Singulair and 3 years

I took my daughter (14yrs old) off of Singulair 2 nights ago after being in the ER. She's been taking this drug for 3 years off and on. We were told she had asthma 3yrs ago and now yesterday after taking the Methacholine challenge test, she doesn't have asthma. Talk about being confused and angry. Over the last three years my daughter changed into a very anxious person, couldn't sleep at nights, very vivid dreams that made her surround herself with pillows thinking her dreams were real, sadness, chest pains, tingling in hands, arms & legs, knee pain (could be sport related?) and a very short fuse. I came across another website and then this one about the side effects of this drug and immediately took her off. She has slept better the last two nights but still has a little chest pain (indigestion), which I hope subsides soon. This has been a terrible stress for her and the whole family and I'm praying being off this drug will help my daughter restore her self confidence and happiness in her life.
A.

I am a 36 year old woman, and I have taken Singulair for the past 8 months. I got a lung infection over the winter, and the clinic I went to put me on the 10mg Singulair. It helped my lungs and got me over the worst of the infection, but I never anticipated the side-effects. For several months, I attributed what I was feeling to hormones (like severe PMS) and the stress in my life. I started to have thoughts of death, especially at night. I also began to have a hard time leaving my house. I would have panic attacks, worrying that the window was left open, the stove was left on, and god forbid there was a dark cloud in the sky (I became convinced that a terrible storm would come). Several times, I nearly got in a car accident racing to get home after work. Then, I started to obsess over getting sick. I was convinced that I would get some terrible disease and die soon. The fears and anxiety got worse and worse until one day (a rainy day), I quit my job of twelve years. It was a good job. I was happy with my work, and I made more than enough money. I ended up moving across the country back in with my estranged husband, because here I would not have to work. I could stay home all the time, away from germs and storms and anything else bad. That was three months ago. Still on the Singulair, I began to obsess over death. The panic attacks were so severe that they triggered asthma attacks, and not being able to breathe triggered more anxiety. I stopped sleeping at night. In three months, I've slept four nights. I began to have nightmares that made me wake up screaming and violently lashing out. I had to urinate 5 or 6 times every night. I developed severe stomach pain and nausea. And I had leg pain (actually, I hurt everywhere, severe pain). I had headaches, dizziness, and fatigue. Slowly, I began to realize that it might be the medicine. I started to research, and yesterday, I took my last pill. Since then, I have not had one panic attack. I have not had one asthma attack. I slept last night with no bad dreams. I know what's happened now, and I'm so sad that I lost so much of my life because of this drug. I really had a good life...friends, a home, a great job... Now, I'm very tired. My body is very weak and still hurting. I'm shaky. But I believe in time, those effects, too, will go away. I feel like my body has been through a war. I'm grateful that I didn't kill myself. There were a couple of really bad days when the urge to be violent towards myself was overwhelming. One day, I punched a fence, making my knuckles bleed. I think I could've killed myself, and I know it was Singulair. It's going to be better now. Just as a note: what helped me withdraw without any major worsening of asthma was Advair 250/50 twice a day.

My daughter who just turned 6 has been on Singulair for about 3 years now. Her behavior has not always been the best, but with her past medical history ( a preemie) and all the things we have gone through some times its just easier to give in than to fight over it!!! So last week she was suffering with her allergies and asthma and the doctor added a Claritin to be taken once daily. I didn't really think to much about it and thought well if it is going to help her the OKay. That was on Wednesday and by the week end she was literally coming "unglued". She was lying on the floor when she should have been in her seat at the dinner table. When she was in her seat she was doing "back bends" over the chair. We finally come to the conclusion that it had to be the Claritin, I looked up the active ingredient loratadine and knew I had to get her off it immediately. So now I started to investigate the Singulair as well, which I should have done long ago. Today will be the last day she takes Singulair as well. She has complained of her stomach hurting for a long time and I always blamed it on constipation, but it could be the Singulair. I can only pray that she will not have any lasting side affects.

Our son, who is now 6 was prescribed Singulair at the age of 3 due to asthma/allergies. He was prescribed this by an ENT/Allergist. I thought our sons mood swings were due to the fact that we were expecting another child. He was always so happy/loving and playful. When the baby arrived 2 months later, his behavior worsened. Again, I put it on the new baby sister in the house. His moods/anger/outbursts increased. He hit, threw things etc. I told the doc about this and he said it was due to his enlarged tonsils, and they were then removed. Well needless to say, his behavior did not change because he was still on the Singulair. I mentioned the possible side effects to his pediatrician and she said it was a possibility, but to keep him on it because he needed it. Well, 3 years later, in March of this year I took him to an allergist that I had seen years ago. He immediately took him off the singulair (and all inhalers). His moods seemed to brighten a bit, but not they are worsening again. Is it possible for the Singulair to have long term damaging effects. I understand kids have tantrums, etc. Kids are kids, I get that. But he punches, kicks, screams, cries etc. My husband are at a loss. We don't know what to do. Oh, and he is now on Veramyst as needed (march-june, Aug-Oct.). Has anyone else experienced long term effects due to Singulair?

hi i am 39 year old male from uk just stopped taking singular 10mg
been on this drug for about 3 years now side effects have been bad circulation in my legs can only sleep about 2 hour at night then get up
again find it very difficult to get off to sleep feel tired alot of the time my eczema never seem to heal like it use to i cant see no difference with my asthma since being on this drug.
my side effects are tiredness ,rash,irritable,weird dreams and bad circulation in my legs

My 11 year old step-daughter has been on Singulair for 3 years and has had trouble sleeping - waking up 8-10 times nightly, sometimes with terrible nightmares as listed on some of the other posts. Thank you so much for sharing this info. We took her to an ENT today and the only thing they offered was to take out her tonsils and adnoids but the were basically normal - all they wanted was money the way I see it. We are taking her off all her meds tonight; she also takes Asmanex, Nasonex and Allegra.

I discovered my son's side effects from singulair a little over 2 years ago. He had used Singulair for approx 3 years. I did not recognize that he was suffering side effects until his ped increased his dosage to 5mg. At that point, it was loud and clear. I discontinued the Singulair in March 2007. The most significant improvements happen after approx 3 weeks. He was like a different child. Even after the 3 weeks, it seemed like he continued to improve a little every day.

