Singulair and suicide

My son is 7 yrs old with allergies and asthma. The Dr. prescribed it and the same day I had talked with a lady which her friends son just committed suicide. They were contributing it to Singular. A quick look up on the internet and I was angry with the pediatrician that the side effect was never discussed with me! After a very reassured conversation I said I would start him with 1/2 dose. I noticed nightmares started right away and I stopped. Asthma got worse decided to star again 3 weeks ago. He started twitching his head, flipping his hair that isn't even long. He was also complaining of stomach aches and not wanting to go to school (very unusual)! He has been off for a week now and is hopefully will not ever have any long term effect! Please follow your instincts and I will let his doctor. know what the side effects were.

My allergies caused nearly constant painful sinus pressure, drippy nose (I should have bought stock in Kleenex to profit from my box-a-day use), asthma, getting gradually worse all the time--it was as though I'd had the flu for 10 years (I'm 54). I was taking Claritin in the morning and Zyrtec at night, which only toned down the most severe symptoms. I was on Prilosec as well, as one doctor though acid-reflux might exacerbate the asthma. My family and I are avid hikers, but I haven't been able to breathe well enough to join them for years, even with daily Ventolin and Flovent. I've only been taking Singulair for two weeks, but it has made all the difference. I feel "normal" instead of sick for the first time in a long time. So, for me, it does work. But my stomach's been killing me--like a bleeding ulcer (which I had 25 years ago). I'm hoping that will subside or going back on Prilosec (expensive!) will counteract it. I've also had the weirdest dreams--very vivid and disturbing. Because I did research online before taking Singulair (Doctor uttered not one syllable about side effects), I recognize the dreams are from the Singulair. Because I understand what is causing them, I can easily set them aside when I wake up. I think anyone who's had mental or emotion problems could be sent over the edge by the dreams unless they had a clear understanding and acceptance that the allergy drug caused them. I would be easy to think something was wrong with you to dream such bizarre, violent stuff. (I'd give examples, but I've truly trained myself to forget all about the dreams as soon as I wake us, so I don't remember the dream events now.) I'm quite concerned about children taking this drug. Maybe not everyone has this disturbing-dream side effect, but how could you explain them away to a four-year old? How would you even know if a younger child was having them? Even children old enough to comprehend shouldn't be subjected to horrific mental images, like the 16 year old above. A tip for people who Singulair helps, but they have the weird dreams--try Melatonin (over-the-counter supplement) at bedtime. I've used it to help me sleep in the past when life events kept my mind too active to sleep for several days at a time. Unlike sleeping pills, it doesn't make your tired the next day, you can wake up easily, and it's not habit-forming--it just lets you drift off on days you otherwise can't. Since I'm concerned about the long-term effects of anything taken frequently, I don't take Melatonin very often, but I did try it after the fourth day of Singulair dreams. I had no memory of weird dreams when I woke up, so it seemed to work, and I didn't remember dreaming the next night either. I only tried it that one day because, as I said, I've trained myself to not be bothered by the dreams.

SINGULAIR'S LABEL HAS BEEN UPDATED:

The following has been added to the "Precautions" section of Singulair's label:

"Neuropsychiatric Events
Neuropsychiatric events have been reported in adult, adolescent, and pediatric patients taking SINGULAIR. Post-marketing reports with SINGULAIR use include agitation, aggressive behavior or hostility, anxiousness, depression, dream abnormalities, hallucinations, insomnia, irritability, restlessness, somnambulism, suicidal thinking and behavior (including suicide), and tremor. The clinical details of some post-marketing reports involving SINGULAIR appear consistent with a drug-induced effect.

Patients and prescribes should be alert for neuropsychiatric events. Patients should be instructed to notify their prescribe if these changes occur. Prescribes should carefully evaluate the risks and benefits of continuing treatment with SINGULAIR if such events occur (see ADVERSE REACTIONS, Post- Marketing Experience)."

Our son, who is now 6 was prescribed Singulair at the age of 3 due to asthma/allergies. He was prescribed this by an ENT/Allergist. I thought our sons mood swings were due to the fact that we were expecting another child. He was always so happy/loving and playful. When the baby arrived 2 months later, his behavior worsened. Again, I put it on the new baby sister in the house. His moods/anger/outbursts increased. He hit, threw things etc. I told the doc about this and he said it was due to his enlarged tonsils, and they were then removed. Well needless to say, his behavior did not change because he was still on the Singulair. I mentioned the possible side effects to his pediatrician and she said it was a possibility, but to keep him on it because he needed it. Well, 3 years later, in March of this year I took him to an allergist that I had seen years ago. He immediately took him off the singulair (and all inhalers). His moods seemed to brighten a bit, but not they are worsening again. Is it possible for the Singulair to have long term damaging effects. I understand kids have tantrums, etc. Kids are kids, I get that. But he punches, kicks, screams, cries etc. My husband are at a loss. We don't know what to do. Oh, and he is now on Veramyst as needed (march-june, Aug-Oct.). Has anyone else experienced long term effects due to Singulair?

