Singulair and medication

My son has been taking Singular as well as Advair and Zyrtec and Nasonix for the past 6 months. He is doing so well. He has not had to go to emergency, he has not been sick, and he has not had mood swings. If you look at the prescription information that comes with Singular, you can see what the side effects can be. My recommendation is to take your child off of them if they have a side effect. I contacted my Dr. and Merck is studying only 1 case with a child that had side effects, but they did not say if this child was on other Psych medicine at the same time. The 2 psych meds that have shown a bad interaction with Singular are Phenobarbital and Rifanpin (spelling may be wrong). With all the posts I have read, very few people indicate if they are taking other medications at the same time as Singular. My suggestion is that you consult your Dr. and then send your case to Merck for more studies. If all you are doing is posting on the web, you are not solving this issue with the makers of the medication.

My 16 year old son took Singular for three days. Almost immediately after taking the first dose, he starting having increased blood pressure, rapid heart beat, tiredness, depression, thoughts of death, muscle soreness, tingling in his arms and legs, numbness, weird dreams (when he was actually able to sleep) and decreased appetite. He seriously thought that he was going crazy. It was not until I did some internet research that I finally linked all of his symptoms to this horrible drug. He stopped taking it on Friday of last week and each day since has been feeling better. He is not 100% back to normal yet, but each day seems to be better. It was a scary three day period while he was using this medication. Hopefully it will only take another day or two to get out of his system completely.

I am nearly 60 yrs old and have been on Singulair for some time. I have noticed mood changes but something even more alarming. My blood pressure usually runs a bit low but since going on Singulair, it has gone up. I have also had many instances of feeling faint and having to sit down and lower my head. I've had two incidents of E.R. treatment due to irregular heart beat, feeling faint, and elevated B.P. When I quit taking the medication for several days, my B.P. was again on the low side and I never felt faint. Although an irregular heart beat is an identified side effect, elevated B.P. and fainting are not. I would like to know if anyone else has experienced these symptoms, as the doctors have told me these are not side effects of the medication.

In response to Wewe's post, I've been wondering the same thing. Since taking my daughter off Singular almost 2 months ago, I'm seeing a different almost typical kid. Four years ago about 2 months after starting Singular my daughter was diagnosed with anxiety. As her condition got worse she was diagnosed with depression. We started to see OCD and tics so they were added as a diagnosis It was determined that it was related to strep infections so she was diagnosed with PANDAS. She was started on Zoloft and klonidine. The Zoloft made her worse. Her fears of hurting herself got so intrusive she was hospitalized. Her cholesterol was high too. The Zoloft was discontinued and Prozac was started. She's had therapy all 4 years. She also neede physical therapy due to muscle and joint pain. Now she's doing better, off Singular. Does she really have PANDAS, OCD? I don't know. She's still on Prozac, we just did a slight decrease this week. Is this medication the trigger for underlying conditions. Learned behaviors can be unlearned, but are there lasting physical effects? If a gene has been turned on, can it be turned off? I wish we knew the answers to help all of our kids.

I'm seeing some posts from parents who say their children have returned to normal after discontinuing the use of this medication. However, there seem to be a lot of diagnosed "ADHD" or "BIPOLAR" conditions. Are your children really returned to normal? Or have they been diagnosed with a psychological issue and are receiving treatment? There seems to be a connection here, even after discontinued use, especially male adolescents. Any thoughts?? The increase in cases of ADD, ADHD, AUTISM, etc has been multiplying at a very disturbing rate in the last 10 years. I'm thinking definite connection to the "new" breed of "receptor blockers". What is it triggering? Any thoughts out there? Lets post anyone with similar cases and see how many are out there.

I have only been taking singulair for about a month. I have noticed that I have become more irritable, grouchy, hateful and just numb, not really wanting to be around anyone, not caring about anyone else's feelings much. I also noticed I have become extremely lethargic, to the point of falling asleep at work as well as heart palpitations and stomach pains. I just started new birth control pills so at first assumed they were causing these side effects, that is until I looked up the side effects of this drug! I have over half of the side effects so I stopped it immediately and can already tell a difference in my mood. I have to sons age 11 and 14, both who have asthma and allergies. The took this medication for a few years with no side effects but have not taken it for about a year now. My youngest son however, has been diagnosed with ADHA and ODD and possibly BiPolar disorder. As I read the other posts, I realize the description of how their children act while on this drug is exactly how my son acts. I wonder if there can be irreversible permanent damage from taking this medicine? He has been on a number of ADHD drugs, none have helped except to make him stop eating and lose weight and he is small for his age, so I have taken him off everything. Has anyone else out there experienced what could be permanent damage from this drug in their children? Even after being off the drug for a year or so? If it could make me miserable within a month, what can it do when one takes it for years? Its sometimes hard to tell the effects of medicine on small children. My son prob starting taking it around 4 yrs old and took it til he was about 8 or 9. Just wondering if anyone else out there has had this happen to them or their children.

My son began taking singulair when he was 6. About that time we were hading into the school years. He was labeled as a "special" child from that time on. Impulsive, aggressive, angry, anti-social, etc. He had a hard time focusing at school and every day was a battle. About 5th grade, after 3 schools, he was diagnosed with ADHD. I never, ever thought that it could be this medication. He was on it for about 4 years off and on during allergy season. I transferred him to a private school for children with behavioral issues and as time went on through therapy and special schooling it seemed to get better. I look back now and see that our "good" times were when he finally went off it for good. The beginning of his Freshman year was great! He had a 3.58 GPA, making friends and finally happy. The unfortunate thing is now that puberty has really kicked in, we are back to the old behaviors but much worse. Impulsive, angry, anxious, afraid of the dark, afraid of death. Violent thoughts, impulsive and very unhappy. I can see now that my son never had ADHD. He was misdiagnosed because thier were no warnings at that time. I don't think it ever "goes away". Even after years of being off of it. Something with the puberty hormones is re-triggering this behavior. IT IS LONG TERM!!!!! Even after discontinued use. Please, please keep an eye on your children. I AM SO ANGRY FOR HIM!! Also, for me. Special school $400 month, psychologist appointments, $300 month, my poor Son in a dark place I can't get him out, PRICELESS. . .I want my Son just to be happy. Thank you all for sharing your stories, it gives me strength that I need for him.