I can tell you from our experience that my son suffered many, many side effects that i did not recognize. He had nightmares, anxiety, fear, frustration, leg pains, stomach pains, dark circles under his eyes, poor appetite, quick to tears and restlessness...just to name a few. On the higher dosage, he began to have a facial tic, dilated pupils and hallucinations.

I am thankful everyday for this website and some higher power that helped me realize what was going on and get him off Singulair. The first week off Singulair, he slept like an angel. No night terrors, no thrashing in his sleep. Week 2, he continued to improve in so many ways. It was nothing short of amazing. Week 3, he began to realize the changes in himself. Fears were a HUGE side effect for him. During week 3, the fears, ALL of them disappeared. He never spoke of them again. It was very strange and truly amazing.

I don't want to tell you to stop the use of Singulair. Only you know your child's health status. I will tell you that stopping Singulair changed our lives and saved my son. He suffered the assault of Singulair for 3 long years. Good luck to you all and your families. Feel free to email me if you have any questions.

I was on Singulair for approx 3 years with zero side effects other than actually being healthy for the first time in my life - no chronic acute bronchitis episodes, no calling in sick to work. Then I switched jobs and HMOs - they immediately took me off of my Singulair and Combivent and put me on Qvar and Proair. Quess what? I began wheezing and sniffling. So they prescribed Claritin and Nasarel on top of the other two. Still not working. So now after a bout with antibiotics and steroids they have prescribed Flonase and over the counter Zyrtec. I have BEGGED to go back on Singulair repeatedly. I have offered to pay the $120/month out of pocket. Now I really am depressed and angry all the time - as well as having intense headaches, tremors, chest pain, insomnia, jitteryness then fatigue then jitteryness again = all because I can't get the stupid Singulair.

My son is 8 and for the past 3 years has been on Singular for seasonal allergies. He has since been diagnose with asthma and he takes Singular daily. After being on it for 3 weeks he is now getting into trouble in school. The teachers say it was like a light switch being turned on. Completely out of character behavior. My question is this......has anyone experienced hyperactivity behavior on Singular?

My son has been on Singulair for about a year and a half...it really seemed to help his allergies...at least at first. This winter has been very dry and I have been having to give him other over the counter allergy medication as the Singulair isn't helping much. He also started losing weight..just not hungry. At first that was ok as he needed to lose a little but then he was getting too thin. He wasn't eating much at school but refused to take a lunch from home. I took him to the doctor just recently to see if he was physical ok since I didn't know what was causing the weight loss. The blood testing showed everything was normal and I just told him he had to start eating better...he has somewhat...but also he finally told me he has been feeling very depressed...seriously depressed and having suicidal thoughts too due to some kids picking on him at school.

I knew there were problems as he complained alot but I had no idea it was this serious. I have taken him out of that school. Right now I don't know if the Singulair could be adding to this depression or if its all just due to the bullies. While he complained a lot he never acted as if it was bothering him that badly or I would have gone to the school about it. Anyway I stopped the Singulair and am going to see if his mood improves or not. After reading some of the scary posts on here regarding the side effects I am wondering if this is a good idea stopping it or not. I am waiting for a call back from his doctor on it. Since its once a day..its kind of hard to wean them off of it...but I could cut it in half ..do that for a few days, then cut it smaller and so forth. His is chewable so I could do that with no problems. He is 13.

My son is 7 years old and was put on singulair for his asthma and allergies, my daughter who is 10, had been on it for over 2 years.
My son started experiencing, night terrors, out burst of crying, difficult to make decisions.
Anxiety attacks, panic attacks, did not want to go to school. After seeing his Doctor it was suggested that we pull him off the medicine. We started noticing changes within a few weeks. Please watch your child closely if on this drug. My daughter did not have side effects however we have taken her off this medicine also.
I would really be careful with this drug. Our family was in complete terror, watching your child struggling like this. USE CAUTION, IF YOU DECIDE TO TAKE THIS MEDICINE....

I'm so happy that I decided to research this drug. My son, who will be 2 on 1/22/09 was prescribed Singulair today. He has been coughing/wheezing, etc since we moved to a different state, 6 months ago. We have tried all kinds of OTC drugs and nothing would work. We finally brought him to the Dr. today and he says he has allergies (which we kinda knew already). I was happy that the Dr. prescribed something that we could not get OTC..to me, that meant that it was going to be better. I went to pick up the prescription and the pharmacist tried to talk me into a different kind of allergy med for my son. I told her that I wanted to stick with the Singulair, since that is what the Dr. prescribed. She told me, in no uncertain terms, to research this drug! She kept asking, "He's only 2, right?" He's only 2, right?" Her behavior was strange, I thought....it turns out that she was my angel today. I gave my son 1 dosage tonight before bed and he WILL NOT get another. Thank you! On Monday, my first order of business is to go back to the pharmacy and thank my angel....

My son is 12 and has been taking Singulair for the last ten months...he has been getting moody and upset for no good reason over the last 3 months and I put it down to "hormones" starting to kick in. He has now gone to feeling very sad and has even told me last night that he has thought about killing himself several times and feels he can't go on, or cope and feels lost and lonely or unwanted and in the way. He is confused and does not understand what is happening to him. I have just realized it may be the Singulair and will be taking him off it immediately. I'm hoping it is this as if it isn't I feel totally helpless as to how to help my child. Please say a prayer for him. He used to be happy go lucky.

I would like to know who is NOT experiencing side effects from Singulair.
We are not.
My 7 years old started Singulair three months ago because of allergy issues. She had asthma attack every other week, running nose all the time, she was so miserable, she missed many days of school and she couldn't exercise .Since she started to take SIngulair her allergy improved, no more asthma, no more running nose. SIngulair did not change her way to be. She is doing very good in school (she is above the average..) she does piano, ice skating, she is purple belt Tae Know Doe, speak two languages, she is doing great in everything. Of course she has her "bad moments" but which child does not?
I tried homeopathy, but it did not work, she got worst and worst. I was supposed to give SIngulair to my daughter a year ago, I did not because I was afraid of the side effects. But I wished I had started before because I could have avoid so much steroids since she had asthma most of the time. The doctor convinced me to use this medicine when she said " You think SIngulair has side effects, yes sometime it does, but do you know the danger of using steroids so frequently in a little body?" Then I thought I had to give a try. I am glad I did. Of course I keep watching my daughter behavior closely and reading all the possible side effects of this medication. I forgot to say that beside singulair my daughter is also taking Pulmicort, two puffs once a day.

