Singulair and drugs

Just wanted to offer a follow-up on our daughters behavior since getting off Singulair and Advair. AMAZING difference. She is a pretty normal 12 year old now. The most noticable thing to me is her voice. On the drugs she always sounded so gruff and angry. Now she sounds sweet. She smiles so much more and is not eager to become angry. I can reason with her more now when there is a disagreement. It will be a long process to break habits of behavior that have developed over the past ten years, (yes, ten years, she started these poisons when she was two years old) We are very hopeful for her future. I am so very thankful that I was led to this site.

What you will not hear elsewhere: Though Singulair is likely safe, it is ridiculously over prescribed. Singulair is indicated for the treatment of allergies and asthma. For allergies, It has not been shown to be more effective than Claritin (which is now generic and over-the-counter). In fact, when Merck-Schering were trying to add Singulair to Claritin, they found it no more effective than Claritin alone (sound familiar?). In this case, they decided not to manufacture this new pill. The most effective agents for allergic rhinitis are inhaled nasal corticosteroids. Flonase is now available as generic fluticasone, and is much more effective then Singulair (which is not generic), Claritin or the combination of the two. Regarding asthma, the updated 2007 NIH guidelines recommend inhaled corticosteroids for asthmatics of all ages. The data is overwhelming, clear and convincing. Singulair, which has much less of an effect is considered alternative therapy by the NIH. Yet, Singulair remains one of the most commonly prescribed drugs for asthma.

I am a loving mother of a 5 1/2 year old boy. He has been on Singulair for over 3 years. In this past 3 years my son has suffered in an unspeakable amount. He came down with Rota Virus and was hospitalized at 2. He then came in contact with Pneumonia in the hospital while he was there. They automatically put him on Singulair, Zyrtec, Prednisone, and antibiotics to treat the pneumonia. Since that day, my son has gone though more tests than I have in my entire life. He has had asthma, sinusitis, leg cramping ( to the point he cannot walk for 2 years), IBS, Acid reflux,(they gave him laxatives for a year that made things worse and addicted to them also), stomach pain, constipation and diarrhea back and forth. He also got Erythema Mulitforme TWICE, while on this drug. All of which the doctors said could NOT be caused by Singulair. He has had several Upper GI's and CT scans. Along with Barium enemas, several hundreds of blood tests, and many many pokes and prodded that were not necessary. All since he has been on Singulair. He now has frequent bathroom trips, depression, confusion, and anger outbursts. He also has to go to the restroom every 5 minutes. He has had genital swelling, and many other aches and pains. None of which his "doctor" ever said could be a result of Singulair. I am 100% sure it was!!!! He currently has anxiety and emotional sporadic issues causing problems in school The teachers and counselors say that it is so strange because there is no TRIGGER and the outbursts are completely inconsistent. His preschool teacher and director are sure he has ADHD. Well, we had him tested and he does not have any part of it. He has no learning disability what-so-ever. So that brought me back to square one. He is in a positive loving enviroment. How could he be depressed and want to hurt everyone around him? He cannot sit still. He cries and says he is 'stupid" and "can't think" like the other boys. He has nightmares and cannot sleep alone. He is scared of everyone and everything. So, as I sit here crying, I realized that this has all been a reaction of his "medicine" Singulair. He never should have gone through all of those painful tests, only to prove they couldn't find anything. So many treatments and sound full advice speeches from his doctors. How could they be so naive and selfish in the life of my son?

When I called my pediatrician of 5 years, she told me that " parents that have children with behavioral problems will LOOK for something to blame their problems on." She also said "drug companies only put side effects on their labels to PROTECT the drug companies. (as she laughed at me) They are not always valid". Then she said "if you take you child off of Singulair you will be playing Russian Roulette in his life." Then she said that all children around 5 or 6 go though this emotional time in their lives." She told me that if I take my child off of Singulair that she would no longer be a part of his health regimen for his asthma. She told me to see a Pulmonologist for further treatment.
Who is paying who? This is my son's life???????? I decided to go with my mother-gut instinct and get him off of this medicine. No matter what. He has been a different person since. He is currently going though a lot of side effects and withdrawals (leg pain, insomnia, hic-ups, emotional distress) but every day is getting better. How can the drug companies say that this is a "wonder drug?" There are more reported side effected patients then clinical studied patients! How can a "medication" that stimulates the brain not be connected to other problems? This "medication" interferes with the bio synthesis and action of LTs and has been marketed as NOVEL medication against asthma and allergic rhinitis. Who the hell is playing God here??? The pocket books of Merck or our over PAID "doctors?" Who pays the price? Our children? Or us. Thank god I found this before it was too late. I would not be able to withstand the pain of losing my son due to their lack of scientific evidence. They are lucky I am one of the smart ones. I will not settle for less than Justice for the drug companies and their paid "doctors?" You all end up in the same place. HELL

There are 18 million people on this drug. Most of them are children. Please save a life if not your own child's life. Thank You

I have been reading a book on anxiety and phobias,it says that the Gene # 23 is shorter for people pre dispositioned for anxiety,If this is the case it makes sense as this drug works genetically,,so i wonder the % of short 23 to long 23, and that would give Merck its % of adverse side effects...betting its more than they are saying.As far as the doctors still saying this is a small %,they are just not asking the right questions,The insurance companies should have a record on clients that filled prescriptions for singulair and anti depressants and adhd drugs.If we all cn figure it out in a week ,Well what does that say

My daughter had been on singulair from the time she was 8 yrs old until she was 14. This will sound as if I am a horrible mother but I just thought that she was a raging bitch. Without my knowledge, she stopped taking her Singulair for a few months and she became a different person. She was so sweet and loving. One night she came in my room having an asthma attack and I asked her if she was taking her meds, she admitted that she had stopped taking her singulair and I got on to her and immediately got her prescription refilled. Within a few days of taking the singulair she turned into a raging, screaming emotional wreck, a TOTALLY different person. I feel so bad that for 6 years of her life I put her on medicine that caused her to have screaming, uncontrollable tantrums, and severe mood swings that caused her to be miserable. It does seem to be the only thing that effectively controls her asthma symptoms but the emotional havoc that is causes her and the people around her is not worth the benefits. We have an appt. with her doctor to see what other options we have.

Hi Everyone,
WBZTV out of Boston interviewed my family this evening about our singulair experience. They seemed very interested in this story as it relates to how families and individuals have been affected by singulair and will be airing it soon....don't know the exact date yet. My son was able to say on camera that it made him feel "crazy" inside when he was taking singulair and that he feels "much better" since he stopped taking it. We told them we feel lucky to have gotten through our experience but there are so many others who have suffered and are currently suffering very badly as a result of the side effects of singulair.
I think the FDA and Merck now need to stand up and start taking some accountability for a drug that is admittedly "over prescribed". Doctors should be divulging the potential side effects of ALL drugs BEFORE prescribing it so the patient can be fully aware. I mean c'mon the warnings are on page 28 of a 33 page patient information pamphlet. Don't you think it should be on page 1? OK, maybe page 2.
They need to black box this drug. People have lost their lives to it and doctor's need to take their fingers out of their ears!

