Simvastatin and coq10

I've been on Simvistatin for several years. I have inherited a very low 'good cholesterol' (HDL) of 28 - 30 no matter what I do. I was on 20 mg for a few years, and my doctor decided to increase it to 40 mg... soon after the increase, I noticed that my ankles couldn't 'bend' and my heels hurt. I'm only 58 but I felt like I was 102! Also, I have put on weight through my middle...particularly in the stomach area. I questioned my doctor about it, especially since my Dad, who has had 2 heart attacks is only on 10 mg of simvistatin. She didn't really listen to me, so I switched doctors. My current Dr. immediately took me off simvistatin and started me on pravasatin along with 200 mg of CoQ10. So far, so good. My ankles feel better, too!

I started taking 20mg of Simvastatin on 10/17 due to high cholesterol. Five days later I came home from work feeling very tired and fell asleep. I woke up feeling severe flu like aches and pains in places I didn't know could hurt and then got the chills. I stayed home from work the next day and it's a good thing I did. I awoke with a severe cramp in my upper right thigh. I have always been prone to calf cramps so wasn't too concerned. However I stopped the meds on 10/22. This continued on a daily basis and I went to the doctor on 10/27. I had an x-ray done which showed a bulging disc and some uncushioned discs. She put me back on the meds BUT with a COq10 am and pm and cut the pill in half. Do you think she knew it could be from the med? I foolishly restarted and by 11/4 took myself back off, had an MRI and such severe nerve pain in my right leg that I thought I would die. It was a bolt of lightening starting at my upper thigh and coming out the bottom of my foot. It felt like a hot poker running down my leg. The episodes were on a daily basis, would come every two hours, and could last as long as 45 minutes with no relief. I am now going for pain management and had an epidural a week ago which got rid of the nerve pain but I am still numb down my right leg to my right ankle. I have been healthy for years and feel that this was all brought on by Simvastatin. Any idiot can figure out that your nerves are running through your muscles. I am angry to think that this could have caused me permanent damage.

August 12, 2009. I have been on Zocor/Simvastatin (40mgs) off and on over 5 years. I do not have any muscle mass left. I am an avid walker and exercise as much as possible in addition to still working in a high pressure position at the age of 72 (thankful for the job). My entire body hurts constantly, hands, fingers, legs, knees, neck, back, head and other parts to numerous to mention. My sex life is the pits. My doctor tells me I have high cholesterol that must be controlled by medication. I had a quad bypass in 1999, a cardiac defibrillator installed in 2003 (Actually 3 of them, first one was defective and went off, got a severe infection on reinstall #2, and 3rd one still is in and working hopefully). I never had a heart attack, no high blood pressure, just clogged up. I take enough medication to kill an elephant. At 72 I am going to trash the Simvastatin because I know it is the basis for my muscle loss and severe pain constantly. Doctor also had me on Lipitor for a long time (5 years). Statins really suck!

My healthy, active 55 yr old husband of 30 yrs was prescribed SIMVASTATIN in Aug. of last year. He started having pains in his legs & back and had an appointment in Oct. with the dr. to check on how he was doing with the new drug. When he went in to the office, he was having terrible pains in his chest, legs & back. The dr. immediately called 911 thinking he was having a heart attack. He was in the hospital for a week while they ran a multitude of tests. All came back clear for his heart. He kept telling the dr. that the back & leg pains were still there. They didn't seem to be concerned about anything except his heart. He was dismissed continuing to have pain. The pain steadly increased over his whole body, then in Feb. of this year, he suffered a major seizure and spent another week in the hospital. This time they wrote it off as epilepsy and put him on anti-seziure pills. After he was released, the symptoms increased, his memory, vision & balance are all effected, he has chest pains, depression, and is in constant pain. He's been sent for numerous MRI's, bone scans, blood tests,etc. He has been to neurologists, neurosurgeons, chiropractors, physical therapists, etc. The entire time, his health has declined because he was being poisoned by Simvastatin. Finally, after doing our own research, we found a neurologist that recognized the problem. He told us that this drug distroys muscle tissue and that the damage may be irreversible. My husband can no longer work, drive, or enjoy life. He walks without a cane or walker, and depends on pain pills because the pain is so severe. He stays in bed most of the time due to the pain and lack of energy. He has been off Simvastatin for a week now with no change. We are hoping & praying for improvement over time. PLEASE, if you are your loved one are taking this drug-STOP IMMEDIATELY. The results can be devastating. I can't imagine why the FDA would approve a drug like this that destroys quality of life.

33 year old, 125lb female with cholesterol of 234. I was put on Simvastatin 40mg, which I took fot 3 night only. All hell broke loose, insomnia, hands are numb, severe joint/back pain, extreme weakness... The thing is, I took it for 3 nights & realized it wasn't for me. I've been off of it for 3 weeks, but the symptoms still persist, rendering me pretty much dead.... I was told by a few that putting me on 40 mg to start off probably did the job... Three week of living hell & my primary physician don't have answers for me!

