Zyrtec and loratidine

I started taking zyrtec a few days ago for seasonal allergies. I had tried the claritin (loratidine) before and it didn't seem to really help me much. I was avoiding the zyrtec because I knew it could potentially make me drowsy and I didn't want to be tired if I was working. I'm a pharmacist so I decicded to try it knowing the potential side effects. It works really well for me - but I started having really vivid strange - and disturbing - dreams. It has only been a week and they havent been too bad so far - but I am going to monitor it and if they get worse I will stop and try something else. The reason this is so strange is I don't normally dream much at all. I maybe remember bits and pieces of a dream - these are wierd and strange and make absolutely no sense. These dreams seem so real and are so clear - I can remember every detail of what was done and said.

I am a 37 year old female ~185lbs already under treatment for clinical depression with two medications. I used to take Alavert (loratidine) for seasonal allergies but found it had "stopped working" well for me. Since Zyrtec (certirizine) went over-the-counter, I decided to try it.

I took it sporadically at 10mg daily for a period of 2-3 weeks, and then, during a particularly bad allergic exacerbation, began to take it consistently at 10mg daily. My depression, which was previous well-controlled on medication, worsened to the point of severity. Extreme despair, emotional detachment, and loss of interest in pleasurable activities--well, in ANY activity beyond sleep.

I am a pharmacist, and on a whim, I decided to do some research into interactions with my other medications, and found several anecdotal reports of depression onset and worsening in Zyrtec users. This particular side effect of Zyrtec was unknown to me, nor have I received any educational materials or reports in my trade literature listing depression as a possible adverse effect.

I have discontinued the medication in both myself and my three year old daughter (5mg daily). I can already see a difference in her disposition, and I am starting to crawl out of my pit of gloom. I'm using Alavert again, as I never had one issue with it, and I'm supplementing with Benadryl (diphenhydramine) at night as needed for exacerbations.

I have no such symptoms with Zyrtec-as a matter of fact it is about the only antihistamine that works for me. I have been back on it for about three months and the only reason I was off it for a while was because the VA did not have it in their formulary so I was put on Loratidine which did not help me much for my allergies.