Hey to All.
I know that the ALA study got everyone upset and I am happy we all emailed her.We all pretty much got the same response from Heather,defending the study and the integrity of the results.If only this investigation would conclude!
The Merck company contacted our Senator and indicated there was a conclusion and then ,they never got back to her before the weekend.I will have news early in the week.Please everyone just keep on voicing your concerns by reaching out any way you can.Sometimes it seems unbearable and I have to take a break with the communications on this website but,I continue my communication with my local contacts and the FDA.
I would love quick results and everyone would love this to get the publicity this story deserves but,if you look at how far we have come getting attention focused on this drug it is amazing.
This website has been here for years and people have complained and nothing has been accomplished until now.Our system is so broken it will take time to fix it.Drugs get approved everyday and when they are put out for multi use,the population benefit -risk ratio changes and there is little oversight on this matter.
The problem is much bigger than just notification of updated side effects,which indeed is why our son died from this drug.It is reporting adverse events to the FDA and the drug company and following up on your report.We can only fight within the system of the government that is in place at the moment and push for change to take place in there programs.
This is what has take place as of this year,The FDA's new 'Safe Use "iniative(which when it gets further developed will increase our partnerships with physicians as well as patients) and the July 2008 AAM report" Education in Safe and Effective Prescribing Practices" which aims to address the education of the next generation of physicians on how to best use medicines.This may help in notification practices and over prescribing but, we want the drug companies to lose the unprecedented control over the clinical research and and evaluation of there own drugs.What other company in the USA, gets to self regulate.Change will come ,we have asked for accountability by having a signature exchange when new and updated side effects are found.Full disclosure of all reported adverse events to doctors from the company representatives,with signature required upon full understanding of the benefit -risk ratio change. A prescriber should know all the good and the bad about a medicine they have chosen to dispense,if not then they should not be able to dispense it.If we were not knowledgeable about selling mushrooms and we sold the poisonous ones ,because we did not take the time it would take to educate ourselves about them,would we not be legally responsible for our actions.
Accountability is what we are asking for and maybe the candyland doctor prescribing practices would stop.They seem to ,not have a responsibility to their patients and the company has no responsibility to the prescribers,so who is responsible for our safety?
I will keep fighting for real change and all you people must do the same ,make an appointment with your representatives and have them contact our Congress representative of NY,maybe with enough onboard we can get the legislation we need to put a law in place for proper notification practices.Kirsten E. Gillibrand Member of the US House of Representatives 120 Cannon House Office Builing Washington, D.C. 20515
This is how change is made ,if you want to help please go forward and do this and don't stop until they listen.I am always willing to do whatever I can,it is physically exhausting and sometimes I just have to step away but, my daily review of this site has not stopped and my fight will continue.Dave and I sit here and our hearts just break for all but, we need people to push their Representatives they do work for the people just remind them of that.Any one with questions or that wants to communicate via private email just ask for my email address or phone number or leave me yours and a time and I will be sure to contact you,Kate M.

Just read an FDA article out today, I believe. The FDA is looking to publish quarterly a list of "potential problem drugs". That is fantastic! But where will this information be posted, and how often should a medical prescriber visit and hunt for such information?

I still maintain every medical professional with the appropriate credentials to prescribe any medication should be required to register with an email address with a database within the FDA to immediately communicate this new-found quarterly list, as well as any investigations launched (as with Merck/Singulair). Wow - what a concept.

I suppose I should be somewhat more optimistic with a slight move in the right direction - but I know with all my heart neither my daughter's pediatrician, nor my personal intern will receive, nor be aware, of any of the quarterly "lists".

Will keep trying to get a change within the FDA.

I apologize that the summary is not ready yet. At this time, I am inclined to believe that the FDA will "black box" Singulair. Maybe, I am just hoping but we will see. I also believe that the FDA will also investigate the entire category of drugs with genetic components and warn doctors that these drugs do NOT behave AS EXPECTED when the patient has a genetic variant.

I am posting this again.

I just wanted everyone to know that I am still here and concerned about everyone who is having side effects from Singulair. Sometime within the next few weeks I am going to post a summary and conclusion about all of the research that I have posted. I hope to come up with a well organized concise statement about why everyone who experiences side effects from Singulair should stop using the drug immediately. Not everyone has an adverse reaction to this drug. For those who do, it is very dangerous to continue this medication even for one more day. STOP IMMEDIATELY IF YOU SUFFER SIDE EFFECTS FROM SINGULAR. WHEN YOU SUFFER SIDE EFFECTS FROM SINGULAIR, THE REASON IS THAT YOU ARE NOT COMPATIBLE WITH THE DRUG'S GENETIC BASED MODEL. Singulair targets the CysLT1 receptor, which is a gene. This gene is not the same for everyone. If your doctor does not understand that the mode of action of Singulair has a genetic component, then tell him/her.

My son has been on Singulair off and on for two years. He goes off in the summertime since his asthma is mostly due to upper respiratory infections. He recently went back on it, maybe three weeks ago. He is 7 years old. Every morning now he wakes up with nightmares. This morning he said that he had a nightmare that all six of his webkinz were killed, except for one. The night before he said a tornado had blow our house away. There have been other nightmares too.

I decided this morning to stop Singulair, then called the allergist. The allergist agreed we should stop it and see what effect would happen. Today during school, the teacher had to call me because he was yelling at other students and was hitting books because he wanted a prize for fund raising. She said he was inconsolable.
During the summer, he was a totally different child -- easy going, laughing a lot. Now he seems stressed out, anxious and depressed.
I also noticed he has begun oversleeping.
Even worse, he was diagnosed with ADHD back in April. All of the surveys filled out by teachers and by me were from when he was on Singulair.

I know that drugs can do this to adults. I was once on a birth control pill that made me so paranoid and neurotic, I had never felt that way before. A different pill was fine and never had that happen again.

I have 2 sons with asthma that have both been taken singulair (the oldest for 3 years & his brother for 2). My younger son's asthma got alot better since he was diagnosed & he was recently taken off Singulair thanks also to my husband hearing a report about the moodiness caused. When he was on it he would cry for no reason, get very irrational & seemed to think the world was against him. In just 2 weeks he is happy & cheerful and has told me he thinks it is due to being off singulair. His older brother's asthma has gotten worse over the years & I'm concerned about taking him off but he too has crazy moods. Just tonight he started a new soccer team & got crazy & suddenly didn't even want to participate in something he loves (wanted me to let him quit right then) until we argued enough he reluctantly participated. He then came home complained of a headache (which is also way too frequent) and now has been asleep for hours. Are there any alternatives to this drug? I'm a stressed out mom that doesn't deal well with these mood swings. He is normally a social butterfly & a sweet kid but lately seems more withdrawn, more irritable (especially tonight) & complaining about leg cramps in addition to these frequent headaches. I can't deal with too many more of these evenings & wonder if all these things are possible side effects. I'm glad to see my other son doing well but miss his normally sweet brother! Even his siblings think he is acting crazy :(

unfreakinbelievable. every single drug ad I see on TV these days for new drugs claims that it will cure you of something. the only catch is: it will give you a million side-effects, half of which can be life threatening!!!

What kind of a job is the FDA doing that it lets these kinds of drugs enter the market and puts people with common problems like asthma in greater danger for developing extreme heart problems and psychological disorders???