My 10 year old son has taken Singulair on and off since he was 5 years old and has been on it for the past 3.5 years. My son at an early age was affected by a bad marriage and then the divorce when he was 5 yrs old. So we always suspected that his behavior issues were caused by this and I had done everything I possibly could to give them the help he needed to get over and through his issues. He was held back his first year of Kindergarden and during his second year midstream he was placed in a special class for behavioral problem children. Nothing ever seemed to help him, everytime we would see some progress and encouragement we were always blind sighted by a behavior that was always worse. Two steps forward and them 5 steps backwards. I always knew that his problems would never get better overnight so I just kept on going. He was diagnosed with ADHD but because he has some ticking issues I had to put him on Strattera which was did not do a thing for him. I always described him as my Dr. Jeckyll/ Mr. Hyde child. He could be really good and sit still and behave but I think he had to try really hard to do so. He eventually was always overpower by the impulse to show negative behaviors. Defiant, extremely impulsive, always negative and completely miserable all the time. He also went through phases of compulsions. There was always a compulsion of the month- germs, bathroom habits, noises, repetitive words. He hated school and always complained of a stomach ache which i thought he was always faking to get out of school. He had confrontations in school everyday for most of the day. I often thought some of this was because of being tired all the time. We had battled over bedtime every single night. He was terrified to go to bed alone, I tried everything to get him to sleep alone. I wore myself out falling asleep next to him, I would then go to my own bed only to be up with him half the night going back and forth. I gave in many a night and slept with him just so we could get a good nights sleep. At age 8.5 I finally got him to go to sleep alone but the lights haf to be on and he has to know that I am still awake before he will fall asleep. He would always say he didn't want to go to sleep because when he does he has bad thoughts about me and people that he loves. He always had an extremely hard time excepting the word "no"- he would flip out and hit his head with whatever was handy, throw things, break things, scream holler etc. It would take hours to get over it. When he did he would be very remorseful and lovable. He was always in turmoil. Finally in February of this year, this graduated to a new level where he would want to just kill himself and would actually go and pull a knife out of the drawer and just shake with anger as he held the knife to his throat. I was terrified although i really didn't think he was going to harm himself he just wanted to scare me. Then at the end of March when i first heard the news about the possible side effects of Singulair, I had only heard about the suicide effect. Oh great just what I needed was this medicine causing him to do that. The doctor was thinking about taking him off if this summer because he wanted to see if he out grew his seasonal allergies so I took him off immediately. Well I had no idea about the other side effects until my son turned into a completely different kid. School noticed a huge difference in him! His grades went up, his is able to control his behavior, he is happy he is NORMAL. I never suspected this drug as the culprit due to the timing of taking it. Our lives have changed completely. When i first found this site, it seemed as though some of the parents were writing about my child. It is amazing. My son still has some old habits to break but overall he is a wonderful and normal 10 year old boy. He did not outgrow his seasonal allergies but Allegra seems to help in through it. I get so angry- his whole early childhood was ruined by this medicine. He is a labled kid in our school system. This whole experience has opened up my eyes. Thank you for letting me share my story.

My son, now 10...has been on singular off and on, since I don't' know how long...today was the second time he was intentionally hurting his cat. He has told me time and time again about visions while he was awake, violent ones, he argues with anyone and everyone. He has no friends at school. Last year I took him off all his medications to see why his behavior was so drastic, he got so calm, it was like a new boy, but then when he started back to public school...he had to be put back on them again, and again with the singular...
If it was not for this site..I would think my son was sick mentally. But after this...he will see his doctor tomorrow and no more singular...
When I took him off all the meds I told his doctor I was really worried about his behavior and they said it will be okay...he went right back to just out of control. Could not sleep, concentrate at school or at home. He is so smart and he is failing school..not because he is slow, but they kept saying he was add...but when I home schooled him and took him off his meds...he was so great, obdient..not perfect by no means, but just a normal boy...
I hear him right now, in the other room, fighting imaginary people...he seems to go go go..and with no sleep...the dreams in the day time I just thought were his imagination...but now that i hear about other children like him...they are to him real..just like he tells me..he also always tells me how mad he stays..he says all the time I am just angry mom, and I would say at what..he just says everything...
Thank God for this site....now i know..it is not in his head, it is just like I told his doctor...it is his medication..now I know just the one it is..
THank you all..
God Bless all the others here suffering with the same problems...it is just shocking that we as parents and patients, even after telling the doctors, are right...I feel vindicated...I will be printing this off and taking it with us to the doctors...

Hi,
I wanted to post this link just to give some small consolation to our concerns about the lack of awareness THAT DOCTORS HAVE ABOUT SINGULAIR.This is a voluntary online informational site,that doctor's can join. It provides updated information on serious label changes and safety concerns on drugs.Most doctors at this point still get snail mail updates,in the paper shuffle a lot of information gets misplaced.The AMA would like to have all information come in online,eventually.The link is ******
read it and tell me if you think more can be done By the way my pediatricians office does not have online communication.Our life is forever changed because of that ! Information is playing a vital role in this drugs destructive path ,or the lack there of information.Again this is voluntary for the Doctors to sign up .In this modern day of communication how does important information not get where it is the most useful, I ask you?When drugs are making multi billion dollar profits,that would be an educated guess.I am doing another interview with CBS affiliate out of Boston on the 23rd of June,they contacted me.I hope it will reach more people who are still unaware of this drugs serious potential side effects.If any of you parents have some connection to media ,please use it to your best advantage to get this very important information out to the publicAlso so many of you ask how to help.Contact your local Senators and keep bothering them to reach out to the FDA to expedite this investigation. Make a pain in the butt out of yourself and be persistent.I will try to make reference to this site so your stories are heard. Dave and I are coming up on a year since our son passed on to our lord .Still fighting Kate and Dave M.

My 9 year old son only took Singuliar for about 5 weeks. He had side effects almost immediately, he was so aggressive, angry all the time, headaches, stomach ache and feeling like he was going to throw up, bad nightmares, a horrible rash, biting his nails, not focusing in school and got into trouble all the time, no appetite but his little body seem puffy all over. He has been off this medication for 3 months and he is still not 100%. He cries at little things and still has the same rash and with meds it is not going away. He had to change schools as he still was having problems in school. He just seems like he is not the same little boy and something is just not right. I do not know what to do at this point. Doctors say it should be out of his system by now, but if it is than there is permanent damage to his brain as he is just not the sharp little guy he was. We have had to take him out of all sports. Anyone else having these same problems???

I have been reading the posts at this site for two weeks, ever since the day I went to my GP for a check on blood pressure and general well being. As I was getting ready to leave the examining room, he asked how I had been since my last visit, and I responded that I'd been OK, except of course that I wasn't sleeping well. I didn't tell him that I'd had obsessive thoughts of death and dying, severe anxiety, morbid depression, horrible mood swings, and compulsive thoughts and actions. Yes, I've been taking Singulair since it was approved for seasonal rhinitis. It seemed to work well with Allegra, although when my allergies were extra severe, I also had to resort to Benadryl or one of the other "drowsy" antihistamines. When I mentioned sleep, he said "You have heard about Singulair, haven't you?" Guess how shocked I was when he told me about the latest information on the medicine I was taking every night for the last 5 years? Unfortunately, I had been under severe stress because of professional and families issues during the same general time frame, so it would never, ever have occurred to me that a prescribed medication could make me so miserable. My psychiatrist had recommending doubling my dose of Cymbalta, but after some trials of that, I became convinced that when I did so, I felt worse. About 6 months ago, my emotional state went from bad to worse. I began to feel a sense of panic when called upon to make the most innocuous decisions, and was always aggravated and nasty to the people I loved most. With my doctor's mention of Singulair, I stopped taking it. I slept better from the second day of not taking it. In the last 2 weeks, my emotional roller coaster has smoothed out, not perfectly, but enough so that I'm much more like my old self. The stresses are similar, but my reactions are different. Zyrtec (1/2 tablet) works much better for itchy eyes and nose than Singulair did in the first place. My husband and son both have continued to take Singulair with no apparent problems. I think that if one has developed unusual or unexpected emotional symptoms it is definitely worth a trial off Singulair. I wish I had been aware of even the smallest possibility of a reaction such as mine when I started taking it.