My eight year old son was diagnosed with mild asthma by our GP and was taking Ventolin for a persistent cough. When this didn't relieve the cough the doctor prescribed Singulair. He started the Singulair in March 2009 and within 2 months we realized that his personality had dramatically changed. It has taken us a while to figure out what was going on because eight year old boys are starting to assert themselves more and I think the side effects have been escalating over the last month. He was angry most of the time, very hateful towards his siblings, saying very dark, nasty, hurtful things. He argued every time we asked him to do something and would snap into a screaming inconsolable emotional wreck at the drop of a hat many times a day over trivial or imagined problems. He was having nightmares and bursts of hyperactivity that were overwhelming. He told us he felt frustrated all the time and hated everything. When we tried to calm him he was unreachable. Just yesterday he had his fist clenched and pulled back ready to punch me when I was trying to help him with a computer problem. He was shaking and his face was contorted with rage and he just wasn't my little boy anymore.
It has been devastating for our family and we were ready to take him to a psychologist. He is normally an incredibly considerate, perceptive, loving child, highly intelligent, helpful and fun loving with a great sense of humor.
He has also complained of leg pains and has been wetting the bed again. It was only yesterday that I began reading about other people's side effects and have taken him off Singulair as of last night. Whilst he has still been argumentative today already the aggressive intensity seems to be easing.
I am absolutely mortified that I allowed this to happen to my son and my family and I am so grateful to others for sharing their experiences.
We still need to address his asthma and will make an appointment with a specialist next week, but given his asthma is so mild he should not have ever had to suffer these side effects.
I only hope now that he has not sustained any long term effects and that his younger brother has not been scarred by the truly horrible things that my son has said to him.

My 13 year old daughter has been taking singulair for 8 months, and started suffering from severe depression 6 months ago. We intervened and prevented her from committing suicide, but barely. We never correlated it with the Singulair until a visit with her pediatrician today. I am so sad I want to cry. I am the one that suggested to her asthma specialist that she be put on Singulair. I am so fortunate her pediatrician caught this. We couldn't figure out why her personality suddenly changed.

As i read some of the news reports on the new FDA comments,i see we are referred to as a handful of reports,the very words handful conjure up a picture of 10 not the thousands that there actually are.Also i noted missing from the news reports was ,that this drug is largely given to children,as young as 6 months,not for 10 days or 2 weeks but everyday,for as long as they need it.i know myself trying to convince my doctor,that my sons depression,insomnia and anxiety,came from this drug was impossible,so i fired him.I am wishing the best to everyone that has suffered,and ask all to please report your adverse effects to the FDA

PLEASE REPORT SIDE EFFECTS OF SINGULAIR TO THE FDA: https://www.accessdata.fda.gov/scripts/medwatch/medwatch-online.htm.

The FDA is continuing to monitor ongoing reports of suicide and other psychiatric problems.

From the FDA's "Updated Information on Leukotriene Inhibitors: Montelukast (marketed as Singulair), Zafirlukast (marketed as Accolate), and Zileuton (marketed as Zyflo and Zyflo CR)"

6/12/2009

Neuropsychiatric events have been reported in some patients taking montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo and Zyflo CR). FDA has requested that manufacturers include a precaution in the drug prescribing information (drug labeling).

Montelukast is used to treat asthma, and the symptoms of allergic rhinitis (sneezing, stuffy nose, runny nose, itching of the nose), and to prevent exercise-induced asthma. Zafirlukast and zileuton are used to treat asthma.

The reported neuropsychiatric events include postmarket cases of agitation, aggression, anxiousness, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal thinking and behavior (including suicide), and tremor.

This information reflects FDA’s current analysis of available data concerning this drug.

Advice to patients and healthcare professionals:

Patients and healthcare professionals should be aware of the potential for neuropsychiatric events with these medications.

Patients should talk with their healthcare providers if these events occur.

Healthcare professionals should consider discontinuing these medications if patients develop neuropsychiatric symptoms.

Background

In April 2009, FDA completed its review of neuropsychiatric events, (mood and behavioral changes) possibly related to drugs that act through the leukotriene pathway (montelukast, zafirlukast, zileuton). As part of its review, FDA reviewed post-marketing reports and also requested that manufacturers submit all available clinical trial data for these products.

The post-market reports of patients on these medications included cases of neuropsychiatric events. Some reports included clinical details consistent with a drug-induced effect. In the clinical trial data submitted by manufacturers, neuropsychiatric events were not commonly observed. However, the available data were limited because the trials were not designed to look for neuropsychiatric events. Sleep disorders (primarily insomnia) were reported more frequently with all three products compared to placebo.

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I took Singulair for about two years. I had developed these now known to be side effects but at the time nobody including the FDA was either aware or honest about the aggression, agitation and other side effects. I assumed this was all due to stress in my life and since it came on so gradually I did not put 2 and 2 together that it was the medication. I lived for two years being an irritable stressed out pain in the you know what struggling with these major aggressive compulsions. Then I saw a story on the news that the FDA was issuing this new warning on Singulair about the aggressive, anxiety and suicidal side effects of this drug. I stopped taking it that day. Luckily my asthma had been fairly well under control, I noticed no increase in asthma symptoms. What I did notice was I stopped being irritable and constantly annoyed and angry within a few days. I am back to being a mellow person, no problems since I quit this drug. I am horrified they are giving this to children. Both doctors and pharmacists should be warning people UP FRONT of this risk.