I used Reactine. The very 1st tablet I used gave me a dream so vivid that I jumped out of bed - I was about 30% conscious and I still believed that I was in that dream. I dream that a Black Widow was in my bed right under my back and when I woke up I actually envisioned the Black Widow. Now consider that I live in Canada where BW's don't even exist. That's how powerful these drugs are and that's why you should stay away from them. I know this sounds crazy, but DON'T BELIEVE A THING YOUR DOCTOR TELLS YOU!!!!! Use common sense in common situations!!! Think for yourself and listen to your gut instinct or you will wind up dead before your time.

Hi to all,
I wanted to take a minute to say Thanks to all who post and search for answers to this drugs confusing and serious side effects.To all who have taken the time to contact the FDA and file a report to help others.Dr.Sarah Sellers is no longer the person to contact at the FDA,she has moved on after concluding her end of the investigation on Singulair.If you have a serious side effect please still take the time to file on the official FDA site for adverse event reporting.In NY. state we are still searching for legislation to help with the notification process for these serious side effects.There are to many Doctors that still do not have a clear idea of the updated side effects,and are not reporting as they should.
Letting your doctor know that good medicine is all about follow up on complaints,such as researching the singulair website to rule out that it may be the drug or it may not.Just dismissing the patient and prescribing another drug is how these drugs go undetected for so long.We want this to stop and only the unfortunate recipients of the horrors of this drug can make this happen.Again thank you for your efforts to change the system with follow through and perserverance.Our horror story is one of many and we want to help those who have survived the ravages of this drug, OUR CHILD DID NOT. Kate and Dave M.

hi everyone my name is Katie, and my son has been on Sindulair for over 6 months now. I took him off 2 nights ago, the day I found this sight. I just cant believe how many families this medication has hurt. When my son was put on, I was never told anything about anything like this happening. I thought his behavior was due to the divorce and child custody things in his life that were going on. It did not cross my mind that it could ever be this medication. He does not take anything else at all.
Some of the things we have been dealing with are, panic attacks at night, bad dreams, aggressiveness, depression, anxiety! Fits that you would not believe. Crying all the time, very emotional. And the newest one, thinking everyone he loves is going to get killed. These are not things a 6 just turned 7 year old should be going through.
I got to thinking that I needed to get him some professional help, this is not normal! I decided to look up Singulair on the net, I did not find anything. I looked up Childrens depression, and angziat, still nothing fit. Then I found this site. Wow did it blow my mind. It fit and it felt right, if you are a mom, I think you know where I am coming from. When you know you just know! So I got him off the medication, and already I am seeing changes. The first night was not grate but better than it has been in a long time, the next day though, he woke up and smiled at me for the first time in way to long, he only had 2 meltdowns that day, when he was having at lest 2 in an hr before. So far so good, I just hope that It keeps going well for him.
Thank you for letting me tell my story!

Sales of Merck's asthma and allergy drug Singulair dropped 1% to $1.1 billion for the second quarter. U.S. sales have been hurt by the recent introduction of an over-the-counter version of rival drug Zyrtec by Johnson & Johnson (JNJ), as well as concerns about the Food and Drug Administration's March alert of a possible association between Singulair and suicide and related behavioral side effects Got this off cnn money,i don't know but thought zyrtec and singulair were different drugs,my son at one time was prescribed both to take at bedtime

My son has been taking Singular as well as Advair and Zyrtec and Nasonix for the past 6 months. He is doing so well. He has not had to go to emergency, he has not been sick, and he has not had mood swings. If you look at the prescription information that comes with Singular, you can see what the side effects can be. My recommendation is to take your child off of them if they have a side effect. I contacted my Dr. and Merck is studying only 1 case with a child that had side effects, but they did not say if this child was on other Psych medicine at the same time. The 2 psych meds that have shown a bad interaction with Singular are Phenobarbital and Rifanpin (spelling may be wrong). With all the posts I have read, very few people indicate if they are taking other medications at the same time as Singular. My suggestion is that you consult your Dr. and then send your case to Merck for more studies. If all you are doing is posting on the web, you are not solving this issue with the makers of the medication.

Dear Friends,

Just want to reconfirm that this drug, that according to the Lab, present this side effects as "rarely" now we can see that it is not, I have a 2.5 year old boy, that is presenting these same side effects that you are mentioning. In a sudden he starts to act really nervous, his eyes turn red and cries while he tries to express something, but he does not know what is going on, in the meantime he has this truly visible crisis, his heartbeat goes up like hell, and his hands shakes. My wife and I got really scared the first time we experienced this with him, and we did not know what to think, we asked the Doctor and the stupid guy told us that he needed a shrink, but we did not believed it. Today he had the second same crisis, not as hard as the last one, and we discussed and came up with the idea to find out what were the side effects of this drug, and voila, is the gdm Singulair. I just can't believe that the Doctors that are prescribing these drugs do not warn the people that this may happen. The only thing that I can do is write my experience to you, thanking you for your attention, and spread the voice to the other parents that are around me that they take care of this and prevent their children to go through this process. I really feel like trash, because I did not do this before starting giving him this drug. Thanks for listening.
By the way this is an international problem, I am writing you from Mexico City.

My daughter has been off Singulair for approx 2 months and is back to her old self. Talkative and happy! How about contacting the media to see if they would be interested in doing a story on the problems that have been associated with this drug. Yesterday morning there was a story regarding the poor health of our children-high cholesterol etc, and my first thought hmm-wonder if they are on Singulair. I think if more light was put to this drug, maybe we could get answers faster.

After reading all the horror stories on here, me and my husband soon began to realize that we were having a lot of the side effects listed here and not listed on my son's actual Singulair prescription. The side effects my son had were behavioral changes, irrational behavior, inattentiveness, not able to stay on task or stay still -- in fact he broke his arm twice being so hyper, yelling, screaming and just plain mean.

We took our son off of Singulair as a trial for a few days. Immediately we began to notice differences in his behavior. He wasn't as agitated and quick to yell or get angry. (He's only 5 years old). He actually would be listening when we would speak to him. He would sit calmy and read books and the one huge thing he would do was look at us and smile. He even said to my husband once, "I love you Daddy," which just brought tears to our eyes. I never realized what a Singulair fog he was in and what it did to him. Here we were pretty close to getting him evaluated for ADHD or even Aspergers. So now we're in the same boat as others that are searching for other asthma meds to give my son. Right now we have gone back to Pulmicort, Xopenex, Nasonex and Allegra. I'm so glad I read this forum because I was desperately searching for answers for my sons behavioral issues. Oh, by the way he was on Singulair for 1-1/2 years.

I'm seeing some posts from parents who say their children have returned to normal after discontinuing the use of this medication. However, there seem to be a lot of diagnosed "ADHD" or "BIPOLAR" conditions. Are your children really returned to normal? Or have they been diagnosed with a psychological issue and are receiving treatment? There seems to be a connection here, even after discontinued use, especially male adolescents. Any thoughts?? The increase in cases of ADD, ADHD, AUTISM, etc has been multiplying at a very disturbing rate in the last 10 years. I'm thinking definite connection to the "new" breed of "receptor blockers". What is it triggering? Any thoughts out there? Lets post anyone with similar cases and see how many are out there.

