it's ever been, knees and feet in horrible condition, hands and wrists unable to open a water bottle. Total body aches so severe it made me want to research something, anything to see what might be the problem.... before seeing the doctor about it!

My shock at seeing my medication here listed with the horrible side effects I'm experiencing has been a revelation~!! I am going to stop the Simvastatinn and see what happens. BTW, I've been an active person all my life, was a 2nd Degree Black Belt and taught Tang Soo Do and know what muscle aches and pains are, know my body (at least I did) and pretty much thought my active life was over.....

Not now~!!! I'm FURIOUS!!

I have been taking simvastatin since June 28, 2008. I am 44 years old and have always been majorly active with my 17 year old daughter. Recently I have become chronically fatigued so much as to want to go back to bed within 2-3 hours after I get up in the morning, (definitely not me). I have felt spaced out,depressed to the point of wanting to cry all the time, have severe back, hip, knee, leg, and hand pain. I go to pain management for my back and hip problems (past surgery), but the usual pain has been intensified over the last 2 months and I wasn't sure why, until i decided to check out the Simvastatin to see if it has made me put on a few pounds, and boy have my eyes been opened!!!!!!!!! I AM STOPPING THE MEDICATION IMMEDIATELY!!!!!!!!!!!! Thanks to all who have spoken up, I wish I would of checked on this sooner!!!!! I'm calling my Dr. first thing in the morning!!!!!!!!!!!

By exhausted in Canton

I was prescribed Simvastatin four days ago, against my wishes, as I had heard about the side effects of muscle pain and numbness in the joints and feet. However, what I had not expected were the terrible nightmarish dreams that followed. On the fourth night I stopped taking Simvastin as I was literally too afraid to go to sleep.
I then slept fitfully but did not experience the vivid and disturbing dreams of the previous three nights.
I shall ask my doctor for alternative medication. If she cannot offer me anything other than statins, I shall stick to Benecol and research further!

Jacqui M.

I started taking 10mg of simvastatin in April and experienced awful hand pain. The pain was mainly in the joints of my fingers, I thought I had arthritis. I stopped taking it and the pain subsided. I began the medication again last week to see if that was the reason I was in such pain and within a few days my hands are hurting and I can hardly hold anything in my fingers. When I told my Doctor about it she didn't take me seriously but she will at my next visit.

I have been taking Simvastatin 20 mg. for about two and 1/2 months now. It really lowered my Cholesterol but I have been extremely fatigued and now I am getting really dizzy when standing up and having some nausea.

I started to take 40mg instead of 20mg of simvastatin on July 16 and began to feel pain on my right shoulder two weeks later. The pain got worse and I went to see a doctor who prescribed inflammatory and muscle relaxing medication but they didn't help and my pain got worse. I got to this website and then stopped taking simvastatin completely on August 2 while continue to take the inflammatory and muscle relaxing medication. Today 95% of my pain has gone. If you have this kind of pain or symptom, stop taking Simvastatin.

I was diagnosed with type II diabetes and extremely high cholesterol about a year and a half ago. I was put on metformin and simvastatin. Through diet, exercise and 'natural' meds (banaba leaf, Gymnema, chromium, vanadium, among others) I got my diabetes under control to the point that I was able to go off metformin, but I was kept on simvastatin. I never experienced any of the horrifying symptoms described in previous postings; however, when I went on vacation a month or so ago I forgot my simvastatin- within 48 hours of going of this med, my libido actually returned- I had attributed the loss of not only function but desire to diabetes. When I resumed taking the pills, my libido once again evaporated. I went off of simvastatin completely a week ago and I feel like a new person!

I have never experienced the side effects of statins myself. I have never taken any - nor would I if my numbers should be too high.

I have had the opportunity - or rather was forced to - to "educate" myself on the cholesterol issue as i had 3 relatives suffering from side effects.

They were all over 70 and had taken Simvastatin (Zocor) for years.

In 2003, when I had just got an Internet connection, I started to look for information and was surprised to find these sites:

******

I also found "Stopped our statins" (google for those words) where there is a lot of information.

Under print articles you will find a very informative article from The Weston Price Foundation about the different statin studies over the years and also about the side effects.

