Singulair and depression

A few years ago Singulair was prescribed for me. I am 56 years old and generally healthy with asthma and allergies. Within only a few days I started to notice that I was very depressed. I was frightened at how hopeless I felt. After a couple of weeks I starting using a new drug. The terrible depression went away within a few days and I was my normal cheerful self. For some people, Singulair is a very dangerous drug. I will NEVER touch this drug again! I'd be especially hesitant to use it on children or teenagers that aren't as aware of changes in their moods.

Sept. 1 (Bloomberg) -- U.S. researchers found no evidence to support regulatory warnings that Merck & Co.'s Singulair asthma and allergy drug, taken by millions of Americans over the past decade, may be linked to depression or suicide.

The findings will be published in the Journal of Allergy and Clinical Immunology, the American Lung Association said in a statement on PRNewswire today. The study was sponsored by the association, which doesn't endorse products, it said.
HOLY COW

I just read an article dated 9/1/08 that stated that the American Lung Association just cleared Singulair as causing depression and suicide. They had researchers study the results from the original test trials because they are supposedly more accurate than after market reports. The article is at ******. I cried when I read this report. My now 8 year old daughter has been on this medication for mild asthma since she was 4. We have thought the stomach aches and tantrums were related to moving to a new town around the time she started taking singulair. But, 3 months ago, she all of a sudden started having depression, ocd about germs, afraid she might hurt herself and then depression and suicidal thoughts. She has been off meds for 8 weeks and still has some problems with thinking she wants to hurt herself and feeling down. She is normally very happy and our family is happy and normal, but dealing with this is difficult. How long does it take to get out of their system?

After taking a "leave of Absence" from this site, I see that Singulair is still up and thriving. I still see ads for it on TV, over and over again. They haven't been altered at all. Makes me sick. I wish there was away to get to other people whose children have died by suicide and investigate as to whether or not they were ever on singulair. Keep fighting. We'll get there! Kate K

5 months Singulair free,yesterday was Matts first day of high school,his first day of regular school in 2 years as he could not leave the house or cope with out panic and fear.7am he awoke by himself and got ready for school,the only thing i saw in his eyes was excitement,he left the house smiling.While he was gone i passed and worried waiting for the phone to ring in case he needed me ,watching the clock and wondering how his day was. he arrived home at 2 thirty still smiling,i asked him how his day was he said fine, i asked him what they did he said nothing ,lol all is good ,thank you thank you thank you

I have been reading all of these posts and have another question. I hope that someone can help. My daughter, 8 years old, has been on Singulair since she was 4. She is normally a very happy girl with a wonderful disposition. For the last year or so, she has been having trouble getting herself to sleep at night. She says that she hears things in her head such as ringing or "noises". A few hours before she knows it's bedtime, she cries and when we ask her why she's crying, she can't give us a reason. We initially thought that she was crying for no reason because she didn't want to go to sleep. I remember reading about the side effects of Singulair causing mood swings, etc., but her's are not violent mood swings. Just very emotional and has a hard time coming down from the "episode". I'm at a loss...I have not talked to her doctor yet about it, but have told her that we will make an appointment this week to discuss it with him. My husband suggested that maybe it sounded like she was having a panic attack or anxiety attack. I hate to label her as that at such a young age. My mind now goes back to the side effects of Singulair and maybe this is to blame. Any help or suggestions would be greatly appreciated. Thank you! Concerned Mom

My son, who just turned 14 this month, was on Singulair for over 2 years.
He was diagnosed with reactive airway disease and possibly Asthma--and prescribed this awful drug-even back in 2004. The doctor said how wonderful this med was and prevents any further attacks.. So, for 2 years-every night, he took this mood altering, destructive drug. He lost all interest in school, his athletics-soccer, skateboarding, biking..in fact became almost a vacant , very unhappy, child-had stomach aches, joint pains and reflux--why--I brought him to the doctor and Pediatric center so frequently--all they kept saying his --his asthma is better, much be other issues...Even after the March 2008 suicide--his doctor said-that is just an isolated incident-just monitor him--It is a good drug. Right, month by month his behavior escalated to wanting to die, no reason to go to school-he said he was stupid and a failure and why don't I understand there is no reason to his life. A usually happy fun-loving boy -my son- didn't want to live. Nothing made him happy-I started to believe what the doctors said--maybe something or someone at school (bully, pedophile??) caused this change. Terrible nightmares and vivid dreams...Until this past July, I asked him want to go to the library for some books or dvd's...he went ballistic-threw everything off his computer desk and tried to break his chair. He is not an aggressive boy but this behavior was becoming a daily issue. Along with everything flying off his table, was his bottle of Singulair pills. It then dawned on me..I have been poisoning my only son. The child I know and love and gave birth to returned within a few days--although I am worried sick about further asthma attacks --all the doctors can prescribe is a steroid drug-asthmex or Pulmicort.. I cannot understand nor comprehend why this drug is being prescribed for children and young adults. The guilt I live with is terrible as my son has lost 2 years of his life--
and thought there was something really wrong with him-At least we woke up---in time--how about some other parents..thinking it's just normal adolescent behavior for their child or their fault???

My son became soo aggressive 3 days after starting Singulair, that he was almost banned from soccer for life because of attacking another player on the field. It resembled what I had heard of 'roid rage'. When I questioned the doctor immediately, was told there was no connection. After months of the aggression, then came depression and self mutilation. My 15 yr old was secretly burning himself to 'punish' himself for things he done wrong or "disappointing" those around him. He now has permanent scars all over his arms from these burns. The depression took to drug abuse and my A student fell to an F student in 6 weeks. He completely lost his will to live and thrive. After 4 months of hell, the dr informed us that the FDA just warned physicians of this side effect. Im furious now that I read through the court documents and find that the drug company knew this all along. I know I am a luckier parent than some whose children committed suicide, but still wish that the FDA would get off their BUTTS and do something to take this drug off the market. I was told by a rep at the FDA that Merck will not take it off the shelf until they're made to because even if they had to pay parents millions for their child's suicide, they would still be pocketing more profit than our children's lives are worth in the court system. Not sure WHY we even HAVE an FDA, they won't do anything to protect us from these money hungry drug companies. A YEAR to do an 'INVESTIGATION" are you kidding me? If the CEO of Merck had to bury his child, it would come off the shelf THAT DAY.

I have asthma that was not controlled. I coughed and wheezed constantly. I had trouble eating, because even the food passing through the esophagus was enough to cause an attack. I was in and out of the emergency room for years, and the Ambulance folks knew to arrive with epinephrine when I'd call.