I have only been taking singulair for about a month. I have noticed that I have become more irritable, grouchy, hateful and just numb, not really wanting to be around anyone, not caring about anyone else's feelings much. I also noticed I have become extremely lethargic, to the point of falling asleep at work as well as heart palpitations and stomach pains. I just started new birth control pills so at first assumed they were causing these side effects, that is until I looked up the side effects of this drug! I have over half of the side effects so I stopped it immediately and can already tell a difference in my mood. I have to sons age 11 and 14, both who have asthma and allergies. The took this medication for a few years with no side effects but have not taken it for about a year now. My youngest son however, has been diagnosed with ADHA and ODD and possibly BiPolar disorder. As I read the other posts, I realize the description of how their children act while on this drug is exactly how my son acts. I wonder if there can be irreversible permanent damage from taking this medicine? He has been on a number of ADHD drugs, none have helped except to make him stop eating and lose weight and he is small for his age, so I have taken him off everything. Has anyone else out there experienced what could be permanent damage from this drug in their children? Even after being off the drug for a year or so? If it could make me miserable within a month, what can it do when one takes it for years? Its sometimes hard to tell the effects of medicine on small children. My son prob starting taking it around 4 yrs old and took it til he was about 8 or 9. Just wondering if anyone else out there has had this happen to them or their children.

My son began taking singulair when he was 6. About that time we were hading into the school years. He was labeled as a "special" child from that time on. Impulsive, aggressive, angry, anti-social, etc. He had a hard time focusing at school and every day was a battle. About 5th grade, after 3 schools, he was diagnosed with ADHD. I never, ever thought that it could be this medication. He was on it for about 4 years off and on during allergy season. I transferred him to a private school for children with behavioral issues and as time went on through therapy and special schooling it seemed to get better. I look back now and see that our "good" times were when he finally went off it for good. The beginning of his Freshman year was great! He had a 3.58 GPA, making friends and finally happy. The unfortunate thing is now that puberty has really kicked in, we are back to the old behaviors but much worse. Impulsive, angry, anxious, afraid of the dark, afraid of death. Violent thoughts, impulsive and very unhappy. I can see now that my son never had ADHD. He was misdiagnosed because thier were no warnings at that time. I don't think it ever "goes away". Even after years of being off of it. Something with the puberty hormones is re-triggering this behavior. IT IS LONG TERM!!!!! Even after discontinued use. Please, please keep an eye on your children. I AM SO ANGRY FOR HIM!! Also, for me. Special school $400 month, psychologist appointments, $300 month, my poor Son in a dark place I can't get him out, PRICELESS. . .I want my Son just to be happy. Thank you all for sharing your stories, it gives me strength that I need for him.

I started singulair and now have a rash that is itchy. Is this a side effect?

HI,

As with many others I found singulair to be a miracle with asthma. No more rescue inhalers. I am not sure which of my current meds is causing the very vivid, often gruesome dreaming I have been having as THREE of them show this as a side effect. I am referring to Cymbalta, Xanax and Singulair. It may be that the combination of the three is just too much and is causing brain toxicity of some sort. I started cutting down the cymbalta, and also the Xanax days ago. I found myself still waking up remembering vivid dreams that I would rather forget. I remember them all like they just happened in living color and detail, days and weeks later. At first I thought it was interesting, but now I just want to FORGET THEM, anyone have ideas???? Help!!! ( I also developed depression and anxiety after being on singulair for several years which is how I ended up with the two additional meds.

Clinical trial of montelukast in the Netherlands.

I noticed two things:

1. The researcher states that sides effects are 10%.
2. The researcher will not allow patients to also take drugs which are metabolized by CYP2C8 because montelukast inhibits that as proved by in vitro (test tube) studies. American studies in vitro said yes montelukast is an inhibitor but in vivo (in people) that it didn't happen. I was always confused by that and would still like to know more
.
******

hi, im not sure what to do. my 3 1/2 year old daughter was today given the prescription for singulair. i voiced my concerns to the doctor after my friend telling me its no good due to the side effects.she said that there are risks and side effects with any drug you take but for some reason i don't feel right about this. don't doctors know better than this. anyway Would like to know if all the people who take singulair suffer some sort of side affects or is it minimal? or going by this side it looks like its probably best not to give it to her at all.

I was put on Singulair about 2 years ago because of my COPD. No allergies were ever mentioned by my Doctor. This site has been a god send for me.
Since starting Singulair I have been put on Digoxin for an irregular heart beat that I never had before. I have been put on Gabapentin for leg pain and cramping in my feet whenever I put my feet up or laid down to TRY and get to sleep. I have been put on so many pain killers for back pain, leg pain, neck pain I can't even count them all. I won't take them, they make me so sick. Now I find that I wake up with a headache every morning, feeling sick..oh yes, I was given medication for nausea also. And I don't want to forget the six months of experiencing never ending dizzy spells. That was another medication to ad to the list of ALL THE MEDICATIONS I HAVE TAKEN OVER THE PAST 2 YEARS for the side effects of Singulair. I stopped taking it a couple of days ago and I woke up this morning feeling so good. Oh, lets not forget the Xanax, Prozac and Cymbalta for depression.......OMG! I'm looking forward to see how many of these medications I can toss now that I've stopped taking Singulair. I just wish I had found this site two years ago, oh yeah, I am on Advair also. I've been, lets say "in a chronic bad mood" too. Some would say a "B". I've already noticed a difference there too.

My daughter, just turned 3, was put on Singulair this past January for allergies. She had chronic runny nose, sinusitis, coughing, often leading to infections. The allergist put her on Singulair combined with Hydroxyzine every night. Now that I have read these postings, I recall that we had one really disturbing episode with her, although I can't now recall exactly how long after starting the drugs. Like some others have described, she woke in the night, seemingly terrified and at the same time in extreme pain. We could not find any way to soothe her or relieve her pain - she simply fought and flipped around, alternately reaching for us and kicking us away while screaming and crying and writhing on the bed. After a time, maybe half an hour, it seemed to just pass and she finally went back to sleep. But then we endured a couple of months of repeated wakings at night, sometimes when she was restless for an hour or more, sometimes upset. She might wake 3, 4, or 5 times in one night.

Lately I have become concerned about her increasingly aggressive behavior towards us, but recently towards others. And I am also very concerned about her physical growth. She is 41" and over 40 pounds and turned 3 a week ago. I am now buying her size 5T clothes. I have finally gotten proactive (why did I wait??!) and consulted with her ped., who has agreed that we should screen her for anything we can. My daughter has been diagnosed with developmental delays (pre-Singulair) and is in a preschool with similar kids. We have been dealing with behavior issues for the last year, and I am astounded that an allergist would put her on Singulair with the current controversy about it's side effects. I took her off it immediately as soon as I found out there were negative reports - thankfully our experience has not been as extreme as many others. But I feel ill at what could have happened! I am now praying that she has not suffered any irreversible damage...

Bless all of you in your struggles.

I started taking Singulair and the first two days I felt better, but by the 3rd day I started feeling like I was trying to get sick. By day 8 I was in the Emergency Room with a very rapid heartbeat (166 beats per minute), and a severe Upper Respiratory Infection. They did blood and urine work, chest x-rays, CAT Scan, etc. and found nothing wrong with me. I kept telling them that I was having a reaction to the Singulair, and even though they never actually admitted it, they did say it was possible. I KNOW it was Singulair. I will NEVER take it again. They need to take it off the market. I was in the hospital for 3 days because of this dangerous drug!

