Topamax and antidepressants

I am a 39 year old man with peripheral neuropathy and migraines. When I was diagnosed 3 years ago, the pain in my right leg was horrible and headaches daily. My Dr. put me on Topamax and I was so happy, it seemed to help but one night( about three weeks into it) I went to bed and awoke in the morning legally blind. Topamax was stopped that day but it took 4 months ( and changing the prescription in my glasses 3 times) for my vision to return to 20/20. The doctors tell me I was lucky as some people have perminate lens damage from the optical pressure change.
My doctor said I could not take any thing in that class of medications as it would probably have the same effect on me. So he decided to put me on Cymbalta for the neuropathy. He said it was being tested as a possible use for neuropathy but had not been proven. It works great for the pain and oddly my migraines have gone down to about two a month.

I've been on Topamax for over a year for hormonal migraines, and it's working great for the headaches. I started out at 25mg twice a day and now I'm up to 100mg twice a day. I've lost 40lb (mostly due to the drug -- but my appetite is starting to come back) and have just recently started experiencing the anxiety and tingling in the extremities. I've always felt I've had trouble concentrating and "finding the word", but I attributed it to lack of sleep because I have two small children. My most recent side effect, however, is most worrisome, which is the reason for my visit to this website. I am experiencing severe abdominal pain, almost constant, and it seems to be increasing. I had abdominal pain and diarrhea when I first started Topamax last year, but it stopped after the first month or so. I'm just wondering if maybe long term use can cause ulcers or other stomach problems. Anyone have any experience with this? I know from experience that Topamax dosages have to gradually weaned up and down, so I'm considering decreasing my dosage to see if my stomach problems will stop. I'm just in so much pain, yet my migraines have almost stopped now with 200mg a day, that I'm reluctant to change my dose.

I love topamax.
I've been taking topamax for depression for 5 months. I started on 25 mgs a day, than worked my way up to 25 in the am and 25 in the pm, and now my doctor is moving me up to 50 in the am and 50 in the pm. I'm 31 years old, and have tried antidepressants since I was 17. I've struggled with depression since I was a kid. Antidepressants always made my depression worse, and caused me to get brain shivers because I don't tolerate serotonin drugs well. Antipsychotics for depression cause me to want to kill myself. Topamax was the only relief I have ever found.
The biggest side effect is sometimes I feel high or stoned like I smoked pot, especially if I am tired from not eating or pushing myself too hard. Most people don't get this, I just have a very strange brain chemistry.
Topamax works in the temporal lobe of your brain and can cause serious cognitive side effects if you do not already have damage in that part of your brain. That's why some people love it and some people hate it.
Weight loss isn't something I have experienced either, which sucks because I am overweight. I actually gained 10 pounds since being on topamax and I love carbonated beverages. But I am also the kind of person that quits smoking and loses 20 pounds, so I don't know if that will be true for you. I've also been way more thirsty since starting topamax, and my feet do fall asleep easier. But circulation improves if I practice a little yoga every day.
Don't be scared of this medication. It could really save your life.

I am taking Topomax for migraines. I always start everything at a really LOW dose since I have a lot of probs with side effects. Started at 15 mg and went right away to 30mg (15mg twice daily) the second week because I was dying from headaches. The other antidepressants prescribed for constant daily headache prevention all of a sudden weren't working. I didn't want to take my abortive med for migraines every day (Amerge) so I was curious if Topomax might help my daily headache pain. Possibly my daily headaches had become migraines... so hard to tell one from the other anymore. I teach exercise for a living and so much of my headache pain is exercise induced. I found that while on topomax, all of a sudden 2 Advil would take away a headache I would get after exercising which never happened before. I would take two Advil before doing some of my hardest exercise to prevent a headache and for the most part that worked too... and that never worked before. I had tried all kinds of NSAID's before and after exercise at the advice of my neurologist to no avail. I did have one diffuse headache yesterday that might have been a true migraine and I took Amerge because Advil didn't help. I have been on the 30 mg two week now. But, now the downside. Since on the 30mg I feel like my chest is heavy a lot of time when I do water exercise... I am exhausted a lot doing my usual routines... I feel edgy, can't sleep well at night. I HAVE to have a two hour nap after teaching in the morning or I can't function mentally or physically. I sleep well for that nap time. Seems like I have thermoregulation problems. I teach water exercise and if the water is a little cold it bothers me and it never used to. Then in the pool awhile I feel hot. Same when I sleep.. I need a lot of covers, then I throw them off. Then they are on again. No I am not menopausal yet. My brain is hazy on topomax as well. I take bellydance lessons and sometimes I realize I can't remember what my teacher just told me. Now people reading this, don't think that just because this happens to me, it will happen to you. I know people who LOVE topomax with zero side effects. They don't tend to write in to posting boards. Also, sometimes side effects go away. Be patient if you want to give topomax a shot. I am thinking I am going to go back to 15 mg again... and see how I tolerate that. Because I teach exercise, the hardest thing is to feel the heaviness in the chest and the lack of ambition. This is not me. It is great not to have the headache pain, but I don't know if this is the drug for me. I was excited about the "losing weight " side effect , and I could see how skinny people who lose their appetite easily might be affected, but it takes a lot to stop me from eating LOL darn! I did read in another chat some poor chap had sinisitis for months and took TONS of antibiotics before finding out Topomax gives sinisitis type side effects in a small amount of people. So if you get sinisitis, don't take antibiotics before checking out if topomax is the culprit.

My heart goes out to every person out there trying to find the magic bullet for their headache, siezures, whatever... ADVICE.. .start with SMALL doses... you may be able to get used to side effects if you work up slowly in ALL drugs. In many drugs that didn't come in small doses, I took out 3/4 of what was inside just to get a mini dose. Ask your doc if you can mix one capsule or one pounded up tab of your med with juice and store it in the referigerator. You can drink say 1/8 cup a day of the juice to get 1/8 of a capsule. It is a lot easier than chopping up a tab into eighths. Also ask your doc about childrens doses that come in liquids with droppers. Topomax makes taking smaller doses easy with the sprinkles.. you are encouraged to open the capsule and sprinkle as little as you want on food. Good luck all. L.