My 7 year old son has been on Singulair since this spring for a dry hacking cough and allergies. The Singulair worked great clearing up his symptoms. We have not seen any behavioral changes. Our doctor said he only needs to take it during fall and spring when his allergy induced asthma is the worst. Both times that I have taken him off of it for a seasonal reprieve he has developed a VERY PAINFUL STOMACH ACHE. He doesn't vomit, but he rolls around complaining that his tummy hurts. I have seen other posts concerning stomach aches when on the medication, but I am wondering if anyone else has had this experience when they went off of it. Even if he forgot his medication a couple of days, the stomach ache will present.

We have a 5 year old daughter who has been on singulair for about 2 - 3 years. She went on singulair due to coughing asthma. We were soo happy about how well the medication worked, it took about three months, but wow, she finally got over her coughing and was living a more active life. I actually was soo impressed with it, I remember mentioning it and promoting it to some of our daughters friends' parents with children in similar situations....wow do I ever feel awful. Anyway, our daughter came down with a terrible flu a few weeks ago and although she didn't seem feverish, had not one, but 2 night terrors, something that we have been worried about and comforting her with for a couple of years. These 2 threw the 2 of us over the edge this time....we thought we had to get her to a psychologist.....she was terrified, and although we were holding her and comforting her, she was still screaming for us, and there was NOTHING we could do this time....we were doubting ourselves and the environments she was exposed to......what could have happened in her life to make her have such awful dreams??? It was about a 1/2 hour later when my husband asked about the possible side effects of the singulair.....I ran and grabbed the pamphlet, of course this is the first time that I actually sat down and read it, which I should have done some time ago....anyway it was then that I discovered how many issues weren't normal that everyone just kept ensuring us was fine. We had been questioning ADHD for some time, and had actually had it on our list to discuss with her teacher as she was sooo hyper on a regular basis...at the age of 5 she still couldn't sit through a movie at a movie theater, as much as she loved going, she couldn't sit through it....anyway, the only thing that made it difficult to think she could have ADHD was she was such a great learner. She was very eager to learn and loved learning and teaching things. But when giving her instructions or asking her to listen, she'd be so jumpy. She complained of severe leg pains which we chalked up to growing pains...poor thing! Her temper tantrums were out of this world.....she is a child that is soo full of love, but when she was in tantrum mode, she was soo destructive and she would feel soooooo awful for her actions, it was like she couldn't control herself. We just feel awful that we couldn't help her and we didn't realize that what she was experiencing was not so much disobedience, but an imbalance due to the medication. We have since taken her off the singulair, we took her off of it immediately following reading the pamphlet. We found that she was VERY emotional for about 3 days, then she pretty well recovered. She has since become a normally active 5 year old, she is soo good, and has not experienced any night terrors, complained of leg pains, and absolutely no tantrums. Oooh how we love her so much.

My 8 year old daughter was on singular for 3 years and she was very active and a little hyper, after taking her off of singular now for almost 8 months she has incurred a tic, I have brought her to a neurologist and he says no its not from the medication or a side effect from it but I really think it is, she has a few vocal and 1 involuntary movement, this is so terrible that these medications that you think help your children are really hurting them, my daughter was on asthma medications since she was 3, and then the neurologist suggests that I put her on an anxiety medication I told him NO, you are not going to make my child stoned I will find other ways to help her with this problem because what I have read is there is no medication that clears tics, they go away on there own and I believe this I will not drug my daughter she has been through enough with all this medication that has caused this. So I do believe SINGULAR and a few others are responsible for our childrens behaviors.

I have an 8y.o. daughter that has been on Singulair for about 3 years now. Since she started taking singulair she has been absolutely miserable! She cries at everything, is very moody, has leg pains, wont leave my side and is tired ALL the time. She has circle under her eyes, she looks like she hasn't slept a wink in days! She has been off her Singulair for about 5 days now and she is a totally different person. She has been "happy-go-lucky" and full of herself, she has even woke up happy (which hasn't happened in I dont know how long). She was put on Singulair by our Doctor b/c she had Pnemonia two times in a row. She has Allergies and Asthma and for the past 3 years has been on: Singulair (4mg), albuterol, flovent, Zyrtec, and Flonase. That is just too much for a little girl to be on. She hardly eats at all, gets headaches. I just see such a difference when she is not on it but, what will she take in place of this? My husband also takes Singulair (he is miserable all the time), he doesnt sleep at night and is always tired. Anyone have alternative to this drug?

It seems that this subject has been extensively documented, but just wanted to confirm that I believe this drug is very dangerous. We JUST put our 5-1/2 year old daughter on it one week ago. She has NEVER had any issues sleeping, is most often in a great mood, and has been protected beyond belief by my wife from negative imagery, TV, etc. The last week was unbelievable. Night terrors every night, with the most vivid and negative imagery when asked to describe the content of her dreams. Things that I would have thought she must have gotten from watching a Stephen King movie. Given the lack of fitful sleep could have been a contribute, but her mood all week was very downtrodden. Hard to say a 5 year old can be depressed, but I would have to say she was, very sullen, moody, despondent to affection.

I can positively say this was a blind test. We didn't really read the label on the medicine until yesterday, so we were not looking into things that weren't there, nor were we focusing in on the sleep issues. We took her off yesterday, and hopefully I will be able to report that the night terrors that I am 95% positive must have come from this drug will abate.

I hear because the chewable format is new, this drug is really being pushed. I hope this drug is pulled instead of being promoted. Buyer beware, especially administering to kids. I can't imagine if our daughter had been a little younger and not able to express herself to the level she can at 5.

