This registry is a place to share positive or negative side effects of using Singulair. If you directly experienced a side effect while using Singulair, then we encourage you to enter it here. Please note that entries here are the experiences of individual users, and in no way means that you or anyone else will experience the same side effect, since the same medication affects people in different ways. Please always contact your physician.
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June 9th
2008
2:47 PM
Everybody here knows that I have been interested in trying to find out if Singulair (montelukast), which is a quinoline, ionizes and forms quinolinic acid under physiological conditions that lower blood pH. Some researchers have also mentioned that another montelukast metabolite that occurs is known to be a toxin. In other words, until someone can get blood tests that confirm what the toxic metabolic is, we are just guessing but I would bet that it is a good guess.
One of the strongest cases for that argument would be what happens to some people during sleep. There are some people whose CO2 levels rise. If the levels rise enough to cause change in pH to a more acid condition, then montelukast can possibly ionizes just enough to create minute amounts of neurotoxins that could cause bad dreams, hallucinations, sleep deprivation or a number of other neuro-psychiatric problems. Compound the effect of night after night of minute amounts of neurotoxins caused by CO2 and montelukast ionization then it would be easy to understand how depression and personality change results. There are other conditions that cause elevated CO2 levels and acidosis such as COPD.
If anyone has any data regarding their CO2 levels from sleep studies or other bloods tests, would you please send me a private message?
-- By concernedcitizen | Reply | Private Message me