Are you sure that a high cholesterol will cause heart problems - or is it just propaganda from the pharmaceutical and health industry?

After having visited some of these webb sites and read some of the books you might have changed your mind - like I did.

Your cholesterol is very important for your body and essential for your brain among other things.

Why should you live better and longer if you use medications to lower it?

It`s just to read all these patient stories - what quality of life is this?

I would suggest that you also read the messages for the other statins such as Lipitor, Zocor (=Simvastatin) etc.

All statins have similar side effects.

Here are some books that you might find interesting. Some about the cholesterol issue.

The Great Cholesterol Con (Antony Colpo)

The Cholesterol Myths (Uffe Ravnskov)

Lipitor - thief of memory (Duane Graveline

Malignant Medical Myths (Joel F. Kauffman)

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Overdosed America (John Abramson)

The Truth about the Drug Companies (Marcia Angell)

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Bitter Pills (Stephen Fried)
about quinolone antibiotics such as Cipro, Ciprofloxacin, Levaquin etc.

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The Antidepressant Fact Book
Your Drug May Be Your Problem
Toxic Psychiatry
Medicine Madness
(Peter R. Breggin - all books about psychotropic drugs)
____

What if medicine disappeared?
(Gerald E. Markle and Francis B. McCrea)

How doctors think
(Jerome Groopman?)

I felt and acted like an invalid, being helped out of bed, up from a chair. Struggled with the toilet. Had very little energy. Was very surprised when Doctor advised to come off the drug and shocked when I read the side effects on the advice sheet as these could have just been written by me from experience. Started taking December 2007 and stopped, after the practice nurse referred me to the Doctor, 9th July. Already feeling 99% better.

I have been on Simvastatin for some years and increasingly felt tired to the point of fatigue, had muscle pain in my legs, arms, neck and back and also gained weight.
After reading an article in a British newspaper I linked my symptoms with taking these tablets and, just over a week ago, I stopped taking them.
I already feel much better. The aches and pains are subsiding and I don't feel so tired. No weight loss yet but I live in hope!
I will be seeing my GP soon and I intend to show him this website.
Good luck everyone - I hope your health improves soon!

As a retired Healthcare Professional, like you I almost died from a statin overdose. If you’re a U.S. resident (FDA Form 3500) or Canadian resident, I would encourage patients/consumers to send their complaint/statin adverse reaction report to the web sites listed below. Also, if your physician is unresponsive to your negative experience from any statin, inform him/her that you refuse to continue with this drug, and have sent an adverse reaction complaint to the FDA/Canadian equivalent. Provide both your doctor and pharmacy with a copy of the FDA Form 3500, if you’re a U.S. resident, so they (medical community) know you're serious (see my recent postings of July 20 and July 25, 2008). In addition, I would bring to the attention of your physician the following clinical experience in quotes of Dr Peter H. Langsjoen, MD, FAAC, a Blue Ribbon Cardiologist: “Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels. We are in the midst of a CHF epidemic in the US with a dramatic increase over the past decade. Are we causing this epidemic through our zealous use of statins? In large part I think the answer is yes. We are now in a position to witness the unfolding of the greatest medical tragedy of all time - never before in history has the medical establishment knowingly (Merck & Co., Inc. has two 1990 patents combining CoQ10 with statins to prevent CoQ10 depletion and attendant side effects) created a life threatening nutrient deficiency in millions of otherwise healthy people, only to then sit back with arrogance and horrific irresponsibility and watch to see what happens - as I see two to three new statin cardiomyopathies per week in my practice, I cannot help but view my once great profession with a mixture of sorrow and contempt.” Finally, I hope you find, as I did the following newsletters/medical information helpful:
http://www.vitacost.com/newsletter/newsletter.cfm?nl=189

http://www.vitacost.com/newsletter/newsletter.cfm?nl=234

http://www.vitacost.com/newsletter/newsletter.cfm?nl=370
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U.S.A.
http://www.fda.gov/opacom/backgrounders/problem.html
CANADA
http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/compli-conform/gui-44_consumer_complaint-plainte_consommateur-eng.pdf
Contact Name: Drug Compliance Verification and Investigation Unit
Tel: (613) 952-9906
Fax: (613) 954-0941
E-Mail: DCVIU_UVCEM@hc-sc.gc.ca

I have been on Simvastatin for about 5 weeks now... I have never been a person who had headaches... but I have a headache almost every day. yesterday, my stomach was upset all day as well.