My 3 year old is on 5mg of singular daily for her constant allergy issues and has had NO trouble at all with it. Her personality has not changed.. she's happy, outgoing, friendly and MUCH better than she was before she started the medication. Prior to starting she was constantly dripping from her nose, she had both ears filled with fluid, had bags under her eyes and was tired and grumpy all the time, due to allergies we could not get under control with other over the counter or prescription meds. Since being on Singulair she's been 100% better than she was. I'm sad to hear that others are having so much trouble with it, but I can say that I am happy my little girl is feeling better.

I am shocked and outraged at the "NEW" list of side effects that were attached to my newly refilled Singulair prescription. I am an adult and have been taking this medication for 3 years. I also know that I have not been happy in three years and every day I feel more and more hopeless and withdrawn. I have little interest in leaving my house, being with other people or anything else. Everything in life seems like an overwhelming task for me. I am filled with ideas about how to 'get away-far away'. I am a decent person, a wife and a mother of 3, but lately I would have done anything to be able to get a divorce and run. I have hated myself for these thoughts, which makes it all worse. I'm always reminding myself that these are people that I'm supposed to love! I ran out of my Singulair right before Thanksgiving and kept putting off refilling it, quite frankly, because I just didn't have the 'energy' to go to the store and pick it up. I did pick it up 2 days ago and that's when I noticed the new labels all over the bottle and was shocked when I read the description of the side effects. It was if they had been written about me. I have not taken any more of it and have now been off for more than a week and I feel like a human being again.

Im 15 and I never knew that singulair had the side effects that included mental/mood change or worsening depression, etc. Although I did find it strange that I always seemed moody or bi-polar, it never occurred to me that it would be caused by singulair. I've been taking it for about 3 years and before I went from 5mg to 10mg i use to have difficulty sleeping, but just last October when I started taking the 10mg i noticed an even greater change in my moods and mental thoughts, i was always sad, doubtful, mad, and was always thinking of all the negative things in life, in fact I even went through a really deep anxiety stage around the end of October, it was a mixture of the medication and stress i'm guessing, but I couldn't stop crying, I'd cry then forget the reason, start crying again, and wonder what i was crying about or why i was crying for such a thing that lasted for about an hour... Then when I ran out, i sort of just put the thought aside to refill them for the whole month of November and noticed i began to feel more... up-beat, very happy, I cant remember the last time I felt so great for such a long period of time, at least not during my pre-teen through teen years so far. All my friends noticed too, normally i would be complaining about how the day is going so bad, but i can't compare November to any other month during the past almost 3 years, although my asthma symptoms came back. So I started taking them again this Monday, and right away that night when I was doing homework, i was studying about tabacco all these thoughts rushed through my head, I felt bad for the people i loved that smoke, and I started crying, almost blaming myself for their smoking, when i stopped crying i started wondering why i cried... it made no sense, normally i'd just be like, "oh man... why do they waste their time doing that.." and forget about it, but the tired, sad, doubtful feelings came back right away. these past few days I've felt like that, and today before i was about to take my pill i looked at some new information that was never included before about the mental/mood changes, worsening feelings of sadness etc... and it all just hit me like a ball going 90mph.

My ADOPTED son almost 6 and was already on Singulair when he came to live with us at age 20mos.
After finding this site just over 2 weeks ago, I took him off on this stuff. Well, after about a week, things were so good that it was scary. His behavior improved so much, that everyone said he doesn't act like Jacob. I said, yes he does, we just didn't know him before going on this med.
He is currently going thru ADHD evaluation and I advised the therapist that I took him off this drug and he was like a new child. Her comment was "did we cure him"? Well, after her one on one with him, she commented, I don't know whats wrong, but he is extremely HYPER and then all hell broke loose on the way home. But, he has been fine since.
I am praying that I don't have to medicate him for ADHD, I am just not ready for that and have been fighting it for a while and then after reading all the side effects on this site, it described my child to a tee. He is in Kindergarten and is doing great academically and the therapist was a bit surprised by that with how hyer he is.
Please tell me with how long my son has been on this drug, that it's going take more than a couple of weeks. He is not near as hyper to us as he was before. Maybe he just got excited about all the toys in her office. He can also be very defiant, that is whole other issue we are dealing with. He does way better for his Dad than Me, so now if he doesn't want to listen to me, he Dad intervenes. I am hoping he will get it, that he can't be disrespectful to his Mom or he will have his Dad to deal with.
Thanks for listening and please pray that his behavior will continue to improve over the next few weeks with the absence of Singulair.

I have been making inquires as to how and if the fda will conduct investigations in to permanent damage left from this drug.Although on taking my son off this drug i saw a 90% improvement,i am still missing the final piece,is it that he lost 3 years to this drug or did it do damage that cannot be fixed,we as parents need to know.The FDA responded to my letter,they said if they see a trend in reports from medwatch,it may prompt an investigation .I am asking all who still have missing pieces to file a report.What has happened is a tragedy,we need to explore ever option for continued success for our childrens future.Good Luck to all,Keep Fighting

Wow! I can't believe what I'm reading. My son just turned 5 years old. He was put on Singular when he was 2 years old because he constantly had sinus infections. For the past year, I've just used it off and on when he starts to get stuffy. He is very well behaved, but has has trouble with nightmares. He just told me a few weeks ago that he knows that monsters aren't real, but he can't get them out of his head. I know people think I'm a softie because I let him fall asleep with me every night (his dad puts him in his own bed after he's fast asleep), but he is petrified to go to sleep by himself. I didn't understand it, but I could see the terror in his eyes. It all makes sense, now. Sometimes he plays so well by himself in his room, but other times he doesn't even want to go to the bathroom by himself because he's scared. I'm betting he was taking Singulair during the times he was scared to go into the bathroom himself. Unbelievable. We have to get the word out about this drug. I feel like such a horrible parent for not searching for these side effects sooner.

I came to the website to see if Singular suppressed the immune system because he's been getting horrible cold sores in the fall for the past 3 years. It seems to correspond with the time he started taking Singular. I know that Singulair can't cause cold sores, but if his immune system was suppressed, his body can't fight off the virus. 80% of us have the virus that causes cold sores, but most of our immune systems are able to keep the virus in check. During a cold or other illness which compromises the immune system, cold sores can pop out.