I started taking Singulair sometime around 1998. I haven't had any serious problems since then with asthma, and have had ZERO side effects.

Every drug has side effects for some people. For me, Claritin causes my heart to race. I can take that or that purple circurlar inhaler thing. I had a terrible reaction to that.

For ME, Singulair works. I am not sure it should be given to children if they are having severe problems. But it certainly should NOT be removed from the market...because people like me needed it to control their asthma.

I am a parent of a 14 year old son. He has been on many meds due to having migraines, adhd, seizures, and asthma. For 3 years his ADHD meds have been switched. Now Thanks to a friend she told me about singular side effects. OH MY GOD. it blows my mind reading this stuff. He has been on singular for 3 years and never once did I think all these problems were caused by that drug. Flipping out over the smallest things, arguing with us his parents, his friends, being mean to us and a real smartass, depression, and MAJOR attitude. Getting upset over nothing at all then crying for no reason What was his Dr. thinking? Needless to say, I took the singular while she was telling me this stuff about her own son, and threw them away, I will never allow my son to take that shit again. I hope in three days like all of you say, that my son will be that loving, caring, friendly person he use to be ! Singular free is how he will be!!

hi everyone my name is Katie, and my son has been on Sindulair for over 6 months now. I took him off 2 nights ago, the day I found this sight. I just cant believe how many families this medication has hurt. When my son was put on, I was never told anything about anything like this happening. I thought his behavior was due to the divorce and child custody things in his life that were going on. It did not cross my mind that it could ever be this medication. He does not take anything else at all.
Some of the things we have been dealing with are, panic attacks at night, bad dreams, aggressiveness, depression, anxiety! Fits that you would not believe. Crying all the time, very emotional. And the newest one, thinking everyone he loves is going to get killed. These are not things a 6 just turned 7 year old should be going through.
I got to thinking that I needed to get him some professional help, this is not normal! I decided to look up Singulair on the net, I did not find anything. I looked up Childrens depression, and angziat, still nothing fit. Then I found this site. Wow did it blow my mind. It fit and it felt right, if you are a mom, I think you know where I am coming from. When you know you just know! So I got him off the medication, and already I am seeing changes. The first night was not grate but better than it has been in a long time, the next day though, he woke up and smiled at me for the first time in way to long, he only had 2 meltdowns that day, when he was having at lest 2 in an hr before. So far so good, I just hope that It keeps going well for him.
Thank you for letting me tell my story!

I've been on Singulair for more than a few years now. I'm 43, with exercise and allergy induced asthma.....but mild. I also have VERY bad allergies. Talk about being allergic to EVERYTHING outside....that's me. I also suffer from migraines and depression. I've been on every antidepressant out there....still depressed. Now I know why...Singulair. I've tried tons of migraine meds....and I'm wondering if some of my side effects are really from Singulair. I'm moody, I don't care about other people's feelings like I used to, I snap at my kids like crazy,I cry at the drop of a hat....at stupid stuff. And now I'm thinking that my joint pain in my hips is from Singulair. But Singulair was my miracle drug for my asthma and a huge help to my Allegra D for my allergies. I'm asking the doc for an alturnative drug. As soon as I get it I'm off Singulair. ADIOS!

My 16 year old son took Singular for three days. Almost immediately after taking the first dose, he starting having increased blood pressure, rapid heart beat, tiredness, depression, thoughts of death, muscle soreness, tingling in his arms and legs, numbness, weird dreams (when he was actually able to sleep) and decreased appetite. He seriously thought that he was going crazy. It was not until I did some internet research that I finally linked all of his symptoms to this horrible drug. He stopped taking it on Friday of last week and each day since has been feeling better. He is not 100% back to normal yet, but each day seems to be better. It was a scary three day period while he was using this medication. Hopefully it will only take another day or two to get out of his system completely.

In response to Wewe's post, I've been wondering the same thing. Since taking my daughter off Singular almost 2 months ago, I'm seeing a different almost typical kid. Four years ago about 2 months after starting Singular my daughter was diagnosed with anxiety. As her condition got worse she was diagnosed with depression. We started to see OCD and tics so they were added as a diagnosis It was determined that it was related to strep infections so she was diagnosed with PANDAS. She was started on Zoloft and klonidine. The Zoloft made her worse. Her fears of hurting herself got so intrusive she was hospitalized. Her cholesterol was high too. The Zoloft was discontinued and Prozac was started. She's had therapy all 4 years. She also neede physical therapy due to muscle and joint pain. Now she's doing better, off Singular. Does she really have PANDAS, OCD? I don't know. She's still on Prozac, we just did a slight decrease this week. Is this medication the trigger for underlying conditions. Learned behaviors can be unlearned, but are there lasting physical effects? If a gene has been turned on, can it be turned off? I wish we knew the answers to help all of our kids.

Here is an example of the fact that the medical community recognizes that there are gene based drugs. Because Singulair is modeled to be a receptor antagonist to the cysLT1 receptor and the cysLT1 receptor is a gene, I'd say that Singulair should be described as a gene based drug. I don't really care how anybody wants to play with the definition. CysLT1 is a gene with known variations. Why isn't there just an "across the board" warning for all gene based drugs that unexpected side effects are possible???? And, that doctors should watch out for individual reactions.

WMJ. 2005 Aug;104(6):61-6.Links
Gene-based drug prescribing: clinical implications of the cytochrome P450 genes.Musana AK, Wilke RA.
Department of General Internal Medicine, Marshfield Clinic, WI, USA.

The Institute of Medicine recently mandated an increased effort to improve patient safety and reduce medical error. With the description of genetic polymorphisms in the drug metabolizing enzymes, the field of pharmacogenetics may improve medical care through a reduction in both therapeutic failure and adverse drug reaction. Investigators at the Marshfield Clinic in central Wisconsin are piloting the process of gene-based drug prescribing in a variety of contexts. This paper reviews the field of cytochrome P450 (CYP) genetics and explores factors that impact the utility of this information in clinical practice.