I am a 41-year old female with allergy induced asthma, who has been taking Singulair for almost 1 1/2 years now. I was diagnosed with depression about 5 years ago (after my sister's death) and was taking 100mg of Zoloft daily, which my doctor upped to 200mg around the same time I started Singulair for allergy problems. I did not know about the Singulair/depression warnings until searching today on Google for drug interactions on the meds I take in hopes of trying to find a reason for my overwhelming depression. For the past 1 1/2 years, I have lived like a zombie, numb to the world and my family, gave up a $72K job, gained alot of weight, have the weirdest and most vivid dreams, and am tired all of the time, only finding rest after 10-15 hours of sleep per day. I am a working professional, have a Master's degree, and have always considered myself a rational objective person, and not a "lemming" that follows the rest over the cliff. However, the side effects I am experiencing ARE NOT NORMAL and ARE NOT IMAGINARY. I do not know if Singulair is causing my symptoms or not, however, I am going to stop taking the medicine today, and switch to something else. For me, QUALITY OF LIFE is the major issue. While Singulair works great to help me breathe comfortably, I can find other meds to do the same thing. However, what I cannot take is a medication possibly responsible for taking my "life" away.

My son has been on Singulair since the age of 6. He is now 13 years old. He developed seizures 3 weeks ago - temporal lobe aura epilepsy during which he was hearing voices. EEG abnormal, MRI normal. He hasn't started medication for the seizures but I have stopped his Singulair immediately! This was just a hunch - searching the net to see if there is any correlation. I have been to the Pediatrician AND the GP the past 3 weeks and no one said anything. I think a great number of children are on Singulair in SA. Does anyone know about the possibility of this danger?

i'm a mother of 1yr 8mths son. my son gets flu n cough about once every month. we went to this doctor that practiced phlegm suction (because babies have phlegm in their bodies). but since he knows how to reject the tube into his mouth, we think we can try another doctor. so we went to see a specialist. after telling her the history of our son, she came into a conclusion that our son has a mild asthma. then she prescribed a ventolin and singulair. the stock is only for 2weeks then we shall continue the medication for 2months. he shows very positive effects- easily sleep (which is very rare except he gets too tired), sleep soundly and gets better quickly. until recently he got high fever and we went to the regular doctor. he said it is not good to feed the baby with the medicine that heals cough quickly because the phlegm won't got out. then we stopped the singulair. when the fever gets higher and shaking, he's admitted. there at the paediatrics we got another opinion saying that early stage of asthma we don't use the singulair. they said, besides expensive it also not appropriate for the kids. though our son got admitted but luckily we got very useful information from the trustful sources! as for our son, he acts like so active like never before. i'm not sure it is because of the side effects or kids are like that..
just 1 thing i don't understand, why people that called themselves paediatricians, children's specialist, don't really know what's best for the kids..what a pity..i think they should read more..

My 17 year old daughter started Singulair last July for Asthma. She is brilliant and scored in the 99% on the ACT college entrance exam. She won 3 scholarships totaling over 60,000 and earned 27 college AP credits while still in high school, volunteering for the Red Cross, singing in choirs, and playing the lead in her high school musical and 3 plays. She was funny, sweet, and had many friends.
She left for college 3 weeks after starting the medication and saying she was breathing better. Her grades were terrible, even though I was able to check to see she went to class every session, as posted online. She became very depressed, withdrawn, staying in her dorm room. She was sleeping up to 20 hours straight without waking up. She didn't call her friends when she came home and only wanted to sleep. She was like a different person. She was so aggressive that she tried to run out in the middle of the night and attacked me when I tried to block her way, to the point I had to call the police. They diagnosed her with new onset major depression and ADD. They started her on Zoloft for 2 months and she got much worse and was removed from Zoloft as a result. She said she was too tired to stay awake even in class. We had a sleep study done for Narcolepsy and it was negative. Until reading these posts, I didn't connect the Singular. Everything I am reading is so familiar, it makes me feel ill. I can't believe I didn't know, I am a nurse. The guilt is horrible. I hope to get my daughter back, but she lost all her scholarships and only managed to pass 16 hours in one entire year of college. I can't afford to send her back without the money she lost. They even put her on a one time only probationary period to ever get Federal or State Financial aids and loans again. Singular had to be to blame. I am simply thankful my daughter is still here, she was very suicidal. My heart breaks for those of you that lost your children to the side effects of the drug. We have to get the word out by each filing a complaint to the FDA, and filling out adverse event forms.
Please don't let Merck get away with this. We need to act, even if your child was one of the lucky ones and is back to normal now.

HI,

As with many others I found singulair to be a miracle with asthma. No more rescue inhalers. I am not sure which of my current meds is causing the very vivid, often gruesome dreaming I have been having as THREE of them show this as a side effect. I am referring to Cymbalta, Xanax and Singulair. It may be that the combination of the three is just too much and is causing brain toxicity of some sort. I started cutting down the cymbalta, and also the Xanax days ago. I found myself still waking up remembering vivid dreams that I would rather forget. I remember them all like they just happened in living color and detail, days and weeks later. At first I thought it was interesting, but now I just want to FORGET THEM, anyone have ideas???? Help!!! ( I also developed depression and anxiety after being on singulair for several years which is how I ended up with the two additional meds.

My 5 years old son has been on Singulair for 9 months. His allergy symptoms have completely gone away. He’s no longer has his night time cough, bloody nose, and frequent croup due to allergies.
My life has been a living HELL from the moment I started this medicine. Before he was on this medicine he was always a pleasant, smart, well-behaved child. Right after he started singulair he began having temper tantrums, becoming increasingly argumentative, not listening. He gets mood swings like you would not believe cry and/or yell at us over the silliest things, kicking, screaming, nightmares, and became very physically aggressive. We were unable to take him places because we never knew how he would behave in public .He was extremely unhappy little 5 year old boy. He also complained of upset stomach and fatigue. Even his school complained about his behavior and they said that he might have PDD. After consulting with doctors we got the assurance that he does not have PDD, but we end up changing his school anyway.
Being a first time mom I never thought it was the medication, I thought it was just a normal behavior. I thought as a parent I must be doing something wrong! I couldn't believe that other parents have gone through the same nightmare.
Two weeks ago the doctor handed me a report about singulair and its suicidal side effect and ask me to stop using this medicine for a while. Since then I started to notice a dramatic change in our son's behavior. He woke up singing, laughing. He wants to help with chores. He is doing great with his school lessons, and very patient with everyone. He is now a more stable and friendly 5 years old.
Wow, I have a completely different child, and thank God I took him off singulair.
As parents, please let’s do something to stop poisoning our children.

My almost 3 year old daughter has been on singulair for almost a year and we have noticed severe mood changes in her behavior. She is become aggressive with sever temper tantrums. This has also affected her nighttime sleep and daily routine. We just decided to take her off singulair and we are hoping that her mood changes. Please be aware of the possible side effects even if your doctor says that the medication is safe to take.

My son (27 months old) has been taking Singular for about a month and a half now to treat his asthma. His asthma is doing great, but since he started taking Singular he has been having awful nightmares. At the suggestion of his doctor we started giving him his medication in the morning instead of at night to see what happened. That just started effecting his naps and night-time sleep.
The doctor is now suggesting taking him off the Singular to see if he nightmares stop. I'm hoping everything improves after stopping Singular, but don't know what to do about the asthma.