It has helped me a lot reading everyone's experiences with the "dreaded" Simvastatin. I have been off this poisonous drug for 7 weeks, and am still feeling rough, and thinking when is this all going to go away ! My doctor swears blind it is nothing to do with the Simvastatin, but I am a 100% sure it is , as I felt fine before I took these nasty tablets. I still have persistent buzzing in the ears , dizziness, palpitations, constantly tired , and generally feel as if I am on another planet. Ive had blood tests , ecg tests and nothing has been found. Im hoping one morning to wake up feeling "normal". I will never , ever, take Cholesterol drugs again , as I don't want to go through all this again. I really feel for everyone that is suffering, and would be interested if anyone is having the same after affects as myself.
Good luck to everyone who is suffering like me .

...See posting below...also I have tingling/numbness in my hands and forearms. I'm also taking the enzyme CoQ10, which is supposed to help. I was told by someone working in a health food/vitamin/supplement store to take red yeast rice.....NOT a good idea. Red yeast rice contains the same basic ingredients as simvastatin.

I have been on Simvastatin for several months. I am now experiencing low back pain, stiff neck on the right-hand side, fatigue feelings in back when standing, fatigue, dizziness and generally feeling "awful." My MD cut me back from 40mg daily to 40mg every other day, but I still continue to feel sick.
I read complaints from others on this site and want to share my symptoms. I have a 78% blockage in my right carotid artery and a 58% blockage in my left carotid artery. I am 72 years old but what else can I do to prevent a possible stroke should these blockages increase without the use of a statin drug????

Have been on Simvastatin since May 2007. Have experienced debilitating headaches every day for the first three months, neck and shoulder pain, lower back pain, tiredness to the point of having to stop what I am doing and go to bed and am wondering now whether any other female taking Simvastatin has experienced a burning sensation when passing very hot water and extremely uncomfortable and painful sex.

I'm 55 year old female and was put on Simvastatin 3 months ago with a cholesterol reading of 6.8. I've been experiencing severe lower back pain, a burning pain in the right side of the groin and severe pain in my right hip and leg. It has become so bad that I'm finding walking difficult. I also have severe itching all over, especially on one part of my arm. I can't take anti-histimes because I am alreading taking beta-histine for vertigo. After reading the postings here I am seeing my doctor this week to have my medication changed. Since I live in the Uk cost is not a problem

I'm a 54 year old female prescribed 10 mg zocor(simvastatin) for slightly elevated cholesterol. Took it for 7 months before I clued in to the cause of my many symptoms. Muscle and joint pain, head fog, blurry vision, weight gain, stomach upset, fatigue, etc... The muscle and joint pain were excruciating at times --especially in my left hip...which had gotten so bad I needed a walking stick for support. I felt so darn old wondering if I would even feel normal again.
After reading many postings I decided to stop my zocor(simvastatin) 6 weeks ago and am very happy to report an improvement in many of my complaints...although far from where I want to be.
I am curious as to the withdrawal effects others may have experienced. The first week coming off I had stomach aches and I had awful headaches which thankfully did stop. The stomach aches and touchy digestive system still plague me though. Am I the only one experiencing this?....

recently was prescribed simvastatin. Pharmacist advised that 50% of people will experience severe muscle & joint pain and burning in the muscles. I can see by reading the site that this is true. Must try since cholesteral and bp are high and dr thinks at 51 I had two mini strokes (tia's). If I experience the severe pain that is discussed i will stop taking. Thank you for all the info! This site is awesome.

Iv been on 40mg for a year now i could be feeling perfectly fine then suddenly an intense tiredness comes over me and i feel very sick and start heaving quite violently and desperately need to lie down until it passes, sometimes i fall asleep and sometimes not. This is a day occurrence, sometimes even 2 to 3 times a day. This only started when i started taking these tablets. The doctor says is not anything to do with the medication but im convinced it is. Has anyone else got these side effects?

My husband was prescribed 40mg of this drug 2 years back,for his high cholesterol reading. He is an ex-services and has always been extremely fit, he was tired for almost a year, then he began having headaches to the point he had a brain scan, because he thought he had a tumor. He also has had knee and neck joint problems and now the joints of his fingers are giving him pain He now wakes up each morning feels really ill and feels as though hes being strangled, the sensation lasts sometime for hours and he has to lie down. His doctor said it was blood pressure but he keeps a monitor and his pressure has been normal. His doctor said he should continue to take it, but when you read all the symptoms that people are getting while taking this drug it makes you realize they are all just guinea pigs for a large scale trial of the drug

I'm 58 years old and I've been on 10 mg Simvastatin for 14 months since I was diagnosed with Diabetes 2. Also Metformin and Glipiside as my bs got up to 499 at diagnosis with high cholesterol.

I had NO IDEA that my suffering the past year could possibly be tied to one of the drugs I've been prescribed. In the first three months after diagnosis, my Diabetes was controlled and I've even backed off some of the meds. My cholesterol also came down beautifully. However, the debilitating weakness and muscle aches (which has increased over the 14 mos.) has become so bad (especially this last week) that I came to the Internet looking for possible reasons for 'body ache'.