PMID: 16218319

Hi,
I wanted to post this link just to give some small consolation to our concerns about the lack of awareness THAT DOCTORS HAVE ABOUT SINGULAIR.This is a voluntary online informational site,that doctor's can join. It provides updated information on serious label changes and safety concerns on drugs.Most doctors at this point still get snail mail updates,in the paper shuffle a lot of information gets misplaced.The AMA would like to have all information come in online,eventually.The link is ******
read it and tell me if you think more can be done By the way my pediatricians office does not have online communication.Our life is forever changed because of that ! Information is playing a vital role in this drugs destructive path ,or the lack there of information.Again this is voluntary for the Doctors to sign up .In this modern day of communication how does important information not get where it is the most useful, I ask you?When drugs are making multi billion dollar profits,that would be an educated guess.I am doing another interview with CBS affiliate out of Boston on the 23rd of June,they contacted me.I hope it will reach more people who are still unaware of this drugs serious potential side effects.If any of you parents have some connection to media ,please use it to your best advantage to get this very important information out to the publicAlso so many of you ask how to help.Contact your local Senators and keep bothering them to reach out to the FDA to expedite this investigation. Make a pain in the butt out of yourself and be persistent.I will try to make reference to this site so your stories are heard. Dave and I are coming up on a year since our son passed on to our lord .Still fighting Kate and Dave M.

This testimony should help strengthen our case for warnings for Singulair.

Neurologist Sought Warning for Pfizer Drug
By JEREMY SINGER-VINE
June 20, 2008; Page B10

A British neurologist who analyzed effects of the drug Neurontin told a court hearing Thursday that he advised its maker -- now a unit of Pfizer Inc. -- to include a warning on the drug's label for potential side effects of depression and aggression, but his advice wasn't followed.

The University of London neurologist, Michael R. Trimble, was testifying at a hearing to decide whether civil cases brought against Pfizer alleging suicides linked to Neurontin can proceed. The hearing was jointly held by judges for U.S. District Court in Boston and a New York state court who are hearing similar cases. In various lawsuits consolidated in the federal court, plaintiffs allege more than 100 suicides were connected to Neurontin usage.

Dr. Trimble described what he said was a "plausible biological pathway" that could lead from the compound gabapentin -- the chemical name for Neurontin -- to suicidal behavior, hostility, and aggression. Dr. Trimble said that in 1995 and 1996, he was hired to write two confidential reports for Parke-Davis -- now a unit of Pfizer -- because the company "was concerned about psychosis in relation to their drug." Dr. Trimble said he was unable to find a link to psychosis, but noted effects of depression and aggression.

Lawyers for Pfizer argued at the hearing that the evidence linking the drug to suicidal side effects wasn't scientifically sound. Under cross-examination, they challenged his description of a pathway as a patchwork of studies that didn't prove a biological connection. Neurontin and generic forms of gabapentin are approved for treating epileptic convulsions, but have also been prescribed widely "off label" for other conditions.

In five of nine patient cases he analyzed in 1996, Dr. Trimble said he saw depression and aggression in patients who had no previous symptoms of the side effects, so he said he recommended to the company that the drug "should carry some kind of warning" for susceptible patients.

Thursday's proceedings were the initial phase of a hearing requested by Pfizer to challenge the opinions of the plaintiffs' experts. Under cross-examination and a subsequent examination by the plaintiffs' attorney, Dr. Trimble said the biological pathway between Pfizer's Neurontin and suicidal events were plausible and supported by a series of peer-reviewed neurology research.

Everybody here knows that I have been interested in trying to find out if Singulair (montelukast), which is a quinoline, ionizes and forms quinolinic acid under physiological conditions that lower blood pH. Some researchers have also mentioned that another montelukast metabolite that occurs is known to be a toxin. In other words, until someone can get blood tests that confirm what the toxic metabolic is, we are just guessing but I would bet that it is a good guess.

One of the strongest cases for that argument would be what happens to some people during sleep. There are some people whose CO2 levels rise. If the levels rise enough to cause change in pH to a more acid condition, then montelukast can possibly ionizes just enough to create minute amounts of neurotoxins that could cause bad dreams, hallucinations, sleep deprivation or a number of other neuro-psychiatric problems. Compound the effect of night after night of minute amounts of neurotoxins caused by CO2 and montelukast ionization then it would be easy to understand how depression and personality change results. There are other conditions that cause elevated CO2 levels and acidosis such as COPD.

If anyone has any data regarding their CO2 levels from sleep studies or other bloods tests, would you please send me a private message?

Last week, I had a PhD psychologist tell me that she is seeing a lot of patients come forward with Singulair stories, much like these. She's had at least 8 patients so far, and she has now added questions about allergy and Singulair to her patient intake procedures. Basically, they've all suffered from some sort of depression and personality change.

My daughter is 4 and has allergies. Last year she was briefly on Zyrtec and I immediately noticed that she became very aggressive. This year her doctor prescribed Singular. She has been on Singular for 8 days. Her appetite has dwindled. She has complained that her stomach hurt which I thought was due to not eating. Last night, she had nightmares - screaming out in a panic. This afternoon she couldn't sleep. This evening she fell asleep in my arms. Suddenly she sat up with glazed eyes wide open and began to relive when she fell and hurt her hand a few days earlier. I thought she was sleep talking with her eyes open. She was in a total panic but appeared to be sleeping. Yet, when her dad approached she held out her arms for him to pick her up. She eventually fell back asleep only to awaken two more times with similar sceneros played out. I could not get these scenes out of my mind. Given the previous experience with Zyrtec, I looked over the side effects of Singular and the word Hallucination jumped out at me. I spoke with a pharmacist who was not aware of anything I have since read on this site. I decided to Google Singular Side Effects and came upon this site. Tears well in my eyes after I read posting after posting. Thank you, thank you to all who have posted their experiences. You have saved my daughter and our family from a true nightmare. Bless you and your family.

I am a 41-year old female with allergy induced asthma, who has been taking Singulair for almost 1 1/2 years now. I was diagnosed with depression about 5 years ago (after my sister's death) and was taking 100mg of Zoloft daily, which my doctor upped to 200mg around the same time I started Singulair for allergy problems. I did not know about the Singulair/depression warnings until searching today on Google for drug interactions on the meds I take in hopes of trying to find a reason for my overwhelming depression. For the past 1 1/2 years, I have lived like a zombie, numb to the world and my family, gave up a $72K job, gained alot of weight, have the weirdest and most vivid dreams, and am tired all of the time, only finding rest after 10-15 hours of sleep per day. I am a working professional, have a Master's degree, and have always considered myself a rational objective person, and not a "lemming" that follows the rest over the cliff. However, the side effects I am experiencing ARE NOT NORMAL and ARE NOT IMAGINARY. I do not know if Singulair is causing my symptoms or not, however, I am going to stop taking the medicine today, and switch to something else. For me, QUALITY OF LIFE is the major issue. While Singulair works great to help me breathe comfortably, I can find other meds to do the same thing. However, what I cannot take is a medication possibly responsible for taking my "life" away.