Singulair gave me multiple bumpy rashes on different areas of my body. It took over a year for the rashes to clear up after stopping my medication, even with prescription cream from my doctor. Very annoying and embarrassing. I had them on the tops of my feet, my right knee, right thigh, abdominal area, and top of my left hand. My doctor was not able to determine why it would give me rashes, so I did some research. It is a little known side effect, so beware! It only happens to 1 out of 10 people, but you could be like me and be that one person. Other than that, I was asthma symptom free - that's why I continued to take it until I couldn't take the rashes anymore.

SINGULAIR IS A PIECE OF SHIT... PLEASE BE AWARE OF IT'S MOOD CHANGING PROPERTIES, NEVER EVER GIVE YOUR CHILD THIS MEDICATION... IT TOTALLY CHANGES YOUR SON'S BEHAVIOUR....

PLEASE LET EVERYBODY KNOW ABOUT THIS, MY CHILD IS ANOTHER PERSON THANKS TO THIS PIECE OF CRAP MEDICINE...

I was put on Singulair about 2 years ago because of my COPD. No allergies were ever mentioned by my Doctor. This site has been a god send for me.
Since starting Singulair I have been put on Digoxin for an irregular heart beat that I never had before. I have been put on Gabapentin for leg pain and cramping in my feet whenever I put my feet up or laid down to TRY and get to sleep. I have been put on so many pain killers for back pain, leg pain, neck pain I can't even count them all. I won't take them, they make me so sick. Now I find that I wake up with a headache every morning, feeling sick..oh yes, I was given medication for nausea also. And I don't want to forget the six months of experiencing never ending dizzy spells. That was another medication to ad to the list of ALL THE MEDICATIONS I HAVE TAKEN OVER THE PAST 2 YEARS for the side effects of Singulair. I stopped taking it a couple of days ago and I woke up this morning feeling so good. Oh, lets not forget the Xanax, Prozac and Cymbalta for depression.......OMG! I'm looking forward to see how many of these medications I can toss now that I've stopped taking Singulair. I just wish I had found this site two years ago, oh yeah, I am on Advair also. I've been, lets say "in a chronic bad mood" too. Some would say a "B". I've already noticed a difference there too.

I would like to urge everyone to report adverse drug reactions to the FDA. Without a supporting data base, things move way too slowly and other people get hurt. I was doing some further work on quinolines/quinolones and ran across a medical researcher who starting writing about quinolones in 2001. The warnings that finally appeared on the quinolone drugs were placed in 2005. Let's do everything to keeping that from happening to parents.

Here is the researcher who wrote about quinolones so that you will have the reference.

******

My Grandson is one of the children who has experienced these horrible side effects. In the two months that he has been taking singulair, I have watched my daughter and her husband become increasingly terrified at the changes in our happy loving little boy. I am urging each and everyone of you to contact Merck and the FDA and file a complaint in order to stop this drug from being used in children. It is one thing as an informed adult to take a medication with potential side effects, it is a totally different thing for a parent to give a medication that they have been led to "Believe" to be safe to their child. There is strength in numbers and if we all contact the news, Merck, FDA, any one we can think of and inform them about what is happening to our children on this drug, we will be able to stop other potential victims from experiencing what our families are going thru....Please I urge you to continue to spread the word about this drug - tell everyone you know. Remember, Merck doesn't really care about our kids. They only care about the bottom line - PROFITS.

I have a three year old son who has severe allergies. He's been taking singulair for 2 years on & off just in the allergy season. He started taking, singulair again in the beginning of April. One morning he woke up and both eyes were really swollen and red, I called his doctor's office and told them i thought he had pink eye, after 2 different drops and no change I brought him into the doctor's to see if it could be his allergies, and they agreed and started him on Zyrtec. I still was not impressed with the results so i brought him back yet again to see if we could see a specialist. Instead they put him on nasonex to try.
In the beginning of March I started to see a change in my usual happy fun loving son. He was scared to sleep in his bed, waking up in the middle of the night from bad dreams, uncontrollable screaming fits that would last up to an hour, saying he wants a Boo Boo. At first we thought it could be jealously over his new brother, or maybe something at his school.
Then i found this website and everything clicked, how scary it must be for a child to have these horrible thoughts and not be able to understand or stop them. What are the people at merck thinking??
Can any one tell me when the symptoms stop. He's been off for a week and we see some improvements. But he still has these fits with almost an OCD tendency to them (mainly when he's overtired), stomach pains, lack of appetite.

My nephew is 7 and has been on Singulair for probably 4 years. His symptoms developed over time but recently have exploded. He has epilepsy so most of the things that he has experienced has been blamed on that. However, today his doctor took him off singulair and said he believes his symptoms are caused from the drug. He started having head drop seizures, fell out of his desk and cut his face one day. He has also been depressed, had severe anxiety attacks for the past 8 months. Several months ago, he started having such severe nightmares that it is almost impossible to get him to go to bed and go to sleep. Recently he began "seeing dead people" and "monsters" that we trying to kill him even when he was awake. He has also cried many nights with leg cramps and severe stomach pain. I will update this page in two - three weeks to let you know if these problems go away now that we have stopped the singulair.

In September of 2007 my then 13 year old daughter was put on Singular for mild asthma. At the time she was a straight A student, vice president of our school and a popular girl who's guidance counselor described as "the glue of her grade" because she was so well liked. In November she told me that she was struggling with advanced Latin and Science. She asked to drop down to on grade Latin so we did. In December her science teacher notified us that she had a C average. She told me that she thought she had ADD/ADHD and she couldn't keep up. At the same time she was having a lot of problems with friends at school and we just attributed it to being 14. 3 weeks ago we discovered that she is significantly behind in English and it was then that she told me that she is been having horrific night mares. She said that they usually involve someone killing her or her killing herself. She said that they were so graphic that she couldn't repeat it out loud. She also said that she would feel waves of anxiety that would come over her at school and she would act "witchy" to the kids in her class for no real reason. She said that sometimes when she is trying to do her homework she will read the same passage for 2 hours and still have no idea what it's about. She also said that the suicidal thoughts from her sleep happened during they day and that she had thoughts of her harming herself. Fortunately her pulminologist told us that this may be caused by singular and we immediately took her off of it which was 2 weeks ago. She has only had 1 "bad dream" not even a nightmare since. She had one anxiety attack 3 days after she was off it and she describes her moods as the "cloud lifting....slowly". Now, we have to pick up the pieces. Her grades have suffered, her friendships have suffered and most of all her self esteem is very low. I'm grateful that we found out the cause but I feel as if my daughter lost a year of her life and I worry that because Merck won't admit there are side effects we can't find out how long it remains in their system. Is anyone else concerned about the long term affect and has anyone pursued a class action suit to try to get this drug tested properly?

This is also a follow up. My daughter 11 was put on Singular 4 years ago. The first symptom we noticed was the rubbing for her thumb abd fingers. We thought that it was anxiety because i had recently been hospitalized. For the past 4 years we have attributed most of her symptoms tp PANDAS. She also found out recently that she has high cholesterol. All of these kids having the same side effects can not be a coincidence. I will file a report with the FDA. We took her off of it about 1&1/2 weeks ago and have seen definite improvement. With everything she's been through I'm sure that she's continue to need support even after this medication gets out of her system.

