Toprol-XL and lexapro

I HAVE BEEN ON TOPROL-XL FOR 2 YEARS. 25 MG. IN AM AND BLOOD PRESSURE WOULD FLUCTUATE UP TO 170/116 AND GO BACK DOWN TO 140/85. THEN WAS ALSO PUT ON NORVASC 25MG. IN PM. I ALSO AM HYPOTHYROID WITH HASHIMOTOS. MY SIDE AFFECTS HAVE BEEN EXTREME. SWEATING, HAVE TO CARRY A PAPER TOWEL OR SCARF TO WIPE SWEAT OFF, SPACED OUT, TIRED, FORGETFULNESS, RACING HEART, LEGS ANKLES SWOLLEN, THEY FEEL SO HEAVY, WEIGHT GAIN, EYES WATER, NOSE WILL HAVE NASAL DRIP, CONSTIPATED, SORE NECK, HEADACHES, THE LIST GOES ON. THIS SUMMER I WENT TO THERAPY FOR MY NECK, HAD ECHO AND WORE 24 HR. HEART HALTER, WHICH I HAVE FOUR EXTRA BEATS, WENT TO ENDRICONE DOCTOR WHO RAN TESTS FOR EVERYTHING, 24 HR. URINE, TESTS CAME BACK WITH TSH HIGH, EVERYTHING ELSE WAS NORMAL BUT FOR MY HEART EXTRA BEATS ENDR. AND FAMILY DOCTOR TOOK ME OFF NORVASC AND PUT ME ON TOPROL-XL 25MG IN PM ALSO AM. WELL FEELING LIKE I WAS READY TO GIVE IT ALL UP, LIKE I WAS DYING, I QUIT TAKING IT LAST NIGHT AND HAVE THOUGHT ABOUT THIS ALL YEAR, TRYING PEPTACE AND CELERY SEED EXTRACT. I FELT SO BAD THAT I KNOW IT COULD BE DANGEROUS TO QUIT THE TOPROL-XL LIKE THAT BUT I FELT LIKE MY HEART WAS GONNA BURST AND IT WAS GANNA TAKE ME OUT ANYWAY, AND DOCS. WOULDN'T LISTEN AND I HAVE BEEN IN TO THEM A LOT WITH ALL MY ISSUES. I AM 56 AND HAVE ALWAYS BEEN ACTIVE, OUTDOORS TYPE PERSON. I WALK 2 MILES ON TREADMILL EVERYDAY AND 30 MIN. OF TAE-BO EXERCISE. I WORK 5 DAYS A WEEK AND HAVE LOTS TO DO AT HOME. THEY TRIED TO PUT ME ON CYMBALTA, LEXAPRO, ELIVOIR FOR THEY SAID WHEN YOU FEEL THAT BAD YOU CAN GET DEPRESSED, I TOLD THEM NO, I AM NOT ADDING ANY MEDS. KNOWING I WOULD GET WORSE. PEOPLE AT WORK, MY FAMILY WILL SAY YOU DON'T LOOK LIKE YOU FEEL GOOD OR IS SOMETHING WRONG, HOW COMPLICATED IT WOULD BE TO EXPLAIN. SO I AM LISTENING TO MY BODY CAUSE FEELING THAT BAD ISN'T RIGHT SO I HOPE THIS WORKS. I COULN'T FEEL ANY WORSE ANYWAY. SO GOOD LUCK TO YOU ALL AND ALL OF US ARE UNIQUE TO FIND WHAT MIGHT WORK FOR US, AND MOST THOSE PRESCRIPTIONS ARE FOR ONE THING AND THEN TRIGGER OFF OTHER THINGS THEN YOU GOTTA TAKE ANOTHER MED. FOR THAT. I AM GLAD TO FIND THIS SITE.

My doctor took me off metopolol (genericToprol), and my last dosage was a week ago. I suffered weight gain, tiredness, and muscle fatigue during my 18 months on the drug.