Last Tuesday, my son was prescribed Singulair by our pediatrician. He was also prescribed Pulmicort by nebulizer at the same time. Within a couple of days, I was noticing a dramatic change in his personality. He's only 21 months old and normally a very happy, lovable, easygoing little boy. He did a complete 360. By Friday, I had to take a day off from work, as I was too scared to send him to daycare. He took his last Singulair chewable tablet on Friday night. Saturday was his worst day by far. I was in shock by his behavior. He was extremely aggressive, punching and slapping anyone who came near him, he was throwing things, throwing himself into walls, etc, just completely out of control. I contemplated even taking him to the hospital, but then started doing some research online. I had my mother contact a pharmacist whom we trust, who advised for us to stop the Singulair, as if he was having any side effect, it would more than likely be from that. On Sunday, I started to see some changes in him. Yesterday he was getting back to normal. Today, he's that much better. We actually went back to the pediatrician this morning and I'm actually thinking of filing a formal complaint against the dr. as he basically swore up and down that his side effects weren't from the Singulair. Well as a parent, does anyone really think I'd want to put my child thru this?? It may be different if he had behavioral issues prior to this, but this came completely from left field. I am beyond upset right now, pissed off that this drug can be on the market. How many children have to be affected??? This is very scary to me. My son was only on Singulair 4 days, and I feel guilty and angry that he had to go through even that short period of time on the drug. And then to have a pediatrician basically discount me and say that it has nothing to do with singulair is a complete slap in the face! I won't stop speaking out against this drug and hopefully it will inform other parents of these harmful consequences!!!!

My seven year old son has been on singular for over four years. He talks a lot about death. He constantly cries about his dead grandmother which he never knew. He is a very smart child and lately I have realized that something bothers him. He is starting to cry often and feels very depressed. This is what he says when he cries: “My brain thinks bad thoughts about you, (mom and dad). Mom, I really love you and daddy, but my brain does not listen to me. My brain tells me bad things about you like to get a knife and stub you to death, or get a gun and kill you. Please mom make my brain squish the bad juice away and live only the good thinking on it. I know that you love me but my brain tells me different.”

My son is begging for help and every day he tries so hard not to have bad thoughts. He tries to hug us and kiss us a lot, but I see on his little eyes that something is wrong. The first time this thing happened I thought maybe a TV show or something made him think so. I am becoming very worried about him and started research on the computer. I don't know what causes his depression, but I know for a fact that he is depressed. He is our only son and gets all the love and attention.

Although he has been on singular for a long time, I have given it to him regularly only the last five months, since his doctor urged me to do so. Before I gave him the singular only when his allergies acted up. When he got better I would completely stop it. I didn't know anything about singular, but I don't like using medicine, and that is the reason I did not use it regularly.

My son has other similar behaviors that are out of his character like no desire to raise, get angry, worry that I would die, behavior problems at school, he thinks he is stupid although he is a straight A student, has nightmares, is scared that he would die, can't concentrate, is scared to be by himself etc.

It brakes my hart to see my baby being depressed. I will stop the singular to see if he will get better. I pray to God he will.

English is my second Language. Sorry for any inconvenience.

My son used a nebulizer 2 to 4 times a day every day from the time he was one and a half years old. When he had just turned three his doctor prescribed Singulair. It was like a wonder drug for us! It took care of his asthma and we didn't have to use the nebulizer any more. He's been on it ever since -- he's 10 now -- he also takes zyrtec and has a rescue inhaler that he uses maybe once a week. About every other year he requires a course of steroids and a week of regular nebulizer use. Also, for the past year he has also required a daily inhaled steroid.
Now, about his mood issues. My son has always been sensitive and intense, moody. The first time I became alarmed was when he was 7, and he told me he wanted to burn his hands on the stove to punish himself for forgetting his homework. I consulted a psychologist who evaluated him and said he was not clinically depressed. Since then he has had periodic "dark" episodes -- especially in the winter. He has said he wants to die. He has had crying jags over things that are upsetting (loss of a pet was the worst) but it seems excessive for him to be saying he "just wants it all to end." He has told me that he is always unhappy and that he hates himself. He has also had problems with moody acting-out with friends. He will brood about hurt feelings until he loses his temper and screams at the friend. I have worked very hard with him on learning to manage his emotions. He hit a friend at school who was teasing him. He accepted his consequences willingly and willingly wrote letters of apology -- he told me he thinks he has anger problems and doesn't want to be this way. And his character is that he is a sweet, caring boy who can't stand to see anyone hurt, but also can't stand to be hurt.
A couple of years ago I asked his allergist if any of the meds he's on are linked with depression. He said no. We have a family history of depression, and I thought my son had gotten the worst combo of all the genes.
Recently, this all got to the point that I decided he needed to see a psychiatrist and quite possibly take medication for depression. Before I made the appointment he had a check-up with his allergist. Going down his list of meds the dr. said, recently Singulair has been linked with depression, have you noticed any moodiness or sadness? My first thought was that I have, but that he's always been like this. My 2nd thought was that he has been on Singulair for most of his life. I said yes and that I'd like to try him off of it.
My son resisted going off of it. He has had enough negative experiences with asthma that he didn't want to risk it, but I insisted. I didn't expect to see any change, but I thought it was important, as I was going to take him to a psychiatrist to consider depression meds, to see how he did off of it for a couple of months.
Less than a week later, he had been in a wonderful mood -- to the point of being silly and giddy all evening -- for 3 days in a row. The kind of mood that I don't see him in often, and when I do I think to myself, "he should be like this more often." One evening he even realized he had forgotten to bring home a homework assignment. I thought, "oh no, here we go, his evening is ruined." But he talked through his options with me, looked a little uncertain, and said, well, okay, I guess I'll have to tell my teacher I don't have it. I'll tell her I'll make it up at lunch if she wants me to. That was it! He didn't mention it again. I didn't say anything about his mood, because I really don't think I can know anything after just a few days -- it could be coincidental. The next day, he said to me that he thinks being off the Singulair is "working." He has now told me that a couple of more times.
I am tentative, but amazed. Even if my son does have a predisposition to be depressed, maybe the Singulair was making everything worse, and things really can improve for him. I am afraid to be to hopeful. At the same time, I feel guilty for giving this medicine to him for 7 years without a second thought.
As an aside, my son has periodically complained of leg pains, that I always told him were growing pains.
I would love any feedback that anyone can give me. So far (these two weeks), his asthma has been controlled with pulmacort, zyrtec and albuterol, so that aspect is okay.