And get this: I take a packet of vitamins every day which includes a daily dose of Q10... BUT I haven't been able to take them for about a week and this last week I felt like I was ready for a wheel chair~!!! Worse than it's ever been, knees and feet in horrible condition, hands and wrists unable to open a water bottle. Total body aches so severe it made me want to research something, anything to see what might be the problem.... before seeing the doctor about it!

My shock at seeing my medication here listed with the horrible side effects I'm experiencing has been a revelation~!! I am going to stop the Simvastatinn and see what happens. BTW, I've been an active person all my life, was a 2nd Degree Black Belt and taught Tang Soo Do and know what muscle aches and pains are, know my body (at least I did) and pretty much thought my active life was over.....

Not now~!!! I'm FURIOUS!!

I have been taking simvastatin since June 28, 2008. I am 44 years old and have always been majorly active with my 17 year old daughter. Recently I have become chronically fatigued so much as to want to go back to bed within 2-3 hours after I get up in the morning, (definitely not me). I have felt spaced out,depressed to the point of wanting to cry all the time, have severe back, hip, knee, leg, and hand pain. I go to pain management for my back and hip problems (past surgery), but the usual pain has been intensified over the last 2 months and I wasn't sure why, until i decided to check out the Simvastatin to see if it has made me put on a few pounds, and boy have my eyes been opened!!!!!!!!! I AM STOPPING THE MEDICATION IMMEDIATELY!!!!!!!!!!!! Thanks to all who have spoken up, I wish I would of checked on this sooner!!!!! I'm calling my Dr. first thing in the morning!!!!!!!!!!!

By exhausted in Canton

As a retired Healthcare Professional, like you I almost died from a statin overdose. If you’re a U.S. resident (FDA Form 3500) or Canadian resident, I would encourage patients/consumers to send their complaint/statin adverse reaction report to the web sites listed below. Also, if your physician is unresponsive to your negative experience from any statin, inform him/her that you refuse to continue with this drug, and have sent an adverse reaction complaint to the FDA/Canadian equivalent. Provide both your doctor and pharmacy with a copy of the FDA Form 3500, if you’re a U.S. resident, so they (medical community) know you're serious (see my recent postings of July 20 and July 25, 2008). In addition, I would bring to the attention of your physician the following clinical experience in quotes of Dr Peter H. Langsjoen, MD, FAAC, a Blue Ribbon Cardiologist: “Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels. We are in the midst of a CHF epidemic in the US with a dramatic increase over the past decade. Are we causing this epidemic through our zealous use of statins? In large part I think the answer is yes. We are now in a position to witness the unfolding of the greatest medical tragedy of all time - never before in history has the medical establishment knowingly (Merck & Co., Inc. has two 1990 patents combining CoQ10 with statins to prevent CoQ10 depletion and attendant side effects) created a life threatening nutrient deficiency in millions of otherwise healthy people, only to then sit back with arrogance and horrific irresponsibility and watch to see what happens - as I see two to three new statin cardiomyopathies per week in my practice, I cannot help but view my once great profession with a mixture of sorrow and contempt.” Finally, I hope you find, as I did the following newsletters/medical information helpful:
http://www.vitacost.com/newsletter/newsletter.cfm?nl=189

http://www.vitacost.com/newsletter/newsletter.cfm?nl=234

http://www.vitacost.com/newsletter/newsletter.cfm?nl=370
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U.S.A.
http://www.fda.gov/opacom/backgrounders/problem.html
CANADA
http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/compli-conform/gui-44_consumer_complaint-plainte_consommateur-eng.pdf
Contact Name: Drug Compliance Verification and Investigation Unit
Tel: (613) 952-9906
Fax: (613) 954-0941
E-Mail: DCVIU_UVCEM@hc-sc.gc.ca

I just spent 3 days in the hospital due to taking simvastatin.
I was having weakness in my legs and arms, to the point that I could not walk up steps. I finally went into emergency when I took an attack that resembled a heart attack, shortness of breath, cold sweat, trembling and
nausea. They flushed my body with saline solution for two days. I now have the use of my legs, but am very weak.

I was taking Lovastatin until the VA told me that it was not on their formulary any longer and I had to take Simvastatin. Within a couple months my feet started burning and a numbness began creeping up my legs. I began falling, staggering and lost the ability to walk without two canes. I thought I was in the early stages of MS or ALS and feared I was dying. My fiance' did research on the internet (Spacedoc.com) and discovered that the symptoms I was suffering from were the result of Statin Poisoning (don't take my word...look it up) I took myself off the Simvastatin at the doctors request and began taking 4 1000mg of Omega 3 Fish Oil, 2 50mg CoQ10, 1 50mg L Carnitine, a multi vitamin, and 1 81mg coated aspirin per day. I still have numbness in my legs and some burning in my feet one and one half years later. My Neurologist has told me (and written a letter to the effect) that I am permanently disabled...that this will never go away. Statins (all Statins) are poison...don't take them....the pharmacutical companies only push them to make MONEY they don't care about you or your health. If you need more information contact me anytime and I'll be happy to share any research I have. ******