I have 2 questions - how long will the drug remain in my system, and has anyone who experienced weight gain while on Toprol or the generic, lost any weight after stopping it?

Thanks, Tony

55 year old female
I have been on Toprol 5 years. 50mg. it works for me but since it went generic,I wonder...I am on 10mg lexapro and December started the vivelle-dot for my hotflashes. It is now June and the last 4 weeks my hair is falling out big time.
It is so thin I have to wear a scarf as not to scare small children at work.!! :)
I have talked to a couple of hairdressers and they have told me many of they're clients with thinning hair were on Toprol.
Anyone heard of this? Please help me figure this out.

I have taken toprol for seven years. I never had any bad side effects and it controlled my blood pressure most of the time. However, I suffer from anxiety and depression and was recently put on Lexapro. My heart rate dropped into the 40's and I was exhausted all the time. Turns out Lexapro interacts with Toprol in that the drug (Toprol) does not break down in your system and keeps building up! Because the Lexapro was helping my anxiety I decided to lower the Toprol dosage. Down to 12.5 mg and still extremely low heart rate and fatigue. Decided to go off the Toprol and monitor my blood pressure, which has been amazingly good so far. Went off completely six days ago and it has been rough. Anxiety, insomnia, pounding heart, heart palpitations. This stuff is a real B*tch to get off from. Have talked to both the pharmacist and my doctor and both said to NOT start taking it again. There are plenty of newer medications out there. I also experienced weight gain when I first started taking it...I think because it slows your metabolism down. So now I am on xanax to counteract the Toprol until the Lexapro kicks in more. It it isn't one thing, it's another.

Update on my experience. I was changed from toprol,because of side effects, to a channel blocker, however, I did not tolerate the channel blocker. I had extreme fatigue and memory loss. Spent two days in bed and actually forgot to turn off my car when I returned home one day. My doctor took me off the channel blocker and wanted me to resume the toprol. I had been off the toprol for a week and a half so I ask to stay off until I can schedule my next appointment with him. He agreed as long as my papitations don't increase. They have not increased so I am hoping I can stay off this drug. Thinking of trying lexapro just to help my anxiety through this time.

I have been on Toprol XL for over 2 years and I can't believe what I am reading on this website. I am so glad that I googled. I have had many of the same problems and I am taking 100 mgs once a day. I cannot lose wait, my memory is horrible, I am always tired, I even had the itching thing go on, my joints ache some thing fierce, so bad that I went to a joint specialsit to have them checked because I thought that I may be getting arthritis at 37. I suffer from both depression and anxiety and was given this medication called Lexapro and had a panic attack in the middle of the night so that was the end of that. I have also had the sleeplessness and the sleeping too much and most importantly the edema of the hands, ankles and feet. I can't wear shoes that are too flat because they swell, I can't wear shoes that are too high because they swell, I can't eat salt because they swell, I can't stay out in the heat or humidity for too long cause they swell, I am so tired of swelling I want to scream. I also get very bad leg cramps and leg pain when I walk too far, also my menstural cycle is crazy. I bleed so much (sorry guys) that I have to buy new at least 2-3 new pairs of jeans a month because of "damage". I get overly fatigued and everything because fo blood loss. I am so tired of this it is not funny, but I like the fact that it is time released and is somewhat gentle. I am going to speak to my doc next week about changing though because I thought that I was in a very small group that was having these issues, even down to the inability to lose weight.

I have been on this med for 8 yrs and trying to get off it. It is a horrible drug. i take it because i had a kidney transplant that messed up my blood preasure. I had all the syptoms of anxiety because this med and now taken lexpro to balance out the anxiety. im glad i came across the page cause i take so many meds for my transplant and on top of the blood preasure and now anxiety meds its taken a tole on my liver. so i will definitley talk to my doctor about getting me off the lexapro and trying a different blood preasure med. I also gained alot of weight but it might because of all the meds i take. i went from 170-263lb in 8 yrs