In any case, I've already flushed the remainder of his pills. He's also complained of stomach and leg aches. In fact, the docs made him give-up milk thinking he was lactose intolerant but it didn't help the stomach aches. Hopefully giving-up Singulair will help his tummy aches, too.

I am a loving mother of a 5 1/2 year old boy. He has been on Singulair for over 3 years. In this past 3 years my son has suffered in an unspeakable amount. He came down with Rota Virus and was hospitalized at 2. He then came in contact with Pneumonia in the hospital while he was there. They automatically put him on Singulair, Zyrtec, Prednisone, and antibiotics to treat the pneumonia. Since that day, my son has gone though more tests than I have in my entire life. He has had asthma, sinusitis, leg cramping ( to the point he cannot walk for 2 years), IBS, Acid reflux,(they gave him laxatives for a year that made things worse and addicted to them also), stomach pain, constipation and diarrhea back and forth. He also got Erythema Mulitforme TWICE, while on this drug. All of which the doctors said could NOT be caused by Singulair. He has had several Upper GI's and CT scans. Along with Barium enemas, several hundreds of blood tests, and many many pokes and prodded that were not necessary. All since he has been on Singulair. He now has frequent bathroom trips, depression, confusion, and anger outbursts. He also has to go to the restroom every 5 minutes. He has had genital swelling, and many other aches and pains. None of which his "doctor" ever said could be a result of Singulair. I am 100% sure it was!!!! He currently has anxiety and emotional sporadic issues causing problems in school The teachers and counselors say that it is so strange because there is no TRIGGER and the outbursts are completely inconsistent. His preschool teacher and director are sure he has ADHD. Well, we had him tested and he does not have any part of it. He has no learning disability what-so-ever. So that brought me back to square one. He is in a positive loving enviroment. How could he be depressed and want to hurt everyone around him? He cannot sit still. He cries and says he is 'stupid" and "can't think" like the other boys. He has nightmares and cannot sleep alone. He is scared of everyone and everything. So, as I sit here crying, I realized that this has all been a reaction of his "medicine" Singulair. He never should have gone through all of those painful tests, only to prove they couldn't find anything. So many treatments and sound full advice speeches from his doctors. How could they be so naive and selfish in the life of my son?

When I called my pediatrician of 5 years, she told me that " parents that have children with behavioral problems will LOOK for something to blame their problems on." She also said "drug companies only put side effects on their labels to PROTECT the drug companies. (as she laughed at me) They are not always valid". Then she said "if you take you child off of Singulair you will be playing Russian Roulette in his life." Then she said that all children around 5 or 6 go though this emotional time in their lives." She told me that if I take my child off of Singulair that she would no longer be a part of his health regimen for his asthma. She told me to see a Pulmonologist for further treatment.
Who is paying who? This is my son's life???????? I decided to go with my mother-gut instinct and get him off of this medicine. No matter what. He has been a different person since. He is currently going though a lot of side effects and withdrawals (leg pain, insomnia, hic-ups, emotional distress) but every day is getting better. How can the drug companies say that this is a "wonder drug?" There are more reported side effected patients then clinical studied patients! How can a "medication" that stimulates the brain not be connected to other problems? This "medication" interferes with the bio synthesis and action of LTs and has been marketed as NOVEL medication against asthma and allergic rhinitis. Who the hell is playing God here??? The pocket books of Merck or our over PAID "doctors?" Who pays the price? Our children? Or us. Thank god I found this before it was too late. I would not be able to withstand the pain of losing my son due to their lack of scientific evidence. They are lucky I am one of the smart ones. I will not settle for less than Justice for the drug companies and their paid "doctors?" You all end up in the same place. HELL

There are 18 million people on this drug. Most of them are children. Please save a life if not your own child's life. Thank You

POLL: If you or your child have been adversely affected by Singulair could you please reply to this and let me know what ethnicity you are and skin tone. (fair, med., dark, etc.) I'm interested in the demographics of this drugs effects.
Thank you!

Just took my 6 year old off Singulair after he began blinking incessantly... very frightening. After a couple of weeks on Singulair, I received a note home from his teacher that he was blinking all day at school. Sure enough, when he got home the blinking continued... non-stop for several days! Fortunately, I was able to find information relating this behavior to Singulair. After a few days off the medication, the blinking stopped and has not returned.

While I am sure that Singulair has adverse effects for some children/teenagers/adults, I took Singulair for 2-3 years (until my asthma symptoms improved to the point where I didn't need to take it) while I was a kid and had no adverse side effects. Started back on Singulair in April after having severe reactions to my new puppy (I am now 21). Since then, I really haven't had any side effects at all. I agree that they should black box Singulair and possibly not prescribe it to some children/teens, but for some people (like myself), it works, and shouldn't be taken off the market completely.

I am happy I found this website to express my concerns about singulair. My husband and I are still shellshocked about how singulair turned our lives upside down. My son was on singulair for 5 years. During that time he had extreme anxiety, nightmares, stomach aches, suicidal thoughts and tendencies, difficulty in school, aggressive behavior. We were at our wits end when we sought therapy at an anxiety clinic a year ago. He never went on any antidepressants or anti anxiety pills, just behavioral therapy. He went to therapy for approximately 5 months once a week. At the time he started therapy, I happened to switch doctors for his asthma due to an asthma flare up. He went to a pulmonology specialist at CHOP. He was taken off of singulair and put on other inhaler medications. Slowly, we began to see improvement in his behavior. I was holding my breath, thinking I was imagining his improvements and hoping his symptoms would not return. My son is now 9 years old and has been off singulair for one year. His horrific symptoms are gone and he no longer needs therapy. He is a happy, active nine year old. He had a successful year in second grade last year. I never realized it could have been singulair that caused his symptoms until I heard it on the news. His symptoms were always related to "behavioral problems". It was such a heart wrenching, frustrating experience because we could not figure out why he was behaving this way. My heart goes out to all the families who have experienced devastating symptoms. I contacted merck and the FDA. I want to contact my state representative. I am looking forward to seeing the results of the FDA study. I am curious how they are obtaining their data because I was never questioned about the details of my experience.