HI,

As with many others I found singulair to be a miracle with asthma. No more rescue inhalers. I am not sure which of my current meds is causing the very vivid, often gruesome dreaming I have been having as THREE of them show this as a side effect. I am referring to Cymbalta, Xanax and Singulair. It may be that the combination of the three is just too much and is causing brain toxicity of some sort. I started cutting down the cymbalta, and also the Xanax days ago. I found myself still waking up remembering vivid dreams that I would rather forget. I remember them all like they just happened in living color and detail, days and weeks later. At first I thought it was interesting, but now I just want to FORGET THEM, anyone have ideas???? Help!!! ( I also developed depression and anxiety after being on singulair for several years which is how I ended up with the two additional meds.

Here I go again, unable to fathom my son's suicide, I'm wondering about things again. Could it be possible that maybe some of the side effects do NOT go away with the discontinuation of Singulair? Can certain effects stay with you and do permanent damage? That is if you're on it long enough. A.J. was on it and off of it, (on it more than off) for 9 years. I never caught on. Now that it's too late, and I've learned about this stupid drug, I've got to ask every question that comes to mind. I, too, have asthma and I am tempted to go to my own doctor and request to be put on it just to see what happens to me. Right now I take Advair and I see where it causes problems that are equally as bad for some people as Singulair. I'm one of the lucky ones. It does me well. My depression comes from the death of my son.

Restless Sleep, depression

In September of 2007 my then 13 year old daughter was put on Singular for mild asthma. At the time she was a straight A student, vice president of our school and a popular girl who's guidance counselor described as "the glue of her grade" because she was so well liked. In November she told me that she was struggling with advanced Latin and Science. She asked to drop down to on grade Latin so we did. In December her science teacher notified us that she had a C average. She told me that she thought she had ADD/ADHD and she couldn't keep up. At the same time she was having a lot of problems with friends at school and we just attributed it to being 14. 3 weeks ago we discovered that she is significantly behind in English and it was then that she told me that she is been having horrific night mares. She said that they usually involve someone killing her or her killing herself. She said that they were so graphic that she couldn't repeat it out loud. She also said that she would feel waves of anxiety that would come over her at school and she would act "witchy" to the kids in her class for no real reason. She said that sometimes when she is trying to do her homework she will read the same passage for 2 hours and still have no idea what it's about. She also said that the suicidal thoughts from her sleep happened during they day and that she had thoughts of her harming herself. Fortunately her pulminologist told us that this may be caused by singular and we immediately took her off of it which was 2 weeks ago. She has only had 1 "bad dream" not even a nightmare since. She had one anxiety attack 3 days after she was off it and she describes her moods as the "cloud lifting....slowly". Now, we have to pick up the pieces. Her grades have suffered, her friendships have suffered and most of all her self esteem is very low. I'm grateful that we found out the cause but I feel as if my daughter lost a year of her life and I worry that because Merck won't admit there are side effects we can't find out how long it remains in their system. Is anyone else concerned about the long term affect and has anyone pursued a class action suit to try to get this drug tested properly?

I'm a 30 year old male, and I've been on Singulair for eight years now to treat chronic asthma. Shortly after I started, there was a noticeable change in my mood and behavior. What I noticed included sadness, thoughts of death, anxiety, and fatigue. I knew that there was something wrong, but just chalked it up to changing life experiences. I was always heavily involved in organized sports (little league through college), but abruptly stopped after college. I thought that the moodiness (or depression) came on because I wasn't as active anymore. Correlation maybe? I don't know. But I do suspect that Singulair is the culprit. I would like to get off for a while, but I literally cannot breathe without it. Does anyone know of any comparable alternatives to Singulair that won't bring on these type of side effects? Thanks all for sharing. Blessings!

I am not a 100% sure the experience I had was due to Singulair but it appears to be. Singulair was prescribed to me for "walking pnemonia". After a couple of days on the medications I was taking, I started experiencing pain in my knees and muscles in my lower legs. My left leg was worse than my right. After 3 days, I could barely walk and the pain was severe. I forgot to take my medicine one day and the next day my knees were much better and had less pain. I just thought I was getting better but the next day when I started the medicine again, the pain came back. I remembered when my son was on Accutane he had similar knee and leg pain because of the dryness caused by Accutane. So I kept taking the antibiotic I was on and stopped the Singulair. The next day I felt much better. On the second day I hardly had any pain at all. I was curious if anyone else had this type of side effect. Most of the postings I have seen have dealt more with depression in teenagers. I am 55.

Quinolinic acid and neurotoxicity:

Montelukast contains a quinoline radical. Quinolinic acid, a well known damaging neurotoxin that kills neurons, can be produced from a quinoline and hydrogen peroxide. The body produces hydrogen peroxide for a numbers of reasons. White blood cells produce hydrogen peroxide when activated by antigens such as bacteria, virus, fungus etc. It is also produced under conditions when the body is stressed. It is also produced in the gastrointestinal track.

If we knew how montelukast could break up to free the quinoline radical, then we might be able to define a number of different scenarios under which hydrogen peroxide could cause montelukast to generate the neurotoxin quinolinic acid.

If we could prove that montelukast is capable of produce quinolinic acid under unusual circumstances (doesn't happen to everybody), then we would have a very good explanation for all of the psychiatric adverse drug reactions that are mentioned here which include hallucinations, anxiety, depression, suicidal ideations, night mares, etc. etc.

Anyone looking for answers should try to pursue the possibility that quinolinic acid is causing bad side effects. I wish that I was much better at chemistry. I am stuck here at the moment. I keep hoping that somebody else with more expertise will come here to tell us how it happens.

