Wellbutrin and benadryl

I began taking Wellbutrin 2 weeks ago and started on a 150mg dosage. I was on 150mg for one week. The second week, I went up to 300mg per the psychiatrist's instructions. I was feeling really angry some of the time and decided to stop the medication. Prior to the last 2 weeks I was taking 40mg of Paxil, which I stopped after the first week of being on Wellbutrin.
The anger was uncomfortable, I stopped taking the Wellbutrin and within 36-48 hours of being off this drug, my feet began to itch mildly at first. Within about 30 minutes of this "mild" itching, the sensations got worse. My feet felt like they were on fire. The only relief was putting them in hot water in the tub. I was screaming with frustration and pain. I attributed this to the cold turkey stopping of wellbutrin. But since I had been on it only 2 weeks, I didn't think anything would happen. Big mistake. After 2 hours of having feet in tub, on the phone with a 24-hour nurse advice line and pharmacist, I went ahead and took 300 mg. The itching stopped within 2 hours. This was a freaking nightmare ! So I am weaning myself off. The doctor who prescribed this, who I spoke with the following day, said...well..stop taking it. Doesn't make sense because when I stopped that's when the extreme itching happened. It's crazy. I'm weaning myself off and taking Benadryl. I also got some hydrocortisone cream. There are scabs on the top of my foot from scratching. No more. I've been on anti-depressants for over 10 years now and I want to stop ALL OF THEM. Within 2 weeks, I should be "clean". Just know that this itching...was so intense I was crying and screaming because there was no relief.

I AM SO RELIEVED TO HEAR ALL OF THIS. MY LIFE HAS BEEN TURNED UPSIDE DOWN AND SHAKEN UP SO BAD FROM THESE HORRIBLE HIVES. TOOK WELLBUTRIN XL 150MG FOR 2 WEEKS AND THEN WENT UP TO 300MG ABOUT 1 WEEK LATER NOW THIS! I AM SO MISERABLE. MY ARMS HURT, MY HEAD FEELS LIKE I HAVE BUGS ALL OVER IT, AND THE HIVES ARE EVERYWHERE. THINGS THAT ARE HELPING ME COPE- AVEENO OATMEAL BATH IN LUKE WARM WATER (NOT HOT!) BENADRYL CAPSULES, AND BENADRYL CREME. I HAVE BEEN TO THE DOCTOR TWICE AND WAS AT THE ER LAST NIGHT DUE TO TIGHT CHEST AND THROAT. WAS TOLD I HAD HIVES INSIDE ON MY ASSOPHAGIS (spelling? lol) ALSO. SO SCARY. I AM PRAYING THEY GO AWAY SOON.

This is the 3rd time I have been on Wellbutrin. Once in 1999, then in 2004, and just started taking it again 3 months ago. The first two times I took it I had joint pain and a lot of muscle inflammation. This go around is different... Just recently, within the past few weeks, I started breaking out with hives, after taking it with no problems for three months! Started on my head and progressively got worse. I break out all over my body, head, legs, back, hands, etc. For some reason it seems to happen more frequently when I lay down in my bed to go to sleep (weird!) One other scary side affect is, I frequently stop breathing when I start to fall asleep, and wake up gasping for air. Has anyone else experienced this?
Since I had never experienced problems with hives the first few times I was on Wellbutrin, I didn't think it was the medication causing the hives. So, I cut my dose in half (50mg/day). The hives didn't go away, so I stopped taking it all together 3 days ago, but still continue to get hives. Does anyone know how long it takes to get it out of your system?

i have been taking wellbutrin for almost 3 months to quit smoking (300mg/daily). BE VERY CAREFUL with antihistamines-i took one not long after i started the wellbutrin & felt that horrible seizure-ish feeling coming on, paranoia, racing thoughts & found out from another doc that they are not supposed to be mixed. which sucks for me, because i have suddenly become allergic to dogs & can't take any benadryl-my allergist says there is nothing that she can do until i can take it.

i asked about weaning off it (this med has me scared s*less now). i took it every other day for about 2 weeks. i haven't had it in about 4 days & i feel ok, a little psycho at times, but nothing out of the ordinary lol (i haven't been on it long at all, so i don't know if someone who's been on it for years should get off it the way i am). i just want it out of my system so i can get some relief from my allergies!!!

Hello.

I am 26 years old with no health issues at all. Wanted to quit smoking, Dr. prescribed me bupropion/Wellbutron SR 150 mg.
I was instructed to take 1 pill a day for 2 weeks. After 2 weeks I set my quit date and then take 2 pills a day. (300mg)
For the first 2 weeks...I really didnt feel like myself. Felt like I can snap at one moment and then calm the next moment. ok, not such a big deal.

During week 3 I quit smoking and increased the dosage to 2 pills a day as instructed. I quit on Saturday, July 16th 2006. On Tuesday i started off with my regionals itching like crazy! I wasnt sure why this was happeneing so i put some anti itch cream and helped some what. I would just keep breaking out with the same bad itch anyway. Then...Wednesday, July 19th I woke up 2:00 AM with real bad chest pains and I was itching all over the place. From my head, neck, arms to my back and front of my body and basically had rashes all over the place.
They would disappear from one spot and appear in a different spot. I then started researching all over the internet about te side effects and I did find a ton of people expereincing the same things. From 2 AM i couldnt go back to sleep because of the pain in my chest and the HORRIBLE ITCHING and rashes.
I went ot the ER around 10:00 AM and stood there till about 5:30 PM. When I was in the ER i started breaking out even worse. My right eye was closing shut and my right hand became so itchy and swollen it looked like i broke my hand.
They quickly gave me a shot of Benadryl and some steroid with it and after about 30-60 minutes... the swelling started going away. They didnt find any realtionship from the Wellbutrin and my chest pain and the itchingness which i didnt understand.

Anyway, i still have some rashes breaking out...I have been using Benadryl which will control it a little bit but then I switched over to Claritin because i couldnt stand feeling like a walking Zombie from the Benadryl.

I am still researching and waiting for my Dr to come back to figure out how I can get rid of the itchy rash breakouts. I also feel just mild pain in my chest about once or twice a day for about 10 minutes.

If anyone knows anything that can help me...I would appreciate it.

thanks.

I am having the same side effect as Guest, #11307 who asked about the brand vs. generic. (Wellbutrin sr vs. bupropion sr). I was perscribed 150 mg XL and was filled with generic bupropion SR 150. This is my first time taking it so I don't know if the branded one would be different.

I've been taking it for about a month and last week began to have itchy areas on the palms of my hands, my upper back and arms. Oral benadryl was providing relief. However in the last three days I've been suffering actual hives and welts, so I'm going to go off of it until I can talk to my doctor.

I have bi-polar II with ADD and have been on Lamictal and a small dose of Celexa for over a year. Depression got better but not the ADD so he added WB for that. I tried Straterra but it made me feel really wierd.

Other than the hives, I haven't noticed any other side effects from adding WB. I'd really like to find something that can help me with ADD.

Is this an allergic reaction?

Took wellbutrin for about 1 year w/no side effects at all. Had
mild depression. Dr. took me off to see how I was. Symptoms
returned so he put me back on 150mg 2 times a day. Today
I had an allergic reaction with hives on my arms, hands, and
stomach. Also had some swelling of the lips. My husband took
me to the ER. Dr. said stop the wellbutrin and put me on
prednisone and benadryl for 5 days. Won't take it again. Had good luck with it, but must have became hypersensitive to it.
Hope to return to zoloft. It worked fine