I took a statin for 18 months, terrible aches and pains. I couldn't turn my head side to side and when a awoke in the morning my legs aches so bad I felt I'd never get out of bed.

Three weeks ago I stopped taking them cold turkey. The aches & pains are long gone and I can now turn my head to see where I'm going when backing up the car.... So far so good. I'm also started taking Serrapeptase to clean up my arteries

Lee...
Long Beach CA

I just spent 3 days in the hospital due to taking simvastatin.
I was having weakness in my legs and arms, to the point that I could not walk up steps. I finally went into emergency when I took an attack that resembled a heart attack, shortness of breath, cold sweat, trembling and
nausea. They flushed my body with saline solution for two days. I now have the use of my legs, but am very weak.

Over 6 years ago, the following Petition was submitted to the FDA. I would encourage every patient being treated with statins to read it and bring it to the immediate attention of their physician:

CITIZEN PETITION TO CHANGE THE LABELING FOR
ALL STATIN DRUGS (MEVACOR, LESCOL, PRAVACHOL, ZOCOR,LIPITOR, AND ADVICOR) RECOMMENDING USE OF 100-200mg PER DAY OF SUPPLEMENTAL CO-ENZYME Q10 TO REDUCE THE RISK OF STATIN-INDUCED MYOPATHIES (INCLUDING
CARDIOMYOPATHY AND CONGESTIVE HEART FAILURE). http://www.fda.gov/OHRMS/DOCKETS/dailys/02/May02/052902/02p-0244-cp00001-01-vol1.pdf
May 24, 2002
Petitioner:
Dr. Julian M. Whitaker, M.D.

This Petition is based on the clinical findings of Dr Peter H. Langsjoen, MD, who also reported it to the FDA as follows:

Statins kill people - lots of people - and they wound many, many more. All patients taking statins become depleted in Coenzyme Q10 (CoQ10), eventually - those patients who start with a relatively low CoQ10 levels (the elderly and patients with heart failure) begin to manifest signs/symptoms of CoQ10 deficiency relatively rapidly - in 6 to 12 months. Younger, healthier people who's only "illness" is the non-illness "hypercholesterolemia" can tolerate statins for several years before getting into trouble with fatigue, muscle weakness and soreness (usually with normal muscle enzyme CPK tests) and most ominously - heart failure. In my practice of 17 years in Tyler, Texas, I have seen a frightening increase in heart failure secondary to statin usage, "statin cardiomyopathy". Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels. We are in the midst of a CHF epidemic in the US with a dramatic increase over the past decade. Are we causing this epidemic through our zealous use of statins? In large part I think the answer is yes. We are now in a position to witness the unfolding of the greatest medical tragedy of all time - never before in history has the medical establishment knowingly (Merck & Co., Inc. has two 1990 patents combining CoQ10 with statins to prevent CoQ10 depletion and attendant side effects) created a life threatening nutrient deficiency in millions of otherwise healthy people, only to then sit back with arrogance and horrific irresponsibility and watch to see what happens - as I see two to three new statin cardiomyopathies per week in my practice, I cannot help but view my once great profession with a mixture of sorrow and contempt.

I am 29 year old type 1 Diabetic. I am healthy and regularly exercise. I recently moved to the east side of London from West London. My new GP would not prescribe Lipostatins that I was on (10mg) and chose to put me on 40mg Simvastatin. I finished my course of Lipostatins and started on Sims' about a month ago. I have only just clocked a relation to the change in drugs to why I feel so exhausted, depressed (nearly finished my relationship because of feeling so low), have pains in my hands and my ankles feel weak (I play football and really my ankles feel weak in comparison to last month).
My GP did not even give me any side effect warnings. I am stopping these drugs immediately for my sanity and the people around me.