My nephew is 7 and has been on Singulair for probably 4 years. His symptoms developed over time but recently have exploded. He has epilepsy so most of the things that he has experienced has been blamed on that. However, today his doctor took him off singulair and said he believes his symptoms are caused from the drug. He started having head drop seizures, fell out of his desk and cut his face one day. He has also been depressed, had severe anxiety attacks for the past 8 months. Several months ago, he started having such severe nightmares that it is almost impossible to get him to go to bed and go to sleep. Recently he began "seeing dead people" and "monsters" that we trying to kill him even when he was awake. He has also cried many nights with leg cramps and severe stomach pain. I will update this page in two - three weeks to let you know if these problems go away now that we have stopped the singulair.

In September of 2007 my then 13 year old daughter was put on Singular for mild asthma. At the time she was a straight A student, vice president of our school and a popular girl who's guidance counselor described as "the glue of her grade" because she was so well liked. In November she told me that she was struggling with advanced Latin and Science. She asked to drop down to on grade Latin so we did. In December her science teacher notified us that she had a C average. She told me that she thought she had ADD/ADHD and she couldn't keep up. At the same time she was having a lot of problems with friends at school and we just attributed it to being 14. 3 weeks ago we discovered that she is significantly behind in English and it was then that she told me that she is been having horrific night mares. She said that they usually involve someone killing her or her killing herself. She said that they were so graphic that she couldn't repeat it out loud. She also said that she would feel waves of anxiety that would come over her at school and she would act "witchy" to the kids in her class for no real reason. She said that sometimes when she is trying to do her homework she will read the same passage for 2 hours and still have no idea what it's about. She also said that the suicidal thoughts from her sleep happened during they day and that she had thoughts of her harming herself. Fortunately her pulminologist told us that this may be caused by singular and we immediately took her off of it which was 2 weeks ago. She has only had 1 "bad dream" not even a nightmare since. She had one anxiety attack 3 days after she was off it and she describes her moods as the "cloud lifting....slowly". Now, we have to pick up the pieces. Her grades have suffered, her friendships have suffered and most of all her self esteem is very low. I'm grateful that we found out the cause but I feel as if my daughter lost a year of her life and I worry that because Merck won't admit there are side effects we can't find out how long it remains in their system. Is anyone else concerned about the long term affect and has anyone pursued a class action suit to try to get this drug tested properly?

This is a follow-up. I have posted about our experience before, but to summarize: 6 year old boy on Singulair for over three years for Asthma. Drug worked wonders, but side effects developed so slowly that we thought those were "phases" that would go away. Side effects were just as everyone else reported: nightmares, fears, depression/sadness (we even went to a child psychologist since we thought this behavior was all due to father's deployment), aggressiveness, crying at the drop off a hat (like a 2 year old, not age appropriate), attention deficit, school performance dropped, and also, at the very end, obsessive compulsive behavior.
We stopped Singulair as soon as we heard about the FDA investigation (on NPR, about 6 to 7 weeks ago). Asthma has not worsened, thank goodness, so we make due with the Flovent for now. Most of the side effects were less prominent after some time, however the obsessive compulsive behavior stopped only a few days ago. We have better days, we have worse days, but slowly the better days outnumber the bad, aggressive, and negative ways.
What I read again and again in the postings is that we all assumed our children entered a bad "phase." A phase that just got worse and never ended!
Reading about the very same side effects in our children, over and over again, alarmed me. Taking my son off the Singulair and seeing the improvements, some faster some slower, totally convinced me. I will never ever have Singulair in my house again.

Both my sons have bad allergies. Both were recently prescribed Singulair after other drugs were not very effective. My oldest, 12, started feeling "strange" and asked to be taken off Singulair. He was not himself on the soccer field or at school. Since we stopped the medication, he has returned to normal. My 8 year old had a much worse reaction. He has bad mood swings and tonight became suicidal. He was searching the kitchen for knives to stab himself. He had fits on the carpet beating himself and the floor until I got him a pillow to take his aggression. My wife notified our doctor and school counselor. We're stopping his Singulair immediately.

concerned citizen,i enjoy reading your posts and research you have been so helpful,but i do have to say,i do expect the doctors that write prescriptions to do their homework and research on these drugs,i do feel that they should be extremely knowledgeable about what they are giving our children,that is why i pay them the big bucks.I told them of my concerns and they poo pooed me,when as it turns out now i was quite possibly right,i will asked them to do another blood test now he is not on meds,and if as i suspect it has gone down i will loudly shout i told you so and demand answers from them.I so often questioned the meds and was always made to feel dumb,Ignorance is not a defense and someone was very ignorant

My daughter has been off Singulair since March 29th. In my previous posting I explained that she had taken it for 2 years and last December started to experience stomach pain, and she became very anxious, agitated, and obsessive compulsive. We had every test possible and her anxiety only grew worse as the weeks went on. In February she was admitted for panic attacks and was given Paxil and Risperdal. When we stopped Singulair we noticed definite changes with her mood swings, personality, and affection. We saw a side of her that over time we forgot existed. She is so much better, but still on the medicines from her hospitalization. We have an appointment to discuss reducing these meds. But has SINGULAIR been out of her system long enough? She endured so much emotional stress that I know just stopping the Singulair will not be the cure all. Any input from anyone would be greatly appreciated.

I spent the weekend reading about the development of Singulair. The early studies recognized that the first phase of the acute asthma response bronco-constriction was probably not caused by leukotrienes. They identified histamines and prostaglandins as the probable sources. I don't think that changed because the Singulair literature states that it should not be considered as a treatment for that. Leukotrienes were a source of inflammation caused by eosinophils and mast cells present in greater numbers (than normal) in airway tissue. So, it was beneficial to find a way to decrease that.

The cysLT1 receptor was identified as source of the signals that tell the cells to produce leukotriene. The receptor, a gene, consist of 337 (they think) amino acids. They modified a compound that would bind to that receptor thus blocking the cells ability to produce leukotrienes. This compound is very specific. It was formulated to bind to the "model" receptor. This compound will not even bind to cysLT receptor sub-types. (That is the good thing.) There is an enormous amount of research that discusses the genetic variability of the chemical reactions that occur in the leukotriene (calling it this for simplicity) pathway. We are also seeing that a number of researchers would like to use gene profiles to predict whether patients will respond favorably to different asthma/allergy drugs. ALL PATIENTS HAVE A RIGHT TO KNOW IF IT IS INHERENT THAT SOME PEOPLE WILL NOT RESPOND TO SINGULAIR OR RESPOND ADVERSELY.

There are many studies from the 1998 era that conclude that montelukast is not effective for everyone. Those researchers stated that it can be predicted that those people who are going to respond favorably will do that within the first 14 days or so. That conclusion would be consistent with a genetic component for efficacy and safety of Singulair. Those doctors concluded that those who did not respond within that time frame should not take Singulair for fear of harming them. That makes good sense.

The Italian researchers wanted to know if there was more going on than blocking leukotrienes in the action of montelukast. They set up a "test tube" study regarding montelukast, the cysLT1 receptor, and some t-cells that they selected. Why? Researchers always have something on their minds. They observed the death of these particular t-cells.