Everyone please go to the American Lung Association home page to read the article on their "research study" into the association between montelukast and depression/suicide and write to: ****** with your experiences. I wrote a letter with my son's negative experience, stating why I thought their study was flawed - they only studied 569 children and adults (I think there are more posts of negative reactions in children on this site alone) and urging them to do a more exaustive and statistically singificant study before releasing the results. This drug is unsafe and we need to take action to get it identified as such by the medical community.

I just read the article in question ,i am not sure what on earth they think mood changes and anxiety is,but i am not surprised as the doctors do not believe us,this has been a complete uphill battle,what would prove it to them,children have died, been poisoned tortured and imprisoned in there minds,and yet they say there is no evidence,the evidence is clear when your child improves when not taking this drug,what do they need.They agree this can happen in rats,but turn a blind eye to children.This article and findings of these so called specialists makes me want to vomit.The researchers should have to take the drug for 3 years and then tell us how they feel

Has anyone experienced difficulty swallowing solid foods? My son has been on it for 2-3 years and this issue has just developed. Not sure if it has to do with the Singulair or not. He's had an Upper GI and no physical problems show up. He is 11 years old and the allergist says the mood swings are due to his age, not the medicine. He has been really down and cries at the strangest things.

I have been reading all of these posts and have another question. I hope that someone can help. My daughter, 8 years old, has been on Singulair since she was 4. She is normally a very happy girl with a wonderful disposition. For the last year or so, she has been having trouble getting herself to sleep at night. She says that she hears things in her head such as ringing or "noises". A few hours before she knows it's bedtime, she cries and when we ask her why she's crying, she can't give us a reason. We initially thought that she was crying for no reason because she didn't want to go to sleep. I remember reading about the side effects of Singulair causing mood swings, etc., but her's are not violent mood swings. Just very emotional and has a hard time coming down from the "episode". I'm at a loss...I have not talked to her doctor yet about it, but have told her that we will make an appointment this week to discuss it with him. My husband suggested that maybe it sounded like she was having a panic attack or anxiety attack. I hate to label her as that at such a young age. My mind now goes back to the side effects of Singulair and maybe this is to blame. Any help or suggestions would be greatly appreciated. Thank you! Concerned Mom

I have asthma that was not controlled. I coughed and wheezed constantly. I had trouble eating, because even the food passing through the esophagus was enough to cause an attack. I was in and out of the emergency room for years, and the Ambulance folks knew to arrive with epinephrine when I'd call.

I started taking Singulair sometime around 1998. I haven't had any serious problems since then with asthma, and have had ZERO side effects.

Every drug has side effects for some people. For me, Claritin causes my heart to race. I can take that or that purple circurlar inhaler thing. I had a terrible reaction to that.

For ME, Singulair works. I am not sure it should be given to children if they are having severe problems. But it certainly should NOT be removed from the market...because people like me needed it to control their asthma.

I am a parent of a 14 year old son. He has been on many meds due to having migraines, adhd, seizures, and asthma. For 3 years his ADHD meds have been switched. Now Thanks to a friend she told me about singular side effects. OH MY GOD. it blows my mind reading this stuff. He has been on singular for 3 years and never once did I think all these problems were caused by that drug. Flipping out over the smallest things, arguing with us his parents, his friends, being mean to us and a real smartass, depression, and MAJOR attitude. Getting upset over nothing at all then crying for no reason What was his Dr. thinking? Needless to say, I took the singular while she was telling me this stuff about her own son, and threw them away, I will never allow my son to take that shit again. I hope in three days like all of you say, that my son will be that loving, caring, friendly person he use to be ! Singular free is how he will be!!

I have 2 sons with asthma that have both been taken singulair (the oldest for 3 years & his brother for 2). My younger son's asthma got alot better since he was diagnosed & he was recently taken off Singulair thanks also to my husband hearing a report about the moodiness caused. When he was on it he would cry for no reason, get very irrational & seemed to think the world was against him. In just 2 weeks he is happy & cheerful and has told me he thinks it is due to being off singulair. His older brother's asthma has gotten worse over the years & I'm concerned about taking him off but he too has crazy moods. Just tonight he started a new soccer team & got crazy & suddenly didn't even want to participate in something he loves (wanted me to let him quit right then) until we argued enough he reluctantly participated. He then came home complained of a headache (which is also way too frequent) and now has been asleep for hours. Are there any alternatives to this drug? I'm a stressed out mom that doesn't deal well with these mood swings. He is normally a social butterfly & a sweet kid but lately seems more withdrawn, more irritable (especially tonight) & complaining about leg cramps in addition to these frequent headaches. I can't deal with too many more of these evenings & wonder if all these things are possible side effects. I'm glad to see my other son doing well but miss his normally sweet brother! Even his siblings think he is acting crazy :(

One month on the drug became aggressive and moody got very anxious about everything to the point of dibilatatingpanic issues. I am a 46 year old male, working full time and attending college at night.Singular has made me almost drop out in my senior year due to panic issues in class.I am now off the drug one complete week feeling better still having mild panic issues.
Does anyone know how long it takes to get out of your system?

negative -aches all over, joint pain, lack of energy and motivation, positive -nil asthma, greatly improved sinuses, less head congestion, was told this was the best drug for asthma, polyps-sinus, aspirin allergy. Have been taking singulair for two months, concerned have also noticed feelings of anger/mild depression. Am female 50yrs, breast ca 3 years ago taking femera for 8 months. Am worried whether to continue singulair aches are killing me but could be side effects of femera to scared to go off it. Want to live and have quality of live, have 13 year old, I need to be fit for parental duties/work.

I have just come across this website and I am so upset. My 10 year old daughter has been on Singulair for 8 years. Since she was 2 years old. About 3 years ago I spoke to her pediatrician about the fact that I was concerned that she had been on it for so long and about the possible long term side effects. She brushed me off and told me that there weren't any.

Over the years she has complained often of stomach aches and pains. We even had her on Miralax for a couple years because the Dr. was sure it was constipation. The last couple of years she has been complaining of leg cramps and I sort of brushed that off as "growing pains."

She is extremely emotional and has serious mood swings. I even asked her Dr. about ADD and she said it was just her personality. I am almost in tears typing this because I have no way of knowing if her actions are because of her age, her personality, or because of this medication. She has been on it for so long that I wouldn't know what her personality would be if she had never taken it.