Aged 39, been on SIMVASTATIN 40mg for 6 days after spending 12 months trying to reduce my cholesterol through diet and seeing it rise to 8. Have been experiencing discomfort and flatulence since 12 hours after taking the first tablet. Have put it down to getting used to the drug, but found this website and wondered... Also been taking Ramipril for BP for a year. I am fit & exercise regularly (I'm used to muscles randomly aching)and although I drink virtually every day I don't smoke. Should I just wait and see?

I was taking Lovastatin until the VA told me that it was not on their formulary any longer and I had to take Simvastatin. Within a couple months my feet started burning and a numbness began creeping up my legs. I began falling, staggering and lost the ability to walk without two canes. I thought I was in the early stages of MS or ALS and feared I was dying. My fiance' did research on the internet (Spacedoc.com) and discovered that the symptoms I was suffering from were the result of Statin Poisoning (don't take my word...look it up) I took myself off the Simvastatin at the doctors request and began taking 4 1000mg of Omega 3 Fish Oil, 2 50mg CoQ10, 1 50mg L Carnitine, a multi vitamin, and 1 81mg coated aspirin per day. I still have numbness in my legs and some burning in my feet one and one half years later. My Neurologist has told me (and written a letter to the effect) that I am permanently disabled...that this will never go away. Statins (all Statins) are poison...don't take them....the pharmacutical companies only push them to make MONEY they don't care about you or your health. If you need more information contact me anytime and I'll be happy to share any research I have. ******

The following article in the WSJ may explain the reason for the significant number of Adverse Reactions to statin drugs.

Why You Can't Tell Where
Your Medication Was Made
April 8, 2008; Page D1- Wall Street Journal
Bananas come with those little stickers listing their country of origin. Why not pharmaceuticals?
That's what some consumers -- and even some physicians -- are asking since the Food and Drug Administration linked the deaths of 19 people to contaminated batches of the blood thinner heparin from China.
******

I encourage every patient with a bad experience taking statins to contact the FDA (see, June 29, 2008 posting for FDA contact info).

After taking Simvastatin for about 6 weeks I started getting very dizzy. The first time only lasted one day. About two weeks later I woke up slightly dizzy and that is lasting now for several days. I also feel pain in my right shoulder blade. I think I'll take myself off this medication to see if things get better.
Side Effects Dizziness - Pain in my right shoulder blade - Fogy short term Memory.

My father is 73 and has been taking this drug now for a few years. In the last year he has been suffering from severe hallucinations , particularly at night. The other evening he walked out of the house and went wandering around the village because he saw people in the house. Has anybody else had similar experiences taking this drug? Clive

I just want to post my experience as it correlates with others. I was on a very low dose of Simvastatin - 5mg - and would have never thought this would have been the issue.

I have been suffering with knee pain for over 18 months. I had to have surgery for cartilage removal and I believe had I not been on Simvastatin my knees cartilage would not have been so brittle and torn. The doctors seemed kind of surprised I was not recovering so quickly after surgery. I never seemed to recover as much as I thought I would have.

Then this June 08 I installed some window air conditioners in my home while I was still taking Simvastatin and I believe I have torn my other knee cartilage. This is what caused me to examine what has changed and why a 50 year old would be having all these issues. My ancestors did not have all these issues.

I started to research Simvastatin. I took myself on and off of Simvastatin twice because I was not certain if this was the culprit. When I started to take Simvastatin on the second pass I had agonizing pain in my knees. I knew. I could hardly walk.

I have discontinued the Simvastatin, my knees have quieted down but I know I must have some damage. I hope is it not permanent.

I am planning to contact my pharmacy to determine when I started with Simvastatin so I can try to time line when I began to have difficulties.

I hope this helps someone else. I do not like being a guinea pig…

I went on Simvastatin 40mgs last Christmas 2007 because of the family history of strokes, I was generally feeling very well .
Since being on statins I have felt awful , with lots of side effects " muscle cramps, upset stomach, really really tired, strange feelings in my chest and bad palpations "... I thought I was really ill.which made me very depressed.and even had test's done at the hospital to try and find what is wrong with me thankfully nothing appears to be seriously wrong" so why feel so dreadful i thought it had to be the statins!!"
I came off them my self four weeks ago ,since then I have been to see my doctor who has agreed for the time being I should be off simvastatin but consider taking a milder statin.
I do feel slightly better after four weeks ,but still get some of the side effects can any one suggest roughly how long it takes to feel like one's old self again.....Please!!!