Montelukast is a quinoline. We basically know of quinilines and quinolones as compounds that were invented as broad spectrum antibiotics. They work because they interference with bacterial DNA so they cannot replicate themselves. Montelukast is a quinoline modified to bind with the cysLT1 receptor (a gene) and prevent that gene from activating. That's consistent with what a quinoline/quinolone does.

So what does montelukast do in blood plasma if it does not bind to the receptor because of genetic mis-match? (If montelukast does bind, then a chemical reaction has occurred and the liver will break down the by-products. Montelukast metabolized in 10-12 hours.) What happens if it doesn't bind? How long before it breaks down? Does it produce toxic by-products?

I want to know what happens to lymphocytes such as t-cells just because montelukast is a quinoline. Maybe nothing but what's up with the Italians researchers? I want to know if montelukast has the capability to interfere with lymphocytes who can clone themselves. That could be a good thing under circumstances when these lymphocytes are causing inflammation. But it could be a bad thing in the case of normal individuals with no problems.

I want to know if the bad side effects are due to the fact that the body has to break down and metabolize a quinoline that did not bind to the receptor for which it was created. The side effects of Singulair are strangely similar to what is observed in the quinolones such as levaquin. I have not as yet been able to compare montelukast as a quinoline to levaquin as a quinolone. I am hoping to find something on these categories. There may be no reason to worry that they cause similar damage. But frankly, I think that there is. There is some terrible chit happening to some people. The scariest is the neurological damage.

All of these questions would be in the everybody pharma knows to ask category. I don't know where the answers are. I haven't found them as of yet. Maybe there are no answers. We have to remember that Singulair and Vioxx were released in the same year. They have continued to be drugs under the current executive management of Merck. If the Vioxx marketing promoters had their ghost writers, why not the Singulair marketing promoters. The genetic component appears to be widely accepted but we haven't heard one thing about even that.

I think that it is sad that maybe the marketing of Singulair as one stop shopping for asthma/allergies may have destroyed the original concept. I really think from reading the original work that they knew that they couldn't engineer a drug for one size fits all. Everybody gets harmed when information is withheld.

Shame on the allergist who yelled at the mother who wanted to discuss issues. Does he know exactly who is allergic to Singulair and who isn't? Get him a dunce hat. Just because Singulair is marketed for allergies does not mean that you cannot be allergic to it. See the power of Madison Avenue? The ad agencies focus group these drugs to death. The ad agencies cleverly craft the product information. A good piece of legislation would be to prohibit consumer drugs ads.

Chris555, what's your motivation here? Why do you keep coming back to tell us that all drugs have side effects? We know that. As someone else commented, we're not a bunch of idiots.

A significant number of us have children who have had MAJOR problems on Singulair. And we are absolutely certain that Singulair caused our children's problems. It is very likely that there are large numbers of children out there who are being erroneously medicated for problems stemming from Singulair. There may be children suffering from depression or suicidal ideation. Posting our stories about our children might actually help someone else's children.

I'd love to know why you feel that you need to convince us that Singulair may not be the cause of our children's problems. What's the point, exactly? What do you have to lose if Singulair gets proper labeling so other families don't have to go through what we've all been through?

I have come to the conclusion that our pediatricians, allergists and various other doctors, have been brainwashed by the drug reps,possibly even bribed. My friend took her son off of Singulair almost a month ago when I told her about all of this. He already suffers from a learning disability, but she feels that his ability has improved along with his disposition and complaints of various aches and pains. She took him for his usual appointment at his allergist and told him what she had done and why and he literally YELLED at her, calling her a fool and demanded that she put him back on it. She stood her ground and refused and now is under the impression that her son will be dismissed as a patient from that practice. That won't be a problem. From what I read and what I hear, a lot of doctors are dismissing the whole deal. They can't be bothered with finding out for themselves, what the truth really is. No, they might miss out on the "perks" from the drug reps, like free samples of the deadly drug, or free pens, or a chance at a vacation in the Bahamas, and the list goes on. The drug reps are a hazard. They lack education on the drugs that they are "dealing", and if they HAVE been educated and are still promoting it,
they are no better than the crack dealers in the alley.

I read that many of you blame Singulair for your side effects when you are also taking multiple drugs. As a public service, I put together a list of side effects from some of the other drugs mentioned on this site. These are by no means all the side effects listed for each drug. The first group is from allergy medications people have mentioned.
Zyrtec & Zyzol -
suicidal ideation, suicide, aggressive reaction, anaphylaxis, cholestasis, convulsions, glomerulonephritis, hallucinations, hemolytic anemia, hepatitis, orofacial dyskinesia, severe hypotension, stillbirth, thrombocytopenia.
abnormal thinking, agitation, amnesia, anxiety, decreased libido, depersonalization, depression, emotional liability, euphoria, impaired concentration, insomnia, nervousness, paroniria, sleep disorder.
accidental injury, asthenia, back pain, chest pain, enlarged abdomen, face edema, fever, generalized edema, hot flashes, increased weight, leg edema, malaise, nasal polyp, pain, pallor, periorbital edema, peripheral edema, rigors.

Benadryl-
Sedation, sleepiness, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, neuritis, convulsions. Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation, Urinary frequency, difficult urination, urinary retention, early menses

Allegra -
insomnia, nervousness, sleep disorders or paroniria, and hypersensitivity reactions (including anaphylaxis, urticaria, angioedema, chest tightness, dyspnea, flushing, pruritus, and rash). Back Pain, Stomach discomfort, Pan in extremity, Headache, Vomiting, Somnolence/Fatigue, diarrhea,

Claritin -
Hypotension; hypertension; palpitations; tachycardia; syncope, Headache; somnolence; fatigue, nervousness; hyperkinesia; paresthesia; dizziness; migraine; tremor; vertigo; impaired concentration; depression; agitation; anxiety;

I'm an 18 year old male and I've been taking Singulair for years; I don't even remember when I started taking it. I've had chronic sinusitis my whole life, and use a Singulair 10mg/ Allegra 180mg combo to control it. I never gave it a second thought. From my adolescent years on, I've been able to sleep (if undisturbed) for 15, 16+ hours a night, and have always felt like I was in a fog during everyday life. Getting out of bed has always been a terrible problem for me.

Throughout high school, I became progressively more depressed and apathetic toward school work, to the point where I dropped a number of classes my junior year. Got put on Prozac for a while, it helped a great deal with the depression, and seemed to give me enough energy to get through the week. I discontinued it after a year or so, everything was going okay (aside from mood swings and tiredness- explained away as symptoms of my age/hormones/going to bed too late), and then I went to college.

I had a mild depression that I think most people get upon leaving home for the first time, but the real problem was anxiety; I had a number of anxiety attacks, and decided to transfer to a school closer to home. I started Celexa and therapy- the celexa seems to take the edge off, but I fear its making me even more tired than before.

I've just heard about the whole Singulair controversy, and I am not taking it from here on out. I really hope that this whole ordeal was brought on primarily by the Singulair. After a month or two, I'll repost to report whether the symptoms went away.

