Singulair Gene Cloning, Gene Researchers, Genetic Variation, Receptor Gene, Pharmaceutical Research

Posted over a year ago

I was put on Singulair about three weeks ago, and noticed immediately that my mood had changed. I am an adult ,and felt this sense of sadness, anxiety, solitude, not wanting to be around anyone. I took myself off the drug and have tics all over my body and eyelids ,which is driving me crazy! I even had heart palpitations ,which are very distressing. Today it seems to be better, and this is day three off the med. The only way I can explain how I felt on this drug is doom and gloom.

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Marsteller6pack - that is the same way that Singulair effected me... did you take the Singulair for allergies or asthma? did you have any other medical conditions (ADD/ADHD, depression, PMS,etc)? reason i'm asking is because i truly believe that the singulair cloned gene cyslt1(DNA) is what's creating all of these adverse reactions and i'm trying to find some sort of 'link' so that i can at least narrow down where/why or what chrom it's affecting to make our bodies react this way. thank you! I'm so glad that you got off of the medicine--i've researched side effects and read that for every day you're on a medication, to give it 2 days to totally subside--so 3 weeks would be 42 days/6 weeks.

Posted over a year ago - Reply

Concernedcitizen - It is possible that genetic variation is the cause of different adverse side effects that do not effect everyone. The bottom line is that Singulair was developed on the basis of a very specific gene model. Gene cloning when it refers to pharmaceutical research means that research identified the gene and were able to duplicate it so that they could study it. Gene researchers have identified several different variants of the cysLT receptor gene. It just means that it is possible for certain people to be incompatible with Singulair. I did look at the ways that certain researchers thought that Singulair was able to bind with the cysLT receptor. I have some theories of what happens with arginine occurs at different locations other than in the gene model. They are nothing but mere hypothesis or speculation. Nobody studies Singulair to try to determine what is wrong. It would be possible to do so but Merck wouldn't spend money on that.

Posted over a year ago - Reply

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