Started Simvastatin 20mg Jan. 08, just quit June 16th. I 've had all the problems the rest of you have had, arm, chest pain, thought I was having a heart attack for about a month, eye problems,no sex drive, memory loss, weird thoughts, stomach problems, so tired I could barely move, just could'nt wake up. Since I've been off this stuff I'm up one day and down another. I can see some progress, but it seems slow. Does anyone know how long it takes to get this stuff out of your system? Talked to a friend of mine who was on a statin, he quit , and told me it took him 6 months before he felt right. It does'nt seem to go away over night. Anyone else feel this way?

I started on 40mg of simvistatin 3 and a half months ago,after being on them for a week i started to get bad headaches and felt really fatigued,so when i told my gp she said its just a matter of your body getting used to them,so i continued taking the pills i seemed ok for a while but 5 weeks ago i started with palpitations,then i got indigestion, and general discomfort in my chest,weakness in my arms and legs, headaches and the fatigue came back worse than ever,i haven't been back to see the doctor,i stopped the pills yesterday,the indigestion has gone already,i want to lose about a stone and try to lower my cholesterol myself ,but how can you exercise when you feel so weak and tired,my cholesterol level is 5 but because i suffer high blood pressure the doc said it needs to be 4.3,does anyone else suffer from the same and is on this medication?

In follow-up to my posting 3-days ago, regarding an adverse reaction to Simvastatin 80mg, I would encourage patients/consumers to directly send their complaint to the web sites listed at the very bottom, if you are either a U.S. (FDA Form 3500) or Canadian resident.

Also, if your physician is unresponsive to your negative experience with generic Simvastatin, inform him/her that you refuse to continue with this drug, and that you have sent an adverse reaction complaint to the FDA/Canadian equivalent. Provide both your doctor and pharmacy with a copy of the FDA Form 3500 if your a U.S. resident, so they know you're serious.

Lastly, I'm back to feeling normal, after I "demanded" my physician switch me to generic Pravastatin 40mg (2 tabs a day - 80mg), manufactured by Teva Pharmaceutical - corporate HQ Israel with manufacturing facility in Pennsylvania. By the way, a 90-day supply of this quality controlled drug is available at Walmart Pharmacy for $10.

I hope this helps, especially seniors on a fixed income.
-------------------------------------------------------------------------------------
U.S.A.
http://www.fda.gov/opacom/backgrounders/problem.html

CANADA
(http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/compli-conform/gui-44_consumer_complaint-plainte_consommateur-eng.pdf).

Contact Name: Drug Compliance Verification and Investigation Unit
Tel: (613) 952-9906
Fax: (613) 954-0941
E-Mail: DCVIU_UVCEM@hc-sc.gc.ca

I am a 47year old male.I,ve been on simvastatin for about 10 weeks now and have been experiencing mild short term memory loss for a few weeks. I put this down to the onset of old age?. I,ve also been getting spurious pains to elbow and finger joints? could these problems be associated with the medication?.

After 3-weeks of being on generic Simvastatin 80mg for elevated LDL, I experienced significant fatigue, shortness of breath with tightness around my chest and a bout of Gout in my left foot.

I would encourage others posting to this web site to report their complaints directly to the FDA through the following web site:

http://www.fda.gov/opacom/backgrounders/problem.html

I am a 58 year old who was on 10mg for about 10 years with no apparent side effects.My GP retired and the new Doctor said my dosage was low and quadrupled it to 40mg. Since I had been on the drug for so long on the low dose, with no problems I did not relate subsequent problems to this med. Initially I had digestive problems, bordering on diarrhea, which I took as age related. I had occasional but severe lower leg pains. I had periodic night sweats and I gained 25 pounds - going to 165 from the 140 I'd been since high school. I had some vision problems as well and began to develop severe memory and reasoning issues to the point where I believed the I was developing Alzheimers. From net reading, I saw that this statin could cause the digestive problems I'd mentioned - so I stopped it. In the interim my GP gave me every test in the book to find out the weight gain and the night sweats. He found nothing and was about to send me to specialists - which I declined. When I finally read that simvastatin could cause the mental issues, the weight gain, the leg pains etc,, I took myself off the med. My weight problem has now resolved no more leg pains, or intestinal issues. From my reading I understand ths some of the memory and mental issues may be permanent - though they no longer progress. When I met with my GP and told hom that I had stopped the med and about these side effects, that I had discovered on the web - he looked at me like I had two heads and gave them no credence.It amazes me that he had no comment. I had brought it up to him in case any of his other patients has similar problems - as information that could help in his practice which has many elderly clients. As an aside, I had mentioned these effects to a trusted friend - who in tern had mentioned them to his practitioner, who is one of the most highly respected doctors in Canada. This doctor's comment was that' you must have read this somewhere as the manufacturer takes pains to conceal these effects". Wonderful, eh?

just another update on my other 2 postings. Things have really hotted up here, lets just say the doctors surgery will get a nasty surprise in the post!! I urge anyone who has been conned into taking this drug to make a stand, sooner or later the medical community is going to have to listen. Websites like this are a godsend, but....POWER TO THE PEOPLE!!!! Give them what for, they can't brush this under the carpet for much longer and they have no right to make anyone take this drug. My doctor behaved as if nothing had happened, I nearly pegged it and they treated me like a nutcase! The most annoying thing is that I already have Crohn's Disease so I should never have been put on it, but they completely disregarded that fact, something they have been aware of for many years...NO EXCUSE at all. There is a definate cover up, have you seen the news this week??? More people are to be started on simvastatin because the government wants to save money on heart operations!!! They are either incredibly stupid (no surprises there), or have been completety sucked into the statin hype. There is going to be a massive strain on the NHS because of all the other health problems this drug causes, I saw 3 different specialists because of my sudden ill health, do they really think it will save them money??? Any one from the Government reading this?? get your bloody finger out and do something! Apart from not saving money, what cost to all that have been put on it??? what about their health? and by the way, I am the patient but I HAD to ask the doctor for a test for muscle wastage even though he knew this had been occurring, non admition of guilt then? National Health? NO National Joke and we are on the recieving end. I am not a lab monkey and don't want to be a test subject for these poxy drug companies and neither should anyone else, get RID of these awful drugs!

I took simvastatin about a year ago and took myself off it because I had really agonizing night cramps in my legs. A different doctor recently persuaded me to take the drug again because my cholesterol was high, but after only two weeks this time I have a swollen throat and tongue and a persistent cough. Last night I had a breathing problem and thought I was going to die - I just couldn't get any breath into my lungs. I woke up every half hour or so in the night, unable to breathe. I'm thinking I shouldn't be taking these things into my body if they have such dreadful effects. Are they common> Does anybody else have these effects?

my doctor just will not react when I want to stop Simvastatin. He just insists on continuing 20 mg a day. Other medicines: ramipril 20 mg, digoxin 62,5 mag, tamsulosin 400, arfarin 5mg.

Has anyone had mouth numbness or metallic taste in mouth? My mouth feels chalky.

have been taking this med for approx 9 months, i have muscle chest pain and an uncomfortable numbness in my left arm.

I am 54 years old and on simvastatin for the past year. My nails have become brittle and break off easily. I have never had this problem before.
On the up side, my symptoms of GERD are better and my joint pains have also improved. I also used to have bleeding from gums while brushing (I do realise it is from plaque build up) but that has disappeared since I started simvastatin. When I stopped the medication for a month, the bleeding re-started from my gums. Simvastatin seems to have an anti-inflammatory effect, but I am worried about what it is doing to my nails. If my nails are getting brittle (? dehydration of cartilage), is it doing the same to the cartilage in other places too, e.g. knees and hips etc?

been on simvastatin for 4 years with no problems then got pills from a different chemist same 40mg but a different maker immediate symptoms were chronic diarrhea, loss of appetite, tiredness, kept taking after all no side effects with previous maker.thought i had a serious stomach disorder.stopped taking when i realized that was the only constant that had changed,immediate results took none for 3 weeks went back to gp he put me back on my original pills,after taking one,thought that the end was nigh ,diarrhea,sweating general feeling of weakness never again they are binned.