One more thing I have noticed is OCD behavior. He is constantly rubbing his index finger and thumb together. At first it was one hand, now it is both hands. This has been going on for about 2 months. When asked why, he says he 'just feels like he has to do it'....

Both my sons have bad allergies. Both were recently prescribed Singulair after other drugs were not very effective. My oldest, 12, started feeling "strange" and asked to be taken off Singulair. He was not himself on the soccer field or at school. Since we stopped the medication, he has returned to normal. My 8 year old had a much worse reaction. He has bad mood swings and tonight became suicidal. He was searching the kitchen for knives to stab himself. He had fits on the carpet beating himself and the floor until I got him a pillow to take his aggression. My wife notified our doctor and school counselor. We're stopping his Singulair immediately.

My 6 year old daughter Started taking Concerta about 3 months ago. Some things I've noticed are, loss of appetite and loss of weight.
She has had very noticeable academic improvement at school. She is concentrating better. At home I l see how she can go through mood swings and emotional episodes. She snaps all of the sudden and cries if things don't go as she expects. I'm not sure why this is happening. She is currently on the 36 mg. I really don't like having her on this or any other medication. It's very frustrating trying to decide what is best for your child.
She is also taking Singulair for her asthma and allergy symptoms. I was reading the reviews Singulair medication and they are scary! I don't know if her emotional episodes have to do anything with singulair or concerta med side effects. For now I'm definitely taking her off Singulair and see what happens.

I have two sons on Singulair, my three old was suspended today from pre-school for bad behavior. Screaming, biting, scratching, and hitting have been going on for the last few months. But worse the past two weeks. He has always been active and played like a boy, but he has been getting violent. We have tried positive reinforcement, praising good behavior both verbally and with rewards, I have tried time-out, being grounded, not being able to participate in activities, no t.v. and old fashioned butt spanking. All of this with no positive results. I am not looking for an excuse for my child's behavior, but could Singulair really be the cause of his aggression?

My son, Wilson, is a bright, easy-going, athletic 12 year old who has a history of asthma and allergies. After several asthmatic episodes from age one year to about four, he was prescribed Singulair. The asthma triggers seemed to be change of season or congestion from a cold, but not from exercise or physical exertion. As I recall, his asthmatic episodes seemed to decrease after he was on 5-10 mg of Singulair, and even more so with each passing year. Over the years, of my three sons, Wilson was the one to catch any virus that came around and missed more school time than both of his brothers combined. Often, he was the only one to get sick from a virus, which never passed to anyone else in the family.
About five years ago, Wilson started complaining of stomach aches. He was tested and was prescribed Prevacid on and off since then with varying success. In the last couple of years, headaches would come and go. He was re-tested for allergies and blood work with no conclusive results. About 2-3 years ago he would complain that he “felt funny…like he needed to do something.” Further conversations revealed that he was expressing anxiety. He’s a good student, has lots of friends at school, and is popular among his sports team mates. Occasionally, a teacher here and there over the last couple of years would note that he did not participate enough in class, or did not appear to be attentive. We thought perhaps he is shy. Still his good behavior, agreeable personality and diligence otherwise earned him good grades overall. He loves school and was very unhappy having to stay home when he was sick.
This past winter, he seemed to catch a virus about once every month and a half which caused him to miss 2-3 days of school. Headaches and stomach aches were common with each illness (sometimes nausea), and sometimes these same symptoms when he was not ill. He would only complain when they were prolonged or significant. Trips to the doctor did not result in anything conclusive. Again, Wilson was only too happy once he returned to school.
He claims that sometimes in school he feels like he’s in a fog and has difficulty concentrating. He gets plenty of sleep and sometimes sleeps up to ten hours during the weekend. We attributed it to adolescence and a busy schedule. He claims that this year is the easiest for him at school, and his social life with his friends is very active. His friends’ parents like him and find him to be an agreeable child. Other adults mistake his sometime mumbling answers and lack of eye contact rude. We concluded that he is just shy. He is the most hyper of his brothers, and has difficulty sitting still and constantly exclaims that he’s bored. We chalked it up to being an active boy. His grades are good in school and we never get complaints about bad behavior.
The last illness started a week ago, and he’s still out of school. The doctor said he had no significant allergy symptoms, other bacterial infections, and his blood work all returned with normal results for white blood counts, liver and kidney functioning and anemia. He can’t return to school because of his constant headaches (which cause pain in different parts of his head), nausea, constant stomach aches, no matter what he eats, and feelings of anxiety, mostly in the evening hours. He’s also complaining of dizziness, leg cramps and other muscle soreness. The notable difference in this illness is the anxiety. My husband and I take turns staying home with him, but if we left him alone for a half an hour at a time while the other was in route picking up a sibling, he became very anxious. In the past, he seemed to enjoy some alone time at home so he could play his computer games. He also becomes easily dizzy with shooting pains in his muscles. The doctor said that viruses can manifest themselves in later stages in the form of sore muscles. However, he was concerned about Wilson’s feelings of anxiety. The anxiety had not been as prevalent in prior illnesses. I finally signed onto the internet reading all the stories about other parent’s observations of their children on Singulair. My husband cautioned me about “internet diagnosing” with symptoms and stories that can be easily taken out of context in hope of self-diagnosis. I’ve always thought that Wilson’s doctors have had good judgment. Both my primary physician and allergist don’t think that Singulair has caused these symptoms, but agreed to take him off as long as we monitored any effect on his asthma.
I don’t know what to think. I want the cause of these problems to be the Singulair, because it’s an easy answer. Today will be the first day he’s off the medication. He probably won’t go to school again tomorrow. We’ll wait and see what happens…

I am writing in response to the last posting and to all others out there who worry about long lasting effects. My son was on Singulair for about 3 years (ages 3-6). He was diagnosed with an anxiety disorder in Kindergarten and we took him to a psychologist and psychiatrist and read a lot on anxiety to try and help him. But despite some success with his behavior using exposure therapy, his mood kept getting worse - he seemed more depressed, and started talking about death. That's when I got desperate and went to the web and googled anxiety and Singulair and found this site in January 2007. After reading post after post describing children suffering in the same way as our son, I immediately stopped the medication, though the doctors were reluctant and assured me the medicine was safe.
Within a day or so I saw a noticeable difference in my son - like a cloud had lifted. The most troubling of his symptoms - such as the talk of death - went away quickly. But his anxiety did not immediately go away. Anxiety - especially over time -can lead to patterns of thinking and habits that can outlast the original problem. Whenever he felt anxious and overwhelmed, he would act out, become easily upset, and was unable to work things out rationally. We continued working on behavior management. One technique that I found very useful is the Collaborative Problem Solving (CPS) method outlined in "The Explosive Child," by Dr. Ross Greene. I also enrolled him in social therapy groups. He also got support at his school. After stopping the medication, he really began to respond to all these interventions. He steadily got better, and by the beginning of 2008 we all noticed a significant shift - not just our family, but his teachers and group counselors. Now he just seems like any other kid. Every once in a while a new situation will raise his hackles a bit, but then we just take it slow, and help him overcome the fear.
Today, when I see him humming a song to himself, skipping down the sidewalk, or shouting out a hello to a friend, I remember that there was a time when I had stopped expecting him to ever do these simple things, and I am so thankful for the parents who posted here in 2006 and 2007 and gave me the courage to follow my instincts.
I have faith that your children will keep improving. But if they are still anxious, there is a lot you can learn about anxiety - either in books or on the web - that can help you understand and enable you to give your child the support he or she may need to navigate their lives as they recover and begin to form new habits and thought patterns.
Good luck!