On the flip side i was on Singulair for about a year and i felt nothing different i never sneezed, never had a cold, or a runny nose. My mom found out that some kids had signs of suicide from Singulair so she instantly took me off of it and since then i have been miserable ever since. My doctors have put me on other allergy medicines, but none of them work with my runny nose and only take away the sneezing... even nose sprays don't work. I actually wish that i was still on singulair it never gave me any side effects and it's the only thing that works with my asthma.

It seems most people on here are blaming their "side effects" on the medicine. Could you quite possibly have health issues anyway? what about those people that don't take Singulair and have the exact same symptoms? Is it because they are THINKING about it?
It's one thing to be informed about medication. It's another to go overboard.

Science has NOT conclusively ruled out a link between Singulair and suicide. In fact, science DID reveal a link between Singulair and depression (a risk factor for suicide). In the clinical trials one montelukast participant dropped out and the investigator cited the reason as depression that was "drug related". Additionally, in the primary and Phase II/BIII Studies, 12 out of 1955 participants taking montelukast reported depression, vs. 5 out of 1108 on placebo, and 1 out of 251 on beclomethasone. This information is presented in the FDA's medical review for Singulair and is available on the FDA website. Depression was not only reported post-marketing as some would like us to believe. As the FDA explained in their update to the investigation, Singulair's clinical trials were not designed to measure neuropsychiatric events so some may not have been reported. Using clinical trial data to prove that Singulair cannot cause a particular symptom or outcome is as foolish as discounting post-marketing reports that show that some neuropsychiatric events associated with Singulair are consistent with a drug-induced effect.

To clear up any misunderstanding about the FDA Singulair investigation.
FROM THE FDA STATEMENT ABOUT THE SINGULAIR INVESTIGATION

"FDA has not yet reached a definitive conclusion regarding the clinical trial data on mood and behavioral adverse events associated with montelukast, zafirlukast, and zileuton."

"although (the clinical trial) data do not suggest that montelukast, zafirlukast, or zileuton are associated with suicide or suicidal behavior, these clinical trials were not designed specifically to examine neuropsychiatric events. As a result, some events may not have been reported."

The FDA is continuing to investigate a link between Singulair and suicide .
They stated that they have not "closed the book on suicidality". Any news reports stating there is no conclusive link are incorrect.

I was shocked last night on the news, when they reported that "there is no link between Singulair and suicide". I guess Merck is going to stick their heads in the sand, and let children continue to be harmed by a drug that I feel should never be prescribed to a child in the first place. I'm shocked at how young some of these children are! It makes me sad that Dr.'s, the FDA, and Merck will continue to put profit before the safety of the people being prescribed this drug and having terrible side effects from it...and most Dr.s are not fully aware of!!!!

OK,well,as you have probably read by now,there was not enough evidence of a link to suicide in the clinical studies,but in the smaller print it notes that this avenue was not really in their study,so maybe those questions were not asked.The FDA says it needs more time,maybe months to figure it out.No surprise there i guess.Amazing to us,who's children have suffered,and clearly saw a recovery take place when stopping singulair,but we are not scientists,just mothers and wives,who do not pocess the intellectual capability to no the ins and outs of science,or so they would like us to believe.Clearly we saw our children suffer,clearly we saw our children recover,clearly the link was singulair

I'm so happy that I decided to research this drug. My son, who will be 2 on 1/22/09 was prescribed Singulair today. He has been coughing/wheezing, etc since we moved to a different state, 6 months ago. We have tried all kinds of OTC drugs and nothing would work. We finally brought him to the Dr. today and he says he has allergies (which we kinda knew already). I was happy that the Dr. prescribed something that we could not get OTC..to me, that meant that it was going to be better. I went to pick up the prescription and the pharmacist tried to talk me into a different kind of allergy med for my son. I told her that I wanted to stick with the Singulair, since that is what the Dr. prescribed. She told me, in no uncertain terms, to research this drug! She kept asking, "He's only 2, right?" He's only 2, right?" Her behavior was strange, I thought....it turns out that she was my angel today. I gave my son 1 dosage tonight before bed and he WILL NOT get another. Thank you! On Monday, my first order of business is to go back to the pharmacy and thank my angel....

I was surprised to hear that Merc, the maker of singulair update their side effects 4 times in one year to include depression, anxiety, suicide, and suicidal thoughts. It was prescribed to me cos of my allergies and asthma. I never really took singulair on a daily basis because it made me feel so tired and out of it. So i would only take it when my allergies were very very bad, like having a bad sneezing fit or nose would be runny non stop which would be at least 1 to 2 times a month. My asthma wasn't really that bad, i would get it when my allergies would act up like i mentioned before. When the fires in California were going on my asthma started acting up because of all the ash in the air. I was having asthma attacks every day. Since singulair works great for asthma i started to take it everyday and noticed my asthma went away. The first couple days were fine..and after two weeks i started noticing i was becoming anxious and irritable. Also depression sunk in...So i wondered what was causing it. I wasn't going trhough any major life changes. So i looked up singuliar side effects and noticed the four new side effects that i mentioned above...I stopped taking the pills to see what would happen and i felt emotionally better but the asthma came back..id rather suck on my inhaler then be anxious and depressed.