I just read a few days ago that Merck is trying to get approval for a new drug. It is a combo of Singulair and the Shering pharm. co. drug Claritin. Isn't it nice to know that while we are suffering from this drug, Merck and another pharmaceutical company are trying to make more money on a drug that is supposed to be under investigation. Fortunately, the FDA is not approving it along with a few other drugs Merck is trying to push. This shows us how concerned they are with public health. They would sell us arsenic if they could get approval for it.

I discovered this site last Wednesday morning - without taking the time to list all of the grief I felt reading through the pediatric postings, I will briefly note my 4 year old daughter has been on Singulair for 2 years now. What I now realize is all the behavior issues, night screaming, etc. are so easily dismissed as stages of a toddler. She has suffered (as well as our family) every symptom and behavior listed by parents on this site with the exception of leg cramps.

Our entire family can see the dramatic results since taking her last pill last Tuesday night. The melt downs and tantrums are all but over, she even commented "hey, I listened right away" on the second day without Singulair. She is still having night terrors - I call them that because they are in no way a dream or nightmare, but rather agonizing moments that break our hearts to hear. I hope those will soon go away as well so her sleep pattern results in a restful night.

Am I angry that we have all suffered for 2 years only to find we have been basically poisoning her? Am I angry that for the 2 years her dad and I have sunk pretty low, feeling inadequate as a parent to teach and discipline our child? Am I angry that after 20 years of marriage, raising a great 16 year old in the midst of all this, we were to the point of the ADD, bipolar, etc. theory that would have been misdiagnosed? Heck no, we are all so thankful to have come across this site and are so giddy and excited to be happy again.

What I am angry about is this - when I called our pediatrician last Wednesday and relayed what I had seen on the Merck website for side effects added in recent months she had not heard this information and asked where I saw it. At that point I had not seen this site. I asked her how is it the well dressed pharmaceutical reps come in with doughnuts, exotic trips, etc. to market a drug with "ABC" treatments and "XYZ" side effects, continue to market the drug and never update the doctors when original selling points are altered - ie; new side effects.

The FDA website is troubling for two reasons: Merck is in charge of their own investigation regarding recent complaints and the FDA expects this to take 9 months. Gee, who gets to investigate themself? Secondly, in February the site notes the FDA and Merck are trying to find the best way to communicate the concerns being investigated to prescribes and patients. HELLO - we live in a world of real time, instant communication methods, two examples being the United States Postal Service and an internet connection.

Today is April 30 - a full two months after "trying to decide how to pass this information on" and my doctor, nor my pharmacist have received any information. Apparantly since we missed the story and coverage on Dateline we are out of luck.

I plan to start from ground zero to get our voices heard to change the way, or the law if you will, to implement an immediate communication link between the FDA and prescribes when an investigation such as this has been initiated. I realize Singulair has most likely benefited more humans than it has destroyed while on the drug and the FDA would have to clearly not communicate "panic". However, when a drug is used for pediatric treatments we need information quickly to assess on behalf of our children. In my case, since my daughter had been on the drug since 2 years old, I do not know what her "normal behavior" should be as that is the age they start to develop and show personality. Additionally, when enclosed prescribing information is updated with a prescription -MARK IT IN RED, "UPDATED INFORMATION". I read every ounce of information that accompanies a new prescription for any family member. I would NOT, however read the information every 30 days for an ongoing, long term prescription over the course of 2 years.

I am looking for anyone that may have started contact with a congressional representative or otherwise to change the communication to our doctors. Please note - I am in no way interested in any legal action regarding Singulair and our nightmare. We are moving forward and do not wish to live the nightmare one moment more. I simply want to see our doctors and pharmacists have vital information as it happens.

Thank you to all for sharing your experiences - I truly believe it is changing lives and making a difference. I am personally telling everyone I know about what is happening with our child and all of yours. Andy by the way, by telling one of my long time friends our amazing discovery, she realized she had been suffering from depression for some time and chalked it up to various things going on in her life. She had her last Singulair last week and feels tremendous! So keep the word going!

As an adult, I have had no problems with the drug. That being said, I wanted to remind readers that very few drugs, if any, are tested on children. As any good pediatrician will tell you, children are not just little adults. Drugs companies and doctors should not just adjust dosages and say that a drug is OK for kids. As a mom, I'm cautious to give my kids any medication that is new, including vaccines that are new, because I know testing has been limited with respect to children.

My 13 yr old daughter was put on Singulair along with Asmanex and Clarinex for her asthma about 6 weeks ago. Everything seemed to be going very well at first and her symptoms were starting to get controlled. I started noticing after about 3 to 4 weeks that her temper and attitude were getting much worse. Anyone with children this age knows what I mean but this was like a 180 degree turn for her. Her actions were becoming totally out of character. Before I knew it she would cry and get highly upset over the least little thing. Week 5 came around and things totally bottomed out. She came home from school and WAS NOT HERSELF. Made comments about how she hated her life and it was not worth living. Later that evening we had a big argument because I was telling her nothing was worth saying that. She went totally out of control and I had to physically restrain her to calm her down. It appeared everything was better so she went to her room. I went down to check on her and she calmly told me that she had taken advil and tylenol pm and things would be better for her forever now. We went to the ER where they made us wait for at least an hour, then finally took her back. She had to drink two cups of charcoal and was poked and prodded repeatedly. They did a catheter to get a urine sample. She was very cooperative but also was in a complete daze so who knows. The poor child couldn't even lift her head up when she started the vomiting to get rid of the drugs. It was very upsetting and sad. Her heart rate and blood pressure went very low and I really thought in the back of my mind that this was it. Finally, after several hours she started coming out of it and they sent us home. The next evening when she was starting to really come around she proceeded to tell me how she had been seeing a man walking around in her bedroom at night and she was afraid to go down there. Breaking down and crying telling me about all of the horrible nightmares she had been having recently and didn't know why. I thought what am I dealing with here? This just isn't her. Three days ago I heard about singulair in the news and looked it up on the internet. OH MY GOD THIS SOUNDED LIKE US!!!!! I immediately had her stop taking it and the next day phoned her asthma specialist who agreed she should stop now. We are going to watch her for two weeks and see if any symptoms return and then decide if she needs something else or will be fine on just the Asmanex. As a side note, she also mentioned being unable to concentrate in school (unable to do even the simplest math problems) and that her brain felt confused or like something was missing. She said this had been bothering her for several weeks. I know it was this drug. They really need to take this off the market NOW and stop flirting with disaster. The only reason I posted this was to let others know they are not alone.

Our son started taking Singulair when he was 2 for severe allergic rhinitis and cough variant asthma (in addition to Zyrtec, which didn’t control all of his symptoms). He is 5 now. For the last three years, he has been an increasingly violent, difficult, defiant, argumentative, volatile child who has intense mood swings--one minute he’s laughing uncontrollably, the next he’s weeping over nothing. His doctor and therapist recommended that we see a psychiatrist to have him evaluated for bipolar disorder, which used to be unknown in children. Because he has such chronic sleep problems, the doctor also suggested we take him off Singulair (and increase his Zyrtec dose) to see if it improved his sleep issues. Within a week, he was sleeping much better and was a calmer, happier, gentler boy. He suddenly could take “no” for an answer without flipping out and trying to hurt me. We thought that we were just in an unusual, calm window that would shift either to mania or intense sadness or both, any minute. We also thought that his behavior change might be due to sleeping better. We were enjoying the rare reprieve. Over the last weekend, his springtime allergies really flared up. We gave him Singulair on Monday and by noon, he was completely out of control. I had to strap him into his car seat at one point to keep him from hurting either me or himself. It finally occurred to me that Singulair might be causing his “bipolar” disorder. Of course, we stopped the Singulair. After two days he was a new boy. Yesterday, I Googled “Singulair bipolar children” and got a few hits. I am stunned to read how similar other families’ experiences have been to ours and I feel sick that we gave this drug to our child for three years.