I am an individual that started taking Singulair about a year ago. I've had allergies to weeds, grasses, and pollens since I was a little girl and have taken a variety of meds including Claritin, Zyrtec, Allegra, Flonase, and allergy shots. Last summer, my usual Claritin just wasn't enough so my doc prescribed Singulair. It worked wonders for my allergies. Soon after, I began to feel "numb" -- that's the best word to describe what I felt. I was depressed. It just so happened that my mother had had surgery and I had moved to a different city about the same time as beginning the Singulair. When I began feeling depressed and disconnected from the world, my doc and I contributed it to depression from life transitions. It didn't go away though. For a year, I isolated myself. I didn't talk to friends and family. I missed over 10 days of work just because I didn't want to get out of bed. I slept almost 15 hours a day, gained 60 lbs, didn't clean my house. I didn't really do anything and I didn't care. I felt so disconnected from the world. I didn't cry. I didn't feel suicidal, but I knew that something was wrong with me. I thought I was having a breakdown or something. My doc checked several things but all test results were normal. It wasn't until my mother seen a CNN report on Singulair that I began to link my depression to when I started the drug. I immediately quit taking Singulair and felt better within 4-5 days. After 2 1/2 weeks, I was back to being my old self. It was so scary feeling so isolated, numb, and disconnected from the world. I never would've thought about it being a side effect from an allergy medicine.

Our son was put on Singular almost 2 years ago to help with his "moderate" asthma. It has been the hardest 2 years for our family. My son who was already very senstive became very depressed. He showed no interest in anything. He was always sad and very down on himself. He had awful night terrors/nightmares. He didn't want to go to school or do anything. We continued to sign him up for sports/piano/scouts and it was a battle to get him to go. He always had headaches, which I thought were because of dehydration and made him drink water. We had him seeing a therapist trying to help him with the sleeping problems and the depression. We switched his room with his sister to physically make him closer to us at night. He was anxious and very irritable. If something went wrong, he couldn't handle it and had complete meltdowns. If he didn't eat anything for a while and his blood sugar got low, he was uncontrollable. To add to the problem was he was never hungry so I would have to force him to eat something about every 2-3 hours to prevent the meltdown.

The good news is that he has been off of Singular for over a month now and he is a new kid. He is excited to go to practice and will ask his dad to play catch with him in the yard. He is happier and we have not heard once "this is the worst day ever" which we had heard all the time before. He has not had one headache and seems to have a little bit of his appetite back. He is happy and holding his head high. Now, he still doesn't want to go to school (what 8 year old boy does), but he doesn't fight me when I tell him it is time to go. He does not have the meltdowns or the irritability. He even showed some empathy to my husband last week.

My husband and I are amazed at how different he is. We are also very upset that for almost 2 years we made his life miserable by forcing him to take this drug. I think for kids that are already sensitive to things it heightens everything! I am filing a complaint with the FDA and spreading the news to all my family and friends. I hope this information helps! I know I have learned a lot from reading these posts.

I read that many of you blame Singulair for your side effects when you are also taking multiple drugs. As a public service, I put together a list of side effects from some of the other drugs mentioned on this site. These are by no means all the side effects listed for each drug. The first group is from allergy medications people have mentioned.
Zyrtec & Zyzol -
suicidal ideation, suicide, aggressive reaction, anaphylaxis, cholestasis, convulsions, glomerulonephritis, hallucinations, hemolytic anemia, hepatitis, orofacial dyskinesia, severe hypotension, stillbirth, thrombocytopenia.
abnormal thinking, agitation, amnesia, anxiety, decreased libido, depersonalization, depression, emotional liability, euphoria, impaired concentration, insomnia, nervousness, paroniria, sleep disorder.
accidental injury, asthenia, back pain, chest pain, enlarged abdomen, face edema, fever, generalized edema, hot flashes, increased weight, leg edema, malaise, nasal polyp, pain, pallor, periorbital edema, peripheral edema, rigors.

Benadryl-
Sedation, sleepiness, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, neuritis, convulsions. Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation, Urinary frequency, difficult urination, urinary retention, early menses

Allegra -
insomnia, nervousness, sleep disorders or paroniria, and hypersensitivity reactions (including anaphylaxis, urticaria, angioedema, chest tightness, dyspnea, flushing, pruritus, and rash). Back Pain, Stomach discomfort, Pan in extremity, Headache, Vomiting, Somnolence/Fatigue, diarrhea,

Claritin -
Hypotension; hypertension; palpitations; tachycardia; syncope, Headache; somnolence; fatigue, nervousness; hyperkinesia; paresthesia; dizziness; migraine; tremor; vertigo; impaired concentration; depression; agitation; anxiety;

I took Singulair for a little over a year. In that time I have quit my job of six years, dropped college classes that I was previously excited about, and generally didn't give a damn any more about anything. My dreams became dark and horribly violent nightmares leaving me shaken throughout the day. I couldn't concentrate and was thinking I should seek professional help. My wife was worried that it was her and I couldn't figure out what my problem was.

About 6 or 7 weeks ago I heard there had been links to mood swings and depression from taking Singulair and immediately stopped taking it. It sounds cloche but it was as if the clouds parted and the sun began to shine again. I have become much more like my old happy and motivated self. My wife has noticed a huge difference as well as my friends and former coworkers. I am still having a little bit of a hard time staying on task but each day gets better and better. I sleep much better and the nightmares have stopped.

I think I'd rather deal with the allergy symptoms rather than take the FDA sanctioned poisons put out by firms like Merck. Their practices are criminally negligent but nothing will probably come of it because the regulatory agencies are in their pockets. It's all about the bottom line profits--public health be damned.

I am a 57 year old man, who has been suffering from asthma several years. This spring my doctor put me on Singulair as an additional medicine to my cortisone-inhalator. after one month I feel symptoms of depression an mood-changing, severe ups and downs.
AND - as an additional symptom i have partially lost my feeling in some fingertips, and now parts of my left thumb and even a feeling of "cold2, mostly in my left hand.
anyone who share that symptom?
M.

I am a 56 year old man who has been suffering of asthma for several years. This spring my doctor put me on Singulair as an additional medicine to my cortisone-inhalator. After one month I have the same experience as many here has told about - depression and periods of "swinging mood", ups and drastical downs.
AND - a growing problem with feeling in my fingertips, seem that with accelerating speed i am loosing feeling in fingertips and now even the hold fingers and parts of my hand, which feels "cold".
Anyone here who recognize these symptoms?

I am a mother of four children (21, 19, 15 and 15) who have varying degrees of asthma and allergy. All of them have some degree of ADHD as well. The oldest took Singulair from grades 7 to 12. It was great for his allergy, but he had a depression which was attributed to his ADHD.

The second is still taking Singulair. She is highly asthmatic and it has been beneficial for her. The severity of her asthma went down to the controllable range, and her migraines (suffered since second grade) significantly decreased (documented side effect).