Oh my gosh. I am on this website because I googled "behavior issues with Singulair" Both of my children are on Singulair. One from as young as 5 months old. Both Pulmonologist, allergist and Internal med Ped. insisted that it was a safe drug. They aren't living with it. My 7 year old has taken it consistently for 5 years and recently upped is having behavior, aggression, insomnia and constant reports back from the teacher on his behavior. We had him psychologically evaluated and they found nothing uncommon to his age. All his issues are described in almost everyone of these side effect threads. I am just afraid to take him off and feel the blame if something serious happens. I am calling tomorrow for possible alternatives.

I was first given Singulair at the age of 21. At which time, I quit a job in which I have yet (at 28) to match its income. My doctor continued to give me samples as I could not afford the medication. During this time, I was very depressed, contemplated suicide often and was given a serious of antidepressants-non of which helped. For one reason or another, I stopped taking everything. At which time, it seemed I had a new lease on life. I went back to college, finished my degree, and got a job in decorating. My asthma began acting up again, and again I took singulair and again had to be given antidepressants. I wound up quiting that job too and worked a serious of low paying jobs. Again, I quit, and again found the urge to "live" again. I never connected the two, until this past week. I was given singulair again by another doctor on Wednesday. Thursday I had nightmares, Friday I spent the day crying, Saturday night I began to think of leaving my husband (I also did that ALL the other times I took the drug and we've been together 14 years-I love him). Today is Sunday, I normally go to bed around 12 or 1 a.m., but I am making myself stay awake and have all day. This drug has ruined a large part of my life, please, if anyone notices even a little depression with this drug, Stop!!!! It is not in your head, it is this drug!!!!

I also have a child who has been on this drug for about a month and as I sit here and read these blogs the more I am remembering complaints made by my son. He has been getting into trouble at school lately, irritable, angry, sad, leg pains, stomach aches and also having trouble getting to sleep at night. I am an RN and it took me to glance at the pill bottle today to realize that I needed to do a little more research about this drug when I saw that it said "mood changes and depression". I feel horrible because after a great 2nd grade year I was disappointed that he was not behaving as well this year. I know know that the $60.00 wasted and tiring reprimanding was all a waste of my time! I owe my poor son an apology as I will be taking him off of this drug today! More information and advocacy needs to be available especially when core users are children who have little to no voice!!!

My daughter was prescribed Singulair in the spring and it worked wonders.Since her allergies and asthma don't bother her in the summer I took her off for those few months.Since she has been back on the last few months I notice once and awhile an aggression/depression behavior.I thought immediately that it was Singulair causing this but it wasn't everyday it happened.I believe that activity,schedule,and even food in combination with this medicine that was cause this rare effect.It's no news to parents that all of these things can change a persons attitude and behavior.I also believe that Singulair may just make people more sensitive to their true self as my daughter has always been paranoid and has lacked self esteem.I think that it is trial and error as with any medicine.Try it and it may or may not work for you.Taking it off the market would be a disgrace as it has saved many lives.

My 8 yr old has been on singulair since May. I never put two and two together until reading these posts. He has been having anxiety at night..crying and looking terrified saying he can't stop the scary thoughts in his head. Tonight I felt so bad for him...because I can't make it go away. I am hoping with tonight being the last night on singulair he will not have such a hard time at night. He also says it's very hard to get to sleep at night. Poor kid. I also know he's a sensitive kid but it seems a bit overboard in the last few months....like getting upset and just not knowing how to handle his emotions so he just shuts down. Please message me if you've had similar experiences. I'm calling his dr. on Monday to figure out some other options if there is any. My son started with a cough in March and finally took him to see the dr. in May and she heard wheezing and started him on singulair and then added zyrtec. I know they control his coughing (wheezing...slight asthma) because if we miss a dose he coughs all day the next day. I'm a bit scared to go off it...but hope it stops the anxiety and moodiness. He had his first asthma attack last week too...and I wasn't prepared as we never have had to use the inhaler...so I didn't have it with us. Anyway, hoping he doesn't get too bad taking him off...and I hope he is able to control the scary thoughts by going off of it too.

I just came across an article on the online "Huffington Post" by Dr. Doug Bremner, who researched the connection between accutane and depression, called "If Prescription Meds Don't Kill You They Might Drive You Crazy" He explains the link between Singulair, Leukotrienes in the brain and depression. There are numerous articles by him as well that are definitely worth reading.

Jenna M.
Parents United for Pharmaceutical Safety and Accountability

I am 15 and have only been on Singulair for a week. But I have already had sever leg cramps and my foot locked into place for a few minutes with extreme pain. I had a nose bleed today too, which is not normal for me. I have also had really bad cramping which I didn't think anything of but now I don't know what to do because I have sever allergies to almost everything outside and this seems to be the only thing that helps. After reading all this I am freaked about everything. And I have been really moody this week, but I thought it was just because I am a teenager but now I don't know.

I have a 7 year old daughter. She is taking singulair. lately she has been complaining about pain in her leg it hurts when she walk. She also have pain in her arm. I gave her a pill tonight but I did not find this website until afterward. I am so glad I came across this site. She was taking zyrtec and she was having behavior problem. So the doctor switch her to singulair. I was hesitant to give her this medication. She also have seasonal asthma so I just got to find another way of treating her. I hope someone have good suggestions.