Her asthma tends to be seasonal and she hasn't had an attack in years. I took her off the meds as soon as I read about the disturbing side effects that hit too close to home. I am upset that her Dr. never warned me about these side effects (that were not listed on the label) and didn't take my concerns seriously.

She is very small for her age and I was concerned that the medication may have stunted her growth....little did I know there were so many other dangerous side effects. I just hope and pray that she doesn't suffer any long term negative effects from this medication that I have given her, thinking I was helping her.

My 3 years old daughter was on Singulair for 8 months, that was prescribed by her Pedestrian from the Asthma clinic in Canada, Quebec. Lately, some of the symptoms of adverse effects are surfacing in her, including depression, action very emotional, constant having bad dreams (which causes tiredness), crying almost whole day in the daycare, refusing to eat and drink, refusing to join her favorite activities... Her Pedestrian told us there is no side effect on Singulair when she renewed the prescription 2 days ago. Because of my doubt about that, I started research on the web and found out that the early communication was issued by FDA. Of course, I took my daughter off from Singulair right away.

I work in the drug development clinical research field. I know that nothing the FDA or Health Canada will pursue until a lot of cases on adverse events (side effects) reported to them. Please everyone, if you or your child has had developed any side effects on this particular drug (Singulair), please report to FDA at once. It got me so upset is that this drug is constantly and widerly prescribed to children, and the Pedestrians are not caution enough to tell the parents. I definitely do not want to see other children suffer the same symptoms as my daughter had.

After reading all the horror stories on here, me and my husband soon began to realize that we were having a lot of the side effects listed here and not listed on my son's actual Singulair prescription. The side effects my son had were behavioral changes, irrational behavior, inattentiveness, not able to stay on task or stay still -- in fact he broke his arm twice being so hyper, yelling, screaming and just plain mean.

We took our son off of Singulair as a trial for a few days. Immediately we began to notice differences in his behavior. He wasn't as agitated and quick to yell or get angry. (He's only 5 years old). He actually would be listening when we would speak to him. He would sit calmy and read books and the one huge thing he would do was look at us and smile. He even said to my husband once, "I love you Daddy," which just brought tears to our eyes. I never realized what a Singulair fog he was in and what it did to him. Here we were pretty close to getting him evaluated for ADHD or even Aspergers. So now we're in the same boat as others that are searching for other asthma meds to give my son. Right now we have gone back to Pulmicort, Xopenex, Nasonex and Allegra. I'm so glad I read this forum because I was desperately searching for answers for my sons behavioral issues. Oh, by the way he was on Singulair for 1-1/2 years.

I'm seeing some posts from parents who say their children have returned to normal after discontinuing the use of this medication. However, there seem to be a lot of diagnosed "ADHD" or "BIPOLAR" conditions. Are your children really returned to normal? Or have they been diagnosed with a psychological issue and are receiving treatment? There seems to be a connection here, even after discontinued use, especially male adolescents. Any thoughts?? The increase in cases of ADD, ADHD, AUTISM, etc has been multiplying at a very disturbing rate in the last 10 years. I'm thinking definite connection to the "new" breed of "receptor blockers". What is it triggering? Any thoughts out there? Lets post anyone with similar cases and see how many are out there.

In 2003 at the age of 31. I had been taking singulair for over 2yrs. I started experiencing muscle weakness and I got to the point I could not sit or lay down. I was extremely in a lot of pain and taking large amounts of pain medicine. It went on for several weeks. I went to the doctor because I was having muscle spams or what I thought was a ruptured disk. I had a MRI done and it didn't show anything. I was sent to a back surgeon and he checked me out and wanted me to list all my medications. I began to tell him about zyrtec and singulair. He asked me how long I had been on singulair? I told him almost 2 years. He told me to get off of it right now because it would kill me. He said the singulair was deteorating my muscles
and causing me to have muscle spasm. I had no muscle tone. He sent me to a massage therapist 3days a week for 6 weeks and I came off of the meds. The doctor told me he had at least 10 patients that had happen to them.That was a wake up call. The doctor also told me his wife was on it 6 months and started throwing up blood and took her to the ER. All because of singulair and my kids have been on it for 3 years and have not had one problem. They are 10 and 7.
My husband is a pharmacist and he had not heard anything bad about it. He filled out a card about the side effect. It only happens in 2% of people taking it.

Hi,
I wanted to post this link just to give some small consolation to our concerns about the lack of awareness THAT DOCTORS HAVE ABOUT SINGULAIR.This is a voluntary online informational site,that doctor's can join. It provides updated information on serious label changes and safety concerns on drugs.Most doctors at this point still get snail mail updates,in the paper shuffle a lot of information gets misplaced.The AMA would like to have all information come in online,eventually.The link is ******
read it and tell me if you think more can be done By the way my pediatricians office does not have online communication.Our life is forever changed because of that ! Information is playing a vital role in this drugs destructive path ,or the lack there of information.Again this is voluntary for the Doctors to sign up .In this modern day of communication how does important information not get where it is the most useful, I ask you?When drugs are making multi billion dollar profits,that would be an educated guess.I am doing another interview with CBS affiliate out of Boston on the 23rd of June,they contacted me.I hope it will reach more people who are still unaware of this drugs serious potential side effects.If any of you parents have some connection to media ,please use it to your best advantage to get this very important information out to the publicAlso so many of you ask how to help.Contact your local Senators and keep bothering them to reach out to the FDA to expedite this investigation. Make a pain in the butt out of yourself and be persistent.I will try to make reference to this site so your stories are heard. Dave and I are coming up on a year since our son passed on to our lord .Still fighting Kate and Dave M.

I have stated many times that I am not an expert. I just post what I find. This has been a mind boggling journey for me. This is way over my head but I struggle to read and understand. Finding answers to why children are suffering from neuro-psychiatric side effects is worth the effort.

I have made the following observations.