P.S. One note about leg pain - both my older sons suffered from this, and the oldest didn't take Singulair. I have always assumed they were growing pains, but who knows? I will say that ibuprofen is very effective, along with rubbing their legs.

Is there anyone out there who has a child with side effects after being off this drug for several months? Our 9 year old boy had such horrible side effects and now even off seems to still not be able to control his emotions. He gets angry so easily and has problems in school with friends and staying focused. He cries a lot still and has lost all his confidence in any decision making. He was never like this before taking this drug. It appears that it is taking him longer to get it out of his system or he has permanent damage. We are so concerned. All doctors tell us it takes 2 to 4 weeks to remove this drug from your body. Our son was only one this for 5 weeks and was very sick.

We have all been saying that our issues regard not being informed about all of the possible side effects. And, we know that Singulair works well for some people. Nobody wants to take a good drug away from those for which it probably performs miracles. People who have toxic side effects have a right to know up front.

My observations about montelukast's chemical structure are either general or not quite 100% correct or could be quite vague - so forgive me. I do not claim to be good at organic chemistry. But from doing a little work, I have come up with some observations.

1. It would seem to me that montelukast might work quite well for people who have developed mold category related asthma. I observed that chloroquinolin, a component of montelukast, is a good fungicide effective against Aspergillus, Alternaria, Cladosporium, Penicillium and Candida. Dust mites can only digest if helped by aspergillus so they go into the mold category. Molds produce millions of spores so anyone who lives in contact with mold would be chronically sick from their presence. Then people get hypersensitized to that.

I am probably wrong but I could imagine that montelukast is: 1) a ligand that binds to an empty cysLT1 receptor for a period of time 2) 7-chloroquinolin-2-yl which either acts intact or breaks down into a quinoline fungicide so that it kills the chronic mold/fungus infection and 3) a sulphur/methyl anti-inflammatory component that tells the t-cells that they are not needed so they will die. Wow, that would be great for mold asthma if it was completely non-toxic. It would be also great under controlled circumstances for many people who are mold-miserable. If I am wrong, I better go out into my garage and start inventing such a drug.

This is my visualization to try to explain the side effects of neurotoxicity. So adverse reactions could be to the quinoline component as an allergic reaction or dose related so that it just built up to a toxic level over time. There are many signs that t-cell populations are significantly reduced by montelukast. The fact that the Italians can do it in the test tube might be that it's a chemical component of montelukast designed to cause the t-cells to die.

Montelukast is a large molecule so Artie says it cannot penetrate the blood brain barrier. That would be an argument if nobody was complaining about neuro-psychiatric side effects. The neuro-psychiatric side effects are identical to quinoline and quinolones. When I read about Lariam, it just sounds like a more extreme version of Singulair side effects. Chloroquinolins were used before they invented Lariam, which is stronger. The malaria Plasmodiums became immune. Hallucinations, anxiety, depression, suicidal thoughts are completely consistent in all of the quinoline/quinolones. If montelukast breaks into sub-molecules then quinolines easily penetrate the blood brain barrier.

I find clinical evidence that montelukast may act as more than more molecule. And, that there is a rational for the existence of the chloroquinolin and evidence that it may be the source of toxicity.

I am glad to risk being called crazy. That is what the internet is for. We can present our ideas and discuss. So, just take this with a grain of salt. If I am close to the truth, this post will find it's proper home.

Chris, truthfully your posts were a waste of your time. The majority of the people here who have actual instances that they can account for. For you to dismiss that is ignorance in it's true form. QUESTION? what drug company do you work for? As you have a valid point there are side effects with any medication prescription/over the counter/herbal, whatever organic/inorganic source it may be. As a medical professional I HAVE SEEN THESE SIDE EFFECTS FIRST HAND! I also have a friend who works for the FDA who has informed me of many developments that unfortunately because it is under investigation I can not post. I also have had a first hand experience with this drug with a young child. I understand some parent/people may also be ignorant and be quick to blame the singulair without ruling out any other possibilities. However the fact of the matter exists here. So again for you to dismiss what the majority of the people here are trying to do is quite frankly rude. To go through hell and back with my four year old innocent child, to take him off the med and now everything is fine. Coincidence... I think not. He was evaluated by psychiatrist, neurologist, his pediatrician-who consulted with 3 others, and an allergist and all come to the same conclusion. I will advocate until every parent/patient knows the risks. It is my responsibility as a parent. If I can prevent another child from going through this, even just one then I accomplished something. So again I ask you to be sensitive here and not try to make those of us who have valid concerns feel as if it may be otherwise. Do your research first!

I am a 50 year old women. I had bronchitis that turned into severe asthma.
Could not stop coughing. I have been on Singulair for over a year. Have had weight gain, Hand numbness,Stomach problems. Even had an colonoscopy but turned up nothing. Now I understand after reading all these posts. The weight gain alone was driving me crazy. Limiting myself to 1200-1400 calories, eating only lean meats and vegetables.Exercising and loosing MINIMAL weight over a 4 month period. I felt like I was doing something wrong. Ive thrown my Singulair away after reading your posts. Will figure out something else if my allergies and or asthma flairs. Just not worth it. Will repost after Ive been off a while.

I'm an 18 year old male and I've been taking Singulair for years; I don't even remember when I started taking it. I've had chronic sinusitis my whole life, and use a Singulair 10mg/ Allegra 180mg combo to control it. I never gave it a second thought. From my adolescent years on, I've been able to sleep (if undisturbed) for 15, 16+ hours a night, and have always felt like I was in a fog during everyday life. Getting out of bed has always been a terrible problem for me.

Throughout high school, I became progressively more depressed and apathetic toward school work, to the point where I dropped a number of classes my junior year. Got put on Prozac for a while, it helped a great deal with the depression, and seemed to give me enough energy to get through the week. I discontinued it after a year or so, everything was going okay (aside from mood swings and tiredness- explained away as symptoms of my age/hormones/going to bed too late), and then I went to college.

I had a mild depression that I think most people get upon leaving home for the first time, but the real problem was anxiety; I had a number of anxiety attacks, and decided to transfer to a school closer to home. I started Celexa and therapy- the celexa seems to take the edge off, but I fear its making me even more tired than before.

I've just heard about the whole Singulair controversy, and I am not taking it from here on out. I really hope that this whole ordeal was brought on primarily by the Singulair. After a month or two, I'll repost to report whether the symptoms went away.