IS THIS SITE AN ANSWER TO OUR PRAYERS?

A little while ago less than two hours, after a very emotional, difficult battle with my daughter, we had yet another heart to heart to try to do better. At the end of our talk WE PRAYED for guidance to know how to help the situation. So I'm here looking for a link to her behavior fron the ADHD medication and I see someone had posted about Singulair side effects. I was floored! I have never thought that Singulair was not a safe drug. No doctor has ever mentioned any negative side effects to me regarding it. The more I'm reading about it the more in shock I am. Have I and her doctors been doing this to my daughter? My 12 1/2 yo daughter has been on Singulair for probably 10 years. She was a 28 week preemie and had severe lung issues so it was a needed medication. Her behavior has worsened the older she has gotten. Because of mostly anger issues and problems in school about a year ago she was started on ADHD medications. We are currently trying to find "the right one" . I feel so awful. Could all her misery have been caused by this little pill that was suppose to help her? Why has her pulmonoligist continued to give it to her although she has not had any serious asthma problems in years? I think I will stop all medications and see what happens. My daughter has also been on amytriptylin for about six months also for severe migraines. What do you think? Should I stop all of them cold turkey or gradually decrease one at a time? I would GREATLY appreciate any advise.
Thank you

My daughter had been on singulair from the time she was 8 yrs old until she was 14. This will sound as if I am a horrible mother but I just thought that she was a raging bitch. Without my knowledge, she stopped taking her Singulair for a few months and she became a different person. She was so sweet and loving. One night she came in my room having an asthma attack and I asked her if she was taking her meds, she admitted that she had stopped taking her singulair and I got on to her and immediately got her prescription refilled. Within a few days of taking the singulair she turned into a raging, screaming emotional wreck, a TOTALLY different person. I feel so bad that for 6 years of her life I put her on medicine that caused her to have screaming, uncontrollable tantrums, and severe mood swings that caused her to be miserable. It does seem to be the only thing that effectively controls her asthma symptoms but the emotional havoc that is causes her and the people around her is not worth the benefits. We have an appt. with her doctor to see what other options we have.

I just started the Singular and it has helped my asthma a lot. I can't tell about the coughing because I also started it while I had a cold. But now and then even before I took singluar I would cough. Sometimes coughs are produced from various types of airborne things, many different types of things. I have a mold aggreviated asthma so that could be why its helping my instead of causing me to go nuts like it does for some. But it doesn't sound like a very good drug for children. It seems as though none of the posts coming from children taken Singular are positive. But so far it's helping me. I made it through the day without grabbing for my inhaler which was a great relief for once.

Sept. 1 (Bloomberg) -- U.S. researchers found no evidence to support regulatory warnings that Merck & Co.'s Singulair asthma and allergy drug, taken by millions of Americans over the past decade, may be linked to depression or suicide.

The findings will be published in the Journal of Allergy and Clinical Immunology, the American Lung Association said in a statement on PRNewswire today. The study was sponsored by the association, which doesn't endorse products, it said.
HOLY COW

I just read an article dated 9/1/08 that stated that the American Lung Association just cleared Singulair as causing depression and suicide. They had researchers study the results from the original test trials because they are supposedly more accurate than after market reports. The article is at ******. I cried when I read this report. My now 8 year old daughter has been on this medication for mild asthma since she was 4. We have thought the stomach aches and tantrums were related to moving to a new town around the time she started taking singulair. But, 3 months ago, she all of a sudden started having depression, ocd about germs, afraid she might hurt herself and then depression and suicidal thoughts. She has been off meds for 8 weeks and still has some problems with thinking she wants to hurt herself and feeling down. She is normally very happy and our family is happy and normal, but dealing with this is difficult. How long does it take to get out of their system?

After taking a "leave of Absence" from this site, I see that Singulair is still up and thriving. I still see ads for it on TV, over and over again. They haven't been altered at all. Makes me sick. I wish there was away to get to other people whose children have died by suicide and investigate as to whether or not they were ever on singulair. Keep fighting. We'll get there! Kate K

SINGULAIR AND ZYRTEC SAME MEDICATION made by different companies. Be careful!

I have been reading all of these posts and have another question. I hope that someone can help. My daughter, 8 years old, has been on Singulair since she was 4. She is normally a very happy girl with a wonderful disposition. For the last year or so, she has been having trouble getting herself to sleep at night. She says that she hears things in her head such as ringing or "noises". A few hours before she knows it's bedtime, she cries and when we ask her why she's crying, she can't give us a reason. We initially thought that she was crying for no reason because she didn't want to go to sleep. I remember reading about the side effects of Singulair causing mood swings, etc., but her's are not violent mood swings. Just very emotional and has a hard time coming down from the "episode". I'm at a loss...I have not talked to her doctor yet about it, but have told her that we will make an appointment this week to discuss it with him. My husband suggested that maybe it sounded like she was having a panic attack or anxiety attack. I hate to label her as that at such a young age. My mind now goes back to the side effects of Singulair and maybe this is to blame. Any help or suggestions would be greatly appreciated. Thank you! Concerned Mom