Is there a potential explanation for the adverse psychiatric side effects of montelukast?

In my opinion, there are at least some very good clues based upon the work of the Chinese researchers.

A 2006 report indicated that they had localized (meaning found it was there) the CystLT1 receptor (same as the receptor that montelukast
Singulair blocks) in the neurons of the brain tissue of rats. In order to do that, they injected rat brain's with NMDA to cause a chemically induced state of excitotoxicity. Excitotoxicity is a common factor in Central Nervous System disease. They concluded that both 5-LOX and CystLT1 were upregulated by the excitotoxicity that they artificially created
with the NMDA. Therefore, there would be a potential link between neuron activity and CystLT1. Nerve cells are damaged by excitotoxicity. These researchers used NMDA to cause nerve damage which caused the CystLT1 to show up. NMDA was often used in human behavior studies to cause brain damage. They would then try to observe whether behavior was compromised to conclude what areas of the brain determined what behavioral response.

So I was thinking about the Chinese researchers as I was reading other posts. One post interested me particularly regarding the mother who described behavior that seemed like hypoglycemics when their snack doesn't arrive on time. So a light bulb went on. Glutamate, another excitotoxin, can build up in the brain to a level that is damaging if humans become excessively hypoglycemic. If glutamate concentration around the synaptic cleft reaches too high a level then neurons die. Clinically, it really does seem that many people experience things that sound like the effects of hypoglycemia. It could be only a coincidence. But then again, maybe not.

The Chinese researchers found the CystLT1 receptor in the rat brain neuron after brain damage. They found the CystLT1 receptor in the normal human brain in the microvascular endothelial cells and in neuron and glial-appearing cells in brain trauma or tumors.

What role does the CystLT1 play in brain function? If it exists in brain tissue, we can assume that it does have a function. If it plays a role in preventing or repairing neuron damage due to excitotoxins, then there would be a very direct link between Singulair and adverse psychiatric side effects.

http://www.chinaphar.com/1671-4083/27/1526.htm

The bottom line is that Merck owes people who take Singulair further research regarding it's effect on the brain.

I have communicated directly with Leslie Hendeles, a leading professor of pharmacology and pediatrics at the University of Florida who's direct quote to me was:
"In response to your last comment, I thing Singulair has modest efficacy, and if we take all of our patients off this drug, THEY WON'T SUFFER. This is NOT an important drug for pediatric asthma, as are inhaled corticosteroids."

Ironically, this is the same individual who was quoted in an ABC news article as saying:
"We have hundreds of children on Singulair and have never heard parents make complaints about psychiatric side effects. Moreover, there is no mechanism for this reaction … We will be telling our patients not to worry about this."

WAKE UP EVERYONE...THIS IS AN ADMITTEDLY OVERPRESECRIBED DRUG THAT HAS WORKED WELL FOR MANY, BUT HAS ALSO RUINED MANY LIVES.

The manner in which this drug is casually overprescribed by so many doctors is freakish. I firmly believe that this drug has caused countless misdiagnoses such as ADHD, Bipolar disorder and others. IT FUELS A GOOD PART OF THE ECONOMY TO PUT SO MANY PEOPLE ON THESE DRUGS. I BELIEVE THE PHARM INDUSTRY IS VERY CALCULATED IN THIS MANNER.

Question what your doctors tell you.
See my other posts under matthewct1. I dealt with a situation where my 5 yr. old son was on the road to being diagnosed with ADHD which couldn't have been further from the truth. Singulair changed him. Since he's been off Singulair everyone (teachers, pediatrician, family, etc.) unanimously agree that he does not show the ADHD symptoms like he did on Singulair.

Hello to everyone, I just came home from a parent teacher conference for my son who is 7 yrs. old, and heard the same old thing, "he is restless, impulsive and has a short attention span". He has been taking Singulair for about 3 yrs.. Since he has started school I have had these complaints and have also been told he displays symptoms of ADHD, which ironically has been for the last 3 years. Like any parent, I question" if I am doing something wrong with my parenting, is his diet good, etc. etc.", I am also a nurse, I realize that medications are needed and beneficial in some circumstances, however I firmly believe and was taught in nursing school that medication is last resort. That being said, I have been very adament about NOT giving my son ADHD medication after doing alot of research on the different meds and their side effects. So, we started him on all natural vitamins, changed his diet some ( kids got to have candy once in a while) and started a more structured routine( the best we can since we both work) and also enrolled him in Sylvan. The teacher says there is a 50% improvement but he is still impulsive and still does not pay attention like he "COULD", again suggesting he needs ADHD meds. I came home in tears and started to do more research online to see what else can I do besides putting him on psych meds?....Then I came accross this site, I just want to cry after reading all these posts. I wonder, could this be his problem, the Singulair?.. About a year ago he use to get up in the middle of the night, 5 out of 7 complaining of nightmares, hearing things at times, headaches, decreased appetite, stomach upset, all AT TIMES, not all the time so I never thought alot about side effects of Singulair. When the school started complaining I did look at side effects of Singulair and seen HYPERACTIVITY and mentioned it to his pediatrician and she shrugged it off saying she never heard of it being a problem. She's a great MD so I listened to her because his asthma was bad when he was younger and it is now under control. But then I think maybe he is outgrowing the asthma. I am afraid to stop Singulair and him have breathing problems again but then I can't help this strong feeling in my heart that says this may have been his problem with everything else all along. We are going to stop the Singulair tonight and see what happens. If anyone else has a child with asthma any suggestions for alternative treatment would be appreciated. I already know what's out there but sometimes it's nice to hear from another parent going through similar situs. Thanks for reading, Bobbie

I have been Singulair-free for 11 days now. I do not entertain any more suicidal thoughts, I feel MUCH happier just generally. I have cried, but haven't felt really low, just sad, normal-sad. I do have more difficulty breathing and tightness in my chest, but I am looking into adopting an anti-inflammatory diet. I have exercised more since stopping the Singulair, so I hope that will help long term with my lung function. I would definitely say I would rather feel some tightness in my chest or breathlessness going up stairs than intense sadness and irrational suicidal ideations. This life is much better than the one I had two weeks ago, and I know it's the same life, nothing has changed, just my perspective. I wonder if taking drugs off the market is going to be like putting up stop signs or traffic lights - we have to wait for a significant number of accidents before that move would be warranted. I really can't believe that all those years I thought it was me. I am a whole new person psychologically and it is because of an asthma medicine that is approved for KIDS! Amazing.

The new April 2008 issue of Reader's Digest has a long article on how the FDA approves drugs and the many problems associated with the agency entitled "Can We Trust the FDA?" The lack of oversight and the fraudulent studies conducted by the pharm industry is all there, it's no wonder this drug was approved. Please read.