My son is 5 years old. He was put on Singulair in August following a case of pnemonia. He has asthma. I found it worked well since I was barely using inhalers anymore. His eczema was even getting better. So I was happy with the medication. He also seemed to be getting more agitated with us. At least three times a day he would have an outburst towards his brother or us, like he was going to punch or hit us. Then I would say "why are you mad at me" and he would say "I'm not mad, I'm frustrated" and then burst in tears. He was getting a lot of time outs. Then two months ago he started saying "this is not a good day" or "this is a sad day". I was wondering if singulair was to blame, but it wasn't until I heard concerns from other moms. I took him off it as an experiment and noticed the next day was without his outbursts. Then I just never gave him anymore...and I am relieved to say he is as "normal" as I remember him before Singulair!!! He also was unable to get to sleep easily on Singulair, sometimes 1, 2 and even three hours to get to sleep. Now he is out in 20 minutes if not less. I haven't talked to the Doctor yet. I have noticed his eczema is flaring up again and he has used his inhaler this week (although he has a cold). I think I can deal with that without Singulair and the problems I am suspicious come from it's use.

As an adult, I have had no problems with the drug. That being said, I wanted to remind readers that very few drugs, if any, are tested on children. As any good pediatrician will tell you, children are not just little adults. Drugs companies and doctors should not just adjust dosages and say that a drug is OK for kids. As a mom, I'm cautious to give my kids any medication that is new, including vaccines that are new, because I know testing has been limited with respect to children.

Hello,
I have posted to this site before since my daughter was on singulair for 2 years. She has not had it for 4 weeks now and so far so good. Although my daughter didn't seem to have the behavioral/psyche side effects many have reported I wanted to take her off because I hated giving her a medication every day and for so long. No one in my family has ever had to take chronic meds like she has. Anyway recently a coworker of mine said his daughter too had been prescribed singulair. I told him about the side effects people were reporting especially in children and gave him this website to check, but up to now he says he hasn't gotten around to it. I guess he's trusting his doctor as so many of us have done. At least he was made aware and warned if anything should come up.

My 5 year old son was taking Singulair for about 2 years when I came upon this site. I immediately called his allergist and got no answers, so I decided to take him off of it. Within 24 hours I noticed a big difference. He use to not sleep. He would be up all night. he uncontrollable outbursts at school, and home stopped. He is now the sweet boy I remember. I really think he was over medicated. He takes Zyrtec in th morning and was taking Singulair at night. I am appalled at the fact that doctors are over medicating our children.

Thank you for this site. I now can love and hug my child agan.

I am a 57 year old man, who has been suffering from asthma several years. This spring my doctor put me on Singulair as an additional medicine to my cortisone-inhalator. after one month I feel symptoms of depression an mood-changing, severe ups and downs.
AND - as an additional symptom i have partially lost my feeling in some fingertips, and now parts of my left thumb and even a feeling of "cold2, mostly in my left hand.
anyone who share that symptom?
M.

My 13 yr old daughter was put on Singulair along with Asmanex and Clarinex for her asthma about 6 weeks ago. Everything seemed to be going very well at first and her symptoms were starting to get controlled. I started noticing after about 3 to 4 weeks that her temper and attitude were getting much worse. Anyone with children this age knows what I mean but this was like a 180 degree turn for her. Her actions were becoming totally out of character. Before I knew it she would cry and get highly upset over the least little thing. Week 5 came around and things totally bottomed out. She came home from school and WAS NOT HERSELF. Made comments about how she hated her life and it was not worth living. Later that evening we had a big argument because I was telling her nothing was worth saying that. She went totally out of control and I had to physically restrain her to calm her down. It appeared everything was better so she went to her room. I went down to check on her and she calmly told me that she had taken advil and tylenol pm and things would be better for her forever now. We went to the ER where they made us wait for at least an hour, then finally took her back. She had to drink two cups of charcoal and was poked and prodded repeatedly. They did a catheter to get a urine sample. She was very cooperative but also was in a complete daze so who knows. The poor child couldn't even lift her head up when she started the vomiting to get rid of the drugs. It was very upsetting and sad. Her heart rate and blood pressure went very low and I really thought in the back of my mind that this was it. Finally, after several hours she started coming out of it and they sent us home. The next evening when she was starting to really come around she proceeded to tell me how she had been seeing a man walking around in her bedroom at night and she was afraid to go down there. Breaking down and crying telling me about all of the horrible nightmares she had been having recently and didn't know why. I thought what am I dealing with here? This just isn't her. Three days ago I heard about singulair in the news and looked it up on the internet. OH MY GOD THIS SOUNDED LIKE US!!!!! I immediately had her stop taking it and the next day phoned her asthma specialist who agreed she should stop now. We are going to watch her for two weeks and see if any symptoms return and then decide if she needs something else or will be fine on just the Asmanex. As a side note, she also mentioned being unable to concentrate in school (unable to do even the simplest math problems) and that her brain felt confused or like something was missing. She said this had been bothering her for several weeks. I know it was this drug. They really need to take this off the market NOW and stop flirting with disaster. The only reason I posted this was to let others know they are not alone.

Singulair does interact with the astrocyte in the brain.

The role of the cysLT1 receptor (Singulair blocks this receptor) and the astrocyte in the brain has been studied. For anyone from Merck to say that there are no mechanisms by which Singulair can affect the
brain is ludicrous. If the Chinese researchers are correct, then Singulair very clearly affects the brain. Certainly, we don't know exactly how or when the effect would be good or bad. Under what circumstances would it be beneficial and under what circumstances would it be harmful.

For quite a while, researchers have been hypothesizing about the role of the astrocyte in brain function. If we go to look for theories, we will find them. Here is the theory of Dr. Dale Antanitus. I am no here to promote anyone's theory in particular but just to point out that they exist.

http://www.antanitus.com/hypothesis

We can see that the Chinese researchers have gone forward to look at potential links between the cysLT1 receptor (Singulair receptor) and inflammatory response in the brain. The 2008 study showed a link between the astrocyte and the cysLT1 receptor (Singulair receptor)

1: Glia. 2008 Jan 1;56(1):27-37. Links
Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation.

Huang XJ, Zhang WP, Li CT, Shi WZ, Fang SH, Lu YB, Chen Z, Wei EQ.
Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, People's Republic of China.

We recently found that 5-lipoxygenase (5-LOX) is activated to produce cysteinyl leukotrienes (CysLTs), and CysLTs may cause neuronal injury and astrocytosis through activation of CysLT(1) and CysLT(2) receptors in the brain after focal cerebral ischemia. However, the property of astrocyte responses to in vitro ischemic injury is not clear; whether 5-LOX, CysLTs, and their receptors are also involved in the responses of ischemic astrocytes remains unknown. In the present study, we performed oxygen-glucose deprivation (OGD) followed by recovery to induce ischemic-like injury in the cultured rat astrocytes. We found that 1-h OGD did not injure astrocytes (sub-lethal OGD) but induced astrocyte proliferation 48 and 72 h after recovery; whereas 4-h OGD moderately injured the cells (moderate OGD) and led to death 24-72 h after recovery. Inhibition of phospholipase A(2) and 5-LOX attenuated both the proliferation and death. Sub-lethal and moderate OGD enhanced the production of CysLTs that was inhibited by 5-LOX inhibitors. Sub-lethal OGD increased the expressions of CysLT(1) receptor mRNA and protein, while moderate OGD induced the expression of CysLT(2) receptor mRNA. Exogenously applied leukotriene D(4) (LTD(4)) induced astrocyte proliferation at 1-10 nM and astrocyte death at 100-1,000 nM. The CysLT(1) receptor antagonist montelukast attenuated astrocyte proliferation, the CysLT(2) receptor antagonist BAY cysLT2 reversed astrocyte death, and the dual CysLT receptor antagonist BAY u9773 exhibited both effects. In addition, LTD(4) (100 nM) increased the expression of CysLT(2) receptor mRNA. Thus, in vitro ischemia activates astrocyte 5-LOX to produce CysLTs, and CysLTs result in CysLT(1) receptor-mediated proliferation and CysLT(2) receptor-mediated death. (c) 2007 Wiley-Liss, Inc.