My son became soo aggressive 3 days after starting Singulair, that he was almost banned from soccer for life because of attacking another player on the field. It resembled what I had heard of 'roid rage'. When I questioned the doctor immediately, was told there was no connection. After months of the aggression, then came depression and self mutilation. My 15 yr old was secretly burning himself to 'punish' himself for things he done wrong or "disappointing" those around him. He now has permanent scars all over his arms from these burns. The depression took to drug abuse and my A student fell to an F student in 6 weeks. He completely lost his will to live and thrive. After 4 months of hell, the dr informed us that the FDA just warned physicians of this side effect. Im furious now that I read through the court documents and find that the drug company knew this all along. I know I am a luckier parent than some whose children committed suicide, but still wish that the FDA would get off their BUTTS and do something to take this drug off the market. I was told by a rep at the FDA that Merck will not take it off the shelf until they're made to because even if they had to pay parents millions for their child's suicide, they would still be pocketing more profit than our children's lives are worth in the court system. Not sure WHY we even HAVE an FDA, they won't do anything to protect us from these money hungry drug companies. A YEAR to do an 'INVESTIGATION" are you kidding me? If the CEO of Merck had to bury his child, it would come off the shelf THAT DAY.

Sales of Merck's asthma and allergy drug Singulair dropped 1% to $1.1 billion for the second quarter. U.S. sales have been hurt by the recent introduction of an over-the-counter version of rival drug Zyrtec by Johnson & Johnson (JNJ), as well as concerns about the Food and Drug Administration's March alert of a possible association between Singulair and suicide and related behavioral side effects Got this off cnn money,i don't know but thought zyrtec and singulair were different drugs,my son at one time was prescribed both to take at bedtime

My daughter has been off Singulair for approx 2 months and is back to her old self. Talkative and happy! How about contacting the media to see if they would be interested in doing a story on the problems that have been associated with this drug. Yesterday morning there was a story regarding the poor health of our children-high cholesterol etc, and my first thought hmm-wonder if they are on Singulair. I think if more light was put to this drug, maybe we could get answers faster.

I started full body internal itching after taking 10 days of Singulair. The physician that prescribed it said it couldn't cause itching. My new doctor tested for Lupus, I have an autoimmune disorder called Churg Strauss. After undergoing several steroid treatments and 3 days of IV Prednisone I got some relief. This has been going on for 6 months now. The itching becomes severe enough to make me want to commit suicide. Luckily it is pretty controlled by taking nightly doses of Atarax along with Periactin. Thank God I found a doctor who cared enough to search out the symptoms and help me get thru day by day.

This testimony should help strengthen our case for warnings for Singulair.

Neurologist Sought Warning for Pfizer Drug
By JEREMY SINGER-VINE
June 20, 2008; Page B10

A British neurologist who analyzed effects of the drug Neurontin told a court hearing Thursday that he advised its maker -- now a unit of Pfizer Inc. -- to include a warning on the drug's label for potential side effects of depression and aggression, but his advice wasn't followed.

The University of London neurologist, Michael R. Trimble, was testifying at a hearing to decide whether civil cases brought against Pfizer alleging suicides linked to Neurontin can proceed. The hearing was jointly held by judges for U.S. District Court in Boston and a New York state court who are hearing similar cases. In various lawsuits consolidated in the federal court, plaintiffs allege more than 100 suicides were connected to Neurontin usage.

Dr. Trimble described what he said was a "plausible biological pathway" that could lead from the compound gabapentin -- the chemical name for Neurontin -- to suicidal behavior, hostility, and aggression. Dr. Trimble said that in 1995 and 1996, he was hired to write two confidential reports for Parke-Davis -- now a unit of Pfizer -- because the company "was concerned about psychosis in relation to their drug." Dr. Trimble said he was unable to find a link to psychosis, but noted effects of depression and aggression.

Lawyers for Pfizer argued at the hearing that the evidence linking the drug to suicidal side effects wasn't scientifically sound. Under cross-examination, they challenged his description of a pathway as a patchwork of studies that didn't prove a biological connection. Neurontin and generic forms of gabapentin are approved for treating epileptic convulsions, but have also been prescribed widely "off label" for other conditions.

In five of nine patient cases he analyzed in 1996, Dr. Trimble said he saw depression and aggression in patients who had no previous symptoms of the side effects, so he said he recommended to the company that the drug "should carry some kind of warning" for susceptible patients.

Thursday's proceedings were the initial phase of a hearing requested by Pfizer to challenge the opinions of the plaintiffs' experts. Under cross-examination and a subsequent examination by the plaintiffs' attorney, Dr. Trimble said the biological pathway between Pfizer's Neurontin and suicidal events were plausible and supported by a series of peer-reviewed neurology research.

My 54-year-old fit, social, successful husband was put on Singulair in January for newly diagnosed asthma. He developed a depression with anxiety, irrational fears, avoidance, mood swings and even one episode of suicidal thoughts out of nowhere. He saw a psychiatrist and a therapist, tried medications, yoga, a vacation, meditation, breathing exercises - everything! But he kept getting worse.

The day he was throwing patio furniture then sobbing uncontrollably was the day he realized he couldn't work in his condition. He negotiated a 60-day leave without pay. Even that didn't help. It was crazy. How could a man who managed hundreds of employees and a major health service system for 20 years suddenly be so paralyzed with fear that he couldn't walk down a beach or go into a Walgreen’s?

We found this site May 26th. He stopped the Singulair immediately. It has been 10 days and he is already 80-90% back to normal. Thank God.