I am a hill walker. My name is Steve and I am 58 years old. I have been recently diagnosed as having type 2 diabetes. Fair enough. I have been given dispersible aspirin, metformin to lower blood sugars, ramipril to reduce blood pressure and SIMVASTATIN to reduce cholesterol. This drug (Simvastatin) made me so Ill that I couldn't walk up my drive without feeling as if I was going to pass out. I also suffered tummy pains, felt very sick and my heart was thumping and banging like a base drum. Every joint in my body ached so badly that I thought my walking days were over for good. I stopped taking it four days ago and already feel better. My doctor has given me a replacement medicine called PRAVASTATIN but I am frightened to take it, fearing that it may create the same or similar problems. Has anyone got any comments or experienced problems with Pravastatin? I would appreciate any feedback that you might be able to give, positive or negative.
Regards,
Steve.

I am 43 yr old woman and have been on simvastatin on and off for the past 3yrs, it's only since coming across this website that I have actually managed to find a connection between this awful drug and a whole heap of medical problems. The most recent course made me so ill that I thought I had an incurable illness that no one could diagnose, at times I have been in so much pain I thought I was going to die. It started with severe knee pain, I have a little arthritis in the knee but doctors were baffled at why it would hurt so much as x-rays on knees and hips were ok. I ended up having an operation to cut a ligament, that was over a year ago and had been in crippling pain ever-since. Also; foggy head, headaches everyday lasting all day, pain in jaw, shoulders, neck, swollen throat, incredible limb swelling, numbness all down right side, kidney problems, weakness in muscles, aching hips and legs, itching, insomnia, to name a few. I complained to my doctor when I was prescribed 50mg of this poison because as soon as I took it, I immediately felt ill and collapsed from terrible weakness, couldn't even lift a feather. They reduced it to 20mg, and I blindly kept taking it, in the meantime, my leg function was worsening, my back was killing me, I couldn't sleep because of the unbelievable burning in my shoulders, hip, neck and legs, everything hurt so much. I have been in tears from the pain and frustration of not knowing what was happening to me, painkillers, even high potency prescriptions just didn't work. I was a healthy gym-going person with a slightly high cholesterol reading, and suddenly, I was almost crippled, unable to function or look after my family, couldn't even handle simple chores that I had done a thousand times before, couldn't think, speak well, do crosswords, it was unbelievable. I have had ECG's, heart stress tests, been to and fro to doctors, hospitals, specialists, even seen an osteopath with these pains, they must have thought I was a hypochondriac! Finally, I insisted on an MRI on my thigh as it had changed shape as there was a lot of muscle wasting in both my right arm and thigh, and so much pain. A lump had also appeared and was really worrying me. The doctor tried to fob me off and said it was a fat lump, I argued that if it was fat it wouldn't hurt so damn much, so the result of the MRI is that I have a tumor which is getting bigger. If I find out that this is a result of the medication, the gates of hell will open.
I took myself off this lethal stuff immediately as soon as I realized there was a connection between it and my debilitating condition, though it's too late to save my 12 yr relationship, that went down the tubes because I just couldn't function well, oh, and my job. and any chance of working after being ill for so long.
I have been off it just a few days but already I feel almost human again. I know it'll be a while before I can see a marked difference and do some of the things I used to be able to do like walk the dog!! but I am furious with my doctor's and have written a letter of complaint, and have told them that I would rather take my chances with god and be a happy person than ever trust them again. I am in no doubt whatsoever that this drug has ruined the last 3 years of my life and probably caused irreversible damage to my leg muscles. Why take a pill because the doctor said so??NEVER AGAIN from now on everything will be checked via websites like this, I am so disgusted that instead of helping me, my own doctor just prescribed other medications I need not have had because of this pill when all he had to do was take me off it. I find it hard to believe that they don't know of these side effects, or pretend not to, how can they not make the connection?? Absolutely furious. I am in worse health now than I ever was, there should be a serious health warning before this is given to anyone, and the first port of call for any complaints should be the doctors who prescribe them instead of offering alternative solutions. This is a time bomb waiting to explode.