PMID: 17910051

The astrocyte has been studied to see how it functions in the brain. The astrocyte:

1. may perform a role in the physical structuring of the brain
2. may perform a role in providing neurons with nutrients
3. may perform a minor role in the maintenance of the blood brain barrier
4. may perform a role in neurotransmitters
5. may perform a role in the regulation of ion concentration in the extracellular spaces
6. may perform a role in neuronal regulation of blood flood
7. may perform a role in the protection and repair of neurons

TO LIE TO PEOPLE REGARDING THEIR HEALTH IS CRIMINAL AND SHOULD BE PROSECUTED. PEOPLE OUT THERE ARE GETTING SICKER IF THEY ARE EXPERIENCING SIDE EFFECTS BECAUSE MERCK IS LYING. SOME PEOPLE MAY NOT EXPERIENCE SIDE EFFECTS BUT WHY NOT TELL THE TRUTH AND SAY THAT THERE COULD BE SOME PEOPLE WHO HAVE PSYCHIATRIC SIDE EFFECTS BECAUSE THERE IS A PATHWAY FOR THAT TO HAPPEN.

One of the most important questions we should be asking as parents is:

How does Singulair - a leukotriene receptor antagonist (blocks the receptors) affect the normal function of the mast cell?

The mast cell is the FRONT LINE DEFENSE against invading micro-organisms. When Singulair was invented, there was limited knowledge regarding the mechanisms by which the mast cell performed it's function. In my opinion, the focus was very narrow - those interested zeroed in on how the leukotriene receptor performed a role in the cause of asthma attacks and how ashma attacks could be prevented. Well, that's good preventing asthma attacks. But what happens to the mast cell if that receptor is blocked on a long term basis. I am not suggesting that blocking the receptor is bad but what if the long term effect is different than what we are are lead to believe-which is this is a safe medication with no known long term effects. What if the leukotriene receptor was just blocked short term a week or two to allow the body to clean up the mess from the last attack?

I seriously question what is going on with all of these infections. Are they related to crippling the mast cell? Parents should be allowed to question. If Merck doesn't want to answer questions regarding what happens to the mast cell (including are the numbers of mast cell decreased on Singulair), then something really BIG is missing. If by any chance (unknown at the moment) that the mast cell is significantly changed and therapy by montelukast is proper on a short but not long term basis, so freakin' what if Singulair is not a huge money maker any more.

Parents deserve every answer possible when decisions regarding their child's growth and development is on the line. I hope that we get some answers.

Of course, what was there in 2002 were new questions-not necessarily answers about the mast cell. Did anybody apply this to Singulair studies?
May 2002

From Journal of Clinical Investigation

Pattern recognition receptors on mast cells
The Toll-like receptors (TLRs) fit the definition of pattern-recognition molecules, which were originally postulated to allow the innate immune system to detect the 'molecular signatures' of various infectious agents. Although the innate immune system has no memory, it shows a degree of specificity, in part because the various TLRs recognize different sets of pathogen-associated molecules. Dermal mast cells are usually associated, not with the innate immune system, but with atopic dermatitis, but Supajatura et al. have found that these cells also express TLRs. They report here that TLR4, which binds the gram-negative product lipopolysaccharide (LPS), and TLR2, which binds peptidoglycan (PGN) from gram-positive organisms like Staphylococcus aureus, induce distinct mast cell responses. Staphylococcus is known to exacerbate allergic dermatitis, but it has generally been thought to act by inducing antibacterial IgE's, which trigger mast cell degranulation by stimulating the IgE receptor. Interestingly, the authors show that the interaction between PGN and TLR2 can provoke mast cell degranulation directly, sidestepping the need for IgE receptor engagement.

Hello to everyone, I just came home from a parent teacher conference for my son who is 7 yrs. old, and heard the same old thing, "he is restless, impulsive and has a short attention span". He has been taking Singulair for about 3 yrs.. Since he has started school I have had these complaints and have also been told he displays symptoms of ADHD, which ironically has been for the last 3 years. Like any parent, I question" if I am doing something wrong with my parenting, is his diet good, etc. etc.", I am also a nurse, I realize that medications are needed and beneficial in some circumstances, however I firmly believe and was taught in nursing school that medication is last resort. That being said, I have been very adament about NOT giving my son ADHD medication after doing alot of research on the different meds and their side effects. So, we started him on all natural vitamins, changed his diet some ( kids got to have candy once in a while) and started a more structured routine( the best we can since we both work) and also enrolled him in Sylvan. The teacher says there is a 50% improvement but he is still impulsive and still does not pay attention like he "COULD", again suggesting he needs ADHD meds. I came home in tears and started to do more research online to see what else can I do besides putting him on psych meds?....Then I came accross this site, I just want to cry after reading all these posts. I wonder, could this be his problem, the Singulair?.. About a year ago he use to get up in the middle of the night, 5 out of 7 complaining of nightmares, hearing things at times, headaches, decreased appetite, stomach upset, all AT TIMES, not all the time so I never thought alot about side effects of Singulair. When the school started complaining I did look at side effects of Singulair and seen HYPERACTIVITY and mentioned it to his pediatrician and she shrugged it off saying she never heard of it being a problem. She's a great MD so I listened to her because his asthma was bad when he was younger and it is now under control. But then I think maybe he is outgrowing the asthma. I am afraid to stop Singulair and him have breathing problems again but then I can't help this strong feeling in my heart that says this may have been his problem with everything else all along. We are going to stop the Singulair tonight and see what happens. If anyone else has a child with asthma any suggestions for alternative treatment would be appreciated. I already know what's out there but sometimes it's nice to hear from another parent going through similar situs. Thanks for reading, Bobbie

I've never written on a blog in my life, and now that I've just read this, my stomach is doing flip flops and my blood is runnung cold. I have an 11 year old son and a 9 year old daughter. They have both been on singulair for quite a few years. My son has been on ADHD meds now since about a year and a half after starting Singulair because we tried to avoid them. Every few weeks he tells me he has this empty feeling inside him that makes him really sad and he doesn't know what it is. It just feels empty. I'll usually read with him or play a game or walk our dog with him to help him feel better.
As for my daughter, she exhibits all of the symptoms I have read about. She talks about life being terrible( trust me, she has it pretty good), she has been diagnosed with an anxiety disorder, OCD and Tourette Syndrome. Every psychiatric medication we have tried has made her worse. She was always a confident, outgoing little girl, and then she just changed. She's had stomach aches, which the docs always thought were in her head. She gets headaches. She is extremely sensitive, won't let me even brush her hair or touch her. She has extreme mood swings and gets upset over the most miniscule things, then writes about them, even saying she realizes her anger was too much for what the situation was! I will stop Singulair immediately and see what happens. What a miracle it would be if all of their symptoms disappeared.