Partly I am writing because it is so hard to read of parents' guilt that they "should have known" etc. Look, unlike a child, my husband is mature and very verbal; he is also a psychiatrist (!) with a capacity for self-examination and a language to describe his inner experience. And me, I'm a psychologist (!) trained in understanding people and I know him very well. And yet with all that training and skill and consultation and treatment, WE STILL COULDN’T FIGURE THIS OUT! So please, don't make yourself feel any worse with guilt. This is awful and tragic enough already.

I would add that the onset of mood and behavioral problems is so insidious that it is hard to connect the problems to the Singulair. Also, I suspect that children and adolescents are at greater risk because of their immature emotional developmental level. An adult l suspect may need some genetic or personal predisposition to mood disturbance, or stress, or both, to trigger these side effects. My husband had a depression episode 30 years ago and had recent traumas that certainly could have triggered the depression. But how treatment resistant that depression was, and those strange paralyzing fears and extreme anxiety – all that I blame squarely on the Singulair.

I have made a report to the FDA. I urge you to do the same.

This is my story. My daughter 14, the most precious child ever born. She has a wonderful disposition always happy, loving, and determined to succeed in whatever she does. She just brightens everyone’s world.
She suffers from severe seasonal allergies and mild asthma. She takes approximately seven allergy/asthma medicines a day during peak season. Over the past two years she has been taking Singular as one of her medicines. Being 14, sick of taking medicine she would not take the Singular on a regular basis. Approximately four months ago “MOM” says, if you take nothing else take your Singular it will work both for the seasonal allergies and your asthma. She has been taking this regularly four the past four months.
She became paranoid, she became a compulsive eater and bites the skin on her fingers. She would eat and chew on her fingers at the same time, until she choked. She had so much anger, she could not even go to the mall without temper tantrums.(As a child she never had any tantrums ) Always afraid. Severe depression set in. She would cry at a moments notice. She would say, I have a very sad life, sad very sad, nothing makes me like this, I’m just sad. She felt she should go live with the homeless people. I asked her why, she didn’t know, she felt maybe that’s where she belonged. Nightmares and sleepless nights.
She needs help quickly. Before calling the Doctor, I went on the internet and entered Singular and depression and I found 1900 entries, all people telling me what I was experiencing. Could this possibly be the answer for us? I called her Dr and told him what I thought, he said he has never had anyone that this has happened to. He hoped it was the answer, but really didn’t think is. He said if it wasn’t the answer she would need therapy, mood stabilizer and Prozac.

Its day four off Singular, she smiling, no tears today, no temper tantrums, looking forward to school next week, wants to play volleyball next year, singing in the car,
I hear that happy voice again.(Hi, Mommy!!!!!!) Every once in a while a glaze comes over her face. She isn’t a 100% back, but I know it is coming.

To all the people that don’t have the happy ending, I will pray for you and hold you in my heart forever.

June 2, 2008

My son has been on Singulair since the age of 6. He is now 13 years old. He developed seizures 3 weeks ago - temporal lobe aura epilepsy during which he was hearing voices. EEG abnormal, MRI normal. He hasn't started medication for the seizures but I have stopped his Singulair immediately! This was just a hunch - searching the net to see if there is any correlation. I have been to the Pediatrician AND the GP the past 3 weeks and no one said anything. I think a great number of children are on Singulair in SA. Does anyone know about the possibility of this danger?

hi, im not sure what to do. my 3 1/2 year old daughter was today given the prescription for singulair. i voiced my concerns to the doctor after my friend telling me its no good due to the side effects.she said that there are risks and side effects with any drug you take but for some reason i don't feel right about this. don't doctors know better than this. anyway Would like to know if all the people who take singulair suffer some sort of side affects or is it minimal? or going by this side it looks like its probably best not to give it to her at all.

Here I go again, unable to fathom my son's suicide, I'm wondering about things again. Could it be possible that maybe some of the side effects do NOT go away with the discontinuation of Singulair? Can certain effects stay with you and do permanent damage? That is if you're on it long enough. A.J. was on it and off of it, (on it more than off) for 9 years. I never caught on. Now that it's too late, and I've learned about this stupid drug, I've got to ask every question that comes to mind. I, too, have asthma and I am tempted to go to my own doctor and request to be put on it just to see what happens to me. Right now I take Advair and I see where it causes problems that are equally as bad for some people as Singulair. I'm one of the lucky ones. It does me well. My depression comes from the death of my son.

Both my sons have bad allergies. Both were recently prescribed Singulair after other drugs were not very effective. My oldest, 12, started feeling "strange" and asked to be taken off Singulair. He was not himself on the soccer field or at school. Since we stopped the medication, he has returned to normal. My 8 year old had a much worse reaction. He has bad mood swings and tonight became suicidal. He was searching the kitchen for knives to stab himself. He had fits on the carpet beating himself and the floor until I got him a pillow to take his aggression. My wife notified our doctor and school counselor. We're stopping his Singulair immediately.

concerned citizen,i enjoy reading your posts and research you have been so helpful,but i do have to say,i do expect the doctors that write prescriptions to do their homework and research on these drugs,i do feel that they should be extremely knowledgeable about what they are giving our children,that is why i pay them the big bucks.I told them of my concerns and they poo pooed me,when as it turns out now i was quite possibly right,i will asked them to do another blood test now he is not on meds,and if as i suspect it has gone down i will loudly shout i told you so and demand answers from them.I so often questioned the meds and was always made to feel dumb,Ignorance is not a defense and someone was very ignorant

Thank you to this doctor for posting a response to Singulair problems. He has experienced problems with headache (actually 18% according to the Europeans). He has a patient who has been cutting and had a serious hospitalization possibly due to Singulair.

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