The last two, identical twins, began taking Singulair four years ago when they developed asthma as they entered puberty. They became oppositional, defiant, prone to rages, and curiously not hustling hard enough at their sports. Prior to this, they were solid, dependable students, with moments of inspiration - and aggressive athletes, leaders at their sports. We always thought the problems were related to puberty and the ADHD. More and more ADHD meds were applied. No more weekends off the meds - because our house would be destroyed.

As 2008 began, my own allergies flared. When the doc offered Singulair, I looked forward to feeling better. Within 48 hours, I could breathe at night, and the tightness in my chest went away. Even my allergic dermatitis improved.

Then a weird thing happened. I got lazy. I heard myself saying things like, "I don't care if I'm fat." I stopped doing my evening chores. I stopped pursuing my hobbies. I almost stopped making dinner. I was wondering why I didn't care, but I didn't care enough to pursue that, either.

Then it got worse. I couldn't handle the least criticism. I was in tears over almost anything. Within a few days, I was trying to find a way to leave my family. I just didn't care about anything any more.

The water-cooler crowd at work was chatting about the news reports about Singulair and suicide. I started to wonder: gee, doesn't depression preceed suicide? Maybe this hopeless feeling I had was related to the Singulair.

So I stopped taking it. 48 hours later, I started to laugh at jokes again. Five days later, I cleaned my kitchen. Now it's been three weeks and I'm back at my hobbies and loving life.

Two weeks ago, I realized that the never-ending laziness and argumentation we've been getting from our twins might be related to Singulair. I checked with the ADHD doc, and their general doc, and got the go-ahead to discontinue the medicine (although not both of them at once). I did this without telling anyone: not the twins, not my husband, no one.

Forty-eight hours after the first kid had stopped taking the Singulair, I came home to a grinning, hugging, 15 year old, who sat me down at the kitchen table to explain the strategy he'd designed to study for his upcoming exams. I was speechless and numb. I didn't tell anyone that he was no longer taking the Singulair (he takes a variety of vitamins and ADHD meds every day). The next day, my husband called me excitedly: the kid was cooperating with him! He didn't know what to make of it. I kept him in the dark for a few more days.

The other twin had been on a lower dose (5mg rather than 10 mg). I stopped his medication as well. The change in him has been more gradual.

Neither of them takes ADHD medicine now on non-school days. They are happy and cooperative. We ask ONCE for chores. There are still a few arguments and stormy moods - but I no longer wonder what's going to get broken next. And they seem to love working as hard as possible at their sports.

The good news is, we all feel better. The bad news is -- how did this happen? How can it be that such an obvious side effect was missed?

It's not like the effect of montelukast on the brain is unexplored. Try searching on "montelukast brain ischemia" - there are many studies that show that montelukast (Singulair) dramatically reduces brain swelling. What does it do for an uninjured brain? Does it dehydrate it? Deprive it of nutrition? If I had to characterize the behavior I saw in my twins, it's this: they acted the way hypoglycemic patients do, when they're late for their next snack. REALLY GRUMPY.

Or do some research on migraines and Singulair. There's an effect there, too. Many asthma patients on Singulair report that their migraines improve.

So the drug clearly affects the brain, and Merck's position that Singulair doesn't cause suicidal ideation is almost irrelevant. The fact is, montelukast has a significant, often-studied effect in the brain. That effect is not fully understood.

In our house, the effect of montelukast on the brain has been significant. We have dragged two kids to many psychiatric evaluations. We've spent hours and hours with teachers and principals and counselors, trying to understand why they just won't get their work done. We've used every performance-management trick in the books to get them to work - without much benefit. The kids have swallowed an awful lot of stimulant medication because it was the only thing that controlled their rages. Who knows what their teachers think of them - are they forever branded as the lazy kids? And we are lucky. From this forum, I've learned that it could have been a lot worse.

My daughter, a happy, stable 13 year old had been taking Singulair for many years for her allergies. Last summer she suffered deep depression with symptoms including self-mutilation ans suicidal ideation. She had to be hospitalized and is now on anti-depressants and in outpatient treatment. I stopped her Singulair as soon as I read the stories at the end of March.

It has been 18 days since my 9 year old daughter has taken Singulair. Our daughter had been taking Singulair for approximately 2 years. It was in the last year that we started to notice some behavior changes and mood swings that were so often unprovoked. We were somewhat concerned and thought like so many other parents that it was a phase. Then in December 2007 she came home from school with a tummy ache and had several episodes of vomiting. She seemed better the following day, but we took her to the pediatrician to be sure that this was a virus. The stomach pains continued, and then anxiety attacks began. Over the next month she began to wake up each day with stomach aches and we began more visits to doctors and more testing. She had abdominal X-rays, CT scan, mekel scan, GI consult and endoscopy. All were ok except she did have some small amounts of acid in her stomach. She was treated with Prevacid with really no significant changes. As weeks passed she missed more and more school, she just could not make it through the day. She had intense separation anxiety, and developed OCD about being sick again and vomiting, fears that she may stop breathing; fear of dying and the list goes on. She was refusing to ride the bus to school, and was having more and more panic attacks that would last for hours. We finally took her to a psychiatrist after we had done every test we could possibly do and all were normal. She woke up with the fear and anxiety, and fell asleep each night the same way. The doctor said she had "OCD" which she believes was triggered by the fear from vomiting. "This was the first time she had vomited since she was an infant.” She was treated with Lexapro, and Klonopin. The symptoms worsened over the next few days even with the new medications. After many calls to the doctor we were finally advised to have her admitted to a children’s psychiatric hospital for closer evaluation where higher doses of medications could be administered. She was there for 4 horrible days with slight improvements. Over the next few weeks the medication did begin to help some and she was able to make it through school each day as long as she was able to call me a few times a day for re-assurance. I thank God each day for her wonderful teacher and staff that have helped us through this. They all have known her for 3 years and knew this was just not her character at all and she was truly struggling. She was always known as "Smiley" to everyone because she always wears a grin. We began therapy with a psychologist as well and she has good and bad days. Then we heard the news about Singulair and I began to trace back other issues she had with focusing in 2nd grade and how things just seemed to progress from there. It all happened so gradually that I would never have put two & two together. She is showing improvements every day with personality, mood, attitude, fears, and the "OCD". She told me today that this was the best day ever!! I have made all the Doctor's involved aware of this information and the progress she has made in the last 2 1/2 weeks. Her doctor did cut her meds in half this week as well. Thanks to everyone that has posted their nightmares as well, and we will pray for you and for full recovery for all those that have suffered.