1. Some quinoline are known to be able to cross the blood brain barrier.
2. Molecules that ionize are known to be more likely to be able to cross cell membranes. So if montelukast ionizes as a result of change in blood pH to sufficient acid conditions that it ionizes, then it could be possible or maybe like that it does in fact cross the blood brain barrier.
3. We know that there are cysLT1 receptors in the brain.
4. We know that researchers believe that montelukast may bind at the arginine of the cysLT1 receptor.
5. We know that arginine contains four nitrogens. And montelukast contains one.
6. We don't know what happens to those nitrogens.
7. We do know what macrophages create nitric oxide as I posted.
8. We do know that if something cause excessive nitric oxide to build in the brain that there would be damage to the neurons.

Some people may remember when I got stuck at the astrocytes, the cysLT1 receptors and glutamate. I keep looking for research reports that may shed more light on this.

Titre du document / Document title
Nitric oxide causes glutamate release from brain synaptosomes
Auteur(s) / Author(s)
MCNAUGHT K. S. P. (1) ; BROWN G. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biochemistry, University of Cambridge, Cambridge, ROYAUME-UNI
Résumé / Abstract
We determined the ability of pathological levels of nitric oxide (NO) to cause glutamate release from isolated rat brain nerve terminals using a fluorometric assay. It was found that NO (0.7 and 2 μM) produced (4 and 10 nmol/mg of synaptosomal protein) Ca2+-independent glutamate release from synaptosomes (after 1 min of exposure). Spermine/NO complex (spermine NONOate; a slow NO donor) and potassium cyanide (an inhibitor of cytochrome oxidase) also caused Ca2+-independent glutamate release. Preincubation of synaptosomes with 5 μM 1H- oxadiazole quinoxalin-1-one (an inhibitor of soluble guanylyl cyclase) had no effect on NO-induced Ca2+-independent glutamate release. Ca2+-independent glutamate release produced by NO was greater in a low-oxygen medium. NO, spermine NONOate, and potassium cyanide inhibited synaptosomal respiration with a similar order of potency with respect to their ability to cause glutamate release. Because NO has been shown previously to inhibit reversibly cytochrome oxidase in competition with oxygen, our findings in this study suggest that NO (and cyanide) causes glutamate release following inhibition of mitochondrial respiration at the level of cytochrome oxidase. Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicty may contribute to neuronal death in neurological diseases.
Revue / Journal Title
Journal of neurochemistry ISSN 0022-3042 CODEN JONRA9
Source / Source
1998, vol. 70, no4, pp. 1541-1546 (29 ref.)

INIST-CNRS, Cote INIST : 4037, 35400007527188.0230

I took my son off Singular a month ago, some slight improvements with the sleep and behavior problems. I voiced my concerns with my doctor twice now he looks at me like Im crazy and then he goes on the PC and says he cant find any of these side affects im talking about. My son was an appointment to see an allergist specialist.

WOW!!! I am glad I came across this website. I have twin boys that will be 7 this month. One has been on Singulair for about 3 years for allergy induced asthma and my other son has been on it for 9 months for allergies. I am taking them both off of it today. The son that is taking the medicine for 3 years has become increasingly angry and gets upset over small things. Over Memorial weekend, he lost a game he was playing on the wii and exploded. He was banging his head and then started to hit me. NEVER in my life have I seen him attack anyone. A few days later he threw rocks at his friend because he wanted the wagon. Over the past 3 years I have noticed some change in him and just took it as growing pains. He has always been a strong will child. However, over the past 3 years he has gotten worse and since he has physically attacked me and his friend, I have decided to send him to counseling. Now I firmly believe it is the Singulair.

My other son has been on it since August. He started to have anxiety within a month of taking it. His behavior has been stressed, depressed and not wanting to play with other kids. He was biting his nails to a nub, licking his hands, not talking to anyone at school and rubbing his head. I have also noticed he does like to look at the person he is talking too. Of course I thought the worse and thought he was being molested. I went to his Teacher and she has worked very hard with him, but he is still a loner. If you knew him before, he played with everyone and enjoyed life. I was told by his Ped. that he had anxiety and to have him see a shrink.

I am hoping that after taking them both off this medicine, I will see improvement.

My son is almost 9, he has been on Singulair for 3 years. Last Friday the pulmonologist took him off of it. My son has been sleep walking since about the time he started singulair, have noticed major behavior changes. He gets very angry over nothing, he is extremely sensitive, he is not the happy little boy he once was. He has horrible dreams. Over time this has gotten progressively worse. I have to say that since last Friday when he was taken off the singulair, I have noticed a huge difference. My happy little boy is coming back! I told the Pulmonologist my concerns ans could this be side effects and he replied "YES", Also, he feels that my son has outgrown his asthma which is wonderful. I feel so horrible for all these children and families going through this. Parents, remember you are your child's best advocate. don't let the children suffer.

In September of 2007 my then 13 year old daughter was put on Singular for mild asthma. At the time she was a straight A student, vice president of our school and a popular girl who's guidance counselor described as "the glue of her grade" because she was so well liked. In November she told me that she was struggling with advanced Latin and Science. She asked to drop down to on grade Latin so we did. In December her science teacher notified us that she had a C average. She told me that she thought she had ADD/ADHD and she couldn't keep up. At the same time she was having a lot of problems with friends at school and we just attributed it to being 14. 3 weeks ago we discovered that she is significantly behind in English and it was then that she told me that she is been having horrific night mares. She said that they usually involve someone killing her or her killing herself. She said that they were so graphic that she couldn't repeat it out loud. She also said that she would feel waves of anxiety that would come over her at school and she would act "witchy" to the kids in her class for no real reason. She said that sometimes when she is trying to do her homework she will read the same passage for 2 hours and still have no idea what it's about. She also said that the suicidal thoughts from her sleep happened during they day and that she had thoughts of her harming herself. Fortunately her pulminologist told us that this may be caused by singular and we immediately took her off of it which was 2 weeks ago. She has only had 1 "bad dream" not even a nightmare since. She had one anxiety attack 3 days after she was off it and she describes her moods as the "cloud lifting....slowly". Now, we have to pick up the pieces. Her grades have suffered, her friendships have suffered and most of all her self esteem is very low. I'm grateful that we found out the cause but I feel as if my daughter lost a year of her life and I worry that because Merck won't admit there are side effects we can't find out how long it remains in their system. Is anyone else concerned about the long term affect and has anyone pursued a class action suit to try to get this drug tested properly?