My husband and I have been increasingly worried about our 11 year old son lately. He had been becoming increasingly unhappy and difficult. He was in the school play, one of the things he loves most, but had no enthusiasm or energy for it. He seemed apathetic about many activities he had always been eager to participate in. I kept thinking maybe he was just tired and too stressed out. It seemed like almost nightly he was sinking into anger and depression. We were walking around on eggshells trying to prevent him from spiraling into one of his angry moods where he would just shut down and say he didn't care about anything. The happy, cooperative, well-adjusted kid we had always known was gone.

Three weeks ago we began to talk about the fact that maybe there was more going on than just adolescent angst. We were beginning to believe some kind of professional intervention might be required.

Two and a half weeks ago our local paper ran the story about the Miller family whose son committed suicide while on Singulair. My son had been taking Singulair for three months.

The same day the newspaper story ran, my son had another tough morning When I went to bed that same night, I found two “suicide” notes from my 11 year old on my pillow. (He had not seen the article.) In one he asked for a gun or knife for his birthday so he could kill himself. In the other, he told me he had been thinking about killing himself since February.

My life for the past month has been filled with conversations and appointments with the suicide hotline, the pediatrician, a psychotherapist, the school social worker, the mother of the boy who committed suicide, the FDA, etc. etc., filling out forms and writing notes and observations.

My son had just recently finished his last bottle of Singulair. I had not yet refilled the prescription, and we have no intention of doing that. The turn around in my son has been extraordinary. My incredibly exuberant and joyful son is back. I did not realize until the past few days how much light he brings to this house and how far away he had faded. But everyday, as the drug leaves his body, his beautiful, loving, affectionate, helpful happy self returns. We just kept thinking for so long… I guess this is normal for a 6th grader. It must be adolescence. It is an incredible gift to see the cloud lifting.

I worry a great deal about the children who are not as severly affected - whose parents are thinking, as we did, maybe this is just typical for kids this age. I am incredibly grateful that my son was finally able to articulate some of the horrible feelings he had inside, and that the article appeared when it did to give us some clue as to what we were really dealing with.

My 9 year old daughter has been on singulair for about 5 months now and she is moody and not a very nice person sometimes. Now she in complaining of headaches and even cry's with the pain I want to take her off but I am a bit scared that if I take her off to quick this might be harmful can anyone let me know if they had any problems when they stopped their childs singulair.
Worried Mum
Australia

I am a mental health professional. I was on Singulair for 6 years. After hearing of the psychiatric side effects, I stopped it. The suicidal ideations have stopped, the depression and anxiety are decreasing. This information should have been made public long before now. And to think that I had actually calculated whether I had enough drugs on hand to accomplish suicide. I hold Merck responsible for putting myself and others through this torment.

Previously posted 8 year old son w/ suicidal ideation and depression...I'm seeing comments about "inattentive." I've been saying my son is ADD for years....How many of you saw this possible side effect? Off of Singulair for 14 days now....behavior unbelievably improved.

I am starting a new post in the hopes that others will see what I am trying to say about the delayed reaction in those that took Singulair for allergies.

If it is consistent that Singulair does not stop allergy symptoms immediately, then the pathways that eventually stop allergy symptoms involve a change in the mast cell function, development and migration (or some combination).

I asked this question for a reason. Are allergy symptoms stopped immediatedly. My question below:

I have a question that will help me continuing looking for information. I can understand that in the case of asthma that Singulair would provide immediate relief. If it is used for seasonal allergies or other allergies without asthma, does it work right away or does it take a period of days or weeks to be effective? If it takes time, could you tell me how long it took in your situation?

My thinking was going in the right direction if the answer below is consistent of everyone or most.

about 2 hours ago on Apr 11, 2008 by catherineevans, #7045
My granddaughter was put on Singulair for allergy symptoms without asthma. Itching, red eyes, terrible congestion, etc. dark circles under her eyes all the time. When we first put her on this, we didn't see any consistent results for 2-3 weeks, then it seemed to 'kick in.' I don't know if this helps. By the way, she was 9, now she's almost 12 and was immediately taken off when this story came out 2 weeks ago.

Then after seeing one response, I gave my reason for asking.

I asked this question because I have a theory of how montelukast really works for allergies as compared to how it works for asthma.

Asthma is a hyper-sensitive state that gets going because the mast cell has a receptor (the leukotriene receptor that Singulair blocks) that sends a signal along a pathway that causes lung tissue to have that extreme response - the wheezing, the airway constriction.

On the mast cell is another receptor the histamine receptor that causes the secretions that make our noses runs and and stuff up. This is not the same immune response as the asthma response. When I saw a post that somebody's doctor said that Singulair is an anti-histamine, NO it is NOT.

So if Singulair does not block histamine immediately and your child's allergies did not go away immediately, then maybe Singulair is working through some other means such as changing normal mast cell homeostasis.
I know that this seems like "what does this mean?" I am really writing this hoping to God that there are people reading this site that know what I am talking about.

Thank you so much for responding. Your answer actually told me what I wanted to know and confirmed my hypothesis. More answers will help. I hope others respond.

PLEASE respond about the length of time that allergies disappeared if you took Singulair for allergies.

A report from the Netherlands discusses depression. I had failed to notice that the report stated that in three cases the onset of the depression after taking Singulair was from 3-14 days.

Discussion and conclusion
Lareb received four reports of depressive symptoms in patients using montelukast.Possible confounding includes that asthma itself has been associated with the development of depression . Inhalated corticosteroids can also exert effects on the central nervous system. Fluticason in combination with salmeterol which is used by patients A, B and D, is associated with hyperactivity and irritability whereas budesonide, which is used by patient C also has been associated with depression .
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The latency of montelukast-induced depressive symptoms varies from 3-14 days.
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In three of the cases a positive dechallenge was seen. The fact that the patients (except for one) did not suffer from depressive symptoms before they started montelukast, the short latency, and recovery after withdrawal of the drug all strengthen our hypothesis that depressive symptoms are an ADR
related to the use of montelukast.

According to the Marketing Authorisation Holder of montelukast, depression will be added to the product information.

Some of you who are following this site may remember that I posted that when I was following the pathways of the leukeotriene receptor antagonist Singulair that I got to a point where I concluded that there has to be a genetic component (meaning that there are different gene groups of people) and that the efficacy of Singulair (and possibly safety) can vary depending upon what gene group people are in. So I took a little time to see if anybody else was already studying that issue. And YES, they are -- including Merck.

quote:

" However, logically one might predict that it will be the combination of the polymorphisms in these different key regulatory enzymes and receptors that may ultimately determine treatment response. There have been some attempts to tease out the possible contribution of different genes important in this pathway for treatment response to a Cys leukotriene receptor 1 antagonist.18 However, because of the number of potential gene variants that may contribute to efficacy, large studies will be needed to fully evaluate the potential contribution of pharmacogenetic variability in this pathway to treatment response to Cys leukotriene receptor 1 antagonists. Work in the cardiovascular field has demonstrated the potential importance of genetic variants in this pathway to disease risk and also to treatment response,19 suggesting the potential for important effects to be defined in asthma."

(Chest. 2006;130:1873-1878.)
© 2006 American College of Chest Physicians

Pharmacogenetics of Asthma
Ian P. Hall, DM
* From the Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK.
Correspondence to: Ian P. Hall, DM, Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham NG7 2UH, UK; e-mail: Ian.Hall@nottingham.ac.uk

http://www.chestjournal.org/cgi/content/full/130/6/1873

And Merck sponsored a study on this which is now completed.

http://clinicaltrials.gov/ct2/show/NCT00116324?intr=%22Montelukast%22&rank=79

Of course, it was sponsored by Merck and paid for by Merck.

I don't know if the study discovered anything but I believe this is an indication that Merck acknowledges genetic differences in populations that may predict the success of montelukast.

I am not any where close to being an expert in this field. I have another background but I believe that there are experts who can tell you exactly why you had side effects from Singulair.

I have posted in the past about my 9 yr old dd who was taking singulair for 3 yrs. Upon finding all this information about singulair and way before it hit the news .My dd was being tested for many different problems nuerologically wise. Trying to rule out depression,bipolar and ADHD. She had an eeg and labs done a few days after stopping singulair. And just today we went in for results and nuerologist says labs are normal but eeg was not . Meaning that she could possibly be having seizures. BUT NOW I AM WONDERING IF IT WAS SINGULAIR CAUSING THIS? I read somewhere that seizures can go unnoticed if they are very mild. But she did having trouble sleeping and concentrating. And at times even just stared off into space after we spoke to her repeatedly. My question is has anyone had any similar experiences with singulair ? Please respond.

I wrote about Singulair and depression at

http://www.huffingtonpost.com/doug-bremner/if-prescription-meds-dont_b_95868.html

Doug Bremner MD

My son is 8 and he has been on singulair for at least three years, maybe four. When I heard about the side effects a few weeks ago, I stopped his medication right away. I have since learned that it should be tapered off, but won't put him back on to do that. He had so many of the depression, I hate myself, everybody hates me, facial tic, stomach ache symptoms . . . Now he is almost two weeks off of singulair and he is throwing screaming fits, kicking, threatening, uncontrollable for up to two hours and more! Is this a side effect of coming off of the medication? Has anyone else had this experience? Please email me at amy-weaver4@sbcglobal.net - I'd really like to hear if anyone else has experienced these symptoms. Thank you! Amy

I am currently a junior in college and I have had severe allergies my whole life. Last summer my doctor prescribed Singulair and I really liked it as an allergy medicine (except for pollen). As a person, I am usually optimistic, happy go lucky, and always trying to make people laugh. I am also an avid learner, and I love school. I usually never miss class...well that was until last fall. I would get up everyday for my 930 class and take a shower and then for some reason just go back to bed. As Christmas approached- I failed my first class, got pneumonia, went on probation for my honor fraternity in which I was an officer, and was close to losing my academic scholarship. I changed my major to something easier in order to bring my grades back up this spring. I was actually excited about my new classes but then the semester started. Same routine- get up, take a shower, sleep and cry all day. I have lost most of friends due to my antisocial habits, gained 45 pounds to become 180 lbs on my 5'1 frame (borderline morbid obese). My parents and lifelong friends were worried I was going to commit suicide due to my downward spiral. My mother and doctor didn't want me to go on antidepressants in fear i would gain more weight. So they decided to change my ADD medicine which helped but not a lot. Then the suicidal effects of Singulair hit the news. I stopped taking it and within a week (spring break) I was back to my normal self like nothing ever happened. Except something did happen- I lost a huge part of me that is going to take awhile to get back. I was so convinced that I was causing the depression on myself and that I was crazy. Now the end of my school semester is wrapping up and I have a lot of catching up to do. There are times out of habit that I still act antisocial (which is completely uncharacteristic of me), but I'm hoping that will fade and I can get back to truly being myself. It's just so scary for me to think that there are unsuspecting prescription drugs that can cause so much pain. If I didn't have my family and true friends supporting me all year and sticking with me through all this, I know for a fact that I wouldn't be here today..

Dr. J. Douglas Bremner's real quote:

There are leukotriene receptors in the brain, and since this drug
binds to this receptor and since depression is mediated through the brain, this suggests a mechanism by which Singulair could cause depression. Could other drugs in this class have similar effects?
The FDA is investigating all of the leukotriene antagonists, probably with good reason.

Thank you Dr. Bremner.

I am not here to promote Dr. Bremner. I will swear that I didn't know about his real quote until less than an hour ago.

This is in answer to concernedcitizen. My son, when he began to have behavior issues, was placed on Tegretol, Wellbutrin, and Abilify. He could not tolerate the Tegretol. So he stopped that. His "depression" seemed better so they took him off the Wellbutrin, he continues to be on the Abilify. We tried to take him off of that once, it wasn't pretty. His anger, frustration, rage, crying, depression, etc all came back....of course he was still taking the Singulair. (little did we know then....) We see his neurologist very soon. I am going to ask about trying again to remove the Abilify. My son is 7. He was started on these meds 4 months after having surgery to remove a cyst in his brain....we thought all the problems were just who he had become after having brain surgery. It was very depressing. I read all of your research with great interest. I had thought it had to be a something in the brain being triggered. My son had a tendency toward these things due to the location of his cyst....we had the "luxury" of knowing he would have behavior problems. So did his doctors.... Now with all the research it would seem someone like my son, who has a cyst in the left temporal lobe (a region that controls behavior) should not have EVER been placed on a medicine like Singulair. At the very least, he should have been taken off that medicine, before being placed on anti-psychotics. Good Grief. Thanks again for all your work. I will be taking some of the literature with me to the Dr. As I am sure others on this board will.
By the way - My son has been off Singulair for 10 days now. He is a very happy boy. Downright giddy. He is annoying his sister to no end. Dad and I are enjoying every blissful minute.